Pdcd1 (programmed cell death 1) - Rat Genome Database

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Gene: Pdcd1 (programmed cell death 1) Mus musculus
Analyze
Symbol: Pdcd1
Name: programmed cell death 1
RGD ID: 1323232
MGI Page MGI
Description: Involved in negative regulation of immune response. Acts upstream of or within negative regulation of apoptotic process; negative regulation of tolerance induction; and positive regulation of apoptotic process. Located in external side of plasma membrane. Is expressed in retina. Used to study dilated cardiomyopathy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1); PARTICIPATES IN T cell receptor signaling pathway; INTERACTS WITH (+)-dexrazoxane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ly101; mPD-1; PD-; PD-1; Pdc; Pdc1; programmed cell death protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,966,027 - 93,980,278 (-)NCBIGRCm39mm39
GRCm39 Ensembl193,966,027 - 93,980,278 (-)Ensembl
GRCm38194,038,305 - 94,052,553 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,038,305 - 94,052,553 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,934,882 - 95,949,130 (-)NCBIGRCm37mm9NCBIm37
MGSCv36195,868,711 - 95,882,959 (-)NCBImm8
Celera196,903,284 - 96,917,529 (-)NCBICelera
Cytogenetic Map1DNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (IMP)
acute myocarditis  (IDA,IMP)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (IMP)
autoimmune hepatitis  (IEP,ISO)
Burns  (IEP,IMP)
cervix uteri carcinoma in situ  (ISO)
Chlamydia pneumonia  (IEP)
Chronic Hepatitis B  (ISO)
Colonic Neoplasms  (IMP)
Colorectal Neoplasms  (ISO)
cryptococcal meningitis  (IMP,ISO)
cystitis  (IMP)
Cytomegalovirus Infections  (ISO)
dilated cardiomyopathy  (IEA,IMP)
Experimental Autoimmune Encephalomyelitis  (IMP)
Experimental Melanoma  (IMP)
Fungemia  (IEP,IMP)
Graves' disease  (ISO)
Helicobacter Infections  (ISO)
Hepatic Echinococcosis  (IEP)
hepatitis  (ISO)
hepatitis A  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
histoplasmosis  (IMP)
human immunodeficiency virus infectious disease  (ISO)
hydronephrosis  (IGI)
intellectual disability  (ISO)
lupus nephritis  (IMP,ISO)
lymphocytic choriomeningitis  (IMP)
melanoma  (IMP,ISO)
multiple sclerosis  (ISO)
myocarditis  (IMP)
periodontitis  (ISO)
Pneumovirus Infections  (IMP)
pre-eclampsia  (ISO)
pulmonary tuberculosis  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
renal cell carcinoma  (ISO)
respiratory syncytial virus infectious disease  (IEP,ISO)
Schistosomiasis Japonica  (IEP,IMP,ISO)
Sepsis  (IMP,ISO)
Spinal Cord Injuries  (ISO)
stomach cancer  (ISO)
Streptococcus pneumonia  (IMP)
systemic lupus erythematosus  (IEA,ISO)
toxic shock syndrome  (ISO)
Transplant Rejection  (IMP,ISO)
triple-receptor negative breast cancer  (IMP)
tuberculosis  (ISO)
type 2 diabetes mellitus  (IEP)
Viral Bronchiolitis  (IEP)
viral encephalitis  (IEP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cardiac muscle contractility  (IAGP)
abnormal cardiac output  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal heart morphology  (IAGP)
abnormal immune tolerance  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal leukopoiesis  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal response to transplant  (IAGP)
abnormal T cell activation  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
abnormal urine cytokine level  (IAGP)
arthritis  (IAGP)
cardiac fibrosis  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased body weight  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating lipase level  (IAGP)
decreased interleukin-17 secretion  (IAGP)
decreased length of allograft survival  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased sensitivity to induced morbidity/mortality  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased T cell proliferation  (IAGP)
decreased T-helper 17 cell number  (IAGP)
decreased T-helper 2 cell number  (IAGP)
decreased tumor growth/size  (IAGP)
dilated heart ventricle  (IAGP)
enlarged heart  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
exophthalmos  (IAGP)
extended life span  (IAGP)
glomerulonephritis  (IAGP)
hepatic necrosis  (IAGP)
increased apoptosis  (IAGP)
increased autoantibody level  (IAGP)
increased B cell number  (IAGP)
increased B cell proliferation  (IAGP)
increased B-1 B cell number  (IAGP)
increased effector memory T-helper cell number  (IAGP)
increased IgA level  (IAGP)
increased IgG2b level  (IAGP)
increased IgG3 level  (IAGP)
increased IgM level  (IAGP)
increased inflammatory response  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased lymphocyte cell number  (IAGP)
increased regulatory T cell number  (IAGP)
increased retinal ganglion cell number  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased T cell proliferation  (IAGP)
increased T-helper 1 cell number  (IAGP)
increased tumor latency  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
insulitis  (IAGP)
lymph node hyperplasia  (IAGP)
oliguria  (IAGP)
pancreas atrophy  (IAGP)
pancreas inflammation  (IAGP)
pancreas necrosis  (IAGP)
premature death  (IAGP)
pulmonary necrosis  (IAGP)
spleen hyperplasia  (IAGP)
thin ventricular wall  (IAGP)
urinary bladder inflammation  (IAGP)
vascular inflammation  (IAGP)
References

