Ido1 (indoleamine 2,3-dioxygenase 1) - Rat Genome Database

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Gene: Ido1 (indoleamine 2,3-dioxygenase 1) Mus musculus
Analyze
Symbol: Ido1
Name: indoleamine 2,3-dioxygenase 1
RGD ID: 731346
MGI Page MGI
Description: Enables tryptophan 2,3-dioxygenase activity. Involved in quinolinate biosynthetic process. Acts upstream of or within several processes, including carboxylic acid metabolic process; regulation of apoptotic process; and regulation of cytokine production. Located in smooth muscle contractile fiber and stereocilium bundle. Is expressed in cerebral cortex; corpus striatum; embryo; extraembryonic component; and hippocampus. Used to study pre-eclampsia. Orthologous to human IDO1 (indoleamine 2,3-dioxygenase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: I; Ido; IDO-1; Indo; indole 2,3-dioxygenase; indoleamine-pyrrole 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39825,074,148 - 25,086,987 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl825,074,152 - 25,087,025 (-)EnsemblGRCm39 Ensembl
GRCm38824,584,133 - 24,596,952 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl824,584,136 - 24,597,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv37825,694,613 - 25,707,481 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36826,049,686 - 26,062,554 (-)NCBIMGSCv36mm8
Celera826,068,313 - 26,081,132 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map812.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
acetylsalicylic acid  (ISO)
aconitic acid  (EXP)
acyclovir  (ISO)
aldehydo-D-glucose  (EXP)
ammonium chloride  (ISO)
anthranilic acid  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
bazedoxifene  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-D-fructofuranose 1,6-bisphosphate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
D-fructofuranose 1,6-bisphosphate  (EXP)
D-glucopyranose 6-phosphate  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
dextran sulfate  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fumaric acid  (EXP)
gadodiamide hydrate  (ISO)
glucose  (EXP)
glycerol 1-phosphate  (EXP)
hexachlorobenzene  (EXP)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin-3'-monoxime  (EXP)
indole-3-methanol  (EXP)
indolin-2-one  (ISO)
keto-D-fructose 1,6-bisphosphate  (EXP)
kynurenine  (EXP)
L-tryptophan  (EXP,ISO)
lasofoxifene  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium chloride  (EXP)
lithium hydride  (EXP)
malathion  (ISO)
malic acid  (EXP)
medroxyprogesterone acetate  (ISO)
muramyl dipeptide  (EXP)
N-nitrosodiethylamine  (ISO)
neopterin  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitric oxide  (ISO)
nitroglycerin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP)
perfluorododecanoic acid  (ISO)
phenethyl caffeate  (ISO)
PhIP  (ISO)
pirinixic acid  (EXP)
poly(I:C)  (ISO)
quercetin  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP)
succinic acid  (EXP)
sulfasalazine  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
XL147  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Tolerogenic Plasmacytoid Dendritic Cells Control Paracoccidioides brasiliensis Infection by Inducting Regulatory T Cells in an IDO-Dependent Manner. Araújo EF, etal., PLoS Pathog. 2016 Dec 19;12(12):e1006115. doi: 10.1371/journal.ppat.1006115. eCollection 2016 Dec.
2. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Bessede A, etal., Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323.
3. Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. Changsirivathanathamrong D, etal., Crit Care Med. 2011 Dec;39(12):2678-83. doi: 10.1097/CCM.0b013e31822827f2.
4. Tryptophan catabolism reflects disease activity in human tuberculosis. Collins JM, etal., JCI Insight. 2020 May 21;5(10). pii: 137131. doi: 10.1172/jci.insight.137131.
5. Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway. Dang Y, etal., Free Radic Biol Med. 2000 Feb 15;28(4):615-24.
6. IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis. De Luca A, etal., PLoS Pathog. 2013;9(7):e1003486. doi: 10.1371/journal.ppat.1003486. Epub 2013 Jul 11.
