Lonrf2 (LON peptidase N-terminal domain and ring finger 2) - Rat Genome Database

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Gene: Lonrf2 (LON peptidase N-terminal domain and ring finger 2) Mus musculus
Analyze
Symbol: Lonrf2
Name: LON peptidase N-terminal domain and ring finger 2
RGD ID: 1558254
MGI Page MGI
Description: Predicted to enable ubiquitin protein ligase activity. Is expressed in central nervous system; ganglia; and neural retina. Orthologous to human LONRF2 (LON peptidase N-terminal domain and ring finger 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2900060P06Rik; AI851349; LON peptidase N-terminal domain and RING finger protein 2
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39138,832,750 - 38,875,768 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl138,832,726 - 38,875,792 (-)EnsemblGRCm39 Ensembl
GRCm38138,793,669 - 38,836,687 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl138,793,645 - 38,836,711 (-)EnsemblGRCm38mm10GRCm38
MGSCv37138,851,354 - 38,878,060 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36138,739,055 - 38,765,761 (-)NCBIMGSCv36mm8
Celera138,580,489 - 38,606,584 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map117.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:18799693   PMID:21267068   PMID:21873635   PMID:34321999   PMID:37474791  


Genomics

Comparative Map Data
Lonrf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39138,832,750 - 38,875,768 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl138,832,726 - 38,875,792 (-)EnsemblGRCm39 Ensembl
GRCm38138,793,669 - 38,836,687 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl138,793,645 - 38,836,711 (-)EnsemblGRCm38mm10GRCm38
MGSCv37138,851,354 - 38,878,060 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36138,739,055 - 38,765,761 (-)NCBIMGSCv36mm8
Celera138,580,489 - 38,606,584 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map117.17NCBI
LONRF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382100,271,875 - 100,322,501 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2100,271,875 - 100,322,501 (-)EnsemblGRCh38hg38GRCh38
GRCh372100,888,337 - 100,938,963 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362100,256,185 - 100,305,627 (-)NCBINCBI36Build 36hg18NCBI36
Celera295,094,286 - 95,143,712 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef294,654,510 - 94,703,915 (-)NCBIHuRef
CHM1_12100,894,158 - 100,943,545 (-)NCBICHM1_1
T2T-CHM13v2.02100,730,785 - 100,781,377 (-)NCBIT2T-CHM13v2.0
Lonrf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8948,524,962 - 48,566,353 (-)NCBIGRCr8
mRatBN7.2941,033,125 - 41,070,551 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,034,628 - 41,070,649 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0945,468,001 - 45,506,448 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl945,466,688 - 45,505,767 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0945,161,417 - 45,200,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4937,793,985 - 37,829,456 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera938,783,004 - 38,821,241 (-)NCBICelera
Cytogenetic Map9q22NCBI
LONRF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21227,903,086 - 27,952,756 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A27,905,854 - 27,955,517 (+)NCBINHGRI_mPanPan1
PanPan1.12A101,255,118 - 101,303,103 (-)NCBIpanpan1.1PanPan1.1panPan2
LONRF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11042,378,459 - 42,412,871 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1042,378,475 - 42,410,076 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1042,301,779 - 42,334,721 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01043,246,934 - 43,279,880 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1043,246,934 - 43,279,340 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11042,967,873 - 43,000,816 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01043,241,595 - 43,274,524 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01043,431,190 - 43,464,138 (+)NCBIUU_Cfam_GSD_1.0
Lonrf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629285,944,309 - 85,984,539 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936661584,942 - 622,823 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936661584,948 - 623,507 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LONRF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl353,941,485 - 53,981,662 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1353,941,583 - 53,982,630 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2356,528,053 - 56,565,809 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LONRF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1144,014,773 - 4,055,193 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041171,630,965 - 171,672,349 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Lonrf2
1838 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3103
Count of miRNA genes:798
Interacting mature miRNAs:1038
Transcripts:ENSMUST00000039612, ENSMUST00000147695
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
10043970Obq23_mobesity QTL 23 (mouse)Not determined1501266539012665Mouse
1301011Cplaq4_mcircadian period of locomotor activity 4 (mouse)Not determined1967344243673601Mouse
14700685Civq2_mcerebral infarct volume QTL 2 (mouse)11134048245340482Mouse
1301073Orch5_mautoimmune orchitis resistance 5 (mouse)Not determined11906535153065454Mouse
1301756Pgia1_mproteoglycan induced arthritis 1 (mouse)Not determined11906535153065454Mouse
1301240Sluc15_msusceptibility to lung cancer 15 (mouse)Not determined11906535153065454Mouse
12880407V125Dq2_mvitamin D active form serum level QTL 2 (mouse)11933908153339081Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
4142433Hbnr1_mHeligmosomoides bakeri nematode resistance 1 (mouse)Not determined2555019158273271Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
12880409V125Dq1_mvitamin D active form serum level QTL 1 (mouse)12603916060039160Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
14700786Syncq1_msynovial calcification QTL 1 (mouse)13813308138971081Mouse

