Oxsr1 (oxidative-stress responsive 1) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Oxsr1 (oxidative-stress responsive 1) Mus musculus
Analyze
Symbol: Oxsr1
Name: oxidative-stress responsive 1
RGD ID: 1553494
MGI Page MGI
Description: Exhibits protein serine/threonine kinase activity. Involved in several processes, including cellular hypotonic response; chemokine (C-C motif) ligand 21 signaling pathway; and positive regulation of T cell chemotaxis. Predicted to localize to cytosol. Is expressed in loop of Henle distal straight tubule and metanephros. Orthologous to human OXSR1 (oxidative stress responsive kinase 1); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2210022N24Rik; 2810422B09Rik; AI462649; AW209236; mKIAA1101; O; Osr1; oxidative stress-responsive 1 protein; serine/threonine-protein kinase OSR1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,067,498 - 119,154,475 (-)NCBIGRCm39mm39
GRCm389119,238,432 - 119,322,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,238,432 - 119,322,427 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,149,784 - 119,213,966 (-)NCBIGRCm37mm9NCBIm37
MGSCv369119,087,131 - 119,171,125 (-)NCBImm8
Celera9119,708,063 - 119,774,018 (-)NCBICelera
Cytogenetic Map9F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12386165   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14621295   PMID:14707132  
PMID:15345747   PMID:15489334   PMID:15741177   PMID:16141072   PMID:16141073   PMID:16382158   PMID:17967808   PMID:18799693   PMID:18800028   PMID:19008908   PMID:19307180   PMID:20091762  
PMID:20231443   PMID:21267068   PMID:21486947   PMID:21873635   PMID:21907141   PMID:21972418   PMID:22648948   PMID:22977235   PMID:23019198   PMID:23386621   PMID:24039833   PMID:24173353  
PMID:24393035   PMID:24808538   PMID:25322850   PMID:25515571   PMID:25565204   PMID:26861815   PMID:27068441   PMID:27400149   PMID:27689697   PMID:27782176   PMID:27853306   PMID:30196744  
PMID:30563844   PMID:31666509   PMID:32325033  


Genomics

Comparative Map Data
Oxsr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,067,498 - 119,154,475 (-)NCBIGRCm39mm39
GRCm389119,238,432 - 119,322,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,238,432 - 119,322,427 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,149,784 - 119,213,966 (-)NCBIGRCm37mm9NCBIm37
MGSCv369119,087,131 - 119,171,125 (-)NCBImm8
Celera9119,708,063 - 119,774,018 (-)NCBICelera
Cytogenetic Map9F3NCBI
OXSR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl338,165,089 - 38,255,484 (+)EnsemblGRCh38hg38GRCh38
GRCh38338,165,051 - 38,255,486 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37338,207,022 - 38,296,979 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,182,030 - 38,271,983 (+)NCBINCBI36hg18NCBI36
Build 34338,182,029 - 38,271,979NCBI
Celera338,142,644 - 38,232,606 (+)NCBI
Cytogenetic Map3p22.2NCBI
HuRef338,248,039 - 38,338,925 (+)NCBIHuRef
CHM1_1338,158,703 - 38,248,663 (+)NCBICHM1_1
Oxsr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08127,920,349 - 128,009,951 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,920,349 - 128,009,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,127,110 - 127,216,712 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,196,599 - 124,286,647 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,217,575 - 124,306,410 (-)NCBI
Celera8118,123,990 - 118,213,225 (-)NCBICelera
Cytogenetic Map8q32NCBI
Oxsr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,575,655 - 25,696,356 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542725,575,655 - 25,696,356 (+)NCBIChiLan1.0ChiLan1.0
OXSR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1338,345,491 - 38,436,279 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,345,504 - 38,436,275 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0338,063,299 - 38,153,609 (+)NCBIMhudiblu_PPA_v0panPan3
OXSR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl237,932,254 - 8,024,323 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1237,931,636 - 8,026,591 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Oxsr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647327,559,756 - 27,658,299 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OXSR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,020,530 - 23,116,958 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,020,839 - 23,116,957 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,225,156 - 25,288,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OXSR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,164,529 - 1,255,935 (-)NCBI
ChlSab1.1 Ensembl151,164,528 - 1,255,925 (-)Ensembl
Oxsr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247312,703,295 - 2,825,017 (+)NCBI