7. LPS-conditioned dendritic cells confer endotoxin tolerance contingent on tryptophan catabolism. Fallarino F, etal., Immunobiology. 2015 Feb;220(2):315-21. doi: 10.1016/j.imbio.2014.09.017. Epub 2014 Sep 28.
8. Drug analog inhibition of indoleamine 2,3-dioxygenase (IDO) activity modifies pattern recognition receptor expression and proinflammatory cytokine responses early during influenza virus infection. Fox JM, etal., J Leukoc Biol. 2014 Sep;96(3):447-52. doi: 10.1189/jlb.3AB0114-046RR. Epub 2014 May 5.
9. Neopterin levels and Kyn/Trp ratios were significantly increased in dengue virus patients and subsequently decreased after recovery. Geisler S, etal., Int J Infect Dis. 2020 Feb;91:162-168. doi: 10.1016/j.ijid.2019.12.005. Epub 2019 Dec 9.
10. IDO1 depletion induces an anti-inflammatory response in macrophages in mice with chronic viral myocarditis. Guo G, etal., Cell Cycle. 2019 Oct;18(20):2598-2613. doi: 10.1080/15384101.2019.1652471. Epub 2019 Aug 15.
11. Blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cells. Hoshi M, etal., Infect Immun. 2014 Nov;82(11):4487-95. doi: 10.1128/IAI.02113-14. Epub 2014 Aug 11.
12. Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection. Huang L, etal., PLoS One. 2013 Jun 13;8(6):e66546. doi: 10.1371/journal.pone.0066546. Print 2013.
13. Indoleamine 2,3-dioxygenase 1 deletion promotes Theiler's virus-induced seizures in C57BL/6J mice. Juda MB, etal., Epilepsia. 2019 Apr;60(4):626-635. doi: 10.1111/epi.14675. Epub 2019 Feb 15.
14. The kynurenine pathway and neurodegenerative disease. Maddison DC and Giorgini F, Semin Cell Dev Biol. 2015 Apr;40:134-41. doi: 10.1016/j.semcdb.2015.03.002. Epub 2015 Mar 12.
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. Epidermal Growth Factor Receptor-Responsive Indoleamine 2,3-Dioxygenase Confers Immune Homeostasis During Shigella flexneri Infection. Mukherjee T, etal., J Infect Dis. 2019 May 5;219(11):1841-1851. doi: 10.1093/infdis/jiz009.
18. Platelet-activating Factor Mediates Endotoxin Tolerance by Regulating Indoleamine 2,3-Dioxygenase-dependent Expression of the Suppressor of Cytokine Signaling 3. Noh KT, etal., J Biol Chem. 2017 Feb 24;292(8):3290-3298. doi: 10.1074/jbc.M116.764464. Epub 2017 Jan 11.
19. Enzymatic studies on tryptophan metabolism disorder in rats chronically exposed to carbon disulfide. Okayama A, etal., Toxicol Appl Pharmacol. 1988 Jul;94(3):356-61.
20. Indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs. Peng K and Monack DM, Infect Immun. 2010 Jun;78(6):2723-33. doi: 10.1128/IAI.00008-10. Epub 2010 Apr 12.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis. Put K, etal., PLoS One. 2016 Feb 25;11(2):e0150075. doi: 10.1371/journal.pone.0150075. eCollection 2016.
24. Mouse MP Annotation Import Pipeline RGD automated import pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Indolamine 2,3-dioxygenase expression by monocytes and dendritic cell populations in hepatitis C patients. Schulz S, etal., Clin Exp Immunol. 2015 Jun;180(3):484-98. doi: 10.1111/cei.12586.
27. Exaggerated IDO1 expression and activity in Langerhans cells from patients with atopic dermatitis upon viral stimulation: a potential predictive biomarker for high risk of Eczema herpeticum. Staudacher A, etal., Allergy. 2015 Nov;70(11):1432-9. doi: 10.1111/all.12699. Epub 2015 Sep 2.
