Chek1 (checkpoint kinase 1) - Rat Genome Database
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Gene: Chek1 (checkpoint kinase 1) Mus musculus
Analyze
Symbol: Chek1
Name: checkpoint kinase 1
RGD ID: 732293
MGI Page MGI
Description: Exhibits histone kinase activity (H3-T11 specific). Involved in several processes, including cell cycle checkpoint; inner cell mass cell proliferation; and regulation of transcription, DNA-templated. Localizes to chromatin; nucleus; and replication fork. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including adrenal medulla; early conceptus; gonad; gut gland; and trunk mesenchyme derived from neural crest. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1); PARTICIPATES IN G2/M DNA damage checkpoint pathway; p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (+)-schisandrin B; 1,1-dichloroethene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C85740; checkpoint kinase 1 homolog; checkpoint kinase-1; Chk1; CHK1 checkpoint homolog; rad27; rad27 homolog; serine/threonine-protein kinase Chk1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39936,619,778 - 36,637,954 (-)NCBIGRCm39mm39
GRCm39 Ensembl936,619,778 - 36,638,361 (-)Ensembl
GRCm38936,708,482 - 36,726,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl936,708,482 - 36,727,065 (-)EnsemblGRCm38mm10GRCm38
MGSCv37936,516,067 - 36,534,243 (-)NCBIGRCm37mm9NCBIm37
MGSCv36936,458,153 - 36,476,298 (-)NCBImm8
Celera933,911,337 - 33,929,618 (-)NCBICelera
Cytogenetic Map9A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methyladenine  (ISO)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
anthocyanin  (ISO)
anthracene-1,8,9-triol  (EXP)
aphidicolin  (EXP)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
atrazine  (ISO)
auraptene  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
berberine  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
Brevetoxin B  (ISO)
busulfan  (ISO)
cadmium atom  (ISO)
caffeine  (EXP,ISO)
camptothecin  (EXP,ISO)
carbamazepine  (ISO)
carmustine  (ISO)
catechol  (EXP)
cefaloridine  (ISO)
chlorpyrifos  (EXP)
cholic acid  (EXP)
choline  (EXP,ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clofarabine  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diepoxybutane  (EXP)
diethyl sulfate  (ISO)
digitoxin  (ISO)
dioscin  (ISO)
doxorubicin  (EXP,ISO)
Enterolactone  (ISO)
equol  (ISO)
Estragole  (ISO)
etoposide  (ISO)
fenofibrate  (ISO)
fisetin  (ISO)
flavonoids  (ISO)
floxuridine  (ISO)
flumequine  (EXP)
folic acid  (EXP,ISO)
furan  (EXP,ISO)
furosemide  (ISO)
genistein  (ISO)
geraniol  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (EXP,ISO)
indole-3-methanol  (ISO)
irinotecan  (ISO)
iron dichloride  (EXP)
iron trichloride  (EXP)
isoflurane  (ISO)
kaempferol  (EXP)
L-methionine  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
lovastatin  (ISO)
MeIQx  (EXP)
melphalan  (ISO)
menadione  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methyl isocyanate  (EXP)
methylmercury chloride  (EXP)
Mezerein  (EXP)
mifepristone  (EXP)
mitomycin C  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nimustine  (ISO)
nocodazole  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
octamethylcyclotetrasiloxane  (ISO)
olaparib  (ISO)
oxaliplatin  (ISO)
oxfendazole  (ISO)
ozone  (EXP)
p-anisidine  (EXP)
paclitaxel  (EXP,ISO)
paracetamol  (EXP)
paraquat  (EXP)
PF-00477736  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP)
platinum  (ISO)
platinum(0)  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
promethazine  (ISO)
propiconazole  (EXP)
Ptaquiloside  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
saccharin  (EXP)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
sodium nitrite  (EXP)
stavudine  (EXP)
sterigmatocystin  (ISO)
styrene oxide  (EXP)
succimer  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (ISO)
tungsten  (EXP)
usnic acid  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
versicolorin A  (ISO)
wortmannin  (ISO)
Xanthatin  (ISO)
zidovudine  (ISO)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9278511   PMID:9382850   PMID:10349636   PMID:10761933   PMID:10859164   PMID:10922068   PMID:10987268   PMID:11042159   PMID:11076861   PMID:11790307   PMID:12477932   PMID:12529385  
