Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | decreases expression | EXP | | 6480464 | vinylidene chloride results in decreased expression of DKK2 mRNA | CTD | PMID:26682919 | 1-naphthyl isothiocyanate | decreases expression | ISO | Dkk2 (Rattus norvegicus) | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of DKK2 mRNA | CTD | PMID:30723492 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | ESR1 protein promotes the reaction [Estradiol results in decreased expression of DKK2 mRNA] | CTD | PMID:25210133 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of DKK2 mRNA | CTD | PMID:23144751 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of DKK2 mRNA | CTD | PMID:19484750 and PMID:25210133 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to DKK2 promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of DKK2 mRNA | CTD | PMID:36370075 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Dkk2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of DKK2 mRNA | CTD | PMID:34747641 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | ISO | Dkk2 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:32109520 | 4,4'-sulfonyldiphenol | increases expression | EXP | | 6480464 | bisphenol S results in increased expression of DKK2 mRNA | CTD | PMID:30951980 | 5-aza-2'-deoxycytidine | increases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Decitabine results in increased expression of DKK2 mRNA | CTD | PMID:27901495 | acrylamide | decreases expression | ISO | Dkk2 (Rattus norvegicus) | 6480464 | Acrylamide results in decreased expression of DKK2 mRNA | CTD | PMID:28959563 | aflatoxin B1 | affects expression | ISO | DKK2 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of DKK2 protein | CTD | PMID:20106945 | all-trans-retinoic acid | increases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of DKK2 mRNA | CTD | PMID:23724009 | antirheumatic drug | affects expression | ISO | DKK2 (Homo sapiens) | 6480464 | Antirheumatic Agents affects the expression of DKK2 mRNA | CTD | PMID:24449571 | atrazine | decreases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of DKK2 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | decreases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of DKK2 mRNA | CTD | PMID:20064835 and PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | DKK2 (Homo sapiens) | 6480464 | Ascorbic Acid inhibits the reaction [Benzo(a)pyrene results in decreased expression of DKK2 mRNA] and Ascorbic Acid inhibits the reaction [Benzo(a)pyrene results in increased methylation of DKK2 promoter] | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | DKK2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of DKK2 exon and Benzo(a)pyrene results in increased methylation of DKK2 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | affects expression | ISO | DKK2 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20382639 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Dkk2 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DKK2 promoter | CTD | PMID:23359474 | bis(2-ethylhexyl) phthalate | increases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of DKK2 mRNA | CTD | PMID:31163220 | bisphenol A | multiple interactions | ISO | Dkk2 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DKK2 promoter | CTD | PMID:23359474 | bisphenol A | decreases methylation | ISO | DKK2 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of DKK2 gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | Dkk2 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of DKK2 mRNA | CTD | PMID:33296240 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of DKK2 mRNA | CTD | PMID:30951980 | bisphenol A | decreases expression | ISO | Dkk2 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of DKK2 mRNA | CTD | PMID:30816183 more ... | bisphenol F | increases expression | EXP | | 6480464 | bisphenol F results in increased expression of DKK2 mRNA | CTD | PMID:30951980 | bisphenol F | multiple interactions | ISO | DKK2 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in decreased methylation of DKK2 gene | CTD | PMID:31601247 | buserelin | multiple interactions | ISO | DKK2 (Homo sapiens) | 6480464 | [Buserelin co-treated with CGB3 protein] results in decreased expression of DKK2 mRNA | CTD | PMID:19955106 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes and Carbon analog results in increased expression of DKK2 mRNA | CTD | PMID:25554681 | celastrol | multiple interactions | EXP | | 6480464 | celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of DKK2 mRNA] | CTD | PMID:31715269 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DKK2 gene | CTD | PMID:20938992 | corosolic acid | multiple interactions | EXP | | 6480464 | corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of DKK2 mRNA] | CTD | PMID:32135139 | deguelin | decreases expression | ISO | DKK2 (Homo sapiens) | 6480464 | deguelin results in decreased expression of DKK2 mRNA | CTD | PMID:19861542 | dextran sulfate | multiple interactions | EXP | | 6480464 | [Dextran Sulfate co-treated with Azoxymethane] results in increased expression of DKK2 mRNA and celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of DKK2 mRNA] | CTD | PMID:31715269 | dibutyl phthalate | multiple interactions | ISO | Dkk2 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DKK2 promoter | CTD | PMID:23359474 | dimethylarsinic acid | decreases expression | ISO | Dkk2 (Rattus norvegicus) | 6480464 | Cacodylic Acid results in decreased expression of DKK2 mRNA | CTD | PMID:37567419 | diquat | decreases expression | EXP | | 6480464 | Diquat results in decreased expression of DKK2 mRNA | CTD | PMID:36851058 | diuron | decreases expression | ISO | Dkk2 (Rattus norvegicus) | 6480464 | Diuron results in decreased expression of DKK2 mRNA | CTD | PMID:25152437 | dorsomorphin | multiple interactions | ISO | DKK2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK2 mRNA | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of DKK2 mRNA | CTD | PMID:16404146 | endosulfan | decreases expression | ISO | Dkk2 (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of DKK2 mRNA | CTD | PMID:29391264 | ethylparaben | increases expression | ISO | DKK2 (Homo sapiens) | 6480464 | ethyl-p-hydroxybenzoate results in increased expression of DKK2 mRNA | CTD | PMID:37690743 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DKK2 gene | CTD | PMID:20938992 | fulvestrant | multiple interactions | ISO | DKK2 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in decreased methylation of DKK2 gene | CTD | PMID:31601247 | indometacin | increases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Indomethacin results in increased expression of DKK2 mRNA | CTD | PMID:24737281 | L-ascorbic acid | multiple interactions | ISO | DKK2 (Homo sapiens) | 6480464 | Ascorbic Acid inhibits the reaction [Benzo(a)pyrene results in decreased expression of DKK2 mRNA] and Ascorbic Acid inhibits the reaction [Benzo(a)pyrene results in increased methylation of DKK2 promoter] | CTD | PMID:27901495 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DKK2 gene | CTD | PMID:20938992 | lipopolysaccharide | affects expression | ISO | DKK2 (Homo sapiens) | 6480464 | Lipopolysaccharides affects the expression of DKK2 mRNA | CTD | PMID:28070326 | lipopolysaccharide | multiple interactions | ISO | DKK2 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:28070326 and PMID:35811015 | malathion | increases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Malathion results in increased expression of DKK2 mRNA | CTD | PMID:37047231 | N,N-diethyl-m-toluamide | multiple interactions | ISO | Dkk2 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of DKK2 gene | CTD | PMID:33148267 | nickel atom | decreases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Nickel results in decreased expression of DKK2 mRNA | CTD | PMID:25583101 | paracetamol | increases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of DKK2 mRNA | CTD | PMID:29067470 | perfluorohexanesulfonic acid | increases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in increased expression of DKK2 mRNA | CTD | PMID:37995155 | permethrin | multiple interactions | ISO | Dkk2 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of DKK2 gene | CTD | PMID:33148267 | phenylmercury acetate | increases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of DKK2 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | DKK2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK2 mRNA | CTD | PMID:27188386 | phorbol 13-acetate 12-myristate | increases expression | EXP | | 6480464 | Tetradecanoylphorbol Acetate results in increased expression of DKK2 mRNA | CTD | PMID:32135139 | phorbol 13-acetate 12-myristate | multiple interactions | EXP | | 6480464 | corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of DKK2 mRNA] | CTD | PMID:32135139 | pirinixic acid | multiple interactions | ISO | DKK2 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DKK2 mRNA | CTD | PMID:19710929 | quercetin | increases expression | ISO | Dkk2 (Rattus norvegicus) | 6480464 | Quercetin results in increased expression of DKK2 mRNA | CTD | PMID:23117658 | raloxifene | decreases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Raloxifene Hydrochloride results in decreased expression of DKK2 mRNA | CTD | PMID:19429434 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | DKK2 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of DKK2 mRNA | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | DKK2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK2 mRNA | CTD | PMID:27188386 | sodium arsenite | affects methylation | ISO | DKK2 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of DKK2 gene | CTD | PMID:28589171 | sodium arsenite | decreases expression | ISO | DKK2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of DKK2 mRNA | CTD | PMID:34032870 | sodium arsenite | increases expression | ISO | DKK2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of DKK2 mRNA | CTD | PMID:29301061 | sodium fluoride | decreases expression | EXP | | 6480464 | Sodium Fluoride results in decreased expression of DKK2 mRNA | CTD | PMID:27862939 | sodium fluoride | decreases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Sodium Fluoride results in decreased expression of DKK2 protein | CTD | PMID:34942272 | sodium fluoride | multiple interactions | ISO | DKK2 (Homo sapiens) | 6480464 | MIR21 mRNA affects the reaction [Sodium Fluoride results in decreased expression of DKK2 protein] | CTD | PMID:34942272 | testosterone enanthate | affects expression | ISO | DKK2 (Homo sapiens) | 6480464 | testosterone enanthate affects the expression of DKK2 mRNA | CTD | PMID:17440010 | trichloroethene | increases expression | ISO | Dkk2 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of DKK2 mRNA | CTD | PMID:33387578 | trichostatin A | increases expression | ISO | DKK2 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of DKK2 mRNA | CTD | PMID:24935251 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of DKK2 mRNA | CTD | PMID:33045310 | valproic acid | increases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of DKK2 mRNA | CTD | PMID:24935251 and PMID:28001369 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of DKK2 mRNA | CTD | PMID:24896083 | vinclozolin | decreases methylation | ISO | Dkk2 (Rattus norvegicus) | 6480464 | vinclozolin results in decreased methylation of DKK2 gene | CTD | PMID:31079544 | zearalenone | decreases expression | EXP | | 6480464 | Zearalenone results in decreased expression of DKK2 mRNA | CTD | PMID:27862621 | zinc atom | decreases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Zinc deficiency results in decreased expression of DKK2 mRNA | CTD | PMID:18356318 | zinc(0) | decreases expression | ISO | DKK2 (Homo sapiens) | 6480464 | Zinc deficiency results in decreased expression of DKK2 mRNA | CTD | PMID:18356318 | |