References - curated
1. null
2. Baban B, etal., Exp Mol Pathol. 2013 Apr;94(2):343-51. doi: 10.1016/j.yexmp.2012.11.004. Epub 2012 Dec 5.
3. Bertsias GK, etal., Arthritis Rheum. 2009 Jan;60(1):207-18. doi: 10.1002/art.24227.
4. Cao J, etal., Chin Med J (Engl). 2009 Aug 20;122(16):1941-6.
5. Chang KC, etal., Crit Care. 2013 May 11;17(3):R85. doi: 10.1186/cc12711.
6. Che YM, etal., J Cell Biochem. 2018 Apr;119(4):3044-3057. doi: 10.1002/jcb.26432. Epub 2017 Dec 26.
7. Chihab H, etal., J Med Virol. 2018 Nov;90(11):1730-1738. doi: 10.1002/jmv.25265. Epub 2018 Aug 13.
8. Cho H, etal., Gut Liver. 2016 Mar;10(2):288-94. doi: 10.5009/gnl14368.
9. Correa-Rocha R, etal., PLoS One. 2018 Aug 30;13(8):e0203419. doi: 10.1371/journal.pone.0203419. eCollection 2018.
10. Dudler J, etal., Transplantation. 2006 Dec 27;82(12):1733-7.
11. Erickson JJ, etal., J Clin Invest. 2012 Aug;122(8):2967-82. doi: 10.1172/JCI62860. Epub 2012 Jul 17.
12. Erickson JJ, etal., J Immunol. 2014 Nov 15;193(10):5108-17. doi: 10.4049/jimmunol.1302208. Epub 2014 Oct 22.
13. Frebel H, etal., J Exp Med. 2012 Dec 17;209(13):2485-99. doi: 10.1084/jem.20121015. Epub 2012 Dec 10.
14. Gao M, etal., Front Immunol. 2020 Mar 5;11:366. doi: 10.3389/fimmu.2020.00366. eCollection 2020.
15. Gutierrez FR, etal., Infect Immun. 2011 May;79(5):1873-81. doi: 10.1128/IAI.01047-10. Epub 2011 Feb 28.
16. Hatam LJ, etal., Clin Cancer Res. 2012 Apr 1;18(7):1925-35. doi: 10.1158/1078-0432.CCR-11-2941. Epub 2012 Feb 9.
17. He H, etal., J Neurotrauma. 2018 Nov 1;35(21):2591-2603. doi: 10.1089/neu.2017.5625. Epub 2018 Jun 7.
18. Hoffmann TW, etal., J Med Genet. 2010 Jan;47(1):54-8. doi: 10.1136/jmg.2009.068841. Epub 2009 Jul 5.
19. Hou Z, etal., Ann Clin Lab Sci. 2017 May;47(3):334-343.
20. Huang X, etal., Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6303-8. doi: 10.1073/pnas.0809422106. Epub 2009 Mar 30.