PMID:12676962   PMID:12904583   PMID:14610273   PMID:14759516   PMID:15261141   PMID:15282163   PMID:15364958   PMID:15389587   PMID:15489334   PMID:15632067   PMID:15674326   PMID:15710331  
PMID:15761153   PMID:15970699   PMID:16002346   PMID:16138010   PMID:16141072   PMID:16141073   PMID:16159883   PMID:16360315   PMID:16675955   PMID:16928871   PMID:17102615   PMID:17242188  
PMID:17290223   PMID:17290426   PMID:17360434   PMID:17967808   PMID:18086870   PMID:18243098   PMID:18424430   PMID:18616928   PMID:18799693   PMID:19129515   PMID:19169280   PMID:19289837  
PMID:19584159   PMID:19805627   PMID:20052416   PMID:20360068   PMID:20473325   PMID:20682638   PMID:20834228   PMID:20887555   PMID:21212274   PMID:21267068   PMID:21425081   PMID:21502314  
PMID:21628425   PMID:21677750   PMID:21737879   PMID:21791608   PMID:21804609   PMID:21873635   PMID:21921034   PMID:21947081   PMID:22266795   PMID:22360967   PMID:22370720   PMID:22430210  
PMID:22448250   PMID:22508511   PMID:22516201   PMID:22522401   PMID:22544319   PMID:22556425   PMID:22560297   PMID:22665067   PMID:22935704   PMID:23418588   PMID:23557358   PMID:23912710  
PMID:24009519   PMID:24037525   PMID:24040138   PMID:24184701   PMID:24356582   PMID:25653093   PMID:25843717   PMID:25843721   PMID:26427872   PMID:26428007   PMID:26496610   PMID:26667770  
PMID:26887372   PMID:27694478   PMID:28276606   PMID:28349497   PMID:28928282   PMID:29167438   PMID:29329412   PMID:29360988   PMID:29378830   PMID:30733279   PMID:30894677   PMID:31379128  
PMID:32325033   PMID:32548123   PMID:32914523   PMID:33147210  


Genomics

Comparative Map Data
Chek1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39936,619,778 - 36,637,954 (-)NCBIGRCm39mm39
GRCm39 Ensembl936,619,778 - 36,638,361 (-)Ensembl
GRCm38936,708,482 - 36,726,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl936,708,482 - 36,727,065 (-)EnsemblGRCm38mm10GRCm38
MGSCv37936,516,067 - 36,534,243 (-)NCBIGRCm37mm9NCBIm37
MGSCv36936,458,153 - 36,476,298 (-)NCBImm8
Celera933,911,337 - 33,929,618 (-)NCBICelera
Cytogenetic Map9A4NCBI
CHEK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11125,625,665 - 125,676,255 (+)EnsemblGRCh38hg38GRCh38
GRCh3811125,624,910 - 125,676,255 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711125,495,031 - 125,546,150 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611125,001,547 - 125,030,847 (+)NCBINCBI36hg18NCBI36
Build 3411125,001,546 - 125,030,847NCBI
Celera11122,655,346 - 122,706,400 (+)NCBI
Cytogenetic Map11q24.2NCBI
HuRef11121,436,397 - 121,487,529 (+)NCBIHuRef
CHM1_111125,381,155 - 125,432,283 (+)NCBICHM1_1
Chek1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2836,420,565 - 36,443,477 (-)NCBI
Rnor_6.0 Ensembl839,181,163 - 39,243,882 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0839,181,162 - 39,201,588 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0839,184,020 - 39,204,446 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4837,954,322 - 37,974,748 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1837,963,088 - 37,983,514 (-)NCBI
Celera838,000,251 - 38,020,582 (+)NCBICelera
Cytogenetic Map8q21NCBI
Chek1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541226,627,606 - 26,650,554 (+)NCBIChiLan1.0ChiLan1.0
CHEK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111124,359,218 - 124,410,385 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v011120,446,352 - 120,478,207 (+)NCBIMhudiblu_PPA_v0panPan3
CHEK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.158,878,511 - 8,910,626 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl58,879,147 - 8,907,669 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha58,923,479 - 8,955,720 (-)NCBI
ROS_Cfam_1.058,821,650 - 8,853,260 (-)NCBI
UMICH_Zoey_3.158,890,756 - 8,922,634 (-)NCBI
UNSW_CanFamBas_1.058,860,679 - 8,892,710 (-)NCBI
UU_Cfam_GSD_1.058,897,288 - 8,929,731 (-)NCBI
Chek1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947107,757,062 - 107,779,783 (+)NCBI
SpeTri2.0NW_0049367432,004,535 - 2,027,287 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHEK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl952,726,885 - 52,790,706 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1952,759,224 - 52,790,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2958,411,395 - 58,444,086 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHEK1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11116,768,141 - 116,809,557 (+)NCBI
