Figla (folliculogenesis specific basic helix-loop-helix) - Rat Genome Database
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Gene: Figla (folliculogenesis specific basic helix-loop-helix) Mus musculus
Analyze
Symbol: Figla
Name: folliculogenesis specific basic helix-loop-helix
RGD ID: 1557106
MGI Page MGI
Description: Is expressed in follicle cell of primary follicle; oocyte of primary follicle; oocyte of secondary follicle; and ovary. Human ortholog(s) of this gene implicated in primary ovarian insufficiency. Orthologous to human FIGLA (folliculogenesis specific bHLH transcription factor); INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bHLHc; bHLHc8; factor in the germline alpha; FIG alpha; FIGalpha; transcription factor FIGa
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,993,476 - 85,997,978 (+)NCBIGRCm39mm39
GRCm39 Ensembl685,993,153 - 85,997,978 (+)Ensembl
GRCm38686,016,494 - 86,020,996 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,016,171 - 86,020,996 (+)EnsemblGRCm38mm10GRCm38
MGSCv37685,967,185 - 85,970,990 (+)NCBIGRCm37mm9NCBIm37
MGSCv36685,982,825 - 85,986,630 (+)NCBImm8
Celera687,951,510 - 87,955,321 (+)NCBICelera
Cytogenetic Map6C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:9362457   PMID:11023867   PMID:11279525   PMID:11731253   PMID:14628051   PMID:14681479   PMID:15044608   PMID:15326356   PMID:15618518   PMID:16416028   PMID:16690745   PMID:17015433  
PMID:17567914   PMID:18331719   PMID:18557763   PMID:18804437   PMID:19014927   PMID:19538736   PMID:20106871   PMID:20479125   PMID:21267068   PMID:21427160   PMID:21504946   PMID:21873635  
PMID:22213070   PMID:23497137   PMID:24183939   PMID:24357321   PMID:24400092   PMID:24552588   PMID:24899573   PMID:24952961   PMID:25679966   PMID:31657143   PMID:32086523   PMID:32418930  


Genomics

Comparative Map Data
Figla
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,993,476 - 85,997,978 (+)NCBIGRCm39mm39
GRCm39 Ensembl685,993,153 - 85,997,978 (+)Ensembl
GRCm38686,016,494 - 86,020,996 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,016,171 - 86,020,996 (+)EnsemblGRCm38mm10GRCm38
MGSCv37685,967,185 - 85,970,990 (+)NCBIGRCm37mm9NCBIm37
MGSCv36685,982,825 - 85,986,630 (+)NCBImm8
Celera687,951,510 - 87,955,321 (+)NCBICelera
Cytogenetic Map6C3NCBI
FIGLA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl270,777,310 - 70,790,643 (-)EnsemblGRCh38hg38GRCh38
GRCh38270,777,310 - 70,790,643 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37271,004,442 - 71,017,775 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36270,857,950 - 70,871,283 (-)NCBINCBI36hg18NCBI36
Celera270,855,120 - 70,868,451 (-)NCBI
Cytogenetic Map2p13.3NCBI
HuRef270,741,238 - 70,754,571 (-)NCBIHuRef
CHM1_1270,933,774 - 70,947,094 (-)NCBICHM1_1
Figla
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24118,432,517 - 118,436,846 (+)NCBI
Rnor_6.0 Ensembl4117,679,342 - 117,683,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04117,679,256 - 117,683,618 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04182,253,804 - 182,257,822 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,156,783 - 120,160,708 (+)NCBIRGSC3.4rn4RGSC3.4
Celera4107,405,749 - 107,409,693 (+)NCBICelera
Cytogenetic Map4q34NCBI
Figla
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542414,393,566 - 14,402,971 (+)NCBIChiLan1.0ChiLan1.0
FIGLA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A71,954,067 - 71,967,290 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A71,954,124 - 71,967,339 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A70,840,305 - 70,853,542 (-)NCBIMhudiblu_PPA_v0panPan3
FIGLA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1069,157,741 - 69,163,028 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11069,148,938 - 69,170,371 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Figla
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649114,979,097 - 14,993,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FIGLA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl371,709,681 - 71,723,699 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1371,709,580 - 71,723,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2375,279,760 - 75,293,830 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FIGLA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11436,320,167 - 36,334,099 (+)NCBI
Figla
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247622,599,627 - 2,612,921 (+)NCBI

Position Markers
G65193  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38686,017,298 - 86,017,418UniSTSGRCm38
MGSCv37685,967,292 - 85,967,412UniSTSGRCm37
Celera687,951,617 - 87,951,737UniSTS
Cytogenetic Map6C3UniSTS
cM Map6 UniSTS
mFigla  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS
Figla  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS
Figla  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS
Figla  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:45
Interacting mature miRNAs:47
Transcripts:ENSMUST00000032070
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000032070   ⟹   ENSMUSP00000032070
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl686,017,191 - 86,020,996 (+)Ensembl
RefSeq Acc Id: ENSMUST00000201361
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl686,016,171 - 86,020,786 (+)Ensembl
RefSeq Acc Id: NM_012013   ⟹   NP_036143
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,994,173 - 85,997,978 (+)NCBI
GRCm38686,017,191 - 86,020,996 (+)NCBI
MGSCv37685,967,185 - 85,970,990 (+)RGD
Celera687,951,510 - 87,955,321 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017321595   ⟹   XP_017177084
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,993,476 - 85,997,915 (+)NCBI
GRCm38686,016,494 - 86,020,933 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036143 (Get FASTA)   NCBI Sequence Viewer  
  XP_017177084 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB97139 (Get FASTA)   NCBI Sequence Viewer  
  AFA28135 (Get FASTA)   NCBI Sequence Viewer  
  EDK99154 (Get FASTA)   NCBI Sequence Viewer  
  O55208 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036143   ⟸   NM_012013
- UniProtKB: O55208 (UniProtKB/Swiss-Prot),   H6UWL1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177084   ⟸   XM_017321595
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000032070   ⟸   ENSMUST00000032070
Protein Domains
bHLH

Promoters
RGD ID:6890262
Promoter ID:EPDNEW_M8582
Type:initiation region
Name:Figla_1
Description:Mus musculus folliculogenesis specific basic helix-loop-helix, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38686,017,268 - 86,017,328EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1349421 AgrOrtholog
Ensembl Genes ENSMUSG00000030001 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000032070 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032070 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26910 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1349421 ENTREZGENE
NCBI Gene 26910 ENTREZGENE
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Figla PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt FIGLA_MOUSE UniProtKB/Swiss-Prot
  H6UWL1 ENTREZGENE, UniProtKB/TrEMBL
  O55208 ENTREZGENE