21. Ito S, etal., Oncology. 2020;98(7):501-511. doi: 10.1159/000506075. Epub 2020 May 7.
22. Jiao L, etal., J Gene Med. 2020 Feb;22(2):e3148. doi: 10.1002/jgm.3148. Epub 2020 Jan 9.
23. Johansson M, etal., Arthritis Rheum. 2005 Jun;52(6):1665-9.
24. Kassel R, etal., Hepatology. 2009 Nov;50(5):1625-37. doi: 10.1002/hep.23173.
25. Kohlhapp FJ, etal., Cell Rep. 2016 Oct 18;17(4):957-965. doi: 10.1016/j.celrep.2016.09.068.
26. La X, etal., Int Immunopharmacol. 2015 Jun;26(2):357-66. doi: 10.1016/j.intimp.2015.04.013. Epub 2015 Apr 20.
27. Li B, etal., Clin Cancer Res. 2009 Mar 1;15(5):1623-34. doi: 10.1158/1078-0432.CCR-08-1825. Epub 2009 Feb 10.
28. Li Z, etal., Oncotarget. 2016 May 3;7(18):26168-80. doi: 10.18632/oncotarget.8435.
29. Liu T, etal., Amino Acids. 2018 Jul;50(7):877-883. doi: 10.1007/s00726-018-2568-9. Epub 2018 May 21.
30. Lázár-Molnár E, etal., Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2658-63. doi: 10.1073/pnas.0711918105. Epub 2008 Feb 11.
31. Ma C, etal., Am J Surg Pathol. 2016 Nov;40(11):1496-1506. doi: 10.1097/PAS.0000000000000698.
32. Mai G, etal., Xenotransplantation. 2007 May;14(3):243-8.
33. Matsumoto K, etal., J Gastroenterol Hepatol. 2014 Jan;29(1):110-5. doi: 10.1111/jgh.12340.
34. McKay JT, etal., J Immunol. 2015 Mar 1;194(5):2289-99. doi: 10.4049/jimmunol.1401673. Epub 2015 Jan 26.
35. MGD data from the GO Consortium
36. MGD IEA
37. Mohania D, etal., Acta Biomed. 2013 Sep 1;84(2):102-9.
38. Nielsen C, etal., Lupus. 2004;13(7):510-6.
39. Okazaki T, etal., J Exp Med. 2005 Dec 19;202(12):1643-8. Epub 2005 Dec 13.
40. Okazaki T, etal., Nat Med. 2003 Dec;9(12):1477-83. Epub 2003 Nov 2.
41. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
42. OMIM Disease Annotation Pipeline
43. Pan T, etal., Mediators Inflamm. 2015;2015:539841. doi: 10.1155/2015/539841. Epub 2015 Apr 30.
44. Patil NK, etal., J Leukoc Biol. 2018 Jan;103(1):23-33. doi: 10.1002/JLB.5HI0917-360R. Epub 2017 Dec 21.
45. Pipeline to import KEGG annotations from KEGG into RGD
46. Reynolds J, etal., Nephrol Dial Transplant. 2012 Apr;27(4):1343-50. doi: 10.1093/ndt/gfr529. Epub 2011 Sep 29.
47. RGD automated import pipeline
48. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. RGD automated import pipeline for gene-chemical interactions
