Mir185 (microRNA 185) - Rat Genome Database
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Gene: Mir185 (microRNA 185) Mus musculus
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Symbol: Mir185
Name: microRNA 185
RGD ID: 1608311
MGI Page MGI
Description: Involved in SMAD protein signal transduction and cellular response to leukemia inhibitory factor. Is expressed in embryo; lung; and retina. Orthologous to human MIR185 (microRNA 185).
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-185; Mirn; Mirn185; mmu-mir-1; mmu-mir-185
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,145,265 - 18,145,329 (-)NCBIGRCm39mm39
GRCm381618,327,401 - 18,327,465 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,327,401 - 18,327,465 (-)EnsemblGRCm38mm10GRCm38
MGSCv371618,327,494 - 18,327,558 (-)NCBIGRCm37mm9NCBIm37
Celera1618,900,146 - 18,900,210 (-)NCBICelera
Cytogenetic Map16A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12554859   PMID:16381832   PMID:17369397   PMID:17597072   PMID:17604727   PMID:18452032   PMID:19559694   PMID:20215419   PMID:20413612   PMID:20439489   PMID:21037258   PMID:21267068  
PMID:21822254   PMID:22570807   PMID:23332760   PMID:23390484   PMID:23699394   PMID:24014023   PMID:24296663   PMID:24936775   PMID:25548489   PMID:25767890   PMID:26523989   PMID:29030639  
PMID:29242628   PMID:29678580   PMID:30054916   PMID:30787286   PMID:31945609   PMID:32514126  


Genomics

Comparative Map Data
Mir185
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,145,265 - 18,145,329 (-)NCBIGRCm39mm39
GRCm381618,327,401 - 18,327,465 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,327,401 - 18,327,465 (-)EnsemblGRCm38mm10GRCm38
MGSCv371618,327,494 - 18,327,558 (-)NCBIGRCm37mm9NCBIm37
Celera1618,900,146 - 18,900,210 (-)NCBICelera
Cytogenetic Map16A3NCBI
MIR185
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2220,033,139 - 20,033,220 (+)EnsemblGRCh38hg38GRCh38
GRCh382220,033,139 - 20,033,220 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372220,020,662 - 20,020,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,400,661 - 18,400,742 (+)NCBINCBI36hg18NCBI36
Celera223,871,865 - 3,871,946 (+)NCBI
Cytogenetic Map22q11.21NCBI
HuRef223,641,080 - 3,641,161 (+)NCBIHuRef
CHM1_12220,020,370 - 20,020,451 (+)NCBICHM1_1
Mir185
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,664,716 - 82,664,795 (+)NCBI
Rnor_6.0 Ensembl1186,812,702 - 86,812,781 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01186,812,702 - 86,812,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01189,906,640 - 89,906,719 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1181,441,729 - 81,441,808 (+)NCBICelera
Cytogenetic Map11q23NCBI
MIR185
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2629,296,004 - 29,296,079 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12629,296,014 - 29,296,069 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
MIR185
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,449,903 - 51,449,978 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,449,903 - 51,449,978 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21455,086,524 - 55,086,599 (+)NCBISscrofa10.2Sscrofa10.2susScr3


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120963024Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122682710Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122702454Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16123079875Mouse
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124445989Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124445989Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128616494Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129856336Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130249113Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130996708Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16350000040000000Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16350000051600000Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16350000064800000Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16400000064800000Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16450000044700000Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16482756438827664Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16595650239956690Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16595650239956690Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16595650239956690Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16595650239956690Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16665914535200846Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16672511565669666Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16731904229406653Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16840730242407302Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16860000091100000Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined161006288144062881Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161203007246030171Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161240654246406653Mouse
15092082Igly9_mIgG glycosylation 9, GP17b (mouse)161495735920284763Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161498410348984214Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161570409149704294Mouse

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Dnmt1mmu-miR-185-5pOncomiRDBexternal_infoNANA21962230
Rhoammu-miR-185-5pOncomiRDBexternal_infoNANA21186079
Six1mmu-miR-185-5pOncomiRDBexternal_infoNANA20603620
Kdm6bmmu-miR-185-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20833714
Aregmmu-miR-185-5pOncomiRDBexternal_infoNANA23417242
Dnmt1mmu-miR-185-5pOncomiRDBexternal_infoNANA23318422

Predicted Targets
Summary Value
Count of predictions:62552
Count of gene targets:20020
Count of transcripts:41483
Interacting mature miRNAs:mmu-miR-185-3p, mmu-miR-185-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000083530
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1618,327,401 - 18,327,465 (-)Ensembl
RefSeq Acc Id: NR_029571
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391618,145,265 - 18,145,329 (-)NCBI
GRCm381618,327,401 - 18,327,465 (-)ENTREZGENE
MGSCv371618,327,494 - 18,327,558 (-)RGD
Celera1618,900,146 - 18,900,210 (-)RGD
cM Map16 ENTREZGENE
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676849 AgrOrtholog
Ensembl Genes ENSMUSG00000065464 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083530 ENTREZGENE
MGD MGI:2676849 ENTREZGENE
miRBase MI0000227 ENTREZGENE
NCBI Gene 387180 ENTREZGENE
PhenoGen Mir185 PhenoGen
RNAcentral URS00004176D4 RNACentral
  URS00004A4E27 RNACentral
  URS000075B989 RNACentral