Ctla4 (cytotoxic T-lymphocyte-associated protein 4) - Rat Genome Database

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Gene: Ctla4 (cytotoxic T-lymphocyte-associated protein 4) Mus musculus
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Symbol: Ctla4
Name: cytotoxic T-lymphocyte-associated protein 4
RGD ID: 737466
MGI Page MGI
Description: Predicted to be involved in several processes, including antigen receptor-mediated signaling pathway; negative regulation of lymphocyte activation; and positive regulation of apoptotic process. Predicted to act upstream of or within adaptive immune response. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); hepatitis B; kidney disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human CTLA4 (cytotoxic T-lymphocyte associated protein 4).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Cd152; CD152 antigen; Ctla; Ctla-4; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte-associated antigen 4; Ly-5; Ly-56
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39160,948,184 - 60,954,991 (+)NCBIGRCm39mm39
GRCm39 Ensembl160,926,159 - 60,954,991 (+)Ensembl
GRCm38160,909,025 - 60,915,832 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl160,887,000 - 60,915,832 (+)EnsemblGRCm38mm10GRCm38
MGSCv37160,965,869 - 60,972,674 (+)NCBIGRCm37mm9NCBIm37
MGSCv36160,853,571 - 60,860,376 (+)NCBImm8
Celera161,424,040 - 61,430,841 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic rhinitis  (IDA)
alopecia areata  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (IMP,ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
asthma  (IDA,IEP,IMP,ISO)
atopic dermatitis  (ISO)
autoimmune hemolytic anemia  (ISO)
autoimmune hepatitis  (ISO)
Autoimmune Hypothyroidism  (ISO)
autoimmune lymphoproliferative syndrome type 2B  (ISO)
Autoimmune Lymphoproliferative Syndrome, Type V  (ISO)
autoimmune thyroiditis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
basal cell carcinoma  (ISO)
Behcet's disease  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
celiac disease  (ISO)
Chronic Bronchitis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Common Variable Immunodeficiency 1  (ISO)
contact dermatitis  (IMP)
Cryptogenic Cirrhosis  (ISO)
Diabetic Nephropathies  (ISO)
end stage renal disease  (ISO)
Enterocolitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveitis  (IMP,ISO)
Experimental Melanoma  (ISO)
genetic disease  (ISO)
Graft vs Host Disease  (IDA,ISO)
granulomatosis with polyangiitis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
hepatitis A  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
immunoglobulin alpha deficiency  (ISO)
Inflammation  (ISO)
iridocyclitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IMP,ISO)
latent autoimmune diabetes in adults  (ISO)
lung disease  (IMP)
lupus nephritis  (ISO)
Lymphadenopathy  (IMP)
Lymphatic Metastasis  (IMP)
malaria  (IMP,ISO)
melanoma  (ISO)
monoclonal gammopathy of uncertain significance  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
Neoplasm Metastasis  (IMP,ISO)
Neurodevelopmental Disorders  (ISO)
non-Hodgkin lymphoma  (ISO)
oral submucous fibrosis  (ISO)
peripheral nervous system disease  (ISO)
primary biliary cholangitis  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
primary immunodeficiency disease  (ISO)
primary pulmonary hypertension  (ISO)
Prostatic Neoplasms  (IMP)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
sarcoidosis  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Splenomegaly  (IMP)
squamous cell carcinoma  (ISO)
systemic lupus erythematosus  (IMP,ISO)
Transplant Rejection  (IMP,ISO)
tropical spastic paraparesis  (ISO)
type 1 diabetes mellitus  (ISO)
type 1 diabetes mellitus 12  (ISO)
urinary schistosomiasis  (ISO)
vitiligo  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lymph node cell ratio  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal splenocyte physiology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
abnormal thymus morphology  (IAGP)
autoimmune response  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased double-positive T cell number  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
enlarged heart  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
increased acute inflammation  (IAGP)
increased autoantibody level  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased double-negative T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased IgE level  (IAGP)
increased IgG level  (IAGP)
increased inflammatory response  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased length of allograft survival  (IAGP)
increased regulatory T cell number  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased T cell number  (IAGP)
increased T cell proliferation  (IAGP)
insulitis  (IAGP)
joint inflammation  (IAGP)
lung inflammation  (IAGP)
lymph node hyperplasia  (IAGP)
lymph node hypoplasia  (IAGP)
myocarditis  (IAGP)
no abnormal phenotype detected  (IAGP)
pancreas inflammation  (IAGP)
premature death  (IAGP)
salivary gland inflammation  (IAGP)
spleen hyperplasia  (IAGP)
stomach inflammation  (IAGP)
variable depigmentation  (IAGP)
vascular inflammation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Prevention of experimental autoimmune myocarditis by hydrodynamics-based naked plasmid DNA encoding CTLA4-Ig gene delivery. Abe S, etal., J Card Fail. 2005 Sep;11(7):557-64.
2. Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells. Abrams JR, etal., J Exp Med. 2000 Sep 4;192(5):681-94.
3. CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis. Agarwal K, etal., J Hepatol. 2000 Apr;32(4):538-41.
4. Genetic polymorphisms in CTLA4 and SLC4A2 are differentially associated with the pathogenesis of primary biliary cirrhosis in Japanese patients. Aiba Y, etal., J Gastroenterol. 2011 Oct;46(10):1203-12. doi: 10.1007/s00535-011-0417-7. Epub 2011 May 19.
5. Promoter region -318 C/ T and -1661 A/G CTLA-4 single nucleotide polymorphisms and type 1 diabetes in North Indians. Baniasadi V, etal., Tissue Antigens. 2006 May;67(5):383-9.
6. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. Beck KE, etal., J Clin Oncol. 2006 May 20;24(15):2283-9. doi: 10.1200/JCO.2005.04.5716.
7. Functional polymorphism in CTLA4 gene influences the response to therapy with inhaled corticosteroids in Slovenian children with atopic asthma. Berce V and Potocnik U, Biomarkers. 2010 Mar;15(2):158-66.
8. Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Beyer M, etal., Blood. 2005 Sep 15;106(6):2018-25. Epub 2005 May 24.
9. In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice. Blazar BR, etal., Blood. 1994 Jun 15;83(12):3815-25.
10. CTLA4 polymorphisms are associated with vitiligo, in patients with concomitant autoimmune diseases. Blomhoff A, etal., Pigment Cell Res. 2005 Feb;18(1):55-8.
11. Increased salivary gland tissue expression of Fas, Fas ligand, cytotoxic T lymphocyte-associated antigen 4, and programmed cell death 1 in primary Sjogren's syndrome. Bolstad AI, etal., Arthritis Rheum. 2003 Jan;48(1):174-85.
12. CTLA-4 promoter variants in patients with Graves' disease and Hashimoto's thyroiditis. Braun J, etal., Tissue Antigens. 1998 May;51(5):563-6.
13. CD28-b7 blockade in organ dysfunction secondary to cold ischemia/reperfusion injury. Chandraker A, etal., Kidney Int. 1997 Dec;52(6):1678-84.
14. Cytotoxic T lymphocyte antigen-4 gene polymorphisms and susceptibility to type 1 autoimmune hepatitis in the Tunisian population. Chaouali M, etal., Genes Dis. 2017 Dec 30;5(3):256-262. doi: 10.1016/j.gendis.2017.12.006. eCollection 2018 Sep.
15. Phenotypic Characteristics of PD-1 and CTLA-4 Expression in Symptomatic Acute Hepatitis A. Cho H, etal., Gut Liver. 2016 Mar;10(2):288-94. doi: 10.5009/gnl14368.
16. CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults. Cosentino A, etal., Ann N Y Acad Sci. 2002 Apr;958:337-40.
17. High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer. Cozar JM, etal., Hum Immunol. 2007 Aug;68(8):698-704. Epub 2007 Jun 6.
18. Prevention of renal damage in murine lupus nephritis by CTLA-4Ig and cyclophosphamide. Cunnane G, etal., Arthritis Rheum. 2004 May;50(5):1539-48.
19. Soluble CTLA-4 receptor an immunological marker of Graves' disease and severity of ophthalmopathy is associated with CTLA-4 Jo31 and CT60 gene polymorphisms. Daroszewski J, etal., Eur J Endocrinol. 2009 Nov;161(5):787-93. doi: 10.1530/EJE-09-0600. Epub 2009 Sep 4.
20. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Demaria S, etal., Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):728-34.
21. CTLA4-IgG reverses asthma manifestations in a mild but not in a more "severe" ongoing murine model. Deurloo DT, etal., Am J Respir Cell Mol Biol. 2001 Dec;25(6):751-60.
22. CD28/CTLA4 double deficient mice demonstrate crucial role for B7 co-stimulation in the induction of allergic lower airways disease. Deurloo DT, etal., Clin Exp Allergy. 2003 Sep;33(9):1297-304.
23. CTLA-4 gene polymorphism is associated with predisposition to coeliac disease. Djilali-Saiah I, etal., Gut 1998 Aug;43(2):187-9.
