Uba5 (ubiquitin-like modifier activating enzyme 5) - Rat Genome Database
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Gene: Uba5 (ubiquitin-like modifier activating enzyme 5) Mus musculus
Analyze
Symbol: Uba5
Name: ubiquitin-like modifier activating enzyme 5
RGD ID: 1323297
MGI Page MGI
Description: Exhibits UFM1 activating enzyme activity. Involved in erythrocyte differentiation; megakaryocyte differentiation; and protein ufmylation. Predicted to localize to cytosol; endoplasmic reticulum membrane; and intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 24 and early infantile epileptic encephalopathy 44. Orthologous to human UBA5 (ubiquitin like modifier activating enzyme 5); INTERACTS WITH 1,2-dimethylhydrazine; 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5730525G14Rik; AW240750; Ube1dc1; ubiquitin-activating enzyme 5; ubiquitin-activating enzyme E1 domain-containing protein 1; ubiquitin-activating enzyme E1-domain containing 1; ubiquitin-like modifier-activating enzyme 5; UFM1-activating enzyme
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399103,923,786 - 103,940,767 (-)NCBIGRCm39mm39
GRCm389104,046,587 - 104,063,176 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9104,046,599 - 104,063,134 (-)EnsemblGRCm38mm10GRCm38
MGSCv379103,948,918 - 103,965,451 (-)NCBIGRCm37mm9NCBIm37
MGSCv369103,905,860 - 103,921,466 (-)NCBImm8
Celera9103,599,621 - 103,615,932 (-)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12819125   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:20018847   PMID:21304510   PMID:21677750  
PMID:21873635   PMID:23152784   PMID:25921334   PMID:26872069   PMID:28378742   PMID:30635284   PMID:32325033  


Genomics

Comparative Map Data
Uba5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399103,923,786 - 103,940,767 (-)NCBIGRCm39mm39
GRCm389104,046,587 - 104,063,176 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9104,046,599 - 104,063,134 (-)EnsemblGRCm38mm10GRCm38
MGSCv379103,948,918 - 103,965,451 (-)NCBIGRCm37mm9NCBIm37
MGSCv369103,905,860 - 103,921,466 (-)NCBImm8
Celera9103,599,621 - 103,615,932 (-)NCBICelera
Cytogenetic Map9F1NCBI
UBA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3132,654,446 - 132,678,097 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3132,654,446 - 132,679,794 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3132,654,446 - 132,678,498 (+)EnsemblGRCh38hg38GRCh38
GRCh383132,654,430 - 132,679,794 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373132,373,290 - 132,397,467 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363133,861,836 - 133,879,312 (+)NCBINCBI36hg18NCBI36
Celera3130,798,783 - 130,822,433 (+)NCBI
Cytogenetic Map3q22.1NCBI
HuRef3129,753,022 - 129,776,586 (+)NCBIHuRef
CHM1_13132,336,305 - 132,359,962 (+)NCBICHM1_1
Uba5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08112,578,607 - 112,594,192 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8112,578,590 - 112,594,261 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08111,967,198 - 111,981,855 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48109,109,592 - 109,124,197 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18109,129,046 - 109,143,652 (-)NCBI
Celera8104,030,471 - 104,045,054 (-)NCBICelera
Cytogenetic Map8q32NCBI
Uba5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555015,841,606 - 5,870,953 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555015,841,516 - 5,864,304 (-)NCBIChiLan1.0ChiLan1.0
UBA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13137,208,916 - 137,227,246 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3137,209,715 - 137,227,147 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03129,732,314 - 129,752,579 (+)NCBIMhudiblu_PPA_v0panPan3
UBA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2329,645,966 - 29,659,019 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12329,645,755 - 29,658,587 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Uba5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365295,997,459 - 6,010,776 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1373,822,920 - 73,868,375 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11373,831,485 - 73,859,781 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21381,403,623 - 81,539,888 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UBA5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11557,596,490 - 57,613,103 (-)NCBI
ChlSab1.1 Ensembl1557,592,728 - 57,612,928 (-)Ensembl
Uba5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247308,791,691 - 8,819,957 (+)NCBI

