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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62159
Species: Mus musculus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases expressionEXP 6480464CTDZearalenone results in increased expression of CASP9 mRNAPMID:34537261
Casp9increases activityISOCasp9 (Rattus norvegicus)6480464CTDZearalenone results in increased activity of CASP9 proteinPMID:24530352
Casp9increases cleavageISOCasp9 (Rattus norvegicus)6480464CTDZearalenone results in increased cleavage of CASP9 proteinPMID:30600648
Casp9increases expressionISOCasp9 (Rattus norvegicus)6480464CTDZearalenone results in increased expression of CASP9 protein modified formPMID:36288102
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDZearalenone results in increased expression of CASP9 mRNAPMID:30668976
Casp9multiple interactionsISOCasp9 (Rattus norvegicus)6480464CTDbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Zearalenone results in increased cleavage of CASP9 protein]PMID:30600648
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDZearalenone promotes the reaction [[Aflatoxin B1 co-treated with deoxynivalenol] results in increased expression of CASP9 mRNA]PMID:30668976
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