24. CD4+/CD25+ cells in systemic inflammation in COPD. Domagala-Kulawik J, etal., Scand J Immunol. 2011 Jan;73(1):59-65. doi: 10.1111/j.1365-3083.2010.02474.x.
25. Cytotoxic T-lymphocyte-associated antigen-4 single nucleotide polymorphisms and haplotypes in primary biliary cirrhosis. Donaldson P, etal., Clin Gastroenterol Hepatol. 2007 Jun;5(6):755-60. doi: 10.1016/j.cgh.2007.02.012. Epub 2007 May 7.
26. Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease. Donner H, etal., J Clin Endocrinol Metab 1997 Dec;82(12):4130-2.
27. Influence of CTLA4 haplotypes on susceptibility and some extraglandular manifestations in primary Sjogren's syndrome. Downie-Doyle S, etal., Arthritis Rheum. 2006 Aug;54(8):2434-40.
28. Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) in isolated vitiligo: a genotype-phenotype correlation. Dwivedi M, etal., Pigment Cell Melanoma Res. 2011 Aug;24(4):737-40. doi: 10.1111/j.1755-148X.2011.00892.x.
29. Circulating soluble CTLA4 (sCTLA4) is elevated in patients with breast cancer. Erfani N, etal., Cancer Invest. 2010 Oct;28(8):828-32. doi: 10.3109/07357901003630934.
30. Association of the T-cell regulatory gene CTLA4 with Graves' disease and autoimmune thyroid disease in the Japanese. Furugaki K, etal., J Hum Genet. 2004;49(3):166-8. Epub 2004 Feb 20.
31. Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model. Gallon L, etal., J Immunol. 1997 Nov 1;159(9):4212-6.
32. Polymorphisms in cytotoxic T lymphocyte associated antigen-4 influence the rate of acute rejection after renal transplantation in 167 Chinese recipients. Gao JW, etal., Transpl Immunol. 2012 Jun;26(4):207-11. doi: 10.1016/j.trim.2012.02.005. Epub 2012 Mar 6.
33. Coding sequence 1 and promoter single nucleotide polymorphisms in the CTLA-4 gene in Wegener's granulomatosis. Giscombe R, etal., J Rheumatol. 2002 May;29(5):950-3.
34. Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: no association in patients from Germany, Hungary and Poland. Greve B, etal., Mult Scler. 2008 Mar;14(2):153-8. Epub 2007 Oct 17.
35. Simultaneous blockade of co-stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation. Guo L, etal., Transpl Immunol. 2003 Oct-Nov;12(1):41-8.
36. The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency. Haimila K, etal., Genes Immun. 2009 Mar;10(2):151-61. doi: 10.1038/gene.2008.89. Epub 2008 Nov 20.
37. The common -318C/T polymorphism in the promoter region of CTLA4 gene is associated with reduced risk of ophthalmopathy in Chinese Graves' patients. Han SZ, etal., Int J Immunogenet. 2006 Aug;33(4):281-7.
38. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) exon 1 polymorphism affects lymphocyte profiles in bronchoalveolar lavage of patients with sarcoidosis. Handa T, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2003 Oct;20(3):190-6.
39. CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis. Harbo HF, etal., Tissue Antigens 1999 Jan;53(1):106-10.
40. No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies. Heward JM, etal., Clin Endocrinol (Oxf). 1998 Sep;49(3):331-4.
41. The development of Graves' disease and the CTLA-4 gene on chromosome 2q33. Heward JM, etal., J Clin Endocrinol Metab. 1999 Jul;84(7):2398-401.
42. Targeting of CD25 and glucocorticoid-induced TNF receptor family-related gene-expressing T cells differentially modulates asthma risk in offspring of asthmatic and normal mother mice. Hubeau C, etal., J Immunol. 2007 Feb 1;178(3):1477-87.
43. A pilot study on cytotoxic T lymphocyte-4 gene polymorphisms in urinary schistosomiasis. Idris ZM, etal., Genet Test Mol Biomarkers. 2012 Jun;16(6):488-92. doi: 10.1089/gtmb.2011.0209. Epub 2012 Jan 30.
44. The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan. Ikegami H, etal., J Clin Endocrinol Metab. 2006 Mar;91(3):1087-92. Epub 2005 Dec 13.
45. Distribution of CTLA-4 polymorphisms in allergic asthma. Jasek M, etal., Int Arch Allergy Immunol. 2006;141(3):223-9. Epub 2006 Aug 22.
46. Polymorphisms within the CTLA4 gene are associated with infant atopic dermatitis. Jones G, etal., Br J Dermatol. 2006 Mar;154(3):467-71.
47. CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis. Kamesh L, etal., Rheumatology (Oxford). 2009 Dec;48(12):1502-5. doi: 10.1093/rheumatology/kep280. Epub 2009 Oct 8.
48. The CTLA-4 gene polymorphisms are associated with CTLA-4 protein expression levels in multiple sclerosis patients and with susceptibility to disease. Karabon L, etal., Immunology. 2009 Sep;128(1 Suppl):e787-96. doi: 10.1111/j.1365-2567.2009.03083.x. Epub 2009 Feb 17.
49. Differences in the contribution of the CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patients. Kawasaki E, etal., Diabetes Care. 2008 Aug;31(8):1608-10. Epub 2008 Apr 28.
50. Effects of inhaled fluticasone propionate on CTLA-4-positive CD4+CD25+ cells in induced sputum in mild asthmatics. Kawayama T, etal., Respirology. 2008 Nov;13(7):1000-1007.
51. Polymorphisms of the CTLA4 gene and kidney transplant rejection in Korean patients. Kim HJ, etal., Transpl Immunol. 2010 Oct;24(1):40-4. doi: 10.1016/j.trim.2010.10.001. Epub 2010 Oct 19.
52. Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig. Knoerzer DB, etal., J Clin Invest. 1995 Aug;96(2):987-93.
53. Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4. Kurup SP, etal., Nat Med. 2017 Oct;23(10):1220-1225. doi: 10.1038/nm.4395. Epub 2017 Sep 11.
54. Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer. Kwon ED, etal., Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8099-103.
55. Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy. Kwon ED, etal., Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15074-9.
56. PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not. LaBerge GS, etal., J Invest Dermatol. 2008 Jul;128(7):1757-62. doi: 10.1038/sj.jid.5701233. Epub 2008 Jan 17.
57. Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury. Lai LW, etal., Kidney Int. 2012 May;81(10):983-92. doi: 10.1038/ki.2011.412. Epub 2011 Dec 21.
58. A DNA vaccine against cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) prevents tumor growth. Lan KH, etal., Biochem Biophys Res Commun. 2013 Oct 18;440(2):222-8. doi: 10.1016/j.bbrc.2013.09.031. Epub 2013 Sep 13.
59. Association of asthma severity and bronchial hyperresponsiveness with a polymorphism in the cytotoxic T-lymphocyte antigen-4 gene. Lee SY, etal., Chest. 2002 Jul;122(1):171-6.
60. Association between cytotoxic T-lymphocyte antigen 4 gene polymorphisms and primary biliary cirrhosis in Chinese population: data from a multicenter study. Li Q, etal., J Gastroenterol Hepatol. 2013 Aug;28(8):1397-402. doi: 10.1111/jgh.12165.
61. CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in mice. Liu F, etal., PLoS One. 2010 Nov 3;5(11):e15404.
62. CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease. Liu Y, etal., Hum Immunol. 2010 Nov;71(11):1141-6. Epub 2010 Aug 21.
63. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Marron MP, etal., Hum Mol Genet 1997 Aug;6(8):1275-82.
64. Cytotoxic T-lymphocyte antigen 4 (CTLA4) +49AG and CT60 gene polymorphisms in Alopecia Areata: a case-control association study in the Italian population. Megiorni F, etal., Arch Dermatol Res. 2013 Sep;305(7):665-70. doi: 10.1007/s00403-013-1348-3. Epub 2013 Apr 9.
65. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
66. MGDs mouse GO annotations MGD data from the GO Consortium
67. Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to chronic hepatitis B. Mohammad Alizadeh AH, etal., World J Gastroenterol. 2006 Jan 28;12(4):630-5.
68. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene polymorphism and susceptibility to non-Hodgkin's lymphoma. Monne M, etal., Am J Hematol. 2004 May;76(1):14-8.
69. Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia. Motta M, etal., Leukemia. 2005 Oct;19(10):1788-93.
70. CTLA-4 polymorphisms in allergy and asthma and the TH1/ TH2 paradigm. Munthe-Kaas MC, etal., J Allergy Clin Immunol. 2004 Aug;114(2):280-7.
71. T cell pathways involving CTLA4 contribute to a model of acute lung injury. Nakajima T, etal., J Immunol. 2010 May 15;184(10):5835-41. Epub 2010 Apr 12.
72. Effect of CTLA-4 chimeric protein on rat autoimmune anti-glomerular basement membrane glomerulonephritis. Nishikawa K, etal., Eur J Immunol. 1994 Jun;24(6):1249-54.
73. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. Nistico L, etal., Hum Mol Genet. 1996 Jul;5(7):1075-80.