Position Markers
AW240750  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389104,047,291 - 104,047,423UniSTSGRCm38
MGSCv379103,949,621 - 103,949,753UniSTSGRCm37
Celera9103,600,320 - 103,600,452UniSTS
Cytogenetic Map9F1UniSTS
Whitehead/MRC_RH91069.72UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:729
Count of miRNA genes:499
Interacting mature miRNAs:590
Transcripts:ENSMUST00000035166, ENSMUST00000140768, ENSMUST00000144195, ENSMUST00000148273
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_025692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006511791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001778969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004935516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC138739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB726528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY768723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000035166   ⟹   ENSMUSP00000035166
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9104,046,599 - 104,063,134 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140768   ⟹   ENSMUSP00000118734
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9104,049,584 - 104,063,063 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144195   ⟹   ENSMUSP00000118535
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9104,047,650 - 104,062,998 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191568
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9104,049,835 - 104,060,462 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214222   ⟹   ENSMUSP00000149909
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9104,049,962 - 104,062,905 (-)Ensembl
RefSeq Acc Id: NM_025692   ⟹   NP_079968
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399103,923,787 - 103,940,320 (-)NCBI
GRCm389104,046,588 - 104,063,121 (-)NCBI
MGSCv379103,948,918 - 103,965,451 (-)RGD
Celera9103,599,621 - 103,615,932 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006511791   ⟹   XP_006511854
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399103,923,786 - 103,940,335 (-)NCBI
GRCm389104,046,587 - 104,063,119 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001778969
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399103,923,786 - 103,940,767 (-)NCBI
GRCm389104,046,587 - 104,063,176 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004935516
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399103,923,786 - 103,940,334 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_079968   ⟸   NM_025692
- UniProtKB: Q8VE47 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006511854   ⟸   XM_006511791
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000118535   ⟸   ENSMUST00000144195
RefSeq Acc Id: ENSMUSP00000035166   ⟸   ENSMUST00000035166
RefSeq Acc Id: ENSMUSP00000118734   ⟸   ENSMUST00000140768
RefSeq Acc Id: ENSMUSP00000149909   ⟸   ENSMUST00000214222
Protein Domains
ThiF

Promoters
RGD ID:6844063
Promoter ID:MM_KWN:58599
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000120854,   OTTMUST00000067872,   OTTMUST00000067873,   OTTMUST00000078584
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369103,965,316 - 103,966,112 (+)MPROMDB
RGD ID:8670654
Promoter ID:EPDNEW_M13358
Type:initiation region
Name:Uba5_1
Description:Mus musculus ubiquitin-like modifier activating enzyme 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389104,063,114 - 104,063,174EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913913 AgrOrtholog
Ensembl Genes ENSMUSG00000032557 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000035166 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000118535 UniProtKB/TrEMBL
  ENSMUSP00000118734 UniProtKB/TrEMBL
  ENSMUSP00000149909 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035166 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000140768 UniProtKB/TrEMBL
  ENSMUST00000144195 UniProtKB/TrEMBL
  ENSMUST00000214222 UniProtKB/TrEMBL
InterPro D-isomer_DH_CS1 UniProtKB/Swiss-Prot
  ThiF_NAD_FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-activating_enz UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66663 UniProtKB/Swiss-Prot
MGD MGI:1913913 ENTREZGENE
NCBI Gene 66663 ENTREZGENE
Pfam ThiF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Uba5 PhenoGen
Superfamily-SCOP SSF69572 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.224935 ENTREZGENE
  Mm.479441 ENTREZGENE
UniProt A0A1L1SSH6_MOUSE UniProtKB/TrEMBL
  D6RH76_MOUSE UniProtKB/TrEMBL
  F6VRI6_MOUSE UniProtKB/TrEMBL
  Q8VE47 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3TG27 UniProtKB/Swiss-Prot
  Q3U8X9 UniProtKB/Swiss-Prot
  Q3U9E7 UniProtKB/Swiss-Prot
  Q9CYD6 UniProtKB/Swiss-Prot