Gene: Uba5 (ubiquitin-like modifier activating enzyme 5) Mus musculus
Analyze
Symbol:
Uba5
Name:
ubiquitin-like modifier activating enzyme 5
Description:
ENCODES a protein that exhibits UFM1 activating enzyme activity; INVOLVED IN protein ufmylation; neuromuscular process (ortholog); protein K69-linked ufmylation (ortholog); ASSOCIATED WITH embryonic lethality during organogenesis, complete penetrance; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); early infantile epileptic encephalopathy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); intracellular membrane-bounded organelle (ortholog); INTERACTS WITH 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
5730525G14Rik; AW240750; Ube1dc1; ubiquitin-activating enzyme 5; ubiquitin-activating enzyme E1 domain-containing protein 1; ubiquitin-activating enzyme E1-domain containing 1; ubiquitin-like modifier-activating enzyme 5; UFM1-activating enzyme
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
UBA5 (ubiquitin like modifier activating enzyme 5) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Uba5 (ubiquitin-like modifier activating enzyme 5) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Uba5 (ubiquitin like modifier activating enzyme 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
UBA5 (ubiquitin like modifier activating enzyme 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
UBA5 (ubiquitin like modifier activating enzyme 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Uba5 (ubiquitin like modifier activating enzyme 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
UBA5 (ubiquitin like modifier activating enzyme 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Uba5 (ubiquitin-like modifier activating enzyme 5)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
UBA5 (ubiquitin like modifier activating enzyme 5)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
uba5 (ubiquitin-like modifier activating enzyme 5)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
Uba5
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
uba-5
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 104,046,587 - 104,063,176 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 103,948,918 - 103,965,451 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 103,905,860 - 103,921,466 (-) NCBI mm8 Celera 9 103,599,621 - 103,615,932 (-) NCBI Celera Cytogenetic Map 9 F1 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
early infantile epileptic encephalopathy ISO RGD:1323296 8554872 ClinVar Annotator: match by term: Early infantile epileptic encephalopathy ClinVar PMID:24033266 more ... early infantile epileptic encephalopathy 44 ISO RGD:1323296 8554872 ClinVar Annotator: match by term: Epileptic encephalopathy, early infantile, 44 ClinVar early infantile epileptic encephalopathy 44 ISO RGD:1323296 8554872 ClinVar Annotator: match by term: Epileptic encephalopathy, early infantile, 44 ClinVar PMID:24033266 more ... early infantile epileptic encephalopathy 44 ISO RGD:1323296 8554872 ClinVar Annotator: match by term: Epileptic encephalopathy, early infantile, 44 ClinVar PMID:25741868 early infantile epileptic encephalopathy 44 ISO RGD:1323296 8554872 ClinVar Annotator: match by term: Epileptic encephalopathy, early infantile, 44 ClinVar PMID:25741868 , PMID:27545674 early infantile epileptic encephalopathy 44 ISO RGD:1323296 8554872 ClinVar Annotator: match by OMIM:617132 ClinVar PMID:27545674 early infantile epileptic encephalopathy 44 ISO RGD:1323296 8554872 ClinVar Annotator: match by OMIM:617132 ClinVar PMID:27545681 Spinocerebellar Ataxia, Autosomal Recessive 24 ISO RGD:1323296 8554872 ClinVar Annotator: match by term: SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 24 ClinVar PMID:26872069
Imported Annotations - CTD
Chemical and Drug Induced Liver Injury ISO RGD:1323296 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26881866 cholestasis ISO RGD:1323296 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26881866 Spinocerebellar Ataxias ISO RGD:1323296 11554173 CTD Direct Evidence: marker/mechanism CTD
Imported Annotations - OMIM
early infantile epileptic encephalopathy 44 ISO RGD:1323296 7240710 OMIM Spinocerebellar Ataxia, Autosomal Recessive 24 ISO RGD:1323296 7240710 OMIM
