Txn1 (thioredoxin 1) - Rat Genome Database

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Gene: Txn1 (thioredoxin 1) Mus musculus
Analyze
Symbol: Txn1
Name: thioredoxin 1
RGD ID: 732442
MGI Page MGI
Description: Enables protein-disulfide reductase activity. Acts upstream of or within cell redox homeostasis; negative regulation of protein export from nucleus; and negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is expressed in several structures, including central nervous system; skeleton; and submandibular gland primordium. Orthologous to human TXN (thioredoxin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADF; ATL-derived factor; AW550880; thioredoxin; trx; Trx1; Txn
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Txn-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39457,943,373 - 57,956,411 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl457,943,373 - 57,956,411 (-)EnsemblGRCm39 Ensembl
GRCm38457,943,373 - 57,956,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl457,943,373 - 57,956,411 (-)EnsemblGRCm38mm10GRCm38
MGSCv37457,956,245 - 57,969,283 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36458,037,427 - 58,050,345 (-)NCBIMGSCv36mm8
Celera457,856,035 - 57,868,968 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map431.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-quinic acid  (ISO)
(-)-selegiline  (EXP,ISO)
(1->4)-beta-D-glucan  (EXP)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (EXP,ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-methylumbelliferyl acetate  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
antimonite  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
atenolol  (ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
auranofin  (ISO)
benfotiamine  (EXP)
benzbromarone  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[d]isothiazol-3-one  (ISO)
benzoic acid  (ISO)
benzyl cinnamate  (ISO)
beta-D-glucosamine  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
brilliant green  (ISO)
Brodifacoum  (ISO)
bromobenzene  (ISO)
bucladesine  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calycosin-7-O-beta-D-glucoside  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
cerium trichloride  (ISO)
chenodeoxycholic acid  (ISO)
chloroacetaldehyde  (ISO)
chloroform  (ISO)
chlorogenic acid  (ISO)
chlorpromazine  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP)
cyproconazole  (EXP)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diphenylcyclopropenone  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dipyridamole  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
finasteride  (ISO)
fipronil  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fumaraldehyde  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gamma-linolenic acid  (ISO)
Ganoderic acid A  (EXP)
genistein  (ISO)
glucose  (EXP,ISO)
herbicide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxycitronellal  (ISO)
ifosfamide  (ISO)
imidazopyrazole  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
inulin  (EXP)
iron(III) nitrilotriacetate  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
KT 5823  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (ISO)
linalool  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP,ISO)
lutein  (ISO)
luteolin  (EXP)
LY294002  (ISO)
lycopene  (EXP)
maneb  (ISO)
manumycin A  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methidathion  (EXP)
methyl non-2-ynoate  (ISO)
methylarsonic acid  (ISO)
methylene blue  (EXP)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
metronidazole  (EXP)
microcystin RR  (ISO)
monosodium L-glutamate  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naloxone  (ISO)
nefazodone  (ISO)
neomycin  (EXP)
nickel atom  (EXP)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitrogen dioxide  (ISO)
Nonidet P-40  (ISO)
obeticholic acid  (ISO)
okadaic acid  (EXP,ISO)
omeprazole  (ISO)
Osajin  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (EXP,ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
perillyl aldehyde  (ISO)
phenethyl isothiocyanate  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidylcholine  (ISO)
phosphatidylethanolamine  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
Pomiferin  (ISO)
potassium dichromate  (ISO)
propiconazole  (EXP)
puerarin  (ISO)
quercetin  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
ribavirin  (ISO)
Rosavin  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salicylic acid  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium selenide  (ISO)
streptozocin  (EXP)
succimer  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
TCEP  (ISO)
teprenone  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (ISO)
toluene 2,4-diisocyanate  (EXP)
tricalcium bis(phosphate)  (EXP)
trimellitic anhydride  (EXP)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP)
vancomycin  (EXP)
vorinostat  (ISO)
zearalenone  (EXP)
zinc atom  (EXP)
zinc oxide  (EXP)
zinc(0)  (EXP)