28. The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. Too LK, etal., Behav Brain Res. 2014 Aug 15;270:179-95. doi: 10.1016/j.bbr.2014.05.018. Epub 2014 May 17.
29. Indoleamine 2,3-Dioxygenase Activity During Acute Toxoplasmosis and the Suppressed T Cell Proliferation in Mice. Ufermann CM, etal., Front Cell Infect Microbiol. 2019 Jun 5;9:184. doi: 10.3389/fcimb.2019.00184. eCollection 2019.
30. Indoleamine 2,3-Dioxygenase Activity in Chlamydia muridarum and Chlamydia pneumoniae Infected Mouse Lung Tissues. Virok DP, etal., Front Cell Infect Microbiol. 2019 Jun 12;9:192. doi: 10.3389/fcimb.2019.00192. eCollection 2019.
31. Role of indoleamine 2,3-dioxygenase in health and disease. Yeung AW, etal., Clin Sci (Lond). 2015 Oct;129(7):601-72. doi: 10.1042/CS20140392.
32. Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation. Zhong W, etal., Oncotarget. 2017 Jun 20;8(25):40486-40500. doi: 10.18632/oncotarget.17119.
33. High expression of IDO1 and TGF-β1 during recurrence and post infection clearance with Chlamydia trachomatis, are independent of host IFN-γ response. Ziklo N, etal., BMC Infect Dis. 2019 Mar 4;19(1):218. doi: 10.1186/s12879-019-3843-4.
Additional References at PubMed
PMID:1937018   PMID:2419335   PMID:9712583   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11553555   PMID:11751753   PMID:11937528   PMID:12209992   PMID:12466851  
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PMID:15541637   PMID:15711557   PMID:15894280   PMID:15967784   PMID:15995970   PMID:16076525   PMID:16135011   PMID:16141072   PMID:16141073   PMID:16157293   PMID:16237046   PMID:16339401  
PMID:16362885   PMID:16785507   PMID:16899371   PMID:17015752   PMID:17055065   PMID:17103092   PMID:17343295   PMID:17360980   PMID:17371982   PMID:17589350   PMID:17609291   PMID:17617580  
PMID:17632406   PMID:17671174   PMID:17710230   PMID:17881253   PMID:17933973   PMID:17947673   PMID:18077788   PMID:18179817   PMID:18221522   PMID:18274832   PMID:18292533   PMID:18332894  
PMID:18384884   PMID:18426872   PMID:18436652   PMID:18452241   PMID:18480171   PMID:18568076   PMID:18694728   PMID:18952840   PMID:18988676   PMID:19000912   PMID:19074614   PMID:19074858  
PMID:19075017   PMID:19088199   PMID:19208362   PMID:19234212   PMID:19234218   PMID:19323847   PMID:19366986   PMID:19494274   PMID:19499519   PMID:19567830   PMID:19635913   PMID:19693771  
PMID:19715679   PMID:19741271   PMID:19828695   PMID:19841163   PMID:19886804   PMID:19924119   PMID:20064452   PMID:20128035   PMID:20160032   PMID:20181893   PMID:20190767   PMID:20233946  
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PMID:22157149   PMID:22355111   PMID:22422885   PMID:22474038   PMID:22609210   PMID:22649518   PMID:22654951   PMID:22751107   PMID:22822050   PMID:22891289   PMID:22895526   PMID:22962681  
PMID:23121975   PMID:23219834   PMID:23291179   PMID:23417792   PMID:23480191   PMID:23578385   PMID:23613752   PMID:23652797   PMID:23669411   PMID:23680027   PMID:23752227   PMID:23786539  
PMID:23840489   PMID:23851696   PMID:23866724   PMID:23891282   PMID:23940687   PMID:23956437   PMID:23973224   PMID:23986400   PMID:23994717   PMID:24039933   PMID:24088531   PMID:24123235  
PMID:24281189   PMID:24402311   PMID:24489090   PMID:24530381   PMID:24580128   PMID:24587363   PMID:24681251   PMID:24752324   PMID:24768802   PMID:24807557   PMID:24826982   PMID:24930629  
PMID:24971697   PMID:25186311   PMID:25322876   PMID:25405209   PMID:25450809   PMID:25602015   PMID:25756191   PMID:25814664   PMID:26033215   PMID:26083579   PMID:26130057   PMID:26216892  
PMID:26235422   PMID:26305550   PMID:26361229   PMID:26426076   PMID:26438837   PMID:26517244   PMID:26601142   PMID:26610689   PMID:26636389   PMID:26727596   PMID:26881431   PMID:26959176  
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PMID:28963880   PMID:28978552   PMID:29104473   PMID:29343435   PMID:29494675   PMID:29677366   PMID:29746927   PMID:29760532   PMID:29942089   PMID:30137504   PMID:30175526   PMID:30268986  