(+)-schisandrin B multiple interactions ISO RGD:1311702 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of UBA5 mRNA] CTD PMID:31150632 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE increases expression ISO RGD:1311702 6480464 Topotecan results in increased expression of UBA5 mRNA CTD PMID:25729387 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactions ISO RGD:1311702 6480464 2 more ... CTD PMID:19414516 17beta-estradiol decreases expression ISO RGD:1311702 6480464 Estradiol results in decreased expression of UBA5 mRNA CTD PMID:20068009 1H-pyrazole increases expression EXP 6480464 pyrazole results in increased expression of UBA5 mRNA CTD PMID:17945193 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of UBA5 mRNA CTD PMID:21570461 2,4,6-trinitrotoluene affects expression ISO RGD:1311702 6480464 Trinitrotoluene affects the expression of UBA5 mRNA CTD PMID:21346803 3',5'-cyclic AMP multiple interactions ISO RGD:1311702 6480464 2 more ... CTD PMID:19414516 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of UBA5 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:1323296 6480464 Aflatoxin B1 results in decreased methylation of UBA5 gene CTD PMID:27153756 antirheumatic drug increases expression ISO RGD:1323296 6480464 Antirheumatic Agents results in increased expression of UBA5 mRNA CTD PMID:24449571 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of UBA5 mRNA CTD PMID:23650126 benzo[a]pyrene decreases expression ISO RGD:1311702 6480464 Benzo(a)pyrene results in decreased expression of UBA5 mRNA CTD PMID:21839799 bisphenol A multiple interactions ISO RGD:1311702 6480464 [bisphenol A co-treated with Genistein] results in increased methylation of UBA5 gene CTD PMID:28505145 bisphenol A decreases expression ISO RGD:1323296 6480464 bisphenol A results in decreased expression of UBA5 mRNA CTD PMID:29275510 bisphenol A increases expression ISO RGD:1311702 6480464 bisphenol A results in increased expression of UBA5 mRNA CTD PMID:25181051 C60 fullerene decreases expression ISO RGD:1311702 6480464 fullerene C60 results in decreased expression of UBA5 mRNA CTD PMID:19167457 chromium(6+) affects expression EXP 6480464 chromium hexavalent ion affects the expression of UBA5 mRNA CTD PMID:28472532 clofibrate multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of UBA5 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UBA5 mRNA] CTD PMID:17585979 clofibrate increases expression EXP 6480464 Clofibrate results in increased expression of UBA5 mRNA CTD PMID:17585979 copper(II) sulfate decreases expression ISO RGD:1323296 6480464 Copper Sulfate results in decreased expression of UBA5 mRNA CTD PMID:19549813 cyclosporin A increases expression ISO RGD:1323296 6480464 Cyclosporine results in increased expression of UBA5 mRNA CTD PMID:27989131 cyproconazole increases expression EXP 6480464 cyproconazole results in increased expression of UBA5 mRNA CTD PMID:22334560 dicrotophos decreases expression ISO RGD:1323296 6480464 dicrotophos results in decreased expression of UBA5 mRNA CTD PMID:28302478 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of UBA5 mRNA CTD PMID:17888722 endosulfan increases expression ISO RGD:1311702 6480464 Endosulfan results in increased expression of UBA5 mRNA CTD PMID:29391264 epoxiconazole increases expression EXP 6480464 epoxiconazole results in increased expression of UBA5 mRNA CTD PMID:22334560 fenofibrate decreases expression EXP 6480464 Fenofibrate results in decreased expression of UBA5 mRNA CTD PMID:21318169 flutamide increases expression ISO RGD:1311702 6480464 Flutamide results in increased expression of UBA5 mRNA CTD PMID:24136188 genistein multiple interactions ISO RGD:1311702 6480464 [bisphenol A co-treated with Genistein] results in increased methylation of UBA5 gene CTD PMID:28505145 glafenine increases expression ISO RGD:1311702 6480464 Glafenine results in increased expression of UBA5 mRNA CTD PMID:24136188 glycidol increases expression ISO RGD:1311702 6480464 glycidol results in increased expression of UBA5 mRNA CTD PMID:24915197 nickel atom decreases expression EXP 6480464 Nickel results in decreased expression of UBA5 mRNA CTD PMID:18922574 paracetamol multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of UBA5 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of UBA5 mRNA] CTD PMID:17585979 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of UBA5 