Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Chek1 (checkpoint kinase 1) Mus musculus
Symbol: Chek1
Name: checkpoint kinase 1
Description: Exhibits histone kinase activity (H3-T11 specific). Involved in several processes, including inner cell mass cell proliferation; negative regulation of cell cycle; and regulation of transcription, DNA-templated. Localizes to the chromatin; nucleus; and replication fork. Predicted to colocalize with the chromosome, telomeric region. Human ortholog(s) of this gene implicated in pancreatic cancer. Is expressed in several structures, including adrenal medulla; early conceptus; gonad; gut gland; and trunk mesenchyme derived from neural crest. Orthologous to human CHEK1 (checkpoint kinase 1); PARTICIPATES IN G2/M DNA damage checkpoint pathway; p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (+)-schisandrin B; 1,1-dichloroethene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C85740; checkpoint kinase 1 homolog; checkpoint kinase-1; Chk1; CHK1 checkpoint homolog; rad27; rad27 homolog; serine/threonine-protein kinase Chk1
Homo sapiens (human) : CHEK1 (checkpoint kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Chek1 (checkpoint kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chek1 (checkpoint kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CHEK1 (checkpoint kinase 1)
Canis lupus familiaris (dog) : CHEK1 (checkpoint kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chek1 (checkpoint kinase 1)
Sus scrofa (pig) : CHEK1 (checkpoint kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38936,708,482 - 36,726,658 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37936,516,067 - 36,534,243 (-)NCBIGRCm37mm9NCBIm37
MGSCv36936,458,153 - 36,476,298 (-)NCBImm8
Celera933,911,337 - 33,929,618 (-)NCBICelera
Cytogenetic Map9 A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Chek1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732293
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.