ChlSab1.1 Ensembl1116,767,944 - 116,801,371 (+)Ensembl
Chek1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249271,609,404 - 1,643,409 (+)NCBI

Position Markers
RH127224  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38936,709,550 - 36,709,765UniSTSGRCm38
MGSCv37936,517,135 - 36,517,350UniSTSGRCm37
Celera933,912,395 - 33,912,610UniSTS
Cytogenetic Map9A5.3UniSTS
PMC316686P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38936,725,802 - 36,726,080UniSTSGRCm38
MGSCv37936,533,387 - 36,533,665UniSTSGRCm37
Celera933,928,762 - 33,929,040UniSTS
Cytogenetic Map9A5.3UniSTS
PMC316691P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38936,725,836 - 36,726,750UniSTSGRCm38
MGSCv37936,533,421 - 36,534,335UniSTSGRCm37
Celera933,928,796 - 33,929,710UniSTS
Cytogenetic Map9A5.3UniSTS
Chek1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38936,710,115 - 36,710,307UniSTSGRCm38
Celera933,912,960 - 33,913,152UniSTS
Cytogenetic Map9A5.3UniSTS
cM Map920.67UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756137395074Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9999947243999472Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91245867446458818Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91347987947479879Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91550045549500594Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91550045549500594Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91550045549500594Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91550045549500594Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91583833149838331Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91583833149838331Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91583833149838331Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91610000050100000Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91610000050100000Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91679834550798345Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91706754451067647Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined92003211054032229Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92024206654242196Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92039490154395074Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92039490154395074Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92039490154395074Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92039490154395074Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92094144454941444Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92500000069000000Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92567618959676285Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92567618959676285Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92567618959676285Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92567618959676285Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92688512460885255Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92688512460885255Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92688512460885255Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92733989761340026Mouse
1301000Obq5_mobesity QTL 5 (mouse)Not determined92859203741888030Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92938163163381774Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92938163163381774Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93014186664141979Mouse
1558949Igan3_mIgA nephropathy 3 (mouse)Not determined93050339840654618Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93082861764828723Mouse
4142455Elnv_mepilepsy naive (mouse)Not determined93136026237395074Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93252326366523557Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93254112166541246Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93259987266600121Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93297840266978536Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93319972567199840Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93406754473531973Mouse
1357682Phdlc1_mplasma HDL cholesterol 1 (mouse)Not determined93419332342853570Mouse
