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Gene: Gjb2 (gap junction protein, beta 2) Mus musculus
Symbol: Gjb2
Name: gap junction protein, beta 2
Description: Exhibits gap junction channel activity. Involved in cell-cell signaling; gap junction assembly; and gap junction-mediated intercellular transport. Localizes to connexin complex and integral component of plasma membrane. Is expressed in several structures, including alimentary system; ear; genitourinary system; meninges; and skin. Used to study autosomal dominant keratitis-ichthyosis-deafness syndrome and autosomal recessive nonsyndromic deafness 1A. Human ortholog(s) of this gene implicated in Bart-Pumphrey syndrome; Vohwinkel syndrome; autosomal dominant keratitis-ichthyosis-deafness syndrome; nonsyndromic deafness (multiple); and palmoplantar keratoderma-deafness syndrome. Orthologous to human GJB2 (gap junction protein beta 2); INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI325222; Cnx26; connexin 26; connexin e; connexin-26; Cx26; Cxne; gap junction beta-2 protein; gap junction membrane channel protein beta 2; Gjb-2
Homo sapiens (human) : GJB2 (gap junction protein beta 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gjb2 (gap junction protein, beta 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gjb2 (gap junction protein beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GJB2 (gap junction protein beta 2)
Canis lupus familiaris (dog) : GJB2 (gap junction protein beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gjb2 (gap junction protein beta 2)
Sus scrofa (pig) : GJB2 (gap junction protein beta 2)
Chlorocebus sabaeus (African green monkey) : GJB2 (gap junction protein beta 2)
Heterocephalus glaber (naked mole-rat) : Gjb2 (gap junction protein beta 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1457,098,600 - 57,104,702 (-)EnsemblGRCm38mm10GRCm38
GRCm381457,098,602 - 57,104,702 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371457,717,439 - 57,723,539 (-)NCBIGRCm37mm9NCBIm37
MGSCv361456,052,728 - 56,058,775 (-)NCBImm8
Celera1454,889,190 - 54,895,282 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1430.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gjb2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1550135
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.