74. The role of CTLA-4 in murine contact hypersensitivity. Nuriya S, etal., J Invest Dermatol. 2001 May;116(5):764-8.
75. SNP analysis of genes implicated in T cell proliferation in primary biliary cirrhosis. Oertelt S, etal., Clin Dev Immunol. 2005 Dec;12(4):259-63. doi: 10.1080/17402520500317859.
76. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
77. CTLA4Ig alters the course of autoimmune disease development in Lyn-/- mice. Oracki SA, etal., J Immunol. 2010 Jan 15;184(2):757-63. doi: 10.4049/jimmunol.0804349. Epub 2009 Dec 4.
78. CTLA4 gene polymorphisms and soluble CTLA4 protein in Behcet's disease. Park KS, etal., Tissue Antigens. 2009 Sep;74(3):222-7. doi: 10.1111/j.1399-0039.2009.01303.x. Epub 2009 Jun 25.
79. CTLA-4 exon 1 polymorphism in patients with autoimmune blood disorders. Pavkovic M, etal., Am J Hematol. 2003 Feb;72(2):147-9.
80. Association between IL4 (-590), ACE (I)/(D), CCR5 (Delta32), CTLA4 (+49) and IL1-RN (VNTR in intron 2) gene polymorphisms and vitiligo. Pehlivan S, etal., Eur J Dermatol. 2009 Mar-Apr;19(2):126-8. doi: 10.1684/ejd.2008.0578. Epub 2009 Jan 7.
81. CTLA-4 genotype and relapse incidence in patients with acute myeloid leukemia in first complete remission after induction chemotherapy. Perez-Garcia A, etal., Leukemia. 2009 Mar;23(3):486-91. doi: 10.1038/leu.2008.339. Epub 2008 Dec 18.
82. CT60 single nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen-4 gene region is associated with Graves' disease in an Italian population. Petrone A, etal., Thyroid. 2005 Mar;15(3):232-8.
83. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
84. Association of CTLA-4 polymorphisms with improved overall survival in melanoma patients treated with CTLA-4 blockade: a pilot study. Queirolo P, etal., Cancer Invest. 2013 Jun;31(5):336-45. doi: 10.3109/07357907.2013.793699. Epub 2013 May 3.
85. In vivo fluctuation of Tax, Foxp3, CTLA-4, and GITR mRNA expression in CD4(+)CD25(+) T cells of patients with human T-lymphotropic virus type 1-associated myelopathy. Ramirez E, etal., Braz J Med Biol Res. 2010 Nov;43(11):1109-15. doi: 10.1590/s0100-879x2010007500107. Epub 2010 Oct 8.
86. CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis. Reynolds J, etal., J Clin Invest. 2000 Mar;105(5):643-51.
87. Mouse MP Annotation Import Pipeline RGD automated import pipeline
88. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
89. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
90. [CD28 and CTLA-4 costimulatory molecules expression on T lymphocytes and NK cells in nonallergic bronchial asthma]. Rutkowski R, etal., Pol Merkur Lekarski. 2006 Feb;20(116):139-44.
91. Topical CTLA4-Ig suppresses ongoing mucosal immune response in presensitized murine model of allergic rhinitis. Sato J, etal., Int Arch Allergy Immunol. 1999 Jul;119(3):197-204.
92. Association of CTLA4 single nucleotide polymorphisms with viral but not autoimmune liver disease. Schott E, etal., Eur J Gastroenterol Hepatol. 2007 Nov;19(11):947-51. doi: 10.1097/MEG.0b013e3282efa240.
93. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Schubert D, etal., Nat Med. 2014 Dec;20(12):1410-6. doi: 10.1038/nm.3746. Epub 2014 Oct 20.
94. Requirement of B7-mediated costimulation in the induction of experimental autoimmune anterior uveitis. Shao H, etal., Invest Ophthalmol Vis Sci. 2001 Aug;42(9):2016-21.
95. Soluble CTLA-4 in sera of patients with bronchial asthma. Shi HZ, etal., J Asthma. 2005 Mar;42(2):133-9.
96. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
97. Prevention of acute lung allograft rejection in rat by CTLA4Ig. Shiraishi T, etal., Am J Transplant. 2002 Mar;2(3):223-8.
98. Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children. Sohn MH, etal., Pediatr Pulmonol. 2007 Jun;42(6):542-7.
99. Distinct tumour necrosis factor alpha, interferon gamma, interleukin 10, and cytotoxic T cell antigen 4 gene polymorphisms in disease occurrence and end stage renal disease in Wegener's granulomatosis. Spriewald BM, etal., Ann Rheum Dis. 2005 Mar;64(3):457-61.