Markers in Region
AI851349  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38138,793,768 - 38,793,883UniSTSGRCm38
MGSCv37138,850,613 - 38,850,728UniSTSGRCm37
Celera138,579,844 - 38,579,959UniSTS
Cytogenetic Map1BUniSTS
Whitehead/MRC_RH1626.98UniSTS
D5S1969  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38138,821,015 - 38,821,168UniSTSGRCm38
GRCm38226,248,819 - 26,249,422UniSTSGRCm38
MGSCv37138,877,860 - 38,878,013UniSTSGRCm37
MGSCv37226,104,339 - 26,104,942UniSTSGRCm37
Celera138,606,384 - 38,606,537UniSTS
Celera225,971,489 - 25,972,092UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map1BUniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000039612   ⟹   ENSMUSP00000047372
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl138,833,590 - 38,860,296 (-)Ensembl
GRCm38.p6 Ensembl138,794,509 - 38,821,215 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147695   ⟹   ENSMUSP00000117600
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl138,832,726 - 38,875,792 (-)Ensembl
GRCm38.p6 Ensembl138,793,645 - 38,836,711 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191724
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl138,874,278 - 38,875,455 (-)Ensembl
GRCm38.p6 Ensembl138,835,197 - 38,836,374 (-)Ensembl
RefSeq Acc Id: NM_001029878   ⟹   NP_001025049
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39138,832,750 - 38,875,768 (-)NCBI
GRCm38138,793,669 - 38,836,687 (-)NCBI
MGSCv37138,851,354 - 38,878,060 (-)RGD
Celera138,580,489 - 38,606,584 (-)RGD
cM Map1 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001025049 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI39128 (Get FASTA)   NCBI Sequence Viewer  
  AAI39131 (Get FASTA)   NCBI Sequence Viewer  
  BAB28978 (Get FASTA)   NCBI Sequence Viewer  
  EDL14547 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000047372.5
  ENSMUSP00000117600
  ENSMUSP00000117600.3
Reference Protein Sequences
RefSeq Acc Id: NP_001025049   ⟸   NM_001029878
- UniProtKB: F6ZE64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000117600   ⟸   ENSMUST00000147695
RefSeq Acc Id: ENSMUSP00000047372   ⟸   ENSMUST00000039612
Protein Domains
Lon N-terminal   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F6ZE64-F1-model_v2 AlphaFold F6ZE64 1-754 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920209 AgrOrtholog
Ensembl Genes ENSMUSG00000048814 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000039612.5 UniProtKB/TrEMBL
  ENSMUST00000147695 ENTREZGENE
  ENSMUST00000147695.9 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  2.30.130.40 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro Lon_prtase_N_sf UniProtKB/TrEMBL
  Pept_S16_N UniProtKB/TrEMBL
  PUA-like_domain UniProtKB/TrEMBL
  TPR-like_helical UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report mmu:381338 UniProtKB/TrEMBL
MGD MGI:1920209 ENTREZGENE
NCBI Gene 381338 ENTREZGENE
PANTHER LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN 2 UniProtKB/TrEMBL
  RING FINGER PROTEIN 127 UniProtKB/TrEMBL
Pfam LON UniProtKB/TrEMBL
  zf-C3HC4_2 UniProtKB/TrEMBL
PhenoGen Lonrf2 PhenoGen
PROSITE LON_N UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART LON UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
Superfamily-SCOP PUA-like UniProtKB/TrEMBL
  RING/U-box UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
UniProt B2RT44_MOUSE UniProtKB/TrEMBL
  F6ZE64 ENTREZGENE, UniProtKB/TrEMBL
  Q9D6F3_MOUSE UniProtKB/TrEMBL