50. Shao R, etal., Crit Care. 2016 May 9;20(1):124. doi: 10.1186/s13054-016-1301-x.
51. Shen L, etal., Tuberculosis (Edinb). 2016 Dec;101:146-150. doi: 10.1016/j.tube.2016.10.001. Epub 2016 Oct 1.
52. Shen W, etal., Blood. 2016 Mar 17;127(11):1449-58. doi: 10.1182/blood-2015-06-652503. Epub 2015 Dec 28.
53. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
54. Shwetank, etal., Front Immunol. 2019 Apr 17;10:783. doi: 10.3389/fimmu.2019.00783. eCollection 2019.
55. Singh A, etal., J Infect Dis. 2013 Aug 15;208(4):603-15. doi: 10.1093/infdis/jit206. Epub 2013 May 9.
56. Starkey MR, etal., Am J Respir Cell Mol Biol. 2016 Apr;54(4):493-503. doi: 10.1165/rcmb.2015-0204OC.
57. Sugino Y, etal., Sci Rep. 2012;2:317. doi: 10.1038/srep00317. Epub 2012 Mar 19.
58. Thompson RH, etal., Clin Cancer Res. 2007 Mar 15;13(6):1757-61.
59. Tian M, etal., Sci Rep. 2016 Jun 9;6:27683. doi: 10.1038/srep27683.
60. Velazquez-Cruz R, etal., Eur J Hum Genet. 2007 Mar;15(3):336-41. Epub 2007 Jan 17.
61. Wang D, etal., Mol Med Rep. 2017 Dec;16(6):8556-8562. doi: 10.3892/mmr.2017.7630. Epub 2017 Sep 26.
62. Wang Y, etal., PLoS Pathog. 2019 Feb 6;15(2):e1007583. doi: 10.1371/journal.ppat.1007583. eCollection 2019 Feb.
63. Wang YW, etal., Chin Med J (Engl). 2011 Mar;124(5):674-8.
64. Wilson JK, etal., Crit Care. 2018 Apr 17;22(1):95. doi: 10.1186/s13054-018-2020-2.
65. Wong M, etal., J Immunol. 2010 Dec 1;185(11):6563-71. doi: 10.4049/jimmunol.0903401. Epub 2010 Nov 1.
66. Wu JF, etal., Am J Pathol. 2012 Jul;181(1):19-25. doi: 10.1016/j.ajpath.2012.03.036. Epub 2012 May 24.
67. Wu YY, etal., Clin Vaccine Immunol. 2011 Jul;18(7):1198-201. doi: 10.1128/CVI.00422-10. Epub 2011 May 11.
68. Xia Q, etal., Mediators Inflamm. 2018 Nov 22;2018:1632902. doi: 10.1155/2018/1632902. eCollection 2018.
69. Xiao W, etal., Infect Genet Evol. 2015 Jun;32:89-96. doi: 10.1016/j.meegid.2015.02.022. Epub 2015 Mar 5.
70. Yang W, etal., Immunology. 2013 Aug;139(4):513-22. doi: 10.1111/imm.12101.
71. Yang X, etal., Shanghai Kou Qiang Yi Xue. 2019 Dec;28(6):591-596.
72. Yao S, etal., Mucosal Immunol. 2015 Jul;8(4):746-59. doi: 10.1038/mi.2014.106. Epub 2014 Dec 3.
73. Zeng Z, etal., PLoS One. 2011;6(9):e23621. doi: 10.1371/journal.pone.0023621. Epub 2011 Sep 1.
74. Zhang J and Braun MY, Int Immunol. 2014 Jul;26(7):407-15. doi: 10.1093/intimm/dxu043. Epub 2014 Mar 19.
75. Zhao Y, etal., Shock. 2019 Mar;51(3):289-297. doi: 10.1097/SHK.0000000000001171.
76. Zheng L, etal., J Clin Immunol. 2010 Nov;30(6):855-60. doi: 10.1007/s10875-010-9450-1. Epub 2010 Aug 11.
77. Zhou S, etal., PLoS Negl Trop Dis. 2016 Oct 28;10(10):e0005094. doi: 10.1371/journal.pntd.0005094. eCollection 2016 Oct.
78. Ülger Y, etal., Int J Immunogenet. 2015 Jun;42(3):133-9. doi: 10.1111/iji.12187. Epub 2015 Mar 4.
Additional References at PubMed
PMID:1396582   PMID:7851902   PMID:9141617   PMID:9332365   PMID:9796923   PMID:10349636   PMID:10485649   PMID:10704469   PMID:11015443   PMID:11042159   PMID:11076861   PMID:11209085  
PMID:11217851   PMID:11857337   PMID:12161284   PMID:12421930   PMID:12444166   PMID:12477932   PMID:12719480   PMID:12796776   PMID:12847135   PMID:12847136   PMID:12847137   PMID:12874215  
PMID:14515261   PMID:14568931   PMID:14724428   PMID:15030776   PMID:15030777   PMID:15100324   PMID:15237109   PMID:15484188   PMID:15542030   PMID:15568026   PMID:15611321   PMID:15685176  
PMID:15749874   PMID:15780994   PMID:15827960   PMID:15905503   PMID:16087865   PMID:16141072   PMID:16141073   PMID:16237069   PMID:16285013   PMID:16443792   PMID:16493037   PMID:16547224  
PMID:16921384   PMID:17116737   PMID:17142723   PMID:17182110   PMID:17267414   PMID:17289811   PMID:17392506   PMID:17414712   PMID:17606980   PMID:17627890   PMID:17629517   PMID:17667813  
PMID:17785507   PMID:17853943   PMID:17899549   PMID:17911591   PMID:17911595   PMID:18076633   PMID:18212277   PMID:18223165   PMID:18299579   PMID:18354207   PMID:18354211   PMID:18577709  
PMID:18593946   PMID:18599457   PMID:18641123   PMID:18651994   PMID:18684942   PMID:18713967   PMID:18771758   PMID:18813109   PMID:18828017   PMID:18832687   PMID:18832734   PMID:18925909  
PMID:18981087   PMID:18996482   PMID:19035251   PMID:19160960   PMID:19182257   PMID:19197390   PMID:19201863   PMID:19211743   PMID:19230866   PMID:19234176   PMID:19234228   PMID:19261693  