100. A suggestive association of fuchs heterochromic cyclitis with cytotoxic T cell antigen 4 gene polymorphism. Spriewald BM, etal., Ophthalmic Res. 2007;39(2):116-20. Epub 2007 Feb 8.
101. Clinical manifestations and analyses of the cytotoxic T-lymphocyte associated-4 gene in two Japanese families with systemic lupus erythematosus. Sugimoto K, etal., Clin Exp Nephrol. 2008 Apr;12(2):149-54. doi: 10.1007/s10157-007-0019-0. Epub 2008 Jan 9.
102. [Effects and mechanism of CD4+ CD25+ T cells on the airway inflammation of asthmatic mice]. Sun K, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Feb;29(2):109-12.
103. Hydrodynamics-based delivery of plasmid DNA encoding CTLA4-Ig prolonged cardiac allograft survival in rats. Takekubo M, etal., J Gene Med. 2008 Mar;10(3):290-7.
104. Involvement of CD28/CTLA4-B7 costimulatory pathway in the development of lymphadenopathy and splenomegaly in MRL/lpr mice. Takiguchi M, etal., J Vet Med Sci. 2000 Jan;62(1):29-36.
105. Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection. Thio CL, etal., J Virol. 2004 Oct;78(20):11258-62. doi: 10.1128/JVI.78.20.11258-11262.2004.
106. CTLA4 gene and Graves' disease: association of Graves' disease with the CTLA4 exon 1 and intron 1 polymorphisms, but not with the promoter polymorphism. Vaidya B, etal., Clin Endocrinol (Oxf). 2003 Jun;58(6):732-5.
107. The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus. Vaidya B, etal., Hum Mol Genet 1999 Jul;8(7):1195-9.
108. Cytotoxic T-lymphocyte antigen-4 A49G polymorphism is associated with susceptibility to and severity of alcoholic liver disease in Italian patients. Valenti L, etal., Alcohol Alcohol. 2004 Jul-Aug;39(4):276-80. doi: 10.1093/alcalc/agh047.
109. Ocular transfer of retinal glial cells transduced ex vivo with adenovirus expressing viral IL-10 or CTLA4-Ig inhibits experimental autoimmune uveoretinitis. Verwaerde C, etal., Gene Ther. 2003 Nov;10(23):1970-81.
110. CTLA-4 exon 1 +49A/G polymorphism is associated with renal involvement in pediatric Henoch-Schonlein purpura. Wang JJ, etal., Pediatr Nephrol. 2012 Nov;27(11):2059-64. doi: 10.1007/s00467-012-2216-7. Epub 2012 Jun 15.
111. Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population. Wang L, etal., BMC Cancer. 2007 Sep 10;7:173.
112. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Waterhouse P, etal., Science 1995 Nov 10;270(5238):985-8.
113. CTLA4 variants, UV-induced tolerance, and risk of non-melanoma skin cancer. Welsh MM, etal., Cancer Res. 2009 Aug 1;69(15):6158-63. doi: 10.1158/0008-5472.CAN-09-0415. Epub 2009 Jul 21.
114. Aberrant expression of soluble co-stimulatory molecules and adhesion molecules in type 2 diabetic patients with nephropathy. Wong CK, etal., J Clin Immunol. 2008 Jan;28(1):36-43. Epub 2007 Nov 17.
115. Reduced function of CD4+25+ regulatory T cell fraction in silicosis patients. Wu P, etal., Int J Immunopathol Pharmacol. 2006 Apr-Jun;19(2):357-68.
116. [Study on mRNA expression of immune-related genes in patients with allergic dermatitis induced by trichloroethylene]. Xu XY, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011 Nov;29(11):816-9.
117. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. Yang JC, etal., J Immunother. 2007 Nov-Dec;30(8):825-30.
118. Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection. Yee LJ, etal., J Infect Dis. 2003 Apr 15;187(8):1264-71. doi: 10.1086/374561. Epub 2003 Apr 2.
119. CTLA4 gene polymorphisms in children and adolescents with autoimmune thyroid diseases. Yesilkaya E, etal., Genet Test. 2008 Sep;12(3):461-4. doi: 10.1089/gte.2008.0053.
120. Genetic profiling in Graves' disease: further evidence for lack of a distinct genetic contribution to Graves' ophthalmopathy. Yin X, etal., Thyroid. 2012 Jul;22(7):730-6. doi: 10.1089/thy.2012.0007. Epub 2012 Jun 4.
121. Cytotoxic T lymphocyte antigen 4 gene polymorphism associated with ST-segment elevation acute myocardial infarction. Yip HK, etal., Circ J. 2007 Aug;71(8):1213-8.