References

References - curated
# Reference Title Reference Citation
1. Redox regulation of resveratrol-mediated switching of death signal into survival signal. Das S, etal., Free Radic Biol Med. 2008 Jan 1;44(1):82-90. Epub 2007 Sep 21.
2. Severe liver steatosis correlates with nitrosative and oxidative stress in rats. Grattagliano I, etal., Eur J Clin Invest. 2008 Jul;38(7):523-30.
3. Plasma thioredoxin levels in patients with unstable angina. Hokamaki J, etal., Int J Cardiol. 2005 Mar 18;99(2):225-31.
4. Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism. Jia J, etal., Thromb Res. 2009 Mar;123(5):727-30. Epub 2009 Jan 6.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
9. Redox proteins thioredoxin 1 and thioredoxin 2 support retinal ganglion cell survival in experimental glaucoma. Munemasa Y, etal., Gene Ther. 2009 Jan;16(1):17-25. Epub 2008 Aug 14.
10. Upregulation of redox-regulating protein, thioredoxin, in endomyocardial biopsy samples of patients with myocarditis and cardiomyopathies. Nimata M, etal., Mol Cell Biochem. 2003 Jun;248(1-2):193-6.
11. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Increased plasma thioredoxin in patients with acute myocardial infarction. Soejima H, etal., Clin Cardiol. 2003 Dec;26(12):583-7.
17. Expression of thioredoxin is enhanced in atherosclerotic plaques and during neointima formation in rat arteries. Takagi Y, etal., Lab Invest. 1998 Aug;78(8):957-66.
18. Elevated thioredoxin after angioplasty in peripheral arterial disease. Wahlgren CM and Pekkari K, Eur J Vasc Endovasc Surg. 2005 Mar;29(3):281-6.
19. [The change of thioredoxin system in myocardial tissue of type 2 diabetic rats undergoing myocardial injury]. Zhao XQ, etal., Sheng Li Xue Bao. 2010 Jun 25;62(3):261-8.
Additional References at PubMed
PMID:2785919   PMID:7835695   PMID:8088797   PMID:8187776   PMID:8649829   PMID:8812119   PMID:8940147   PMID:10349636   PMID:10843682   PMID:10922068   PMID:11042159   PMID:11076861  
PMID:11213470   PMID:11732570   PMID:11751890   PMID:11841834   PMID:11985582   PMID:12008049   PMID:12477932   PMID:12520002   PMID:12717382   PMID:14610273   PMID:14688250   PMID:15313215  
PMID:15458846   PMID:15489334   PMID:15965489   PMID:16141072   PMID:16141073   PMID:16322089   PMID:16449798   PMID:16474438   PMID:16678011   PMID:16987018   PMID:16987036   PMID:16987041  
PMID:17157166   PMID:17488888   PMID:17967808   PMID:18450962   PMID:18555775   PMID:18614015   PMID:18710947   PMID:19114066   PMID:19244202   PMID:19276128   PMID:19319191   PMID:19466610  
PMID:20385180   PMID:20512310   PMID:20536427   PMID:21074540   PMID:21183740   PMID:21267068   PMID:21521879   PMID:21732914   PMID:21858002   PMID:21873593   PMID:21908620   PMID:22229939  
PMID:22384152   PMID:22457359   PMID:22516068   PMID:22961094   PMID:23085515   PMID:23105116   PMID:23747528   PMID:23850970   PMID:23950917   PMID:23982205   PMID:23994289   PMID:24039713  
PMID:24140863   PMID:24244404   PMID:24338024   PMID:24457600   PMID:24506865   PMID:24509157   PMID:24878227   PMID:25265386   PMID:25350977   PMID:25539854   PMID:25726727   PMID:25737280  
PMID:25753394   PMID:25975898   PMID:26164633   PMID:26173459   PMID:26327408   PMID:26370502   PMID:26410624   PMID:26932791   PMID:27000416   PMID:27113764   PMID:27436123   PMID:27511023  
PMID:27581528   PMID:27587398   PMID:27639450   PMID:27698473   PMID:28003361   PMID:28378742   PMID:28658624   PMID:28686716   PMID:28782589   PMID:28807201   PMID:28939765   PMID:29382714  
PMID:29749372   PMID:29981334   PMID:30104382   PMID:30384364   PMID:30404832   PMID:30409884   PMID:30457570   PMID:30550785   PMID:30648404   PMID:30802940   PMID:30971427   PMID:31045571  
PMID:31049129   PMID:31162944   PMID:31276937   PMID:31280865   PMID:31584633   PMID:31911946   PMID:31968349   PMID:32096759   PMID:32203791   PMID:32325033   PMID:32581705   PMID:33539996  
PMID:34132424   PMID:34133714   PMID:34890296   PMID:35993020   PMID:36114006   PMID:36263912   PMID:36417873   PMID:36480290   PMID:36780445   PMID:37771783   PMID:38171410  


