Oxsr1 (oxidative-stress responsive 1) - Rat Genome Database
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Gene: Oxsr1 (oxidative-stress responsive 1) Mus musculus
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Symbol: Oxsr1
Name: oxidative-stress responsive 1
RGD ID: 1553494
MGI Page MGI
Description: Exhibits protein serine/threonine kinase activity. Involved in several processes, including cellular hypotonic response; chemokine (C-C motif) ligand 21 signaling pathway; and positive regulation of T cell chemotaxis. Predicted to localize to cytosol. Is expressed in loop of Henle distal straight tubule and metanephros. Orthologous to human OXSR1 (oxidative stress responsive kinase 1); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2210022N24Rik; 2810422B09Rik; AI462649; AW209236; mKIAA1101; O; Osr1; oxidative stress-responsive 1 protein; serine/threonine-protein kinase OSR1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,067,498 - 119,154,475 (-)NCBIGRCm39mm39
GRCm389119,238,432 - 119,322,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,238,432 - 119,322,427 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,149,784 - 119,213,966 (-)NCBIGRCm37mm9NCBIm37
MGSCv369119,087,131 - 119,171,125 (-)NCBImm8
Celera9119,708,063 - 119,774,018 (-)NCBICelera
Cytogenetic Map9F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12386165   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14621295   PMID:14707132  
PMID:15345747   PMID:15489334   PMID:15741177   PMID:16141072   PMID:16141073   PMID:16382158   PMID:17967808   PMID:18799693   PMID:18800028   PMID:19008908   PMID:19307180   PMID:20091762  
PMID:20231443   PMID:21267068   PMID:21486947   PMID:21873635   PMID:21907141   PMID:21972418   PMID:22648948   PMID:22977235   PMID:23019198   PMID:23386621   PMID:24039833   PMID:24173353  
PMID:24393035   PMID:24808538   PMID:25322850   PMID:25515571   PMID:25565204   PMID:26861815   PMID:27068441   PMID:27400149   PMID:27689697   PMID:27782176   PMID:27853306   PMID:30196744  
PMID:30563844   PMID:31666509   PMID:32325033  


Genomics

Comparative Map Data
Oxsr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,067,498 - 119,154,475 (-)NCBIGRCm39mm39
GRCm389119,238,432 - 119,322,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,238,432 - 119,322,427 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,149,784 - 119,213,966 (-)NCBIGRCm37mm9NCBIm37
MGSCv369119,087,131 - 119,171,125 (-)NCBImm8
Celera9119,708,063 - 119,774,018 (-)NCBICelera
Cytogenetic Map9F3NCBI
OXSR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl338,165,089 - 38,255,484 (+)EnsemblGRCh38hg38GRCh38
GRCh38338,165,051 - 38,255,486 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37338,207,022 - 38,296,979 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,182,030 - 38,271,983 (+)NCBINCBI36hg18NCBI36
Build 34338,182,029 - 38,271,979NCBI
Celera338,142,644 - 38,232,606 (+)NCBI
Cytogenetic Map3p22.2NCBI
HuRef338,248,039 - 38,338,925 (+)NCBIHuRef
CHM1_1338,158,703 - 38,248,663 (+)NCBICHM1_1
Oxsr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08127,920,349 - 128,009,951 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,920,349 - 128,009,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,127,110 - 127,216,712 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,196,599 - 124,286,647 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,217,575 - 124,306,410 (-)NCBI
Celera8118,123,990 - 118,213,225 (-)NCBICelera
Cytogenetic Map8q32NCBI
Oxsr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,575,655 - 25,696,356 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542725,575,655 - 25,696,356 (+)NCBIChiLan1.0ChiLan1.0
OXSR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1338,345,491 - 38,436,279 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,345,504 - 38,436,275 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0338,063,299 - 38,153,609 (+)NCBIMhudiblu_PPA_v0panPan3
OXSR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl237,932,254 - 8,024,323 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1237,931,636 - 8,026,591 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Oxsr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647327,559,756 - 27,658,299 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OXSR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,020,530 - 23,116,958 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,020,839 - 23,116,957 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,225,156 - 25,288,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OXSR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,164,529 - 1,255,935 (-)NCBI
ChlSab1.1 Ensembl151,164,528 - 1,255,925 (-)Ensembl
Oxsr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247312,703,295 - 2,825,017 (+)NCBI