122. [The implications of nasal associated lymphoid tissue in development of respiratory allergic diseases in children]. Zakrzewska A, etal., Med Wieku Rozwoj. 2007 Apr-Jun;11(2 Pt 1):129-34.
123. Intraarticular gene delivery of CTLA4-FasL suppresses experimental arthritis. Zhang W, etal., Int Immunol. 2012 Jun;24(6):379-88. doi: 10.1093/intimm/dxs041. Epub 2012 Feb 21.
124. Association of the CTLA4 gene with Graves' disease in the Chinese Han population. Zhao SX, etal., PLoS One. 2010 Mar 23;5(3):e9821. doi: 10.1371/journal.pone.0009821.
125. Cytotoxic T-lymphocyte antigen-4 microsatellite polymorphism is associated with multiple myeloma. Zheng C, etal., Br J Haematol. 2001 Jan;112(1):216-8.
126. Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas. Zhou G, etal., Gastroenterology. 2017 Oct;153(4):1107-1119.e10. doi: 10.1053/j.gastro.2017.06.017. Epub 2017 Jun 23.
127. CTLA4 gene polymorphisms are associated with chronic bronchitis. Zhu G, etal., Eur Respir J. 2009 Sep;34(3):598-604. Epub 2009 Apr 22.
Additional References at PubMed
PMID:1281186   PMID:1347472   PMID:1351769   PMID:1387109   PMID:1544892   PMID:1671668   PMID:1672292   PMID:1685142   PMID:1713603   PMID:1832015   PMID:1962752   PMID:2571577  
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PMID:35172142  


Genomics

Comparative Map Data
Ctla4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39160,948,184 - 60,954,991 (+)NCBIGRCm39mm39
GRCm39 Ensembl160,926,159 - 60,954,991 (+)Ensembl
GRCm38160,909,025 - 60,915,832 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl160,887,000 - 60,915,832 (+)EnsemblGRCm38mm10GRCm38
MGSCv37160,965,869 - 60,972,674 (+)NCBIGRCm37mm9NCBIm37
MGSCv36160,853,571 - 60,860,376 (+)NCBImm8
Celera161,424,040 - 61,430,841 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.58NCBI
CTLA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382203,867,771 - 203,873,965 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2203,853,888 - 203,873,965 (+)EnsemblGRCh38hg38GRCh38
GRCh372204,732,494 - 204,738,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362204,440,754 - 204,446,928 (+)NCBINCBI36hg18NCBI36
Build 342204,558,016 - 204,564,189NCBI
Celera2198,487,330 - 198,493,462 (+)NCBI
Cytogenetic Map2q33.2NCBI
HuRef2196,579,809 - 196,585,939 (+)NCBIHuRef
CHM1_12204,739,066 - 204,745,196 (+)NCBICHM1_1
T2T-CHM13v2.02204,349,656 - 204,355,847 (+)NCBI
Ctla4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2962,318,874 - 62,325,978 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl962,319,312 - 62,324,963 (+)Ensembl
Rnor_6.0967,699,397 - 67,706,068 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl967,699,379 - 67,706,065 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0967,509,236 - 67,515,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4959,495,773 - 59,501,300 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1959,642,754 - 59,648,282 (+)NCBI
Celera959,742,231 - 59,747,758 (+)NCBICelera
Cytogenetic Map9q32NCBI
Ctla4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545711,028,698 - 11,073,460 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545711,028,707 - 11,034,898 (-)NCBIChiLan1.0ChiLan1.0
CTLA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B209,239,417 - 209,244,498 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B209,239,417 - 209,244,498 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B91,054,917 - 91,106,234 (+)NCBIMhudiblu_PPA_v0panPan3
CTLA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13712,647,712 - 12,653,874 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3712,634,563 - 12,653,874 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3713,530,863 - 13,537,025 (+)NCBI
ROS_Cfam_1.03712,584,278 - 12,590,425 (+)NCBI
ROS_Cfam_1.0 Ensembl3712,528,644 - 12,590,422 (+)Ensembl
UMICH_Zoey_3.13712,541,354 - 12,547,516 (+)NCBI
UNSW_CanFamBas_1.03712,504,724 - 12,510,894 (+)NCBI
UU_Cfam_GSD_1.03712,505,745 - 12,511,890 (+)NCBI
Ctla4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303160,849,279 - 160,854,996 (+)NCBI
SpeTri2.0NW_004936631484,356 - 489,643 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTLA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15107,282,927 - 107,289,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115107,283,081 - 107,288,041 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215118,627,675 - 118,632,732 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTLA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11089,637,176 - 89,644,436 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1089,638,314 - 89,642,344 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040109,742,081 - 109,748,529 (-)NCBIVero_WHO_p1.0
Ctla4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476512,449,205 - 12,454,324 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476512,449,205 - 12,454,324 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
X05719  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38160,915,251 - 60,915,442UniSTSGRCm38
MGSCv37160,972,095 - 60,972,286UniSTSGRCm37
Celera161,430,262 - 61,430,453UniSTS
