Cuzd1 (CUB and zona pellucida-like domains 1) - Rat Genome Database

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Gene: Cuzd1 (CUB and zona pellucida-like domains 1) Mus musculus
Analyze
Symbol: Cuzd1
Name: CUB and zona pellucida-like domains 1
RGD ID: 733940
MGI Page MGI
Description: Involved in trypsinogen activation. Located in zymogen granule membrane. Orthologous to human CUZD1 (CUB and zona pellucida like domains 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CUB and zona pellucida-like domain-containing protein 1; CUB and ZP domain-containing protein 1; ERG-; ERG-1; integral membrane-associated protein 1; Itm; Itmap1; UO-4; UO-44; USG; UTCZ; UTCZP
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397130,910,283 - 130,924,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7130,910,283 - 130,924,021 (-)EnsemblGRCm39 Ensembl
GRCm387131,308,554 - 131,322,292 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7131,308,554 - 131,322,292 (-)EnsemblGRCm38mm10GRCm38
MGSCv377138,452,068 - 138,465,806 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367131,099,702 - 131,113,440 (-)NCBIMGSCv36mm8
Celera7131,119,865 - 131,133,706 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map773.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:9480914   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12401800   PMID:12477932   PMID:16141072   PMID:16141073   PMID:17393098   PMID:20562862   PMID:21677750   PMID:21873635  
PMID:28278176   PMID:29321207   PMID:33505018  


Genomics

Comparative Map Data
Cuzd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397130,910,283 - 130,924,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7130,910,283 - 130,924,021 (-)EnsemblGRCm39 Ensembl
GRCm387131,308,554 - 131,322,292 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7131,308,554 - 131,322,292 (-)EnsemblGRCm38mm10GRCm38
MGSCv377138,452,068 - 138,465,806 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367131,099,702 - 131,113,440 (-)NCBIMGSCv36mm8
Celera7131,119,865 - 131,133,706 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map773.81NCBI
CUZD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810122,832,158 - 122,845,857 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10122,832,158 - 122,846,175 (-)EnsemblGRCh38hg38GRCh38
GRCh3710124,591,674 - 124,605,373 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610124,581,664 - 124,595,681 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410124,581,660 - 124,600,300NCBI
Celera10118,298,121 - 118,312,137 (-)NCBICelera
Cytogenetic Map10q26.13NCBI
HuRef10118,209,163 - 118,223,182 (-)NCBIHuRef
CHM1_110124,873,349 - 124,887,368 (-)NCBICHM1_1
T2T-CHM13v2.010123,707,147 - 123,720,845 (-)NCBIT2T-CHM13v2.0
Cuzd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,519,609 - 195,532,733 (-)NCBIGRCr8
mRatBN7.21186,089,422 - 186,130,536 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1186,089,423 - 186,102,546 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1194,439,582 - 194,452,711 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01201,617,109 - 201,630,102 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01194,288,869 - 194,301,992 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01201,881,846 - 201,894,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1201,881,836 - 201,894,775 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01208,914,609 - 208,927,737 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41190,887,527 - 190,900,654 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11191,037,408 - 191,050,535 (-)NCBI
Celera1183,844,186 - 183,857,299 (-)NCBICelera
Cytogenetic Map1q41NCBI
Cuzd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554771,055,229 - 1,069,913 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554771,055,245 - 1,067,702 (-)NCBIChiLan1.0ChiLan1.0
CUZD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28134,682,402 - 134,696,673 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110134,686,822 - 134,702,025 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010119,395,492 - 119,409,696 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110123,669,429 - 123,716,925 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10123,667,289 - 123,716,925 (-)Ensemblpanpan1.1panPan2
CUZD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12832,452,557 - 32,465,111 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2832,452,772 - 32,465,051 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2832,518,689 - 32,531,263 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02833,009,225 - 33,021,810 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2833,009,458 - 33,021,748 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12832,533,078 - 32,545,649 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02832,557,175 - 32,569,757 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02832,808,667 - 32,821,256 (-)NCBIUU_Cfam_GSD_1.0
Cuzd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721314,000,432 - 14,010,842 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648611,550,562 - 11,560,853 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648611,550,513 - 11,560,853 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUZD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19115,539,466 - 115,553,955 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9115,539,499 - 115,553,178 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604876,847,948 - 76,861,983 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cuzd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247378,665,998 - 8,676,520 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cuzd1
722 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:216
Count of miRNA genes:179
Interacting mature miRNAs:193
Transcripts:ENSMUST00000046611
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122250663135170901Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse

Markers in Region
U69699  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387131,308,635 - 131,308,724UniSTSGRCm38
MGSCv377138,452,149 - 138,452,238UniSTSGRCm37
Celera7131,119,946 - 131,120,035UniSTS
Cytogenetic Map7F3UniSTS
Whitehead/MRC_RH71346.58UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000046611   ⟹   ENSMUSP00000037168
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7130,910,283 - 130,924,021 (-)Ensembl
GRCm38.p6 Ensembl7131,308,554 - 131,322,292 (-)Ensembl
RefSeq Acc Id: NM_008411   ⟹   NP_032437
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397130,910,283 - 130,924,021 (-)NCBI
GRCm387131,308,554 - 131,322,292 (-)ENTREZGENE
MGSCv377138,452,068 - 138,465,806 (-)RGD
Celera7131,119,865 - 131,133,706 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032437 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC24898 (Get FASTA)   NCBI Sequence Viewer  
  AAI40993 (Get FASTA)   NCBI Sequence Viewer  
  BAB31520 (Get FASTA)   NCBI Sequence Viewer  
  EDL17697 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000037168
  ENSMUSP00000037168.8
GenBank Protein P70412 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032437   ⟸   NM_008411
- Peptide Label: precursor
- UniProtKB: P70412 (UniProtKB/Swiss-Prot),   Q9CTZ7 (UniProtKB/Swiss-Prot),   B2RU69 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000037168   ⟸   ENSMUST00000046611
Protein Domains
CUB   ZP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70412-F1-model_v2 AlphaFold P70412 1-607 view protein structure

Promoters
RGD ID:8665825
Promoter ID:EPDNEW_M10944
Type:initiation region
Name:Cuzd1_1
Description:Mus musculus CUB and zona pellucida-like domains 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387131,322,058 - 131,322,118EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1202881 AgrOrtholog
Ensembl Genes ENSMUSG00000040205 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000046611 ENTREZGENE
  ENSMUST00000046611.9 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.290 UniProtKB/Swiss-Prot
  2.60.40.4100 UniProtKB/Swiss-Prot
  Zona pellucida, ZP-N domain UniProtKB/Swiss-Prot
InterPro CUB_dom UniProtKB/Swiss-Prot
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot
  ZP-C UniProtKB/Swiss-Prot
  ZP_chr UniProtKB/Swiss-Prot
  ZP_dom UniProtKB/Swiss-Prot
KEGG Report mmu:16433 UniProtKB/Swiss-Prot
MGD MGI:1202881 ENTREZGENE
NCBI Gene 16433 ENTREZGENE
PANTHER CUB AND ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot
  ENDOGLIN/TGF-BETA RECEPTOR TYPE III UniProtKB/Swiss-Prot
Pfam CUB UniProtKB/Swiss-Prot
  Zona_pellucida UniProtKB/Swiss-Prot
PhenoGen Cuzd1 PhenoGen
PRINTS ZPELLUCIDA UniProtKB/Swiss-Prot
PROSITE CUB UniProtKB/Swiss-Prot
  ZP_2 UniProtKB/Swiss-Prot
SMART CUB UniProtKB/Swiss-Prot
  SM00241 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49854 UniProtKB/Swiss-Prot
UniProt B2RU69 ENTREZGENE
  CUZD1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9CTZ7 ENTREZGENE
UniProt Secondary B2RU69 UniProtKB/Swiss-Prot
  Q9CTZ7 UniProtKB/Swiss-Prot