Position Markers
AW209236  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,238,583 - 119,238,688UniSTSGRCm38
MGSCv379119,147,701 - 119,147,806UniSTSGRCm37
Celera9119,705,980 - 119,706,085UniSTS
Cytogenetic Map9F3UniSTS
Whitehead/MRC_RH91175.69UniSTS
AI462649  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,240,717 - 119,240,804UniSTSGRCm38
MGSCv379119,149,835 - 119,149,922UniSTSGRCm37
Celera9119,708,114 - 119,708,201UniSTS
Cytogenetic Map9F3UniSTS
Whitehead/MRC_RH91179.61UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1984
Count of miRNA genes:744
Interacting mature miRNAs:936
Transcripts:ENSMUST00000040853, ENSMUST00000128880, ENSMUST00000136902, ENSMUST00000143728
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000040853   ⟹   ENSMUSP00000042155
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,238,432 - 119,322,427 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128880   ⟹   ENSMUSP00000122692
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,240,670 - 119,322,322 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136902
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,241,145 - 119,243,362 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143728   ⟹   ENSMUSP00000117327
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,242,768 - 119,264,772 (-)Ensembl
RefSeq Acc Id: NM_001359582   ⟹   NP_001346511
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,067,498 - 119,151,493 (-)NCBI
GRCm389119,238,432 - 119,322,427 (-)NCBI
Sequence:
RefSeq Acc Id: NM_133985   ⟹   NP_598746
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,067,498 - 119,151,493 (-)NCBI
GRCm389119,238,432 - 119,322,427 (-)NCBI
MGSCv379119,149,784 - 119,213,966 (-)RGD
Celera9119,705,829 - 119,791,544 (-)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_045693
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,067,498 - 119,151,493 (-)NCBI
GRCm389119,238,432 - 119,322,427 (-)NCBI
Celera9119,705,829 - 119,791,544 (-)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030244002   ⟹   XP_030099862
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,067,504 - 119,154,475 (-)NCBI
GRCm389119,238,438 - 119,322,684 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598746   ⟸   NM_133985
- UniProtKB: Q6P9R2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001346511   ⟸   NM_001359582
RefSeq Acc Id: XP_030099862   ⟸   XM_030244002
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000117327   ⟸   ENSMUST00000143728
RefSeq Acc Id: ENSMUSP00000042155   ⟸   ENSMUST00000040853
RefSeq Acc Id: ENSMUSP00000122692   ⟸   ENSMUST00000128880
Protein Domains
Protein kinase

Promoters
RGD ID:6844901
Promoter ID:MM_KWN:59124
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung
Transcripts:UC009SAN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,148,094 - 119,148,594 (-)MPROMDB
RGD ID:6844899
Promoter ID:MM_KWN:59125
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000074553
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,152,926 - 119,153,426 (-)MPROMDB
RGD ID:8671186
Promoter ID:EPDNEW_M13624
Type:initiation region
Name:Oxsr1_1
Description:Mus musculus oxidative-stress responsive 1 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389119,322,437 - 119,322,497EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917378 AgrOrtholog
Ensembl Genes ENSMUSG00000036737 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000042155 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000117327 UniProtKB/TrEMBL
  ENSMUSP00000122692 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000040853 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000128880 UniProtKB/TrEMBL
  ENSMUST00000143728 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/Swiss-Prot
  Oxsr1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:108737 UniProtKB/Swiss-Prot
MGD MGI:1917378 ENTREZGENE
NCBI Gene 108737 ENTREZGENE
PANTHER PTHR24361:SF435 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam OSR1_C UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Oxsr1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.293565 ENTREZGENE
UniProt D6RFV0_MOUSE UniProtKB/TrEMBL
  F7AVI9_MOUSE UniProtKB/TrEMBL
  OXSR1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8VDZ9_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8BVZ9 UniProtKB/Swiss-Prot
  Q8C0B9 UniProtKB/Swiss-Prot