Cytogenetic Map1CUniSTS
cM Map130.1UniSTS
Whitehead_YAC1 UniSTS
Cd152  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38160,915,580 - 60,915,725UniSTSGRCm38
MGSCv37160,972,424 - 60,972,569UniSTSGRCm37
Celera161,430,591 - 61,430,736UniSTS
Cytogenetic Map1CUniSTS
cM Map130.1UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14086800867270256Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14086800867270256Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14086800867270256Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
12879917Shm3_msperm head morphology 3 (mouse)14418690462946882Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14541777372975057Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5196402570406589Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse
4141724Idd5.1_minsulin dependent diabetes susceptibility 5.1 (mouse)Not determined5772827662946882Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:498
Count of miRNA genes:332
Interacting mature miRNAs:379
Transcripts:ENSMUST00000027164, ENSMUST00000097720, ENSMUST00000124816
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001281976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB097214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF142145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI323635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL663047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR936839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ420692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ420693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U58336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U90270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000027164   ⟹   ENSMUSP00000027164
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl160,948,184 - 60,954,991 (+)Ensembl
GRCm38.p6 Ensembl160,909,025 - 60,915,832 (+)Ensembl
RefSeq Acc Id: ENSMUST00000097720   ⟹   ENSMUSP00000095327
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl160,948,330 - 60,953,928 (+)Ensembl
GRCm38.p6 Ensembl160,909,171 - 60,914,769 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124816
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl160,926,159 - 60,951,875 (+)Ensembl
GRCm38.p6 Ensembl160,887,000 - 60,912,716 (+)Ensembl
RefSeq Acc Id: NM_001281976   ⟹   NP_001268905
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39160,948,184 - 60,954,991 (+)NCBI
GRCm38160,909,025 - 60,915,832 (+)NCBI
Celera161,424,040 - 61,430,843 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009843   ⟹   NP_033973
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39160,948,184 - 60,954,991 (+)NCBI
GRCm38160,909,025 - 60,915,832 (+)NCBI
MGSCv37160,965,869 - 60,972,674 (+)RGD
Celera161,424,040 - 61,430,843 (+)NCBI
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036156357   ⟹   XP_036012250
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39160,950,848 - 60,954,983 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033973   ⟸   NM_009843
- Peptide Label: isoform 1 precursor
- UniProtKB: P09793 (UniProtKB/Swiss-Prot),   Q6GTR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001268905   ⟸   NM_001281976
- Peptide Label: isoform 2 precursor
- UniProtKB: Q5SSM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027164   ⟸   ENSMUST00000027164
RefSeq Acc Id: ENSMUSP00000095327   ⟸   ENSMUST00000097720
RefSeq Acc Id: XP_036012250   ⟸   XM_036156357
- Peptide Label: isoform X1
Protein Domains
Ig-like   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09793-F1-model_v2 AlphaFold P09793 1-223 view protein structure

Promoters
RGD ID:6873888
Promoter ID:EPDNEW_M395
Type:multiple initiation site
Name:Ctla4_1
Description:Mus musculus cytotoxic T-lymphocyte-associated protein 4 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38160,909,093 - 60,909,153EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88556 AgrOrtholog
Ensembl Genes ENSMUSG00000026011 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000027164 ENTREZGENE
  ENSMUSP00000027164.3 UniProtKB/TrEMBL
  ENSMUSP00000095327 ENTREZGENE
  ENSMUSP00000095327.4 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027164 ENTREZGENE
  ENSMUST00000027164.9 UniProtKB/TrEMBL
  ENSMUST00000097720 ENTREZGENE
  ENSMUST00000097720.4 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CTLA4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTLA4/CD28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12477 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88556 ENTREZGENE
NCBI Gene 12477 ENTREZGENE
PANTHER PTHR11494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11494:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CTLA4 RGD
PhenoGen Ctla4 PhenoGen
PRINTS CTLANTIGEN4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CTLA4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5SSM0 ENTREZGENE, UniProtKB/TrEMBL
  Q6GTR6 ENTREZGENE, UniProtKB/TrEMBL
  Q7TMX1_MOUSE UniProtKB/TrEMBL
  Q8CH94_MOUSE UniProtKB/TrEMBL
  Q9Z1A8_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q9QZZ7 UniProtKB/Swiss-Prot