mRNA CTD PMID:21318169 pirinixic acid multiple interactions EXP 6480464 PPARA protein affects the reaction [pirinixic acid results in decreased expression of UBA5 mRNA] CTD PMID:21318169 propiconazole increases expression EXP 6480464 propiconazole results in increased expression of UBA5 mRNA CTD PMID:21278054 , PMID:22334560 quercetin decreases expression ISO RGD:1323296 6480464 Quercetin results in decreased expression of UBA5 mRNA CTD PMID:21632981 tetrachloroethene decreases expression EXP 6480464 Tetrachloroethylene results in decreased expression of UBA5 mRNA CTD PMID:28973375 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of UBA5 mRNA CTD PMID:27339419 tetrachloromethane increases expression ISO RGD:1311702 6480464 Carbon Tetrachloride results in increased expression of UBA5 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions ISO RGD:1311702 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of UBA5 mRNA] CTD PMID:31150632 topotecan increases expression ISO RGD:1311702 6480464 Topotecan results in increased expression of UBA5 mRNA CTD PMID:25729387 tunicamycin increases expression EXP 6480464 Tunicamycin results in increased expression of UBA5 mRNA CTD PMID:17127020 valproic acid decreases methylation ISO RGD:1323296 6480464 Valproic Acid results in decreased methylation of UBA5 gene CTD PMID:29154799 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of UBA5 mRNA CTD PMID:17292431 valproic acid increases expression ISO RGD:1323296 6480464 Valproic Acid results in increased expression of UBA5 mRNA CTD PMID:23179753 , PMID:29154799 vinclozolin affects expression ISO RGD:1311702 6480464 vinclozolin affects the expression of UBA5 mRNA CTD PMID:19015723 vinclozolin decreases expression ISO RGD:1311702 6480464 vinclozolin results in decreased expression of UBA5 mRNA CTD PMID:23034163
Biological Process neuromuscular process ISO UniProtKB:Q9GZZ9 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein K69-linked ufmylation ISO UniProtKB:Q9GZZ9 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein modification by small protein conjugation IBA FB:FBgn0023143 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein modification by small protein conjugation IBA FB:FBgn0023143 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein ufmylation ISO UniProtKB:Q9GZZ9 2290270 (MGI:MGI:5478659, PMID:23152784) MGI GO_REF:0000096 more ... protein ufmylation IBA MGI:MGI:1913913 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein ufmylation IDA 2290270 (MGI:MGI:4441024, PMID:20018847) UniProtKB MGI:MGI:4441024 , PMID:20018847 regulation of intracellular estrogen receptor signaling pathway ISO UniProtKB:Q9GZZ9 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 response to endoplasmic reticulum stress ISO UniProtKB:Q9GZZ9 2290270 (MGI:MGI:5478659, PMID:23152784) MGI MGI:MGI:5478659 , PMID:23152784 Cellular Component cytoplasm IBA EcoGene:EG10154 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 cytoplasm ISS UniProtKB:Q9GZZ9 2290270 (MGI:MGI:5816407, PMID:26872069) UniProtKB MGI:MGI:5816407 , PMID:26872069 cytoplasm ISO UniProtKB:Q9GZZ9 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cytosol IBA PANTHER:PTN000102296 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 cytosol ISO UniProtKB:Q9GZZ9 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 Golgi apparatus IEA UniProtKB-KW:KW-0333 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 intracellular membrane-bounded organelle ISO UniProtKB:Q9GZZ9 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus IEA UniProtKB-KW:KW-0539 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Molecular Function ATP binding IEA UniProtKB-KW:KW-0067 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nucleotide binding IEA UniProtKB-KW:KW-0547 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 ubiquitin-like modifier activating enzyme activity IEA InterPro:IPR000594 , InterPro:IPR035985 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 UFM1 activating enzyme activity IMP 2290270 (MGI:MGI:4441024, PMID:20018847) MGI MGI:MGI:4441024 , PMID:20018847 UFM1 activating enzyme activity IBA MGI:MGI:1913913 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 UFM1 activating enzyme activity ISO UniProtKB:Q9GZZ9 2290270 MGI GO_REF:0000096, MGI:MGI:4834177
Gene-Chemical Interaction Annotations