PMID:19299723   PMID:19302141   PMID:19339692   PMID:19368976   PMID:19380790   PMID:19417208   PMID:19420345   PMID:19420358   PMID:19443704   PMID:19454657   PMID:19454660   PMID:19454662  
PMID:19497561   PMID:19553535   PMID:19642196   PMID:19710450   PMID:19723542   PMID:19783989   PMID:19805226   PMID:19811462   PMID:19901343   PMID:19949087   PMID:19955307   PMID:19959639  
PMID:20007574   PMID:20113370   PMID:20139271   PMID:20160101   PMID:20215643   PMID:20382886   PMID:20410257   PMID:20453843   PMID:20484136   PMID:20506224   PMID:20570856   PMID:20624978  
PMID:20653631   PMID:20679213   PMID:20686128   PMID:20959049   PMID:21047981   PMID:21118907   PMID:21159661   PMID:21172867   PMID:21263073   PMID:21300912   PMID:21383057   PMID:21385853  
PMID:21393583   PMID:21422469   PMID:21441014   PMID:21464221   PMID:21469086   PMID:21525385   PMID:21576466   PMID:21589883   PMID:21623380   PMID:21697455   PMID:21700764   PMID:21724589  
PMID:21737801   PMID:21739608   PMID:21750671   PMID:21768399   PMID:21873525   PMID:21873635   PMID:21884581   PMID:21906434   PMID:21943489   PMID:21997806   PMID:22003198   PMID:22144176  
PMID:22186141   PMID:22210912   PMID:22319445   PMID:22459706   PMID:22459947   PMID:22491251   PMID:22539724   PMID:22539813   PMID:22544394   PMID:22641383   PMID:22684103   PMID:22711893  
PMID:22798683   PMID:22859605   PMID:22902234   PMID:22906740   PMID:22915761   PMID:22949674   PMID:22993390   PMID:23070399   PMID:23121978   PMID:23178752   PMID:23209326   PMID:23242415  
PMID:23254567   PMID:23303666   PMID:23337809   PMID:23417675   PMID:23530125   PMID:23545706   PMID:23566283   PMID:23583643   PMID:23633484   PMID:23636058   PMID:23686498   PMID:23756664  
PMID:23782245   PMID:23804712   PMID:23851694   PMID:23853599   PMID:23883516   PMID:23888055   PMID:23966393   PMID:23977133   PMID:24021877   PMID:24031027   PMID:24043779   PMID:24065812  
PMID:24076050   PMID:24165808   PMID:24227786   PMID:24240160   PMID:24247196   PMID:24257598   PMID:24316071   PMID:24319287   PMID:24353266   PMID:24379123   PMID:24412610   PMID:24529703  
PMID:24589924   PMID:24672046   PMID:24691202   PMID:24711622   PMID:24728077   PMID:24813249   PMID:24853068   PMID:24886298   PMID:24975127   PMID:25027060   PMID:25047812   PMID:25080485  
PMID:25082151   PMID:25113973   PMID:25219397   PMID:25236923   PMID:25299080   PMID:25358006   PMID:25404033   PMID:25404361   PMID:25464856   PMID:25488990   PMID:25609381   PMID:25623164  
PMID:25630305   PMID:25641586   PMID:25695838   PMID:25733520   PMID:25741704   PMID:25794782   PMID:25799228   PMID:25803808   PMID:25810391   PMID:25825451   PMID:25851535   PMID:25877928  
PMID:25902191   PMID:25934860   PMID:25964334   PMID:26034050   PMID:26043977   PMID:26048148   PMID:26105028   PMID:26109574   PMID:26162855   PMID:26208901   PMID:26247556   PMID:26266810  
PMID:26272364   PMID:26277582   PMID:26278059   PMID:26318293   PMID:26359984   PMID:26373277   PMID:26378076   PMID:26392556   PMID:26396175   PMID:26410627   PMID:26467188   PMID:26608464  
PMID:26696540   PMID:26750587   PMID:26769487   PMID:26824266   PMID:26824999   PMID:26910562   PMID:26913605   PMID:26974441   PMID:27060346   PMID:27197251   PMID:27197661   PMID:27217330  
PMID:27244558   PMID:27281199   PMID:27288425   PMID:27294527   PMID:27410049   PMID:27496729   PMID:27533014   PMID:27556047   PMID:27705792   PMID:27717876   PMID:27731324   PMID:27749818  
PMID:27760221   PMID:27760760   PMID:27821498   PMID:27825115   PMID:27835962   PMID:27856425   PMID:27895178   PMID:28096382   PMID:28151427   PMID:28153727   PMID:28153736   PMID:28173160  
PMID:28265006   PMID:28270509   PMID:28320090   PMID:28331165   PMID:28410988   PMID:28427861   PMID:28490441   PMID:28514441   PMID:28530662   PMID:28539588   PMID:28586108   PMID:28670716  
PMID:28681455   PMID:28686578   PMID:28687491   PMID:28698201   PMID:28710273   PMID:28747424   PMID:28756224   PMID:28768188   PMID:28768724   PMID:28819064   PMID:28829048   PMID:28847007  
PMID:28848055   PMID:28912267   PMID:28931759   PMID:28939757   PMID:28953925   PMID:29018057   PMID:29058703   PMID:29108460   PMID:29143824   PMID:29303012   PMID:29439955   PMID:29493401  
