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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit3increases expressionEXP 6480464CTDZearalenone results in increased expression of DDIT3 proteinPMID:30394307 PMID:31982503
Ddit3multiple interactionsEXP 6480464CTD2-aminoethyl diphenylborinate inhibits the reaction [Zearalenone results in increased expression of DDIT3 protein]; 4-phenylbutylamine promotes the reaction [Zearalenone results in increased expression of DDIT3 protein]PMID:30394307 PMID:31982503
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