1300868Tlf_mT lymphocyte fraction (mouse)Not determined93492645237395074Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93512317869123299Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93512317869123299Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93512317869123299Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3295
Count of miRNA genes:788
Interacting mature miRNAs:1056
Transcripts:ENSMUST00000034625, ENSMUST00000172702, ENSMUST00000172742, ENSMUST00000173534, ENSMUST00000173796, ENSMUST00000173963, ENSMUST00000173977, ENSMUST00000174105, ENSMUST00000174794
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034625   ⟹   ENSMUSP00000034625
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl936,708,482 - 36,726,658 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172702   ⟹   ENSMUSP00000134388
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl936,708,482 - 36,726,374 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172742   ⟹   ENSMUSP00000133589
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl936,723,862 - 36,726,451 (-)Ensembl
RefSeq Acc Id: ENSMUST00000173796
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl936,722,649 - 36,727,065 (-)Ensembl
RefSeq Acc Id: ENSMUST00000173963   ⟹   ENSMUSP00000134029
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl936,710,157 - 36,725,863 (-)Ensembl
RefSeq Acc Id: ENSMUST00000173977
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl936,723,603 - 36,726,570 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174105
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl936,709,440 - 36,726,585 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174794
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl936,713,744 - 36,722,745 (-)Ensembl
RefSeq Acc Id: NM_007691   ⟹   NP_031717
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39936,619,778 - 36,637,954 (-)NCBI
GRCm38936,708,482 - 36,726,658 (-)ENTREZGENE
MGSCv37936,516,067 - 36,534,243 (-)RGD
Celera933,911,337 - 33,929,618 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017313117   ⟹   XP_017168606
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39936,619,935 - 36,637,175 (-)NCBI
GRCm38936,708,639 - 36,723,582 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031717   ⟸   NM_007691
- UniProtKB: O35280 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017168606   ⟸   XM_017313117
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000133589   ⟸   ENSMUST00000172742
RefSeq Acc Id: ENSMUSP00000134388   ⟸   ENSMUST00000172702
RefSeq Acc Id: ENSMUSP00000034625   ⟸   ENSMUST00000034625
RefSeq Acc Id: ENSMUSP00000134029   ⟸   ENSMUST00000173963
Protein Domains
Protein kinase

Promoters
RGD ID:6844324
Promoter ID:MM_KWN:56825
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_007691,   UC009OTV.1,   UC009OTX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36936,533,826 - 36,534,392 (-)MPROMDB
RGD ID:8669204
Promoter ID:EPDNEW_M12633
Type:multiple initiation site
Name:Chek1_1
Description:Mus musculus checkpoint kinase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38936,726,601 - 36,726,661EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1202065 AgrOrtholog
Ensembl Genes ENSMUSG00000032113 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034625 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000133589 UniProtKB/TrEMBL
  ENSMUSP00000134029 UniProtKB/TrEMBL
  ENSMUSP00000134388 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034625 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000172702 UniProtKB/Swiss-Prot
  ENSMUST00000172742 UniProtKB/TrEMBL
  ENSMUST00000173963 UniProtKB/TrEMBL
InterPro Chk1_catalytic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12649 UniProtKB/Swiss-Prot
MGD MGI:1202065 ENTREZGENE
NCBI Gene 12649 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CHEK1 RGD
PhenoGen Chek1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CHK1_MOUSE UniProtKB/Swiss-Prot
  G3UX84_MOUSE UniProtKB/TrEMBL
  G3UYC5_MOUSE UniProtKB/TrEMBL
  O35280 ENTREZGENE
  Q497T8_MOUSE UniProtKB/TrEMBL
UniProt Secondary O54925 UniProtKB/Swiss-Prot
  Q8CI40 UniProtKB/Swiss-Prot
  Q9D0N2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-14 Chek1  checkpoint kinase 1  Chek1  checkpoint kinase 1 homolog (S. pombe)  Symbol and/or name change 5135510 APPROVED