Position Markers
AW209236  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,238,583 - 119,238,688UniSTSGRCm38
MGSCv379119,147,701 - 119,147,806UniSTSGRCm37
Celera9119,705,980 - 119,706,085UniSTS
Cytogenetic Map9F3UniSTS
Whitehead/MRC_RH91175.69UniSTS
AI462649  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,240,717 - 119,240,804UniSTSGRCm38
MGSCv379119,149,835 - 119,149,922UniSTSGRCm37
Celera9119,708,114 - 119,708,201UniSTS
Cytogenetic Map9F3UniSTS
Whitehead/MRC_RH91179.61UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1984
Count of miRNA genes:744
Interacting mature miRNAs:936
Transcripts:ENSMUST00000040853, ENSMUST00000128880, ENSMUST00000136902, ENSMUST00000143728
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000040853   ⟹   ENSMUSP00000042155
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,238,432 - 119,322,427 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128880   ⟹   ENSMUSP00000122692
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,240,670 - 119,322,322 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136902
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,241,145 - 119,243,362 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143728   ⟹   ENSMUSP00000117327
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,242,768 - 119,264,772 (-)Ensembl
RefSeq Acc Id: NM_001359582   ⟹   NP_001346511
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,067,498 - 119,151,493 (-)NCBI
GRCm389119,238,432 - 119,322,427 (-)NCBI
Sequence:
RefSeq Acc Id: NM_133985   ⟹   NP_598746
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,067,498 - 119,151,493 (-)NCBI
GRCm389119,238,432 - 119,322,427 (-)NCBI
MGSCv379119,149,784 - 119,213,966 (-)RGD
Celera9119,705,829 - 119,791,544 (-)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_045693
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,067,498 - 119,151,493 (-)NCBI
GRCm389119,238,432 - 119,322,427 (-)NCBI
Celera9119,705,829 - 119,791,544 (-)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030244002   ⟹   XP_030099862
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,067,504 - 119,154,475 (-)NCBI
GRCm389119,238,438 - 119,322,684 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598746   ⟸   NM_133985
- UniProtKB: Q6P9R2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001346511   ⟸   NM_001359582
RefSeq Acc Id: XP_030099862   ⟸   XM_030244002
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000117327   ⟸   ENSMUST00000143728
RefSeq Acc Id: ENSMUSP00000042155   ⟸   ENSMUST00000040853
RefSeq Acc Id: ENSMUSP00000122692   ⟸   ENSMUST00000128880
Protein Domains
Protein kinase

Promoters
RGD ID:6844901
Promoter ID:MM_KWN:59124
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung
Transcripts:UC009SAN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,148,094 - 119,148,594 (-)MPROMDB
RGD ID:6844899
Promoter ID:MM_KWN:59125
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000074553
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,152,926 - 119,153,426 (-)MPROMDB
RGD ID:8671186
Promoter ID:EPDNEW_M13624
Type:initiation region
Name:Oxsr1_1
Description:Mus musculus oxidative-stress responsive 1 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389119,322,437 - 119,322,497EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917378 AgrOrtholog
Ensembl Genes ENSMUSG00000036737 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000042155 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000117327 UniProtKB/TrEMBL
  ENSMUSP00000122692 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000040853 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000128880 UniProtKB/TrEMBL
  ENSMUST00000143728 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/Swiss-Prot
  Oxsr1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:108737 UniProtKB/Swiss-Prot
MGD MGI:1917378 ENTREZGENE
NCBI Gene 108737 ENTREZGENE
PANTHER PTHR24361:SF435 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam OSR1_C UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Oxsr1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.293565 ENTREZGENE
UniProt D6RFV0_MOUSE UniProtKB/TrEMBL
  F7AVI9_MOUSE UniProtKB/TrEMBL
  OXSR1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8VDZ9_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8BVZ9 UniProtKB/Swiss-Prot
  Q8C0B9 UniProtKB/Swiss-Prot