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Gene: Pak2 (p21 (RAC1) activated kinase 2) Mus musculus
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Symbol: Pak2
Name: p21 (RAC1) activated kinase 2
Description: Exhibits protein kinase activity. Involved in cellular response to organic cyclic compound and dendritic spine development. Localizes to glutamatergic synapse and postsynaptic density. Is expressed in several structures, including brain. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2); PARTICIPATES IN vascular endothelial growth factor signaling pathway; epidermal growth factor/neuregulin signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5330420P17Rik; A130002K10Rik; AI836325; D16Ertd269e; gamma-PAK; hypothetical protein LOC77101; KIAA4182; mKIAA4182; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; PAK-2; RIKEN cDNA 5330420P17 gene; serine/threonine-protein kinase PAK 2
Orthologs:
Homo sapiens (human) : PAK2 (p21 (RAC1) activated kinase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pak2 (p21 (RAC1) activated kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pak2 (p21 (RAC1) activated kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PAK2 (p21 (RAC1) activated kinase 2)
Canis lupus familiaris (dog) : PAK2 (p21 (RAC1) activated kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pak2 (p21 (RAC1) activated kinase 2)
Sus scrofa (pig) : PAK2 (p21 (RAC1) activated kinase 2)
Chlorocebus sabaeus (African green monkey) : PAK2 (p21 (RAC1) activated kinase 2)
Heterocephalus glaber (naked mole-rat) : Pak2 (p21 (RAC1) activated kinase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1632,016,290 - 32,079,342 (-)EnsemblGRCm38mm10GRCm38
GRCm381632,016,290 - 32,079,342 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371632,017,949 - 32,079,359 (-)NCBIGRCm37mm9NCBIm37
MGSCv361631,937,610 - 31,999,020 (-)NCBImm8
Celera1632,511,700 - 32,575,354 (-)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1622.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Pak2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62246
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.