PMID:29531164   PMID:29617671   PMID:29654146   PMID:29695634   PMID:29712685   PMID:29867974   PMID:29911570   PMID:29967259   PMID:29980219   PMID:30054205   PMID:30076099   PMID:30089911  
PMID:30127438   PMID:30206757   PMID:30213644   PMID:30257954   PMID:30262908   PMID:30274786   PMID:30305604   PMID:30333312   PMID:30382588   PMID:30420753   PMID:30463004   PMID:30485411  
PMID:30487606   PMID:30545915   PMID:30564277   PMID:30565754   PMID:30587557   PMID:30587849   PMID:30619369   PMID:30693001   PMID:30709740   PMID:30718426   PMID:30771904   PMID:30804928  
PMID:30943039   PMID:30971695   PMID:30978356   PMID:31001256   PMID:31028147   PMID:31031760   PMID:31112568   PMID:31227606   PMID:31241175   PMID:31277964   PMID:31429085   PMID:31533057  
PMID:31534051   PMID:31676858   PMID:31681332   PMID:31723059   PMID:31742928   PMID:31788554   PMID:31857157   PMID:31901074   PMID:31926212   PMID:31926851   PMID:32014811   PMID:32048861  
PMID:32059873   PMID:32113187   PMID:32122466   PMID:32134744   PMID:32265932   PMID:32306409   PMID:32310956   PMID:32333082   PMID:32347357   PMID:32484460   PMID:32602900   PMID:32610128  
PMID:32719675   PMID:32737343   PMID:32778730   PMID:32933159   PMID:33232786   PMID:33233585   PMID:33300057   PMID:33320839   PMID:33513345   PMID:33744709   PMID:33815358   PMID:33980853  


Genomics

Comparative Map Data
Pdcd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,966,027 - 93,980,278 (-)NCBIGRCm39mm39
GRCm39 Ensembl193,966,027 - 93,980,278 (-)Ensembl
GRCm38194,038,305 - 94,052,553 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,038,305 - 94,052,553 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,934,882 - 95,949,130 (-)NCBIGRCm37mm9NCBIm37
MGSCv36195,868,711 - 95,882,959 (-)NCBImm8
Celera196,903,284 - 96,917,529 (-)NCBICelera
Cytogenetic Map1DNCBI
PDCD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2241,849,884 - 241,858,894 (-)EnsemblGRCh38hg38GRCh38
GRCh382241,849,881 - 241,858,908 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372242,792,036 - 242,801,046 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,440,711 - 242,449,731 (-)NCBINCBI36hg18NCBI36
Celera2236,456,683 - 236,465,707 (-)NCBI
Cytogenetic Map2q37.3NCBI
HuRef2234,541,510 - 234,550,535 (-)NCBIHuRef
CHM1_12242,797,131 - 242,806,156 (-)NCBICHM1_1
Pdcd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2994,418,786 - 94,431,945 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl9101,025,313 - 101,038,625 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl9101,307,764 - 101,319,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.09101,305,742 - 101,319,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.09100,676,274 - 100,690,991 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4993,172,543 - 93,185,687 (-)NCBIRGSC3.4rn4RGSC3.4
Celera991,952,891 - 91,966,035 (-)NCBICelera
Cytogenetic Map9q36NCBI
Pdcd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495554249,259 - 58,823 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495554249,290 - 57,747 (+)NCBIChiLan1.0ChiLan1.0
PDCD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v02B129,111,509 - 129,121,127 (-)NCBIMhudiblu_PPA_v0panPan3
PDCD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,606,559 - 51,618,903 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2551,608,173 - 51,618,723 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,830,362 - 51,840,346 (-)NCBI
ROS_Cfam_1.02551,809,256 - 51,820,132 (-)NCBI
UMICH_Zoey_3.12551,659,966 - 51,669,894 (-)NCBI
UNSW_CanFamBas_1.02551,399,146 - 51,409,148 (-)NCBI
UU_Cfam_GSD_1.02551,676,302 - 51,686,322 (-)NCBI
Pdcd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303193,055,706 - 193,066,914 (-)NCBI
SpeTri2.0NW_004936745152,571 - 163,712 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDCD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15140,336,210 - 140,347,478 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115140,337,353 - 140,347,493 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PDCD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,877,383 - 127,886,234 (-)NCBI
ChlSab1.1 Ensembl10127,878,554 - 127,886,088 (-)Ensembl
Vero_WHO_p1.0NW_02366604071,433,325 - 71,442,153 (+)NCBI
Pdcd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248475,732,922 - 5,741,908 (-)NCBI