PMID:30374077   PMID:30403776   PMID:30478397   PMID:30679179   PMID:30693061   PMID:30747725   PMID:30760924   PMID:30973865   PMID:31008530   PMID:31325428   PMID:31464185   PMID:31555267  
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PMID:39242914   PMID:39467780  


Genomics

Comparative Map Data
Ido1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39825,074,148 - 25,086,987 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl825,074,152 - 25,087,025 (-)EnsemblGRCm39 Ensembl
GRCm38824,584,133 - 24,596,952 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl824,584,136 - 24,597,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv37825,694,613 - 25,707,481 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36826,049,686 - 26,062,554 (-)NCBIMGSCv36mm8
Celera826,068,313 - 26,081,132 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map812.76NCBI
IDO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38839,913,891 - 39,928,790 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl839,902,275 - 39,928,790 (+)EnsemblGRCh38hg38GRCh38
GRCh37839,771,410 - 39,786,309 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36839,890,485 - 39,905,107 (+)NCBINCBI36Build 36hg18NCBI36
Build 34839,890,484 - 39,905,102NCBI
Celera838,723,061 - 38,737,682 (+)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef838,304,038 - 38,319,017 (+)NCBIHuRef
CHM1_1839,817,930 - 39,832,909 (+)NCBICHM1_1
T2T-CHM13v2.0840,190,729 - 40,205,625 (+)NCBIT2T-CHM13v2.0
Ido1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81674,133,259 - 74,145,328 (+)NCBIGRCr8
mRatBN7.21667,430,654 - 67,442,726 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,430,578 - 67,442,730 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1672,707,823 - 72,719,592 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01676,112,135 - 76,124,005 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01671,361,330 - 71,373,199 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01672,216,326 - 72,228,098 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1672,216,326 - 72,228,098 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,866,330 - 71,878,339 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,866,340 - 71,878,373 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11671,866,604 - 71,878,638 (+)NCBI
Celera1665,330,156 - 65,341,814 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
Ido1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555362,943,611 - 2,955,829 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555362,944,770 - 2,955,829 (-)NCBIChiLan1.0ChiLan1.0
IDO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2758,370,241 - 58,385,003 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1834,087,337 - 34,102,106 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0839,108,310 - 39,123,611 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1836,606,721 - 36,632,371 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl836,617,312 - 36,632,352 (+)Ensemblpanpan1.1panPan2
IDO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11625,391,759 - 25,407,161 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1625,391,754 - 25,407,048 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1625,901,596 - 25,916,857 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01627,218,925 - 27,234,204 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1627,218,820 - 27,234,153 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11625,516,922 - 25,532,182 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01626,072,694 - 26,087,946 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01626,131,508 - 26,146,796 (-)NCBIUU_Cfam_GSD_1.0
Ido1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494348,593,856 - 48,608,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936843657,979 - 672,700 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936843658,058 - 672,662 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,245,196 - 9,260,473 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1179,245,283 - 9,260,140 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21710,913,978 - 10,928,837 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1837,930,910 - 37,950,790 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl837,930,562 - 37,946,505 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660523,981,103 - 3,996,711 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ido1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247803,685,069 - 3,697,474 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247803,684,941 - 3,697,506 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ido1