Genomics

Comparative Map Data
Txn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39457,943,373 - 57,956,411 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl457,943,373 - 57,956,411 (-)EnsemblGRCm39 Ensembl
GRCm38457,943,373 - 57,956,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl457,943,373 - 57,956,411 (-)EnsemblGRCm38mm10GRCm38
MGSCv37457,956,245 - 57,969,283 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36458,037,427 - 58,050,345 (-)NCBIMGSCv36mm8
Celera457,856,035 - 57,868,968 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map431.87NCBI
TXN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389110,243,810 - 110,256,507 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9110,243,810 - 110,256,507 (-)EnsemblGRCh38hg38GRCh38
GRCh379113,006,090 - 113,018,787 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369112,046,131 - 112,058,599 (-)NCBINCBI36Build 36hg18NCBI36
Build 349110,085,864 - 110,098,333NCBI
Celera983,507,936 - 83,520,398 (-)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef982,607,811 - 82,620,710 (-)NCBIHuRef
CHM1_19113,152,543 - 113,165,343 (-)NCBICHM1_1
T2T-CHM13v2.09122,413,340 - 122,426,045 (-)NCBIT2T-CHM13v2.0
Txn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8577,507,455 - 77,519,685 (-)NCBIGRCr8
mRatBN7.2572,712,334 - 72,724,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl572,711,933 - 72,724,629 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx574,603,651 - 74,615,881 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0576,425,269 - 76,437,499 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0576,397,400 - 76,409,630 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0575,049,735 - 75,057,731 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl575,049,747 - 75,057,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0579,201,386 - 79,209,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4575,921,365 - 75,933,595 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1575,926,428 - 75,938,789 (-)NCBI
Celera571,558,162 - 71,570,393 (-)NCBICelera
RH 3.4 Map5494.0RGD
Cytogenetic Map5q24NCBI
TXN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21129,150,207 - 29,162,897 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1929,152,695 - 29,165,262 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0981,399,056 - 81,411,607 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19109,565,557 - 109,578,311 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9109,565,557 - 109,578,311 (-)Ensemblpanpan1.1panPan2
LOC100687127
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X82,986,288 - 82,986,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX69,064,524 - 69,064,989 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X84,637,255 - 84,637,720 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X82,113,902 - 82,114,367 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X83,808,036 - 83,808,501 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X83,636,876 - 83,637,341 (-)NCBIUU_Cfam_GSD_1.0
Txn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947180,444,054 - 180,454,833 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365592,811,782 - 2,822,528 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365592,811,786 - 2,822,528 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,263,175 - 251,277,988 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,264,180 - 251,278,000 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21282,027,082 - 282,035,642 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1qNCBI
TXN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11229,296,166 - 29,308,979 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603513,456,569 - 13,469,439 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247581,318,529 - 1,329,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247581,318,108 - 1,329,011 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Txn1
451 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:120
Interacting mature miRNAs:122
Transcripts:ENSMUST00000030051
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663283678Mouse
1301786Bpq3_mblood pressure QTL 3 (mouse)Not determined44240224076402381Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
1301941Mmtg1_mmodifier of mammary tumor growth 1 (mouse)Not determined44565844283099157Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
12879977Bod2_mbone length and organs 2 (mouse)44628353180283678Mouse
10043880Adip23_madiposity 23 (mouse)Not determined44628353180283678Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
10449022Aanq1_maristolochic acid nephrotoxicity QTL 1 (mouse)44660382680603826Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
11532688Mh_mmodifier of hemostasis (mouse)44830477582304775Mouse
25314308Mlh1fc1_mMLH1 foci count 1 (mouse)44850000076918237Mouse
1301995Lprm1_mlymphoproliferation modifier 1 (mouse)Not determined45010026284100408Mouse
1301213Lgth3_mbody length 3 (mouse)Not determined45010026284100408Mouse
13207572Spir2_mStreptococcus pneumoniae infection resistance 2 (mouse)45068279588510637Mouse
1301033Abbp2_mA/J and C57BL/6 blood pressure 2 (mouse)Not determined45355083993763305Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
26884434Zlq1_mzygomatic length QTL 1, 5 week (mouse)453700000103257197Mouse
13524838Hbasrq1a_mhabituation of the acoustic startle response QTL 1a (mouse)45447158988471589Mouse
13524841Hbasrq1_mhabituation of the acoustic startle response QTL 1 (mouse)45447158988471589Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
27095934Ulnl2_mulna length 2, 5 week (mouse)45770000094788237Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse

Markers in Region
AW550880  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38457,951,813 - 57,951,905UniSTSGRCm38
GRCm38144,464,119 - 44,464,211UniSTSGRCm38
MGSCv37144,520,964 - 44,521,056UniSTSGRCm37
MGSCv37457,964,685 - 57,964,777UniSTSGRCm37
Celera457,864,370 - 57,864,462UniSTS
Celera144,803,584 - 44,803,676UniSTS
Cytogenetic Map1C1.1UniSTS
Cytogenetic Map4B3UniSTS
cM Map424.6UniSTS
Whitehead/MRC_RH4945.54UniSTS
RH94605  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38457,943,798 - 57,943,894UniSTSGRCm38
GRCm38144,463,807 - 44,463,902UniSTSGRCm38
MGSCv37144,520,652 - 44,520,747UniSTSGRCm37
MGSCv37457,956,670 - 57,956,766UniSTSGRCm37
Celera457,856,460 - 57,856,556UniSTS
Celera144,803,272 - 44,803,367UniSTS
Cytogenetic Map1C1.1UniSTS
Cytogenetic Map4B3UniSTS
cM Map424.6UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000030051   ⟹   ENSMUSP00000030051
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl457,943,373 - 57,956,411 (-)Ensembl
GRCm38.p6 Ensembl457,943,373 - 57,956,411 (-)Ensembl
RefSeq Acc Id: NM_011660   ⟹   NP_035790
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39457,943,373 - 57,956,411 (-)NCBI
GRCm38457,943,373 - 57,956,411 (-)ENTREZGENE
MGSCv37457,956,245 - 57,969,283 (-)RGD
Celera457,856,035 - 57,868,968 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035790   ⟸   NM_011660
- UniProtKB: Q52KC4 (UniProtKB/Swiss-Prot),   Q9D8R0 (UniProtKB/Swiss-Prot),   P10639 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000030051   ⟸   ENSMUST00000030051
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10639-F1-model_v2 AlphaFold P10639 1-105 view protein structure

Promoters
RGD ID:6883506
Promoter ID:EPDNEW_M5203
Type:initiation region
Name:Txn1_1
Description:Mus musculus thioredoxin 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38457,956,291 - 57,956,351EPDNEW
RGD ID:6836590
Promoter ID:MM_KWN:37787
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_011660
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36457,969,066 - 57,969,657 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98874 AgrOrtholog
Ensembl Genes ENSMUSG00000028367 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030051 ENTREZGENE
  ENSMUST00000030051.6 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro Thioredoxin UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
  Thioredoxin_CS UniProtKB/Swiss-Prot
  Thioredoxin_domain UniProtKB/Swiss-Prot
KEGG Report mmu:22166 UniProtKB/Swiss-Prot
MGD MGI:98874 ENTREZGENE
NCBI Gene 22166 ENTREZGENE
PANTHER THIOREDOXIN-LIKE PROTEIN 1 UniProtKB/Swiss-Prot
  THIOREDOXIN-LIKE PROTEIN 1 UniProtKB/Swiss-Prot
Pfam Thioredoxin UniProtKB/Swiss-Prot
PhenoGen Txn1 PhenoGen
PIRSF Thioredoxin UniProtKB/Swiss-Prot
PRINTS THIOREDOXIN UniProtKB/Swiss-Prot
PROSITE THIOREDOXIN_1 UniProtKB/Swiss-Prot
  THIOREDOXIN_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt P10639 ENTREZGENE
  Q52KC4 ENTREZGENE
  Q9D8R0 ENTREZGENE
  THIO_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q52KC4 UniProtKB/Swiss-Prot
  Q9D8R0 UniProtKB/Swiss-Prot