Position Markers
X67914  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38194,038,694 - 94,038,838UniSTSGRCm38
MGSCv37195,935,271 - 95,935,415UniSTSGRCm37
Celera196,903,675 - 96,903,819UniSTS
Cytogenetic Map1DUniSTS
Whitehead/MRC_RH11322.98UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139093727126517573Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162907596120601949Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163880843153681816Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167300000129800000Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170205811104211835Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173227055108910684Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73687970107688108Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173687970107688108Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173716016147249632Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74477076148839837Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174952818133363199Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)176000000128600000Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)176000000148900000Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)176000000181500000Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177146478110608345Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17750000095900000Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179930958113931066Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179930958113931066Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180267876126458780Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782314261147249632Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182665468135687641Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182904910116904910Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182904910116904910Mouse
11667074Led2_mlate embryonic death 2 (mouse)185768306117267351Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186556204120556204Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89858782123858782Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189858782123858782Mouse
4141347Reb1_mrepetitive behavior 1 (mouse)Not determined91540544100485942Mouse
1357760Synch3_msynechia 3 (mouse)Not determined192973712126973820Mouse
4141627Bwq7_mbody weight, QTL 7 (mouse)Not determined193013187124570059Mouse
12879491Hfnq1_mhair follicle number QTL 1 (mouse)193382588123709030Mouse
10045976Tir6_mtrypanosome infection response 6 (mouse)Not determined193609133120601949Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:328
Count of miRNA genes:261
Interacting mature miRNAs:277
Transcripts:ENSMUST00000027507
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000027507   ⟹   ENSMUSP00000027507
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl194,038,305 - 94,052,553 (-)Ensembl
RefSeq Acc Id: NM_008798   ⟹   NP_032824
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39193,966,027 - 93,980,278 (-)NCBI
GRCm38194,038,305 - 94,052,553 (-)ENTREZGENE
MGSCv37195,934,882 - 95,949,130 (-)RGD
Celera196,903,284 - 96,917,529 (-)RGD
cM Map1 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032824   ⟸   NM_008798
- Peptide Label: precursor
- UniProtKB: Q02242 (UniProtKB/Swiss-Prot),   Q544F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027507   ⟸   ENSMUST00000027507
Protein Domains
Ig-like   Ig-like V-type

Promoters
RGD ID:6874588
Promoter ID:EPDNEW_M745
Type:initiation region
Name:Pdcd1_1
Description:Mus musculus programmed cell death 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38194,052,566 - 94,052,626EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104879 AgrOrtholog
Ensembl Genes ENSMUSG00000026285 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000027507 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027507 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDCD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18566 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104879 ENTREZGENE
NCBI Gene 18566 ENTREZGENE
PANTHER PTHR15264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdcd1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt PDCD1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q544F3 ENTREZGENE, UniProtKB/TrEMBL