1177 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:59
Interacting mature miRNAs:61
Transcripts:ENSMUST00000033956, ENSMUST00000110667
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse

Markers in Region
M69109  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38824,584,251 - 24,584,379UniSTSGRCm38
MGSCv37825,694,723 - 25,694,851UniSTSGRCm37
Celera826,068,423 - 26,068,551UniSTS
Cytogenetic Map8A2UniSTS
Whitehead/MRC_RH8288.35UniSTS
Ido  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A2UniSTS
cM Map8 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000033956   ⟹   ENSMUSP00000033956
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl825,074,152 - 25,087,025 (-)Ensembl
GRCm38.p6 Ensembl824,584,136 - 24,597,009 (-)Ensembl
Ensembl Acc Id: ENSMUST00000110667   ⟹   ENSMUSP00000106295
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl825,074,152 - 25,085,682 (-)Ensembl
GRCm38.p6 Ensembl824,584,136 - 24,595,666 (-)Ensembl
RefSeq Acc Id: NM_001293690   ⟹   NP_001280619
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39825,074,148 - 25,085,682 (-)NCBI
GRCm38824,584,133 - 24,595,666 (-)NCBI
Celera826,068,305 - 26,081,075 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008324   ⟹   NP_032350
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39825,074,148 - 25,086,987 (-)NCBI
GRCm38824,584,133 - 24,596,952 (-)NCBI
MGSCv37825,694,613 - 25,707,481 (-)RGD
Celera826,068,305 - 26,081,075 (-)NCBI
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032350   ⟸   NM_008324
- Peptide Label: isoform 1
- UniProtKB: P28776 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001280619   ⟸   NM_001293690
- Peptide Label: isoform 2
- UniProtKB: D3YXV1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000106295   ⟸   ENSMUST00000110667
Ensembl Acc Id: ENSMUSP00000033956   ⟸   ENSMUST00000033956

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28776-F1-model_v2 AlphaFold P28776 1-407 view protein structure

Promoters
RGD ID:8666727
Promoter ID:EPDNEW_M11395
Type:initiation region
Name:Ido1_2
Description:Mus musculus indoleamine 2,3-dioxygenase 1 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11396  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38824,595,644 - 24,595,704EPDNEW
RGD ID:8666729
Promoter ID:EPDNEW_M11396
Type:multiple initiation site
Name:Ido1_1
Description:Mus musculus indoleamine 2,3-dioxygenase 1 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11395  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38824,596,971 - 24,597,031EPDNEW
RGD ID:6843310
Promoter ID:MM_KWN:53980
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Kidney,   Lung
Transcripts:ENSMUST00000110667
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36825,705,986 - 25,706,486 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96416 AgrOrtholog
Ensembl Genes ENSMUSG00000031551 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033956 ENTREZGENE
  ENSMUST00000033956.7 UniProtKB/Swiss-Prot
  ENSMUST00000110667 ENTREZGENE
Gene3D-CATH 1.20.58.480 UniProtKB/Swiss-Prot
InterPro Indolamine_dOase UniProtKB/Swiss-Prot
  Trp/Indoleamine_2_3_dOase-like UniProtKB/Swiss-Prot
KEGG Report mmu:15930 UniProtKB/Swiss-Prot
MGD MGI:96416 ENTREZGENE
NCBI Gene 15930 ENTREZGENE
PANTHER INDOLEAMINE 2,3-DIOXYGENASE 1 UniProtKB/Swiss-Prot
  PTHR28657 UniProtKB/Swiss-Prot
Pfam IDO UniProtKB/Swiss-Prot
PhenoGen Ido1 PhenoGen
PROSITE IDO_1 UniProtKB/Swiss-Prot
  IDO_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF140959 UniProtKB/Swiss-Prot
UniProt D3YXV1 ENTREZGENE, UniProtKB/TrEMBL
  I23O1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE