Tgfb2 (transforming growth factor, beta 2) - Rat Genome Database

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Gene: Tgfb2 (transforming growth factor, beta 2) Mus musculus
Symbol: Tgfb2
Name: transforming growth factor, beta 2
RGD ID: 730954
Description: Predicted to enable several functions, including amyloid-beta binding activity; protein homodimerization activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including circulatory system development; regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including circulatory system development; neuron differentiation; and positive regulation of apoptotic process. Located in several cellular components, including axon; endosome; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Loeys-Dietz syndrome. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4; colorectal cancer; and pancreatic adenosquamous carcinoma. Orthologous to human TGFB2 (transforming growth factor beta 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: BB105277; Tgf-beta; TGF-beta-2; Tgf-beta2; Tgfb-2; transforming growth factor beta-2; transforming growth factor beta-2 proprotein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391186,354,984 - 186,441,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1186,354,989 - 186,438,186 (-)EnsemblGRCm39 Ensembl
GRCm381186,622,787 - 186,709,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,622,792 - 186,705,989 (-)EnsemblGRCm38mm10GRCm38
MGSCv371188,447,065 - 188,529,871 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361188,324,430 - 188,406,777 (-)NCBIMGSCv36mm8
Celera1193,563,609 - 193,649,724 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map189.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-nitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-nitrophenol  (EXP)
4-tert-Octylphenol  (EXP)
5'-S-methyl-5'-thioadenosine  (EXP)
5-fluorouracil  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetaldehyde  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
Allylamine  (ISO)
AM-251  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP,ISO)
astemizole  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (EXP)
Benzo[k]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
Brevetoxin B  (ISO)
bromochloroacetic acid  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
calcitriol  (ISO)
cantharidin  (EXP)
capsaicin  (ISO)
carbamazepine  (EXP)
carbaryl  (ISO)
carbofuran  (ISO)
CGP 52608  (ISO)
chloroform  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichromium trioxide  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (EXP)
diethyl malate  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
divanadium pentaoxide  (ISO)
dobutamine  (ISO)
donepezil hydrochloride  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
fenamic acid  (ISO)
fenamidone  (EXP)
fenvalerate  (ISO)
flusilazole  (EXP)
fructose  (EXP)
furan  (ISO)
furosemide  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (ISO)
Glutathione ethyl ester  (EXP)
glycine betaine  (ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (EXP)
hydrogen cyanide  (EXP)
hydrogen peroxide  (ISO)
indirubin-3'-monoxime  (EXP)
indole-3-methanol  (EXP)
iron(III) nitrilotriacetate  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (EXP)
L-cysteine  (ISO)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leptomycin B  (EXP)
Licochalcone B  (ISO)
linuron  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metaproterenol  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
minocycline  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
naproxen  (ISO)
neomycin  (EXP)
nickel atom  (ISO)
nicotinamide  (ISO)
nitrates  (ISO)
nitrofen  (ISO)
nitrofurantoin  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
oleic acid  (ISO)
orciprenaline  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenylbutazone  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (EXP)
prazosin  (ISO)
progesterone  (ISO)
propanal  (ISO)
prostaglandin E2  (EXP)
pyrethrins  (ISO)
quercetin  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sodium tungstate  (ISO)
sphingosine 1-phosphate  (ISO)
styrene  (ISO)
styrene oxide  (ISO)
sulfadimethoxine  (ISO)
sumatriptan  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
topotecan  (ISO)
torcetrapib  (ISO)
tranexamic acid  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (EXP)
troglitazone  (EXP,ISO)
urethane  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
zearalenone  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation-induced cell death of T cells  (IDA)
ascending aorta morphogenesis  (IMP)
atrial septum morphogenesis  (IMP)
atrial septum primum morphogenesis  (IMP)
atrioventricular valve morphogenesis  (IMP)
axon guidance  (IMP)
blood vessel development  (IMP)
blood vessel remodeling  (IMP)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac left ventricle morphogenesis  (TAS)
cardiac muscle cell proliferation  (ISO)
cardiac right ventricle morphogenesis  (IMP,TAS)
cardioblast differentiation  (ISO)
cartilage condensation  (IGI)
cell migration  (ISO)
cell morphogenesis  (ISO)
cell-cell junction organization  (ISO)
collagen fibril organization  (ISO)
cranial skeletal system development  (IMP)
digestive tract development  (ISO)
dopamine biosynthetic process  (IMP)
embryonic digestive tract development  (ISO)
embryonic limb morphogenesis  (IMP)
embryonic neurocranium morphogenesis  (ISO)
endocardial cushion fusion  (IMP)
endocardial cushion morphogenesis  (IMP)
epithelial cell differentiation  (ISO)
epithelial to mesenchymal transition  (ISO)
extracellular matrix organization  (IMP)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IDA)
eye development  (ISO)
face morphogenesis  (IEP)
female pregnancy  (ISO)
frontal suture morphogenesis  (ISO)
glial cell migration  (ISO)
hair follicle development  (IMP,ISO)
hair follicle morphogenesis  (IMP)
heart development  (IMP,ISO)
heart morphogenesis  (ISO)
heart valve morphogenesis  (IMP)
hemopoiesis  (IMP)
hindbrain development  (ISO)
inner ear development  (IMP,ISO)
kidney development  (IMP,ISO)
male gonad development  (IMP)
membranous septum morphogenesis  (IMP)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cartilage development  (IMP)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (IMP)
negative regulation of gene expression  (IDA,ISO)
negative regulation of keratinocyte differentiation  (NAS)
negative regulation of macrophage cytokine production  (ISO)
negative regulation of Ras protein signal transduction  (IMP)
negative regulation of release of sequestered calcium ion into cytosol  (ISO)
neural retina development  (IMP)
neural tube closure  (IMP)
neuron development  (IMP)
neuron fate commitment  (IDA)
neutrophil chemotaxis  (ISO)
outflow tract morphogenesis  (IMP,TAS)
outflow tract septum morphogenesis  (IMP)
pancreas development  (ISO)
pericyte cell differentiation  (IMP)
pharyngeal arch artery morphogenesis  (IMP)
positive regulation of activation-induced cell death of T cells  (IDA)
positive regulation of apoptotic process  (ISO)
positive regulation of cardiac epithelial to mesenchymal transition  (IMP)
positive regulation of cardioblast differentiation  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell cycle  (IMP)
positive regulation of cell division  (IEA)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (IMP)
positive regulation of extracellular matrix disassembly  (IDA)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IDA)
positive regulation of gene expression  (IDA)
positive regulation of heart contraction  (ISO)
positive regulation of immune response  (ISO)
positive regulation of integrin biosynthetic process  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to nucleus  (IDA)
positive regulation of protein secretion  (ISO)
positive regulation of SMAD protein signal transduction  (IDA,ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of timing of catagen  (ISO)
pulmonary valve morphogenesis  (IMP)
regulation of actin cytoskeleton organization  (IDA)
regulation of apoptotic process  (IMP)
regulation of apoptotic process involved in outflow tract morphogenesis  (IMP)
regulation of cell population proliferation  (IBA,ISO)
regulation of complement-dependent cytotoxicity  (ISO)
regulation of extracellular matrix organization  (IMP)
regulation of timing of catagen  (ISO)
regulation of transforming growth factor beta2 production  (ISO)
response to cytokine  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)
response to laminar fluid shear stress  (ISO)
response to organonitrogen compound  (ISO)
response to progesterone  (ISO)
response to retinoic acid  (ISO)
response to vitamin D  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
salivary gland morphogenesis  (ISO)
secondary palate development  (IMP)
signaling  (ISO)
skeletal muscle tissue development  (ISO)
skeletal system development  (IMP)
somatic stem cell division  (IDA)
substantia propria of cornea development  (IMP)
thyroid gland development  (ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IDA,ISO)
uterus development  (IMP)
ventricular septum morphogenesis  (IMP,TAS)
ventricular trabecula myocardium morphogenesis  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
aberrant origin of the right subclavian artery  (IAGP)
abnormal aorta morphology  (IAGP)
abnormal aorta wall morphology  (IAGP)
abnormal aqueous drainage system morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal bulbourethral gland morphology  (IAGP)
abnormal bulbourethral gland physiology  (IAGP)
abnormal canal of Schlemm morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiovascular development  (IAGP)
abnormal cartilage development  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal clavicle morphology  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear ganglion morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal cornea posterior stroma morphology  (IAGP)
abnormal corneal stroma morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal digit development  (IAGP)
abnormal eye posterior chamber morphology  (IAGP)
abnormal femur morphology  (IAGP)
abnormal heart septum morphology  (IAGP)
abnormal heart ventricle outflow tract morphology  (IAGP)
abnormal humerus morphology  (IAGP)
abnormal interdigital cell death  (IAGP)
abnormal iris stroma morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lens epithelium morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal renal tubule epithelium morphology  (IAGP)
abnormal retina apoptosis  (IAGP)
abnormal retina inner nuclear layer morphology  (IAGP)
abnormal retina neuronal layer morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal scala vestibuli morphology  (IAGP)
abnormal semilunar valve morphology  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal thoracic cage shape  (IAGP)
abnormal trabecular meshwork morphology  (IAGP)
abnormal trochanter morphology  (IAGP)
abnormal truncus arteriosus septation  (IAGP)
abnormal uterine horn morphology  (IAGP)
abnormal xiphoid process morphology  (IAGP)
absent alisphenoid bone  (IAGP)
absent corneal endothelium  (IAGP)
absent deltoid tuberosity  (IAGP)
absent Descemet membrane  (IAGP)
absent eye anterior chamber  (IAGP)
absent interdental cells  (IAGP)
absent kidney  (IAGP)
absent mandibular angle  (IAGP)
absent maxillary shelf  (IAGP)
absent occipital bone  (IAGP)
absent pterygoid process  (IAGP)
absent Rosenthal canal  (IAGP)
absent spiral limbus  (IAGP)
aortic aneurysm  (IAGP)
aortic arch hypoplasia  (IAGP)
ascending aorta hypoplasia  (IAGP)
atelectasis  (IAGP)
atrioventricular septal defect  (IAGP)
bulbourethral gland cyst  (IAGP)
bulbourethral gland hyperplasia  (IAGP)
cleft secondary palate  (IAGP)
complete atrioventricular septal defect  (IAGP)
cyanosis  (IAGP)
decreased body weight  (IAGP)
decreased cornea thickness  (IAGP)
decreased corneal stroma thickness  (IAGP)
decreased dopamine level  (IAGP)
decreased dopaminergic neuron number  (IAGP)
decreased enterocyte apoptosis  (IAGP)
decreased retina apoptosis  (IAGP)
dilated aorta bulb  (IAGP)
dilated heart right ventricle  (IAGP)
dilated renal tubule  (IAGP)
dilated respiratory conducting tube  (IAGP)
double inlet heart left ventricle  (IAGP)
double outlet right ventricle  (IAGP)
ectopic adrenal gland  (IAGP)
ectopic testis  (IAGP)
failure of atrioventricular cushion closure  (IAGP)
failure of heart looping  (IAGP)
failure of palatal shelf elevation  (IAGP)
fused cornea and lens  (IAGP)
heart valve hyperplasia  (IAGP)
hydronephrosis  (IAGP)
increased urine protein level  (IAGP)
inlet ventricular septal defect  (IAGP)
interdigital webbing  (IAGP)
interrupted aortic arch  (IAGP)
large fontanelles  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
ocular hypertension  (IAGP)
oligozoospermia  (IAGP)
ostium primum atrial septal defect  (IAGP)
patent aortic valve  (IAGP)
patent pulmonary valve  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistence of hyaloid vascular system  (IAGP)
persistent right dorsal aorta  (IAGP)
primary vitreous hyperplasia  (IAGP)
prostate gland anterior lobe hyperplasia  (IAGP)
pulmonary artery hypoplasia  (IAGP)
respiratory distress  (IAGP)
retina hyperplasia  (IAGP)
retrognathia  (IAGP)
rib fusion  (IAGP)
short mandible  (IAGP)
short radius  (IAGP)
short ulna  (IAGP)
small frontal bone  (IAGP)
small interparietal bone  (IAGP)
small mandibular condyloid process  (IAGP)
small mandibular coronoid process  (IAGP)
small olecranon  (IAGP)
small parietal bone  (IAGP)
small temporal bone  (IAGP)
spina bifida occulta  (IAGP)
teratozoospermia  (IAGP)
testis hypoplasia  (IAGP)
thick aortic valve cusps  (IAGP)
thick mitral valve  (IAGP)
thick pulmonary valve cusps  (IAGP)
thick tricuspid valve  (IAGP)
trabecula carnea hypoplasia  (IAGP)
vitreous body deposition  (IAGP)

References - curated
# Reference Title Reference Citation
1. TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Alvarez J, etal., Development. 2002 Apr;129(8):1913-24.
2. Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathy. Anjaneyulu M, etal., Exp Neurol. 2008 Jun;211(2):469-79. Epub 2008 Mar 2.
3. The effect of antibodies to TGF-beta1 and TGF-beta2 at a site of sciatic nerve repair. Atkins S, etal., J Peripher Nerv Syst. 2006 Dec;11(4):286-93.
4. Novel methylation panel for the early detection of neoplasia in high-risk ulcerative colitis and Crohn's colitis patients. Azuara D, etal., Inflamm Bowel Dis. 2013 Jan;19(1):165-73. doi: 10.1002/ibd.22994.
5. Differential expression of transforming growth factors-beta1, -beta2 and -beta3 in human colon carcinoma. Bellone G, etal., Eur J Cancer. 2001 Jan;37(2):224-33.
6. Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats. Deten A, etal., Mol Cell Biochem. 2003 Sep;251(1-2):127-37.
7. Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Engle SJ, etal., Cancer Res. 1999 Jul 15;59(14):3379-86.
8. Inhibition of ALK5 signaling induces physeal dysplasia in rats. Frazier K, etal., Toxicol Pathol. 2007;35(2):284-95.
9. Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival. Friess H, etal., Gastroenterology. 1993 Dec;105(6):1846-56. doi: 10.1016/0016-5085(93)91084-u.
10. Dynamic expression patterns of transforming growth factor-beta(2) and transforming growth factor-beta receptors in experimental glomerulonephritis. Hartner A, etal., J Mol Med. 2003 Jan;81(1):32-42. Epub 2002 Dec 14.
11. Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein. Hashimoto Y, etal., Mol Cell Biol. 2005 Nov;25(21):9304-17.
12. A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. Jamora C, etal., PLoS Biol. 2005 Jan;3(1):e11. Epub 2004 Dec 28.
13. Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles. Javelaud D and Mauviel A, Int J Biochem Cell Biol. 2004 Jul;36(7):1161-5.
14. Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. Jude EB, etal., Diabet Med. 2002 Jun;19(6):440-7.
15. Divergent expression of liver transforming growth factor superfamily cytokines after successful portoenterostomy in biliary atresia. Kerola A, etal., Surgery. 2019 May;165(5):905-911. doi: 10.1016/j.surg.2018.12.003. Epub 2019 Jan 25.
16. Chemoresponsiveness associated with canonical molecular changes in colorectal adenocarcinomas. Kim JC, etal., Anticancer Res. 2009 Aug;29(8):3115-23.
17. The effects of treatment with antibodies to transforming growth factor beta1 and beta2 following spinal cord damage in the adult rat. King VR, etal., Neuroscience. 2004;126(1):173-83.
18. Chronic hyperglycaemia increases TGFbeta2 signaling and the expression of extracellular matrix proteins in the rat parotid gland. Lamers ML, etal., Matrix Biol. 2007 Sep;26(7):572-82. Epub 2007 May 16.
19. Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. Latasa MU, etal., PLoS One. 2010 Dec 29;5(12):e15690. doi: 10.1371/journal.pone.0015690.
20. Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats. Marks G, etal., Acta Cir Bras. 2006;21 Suppl 4:51-6.
21. MGDs mouse GO annotations MGD data from the GO Consortium
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Transforming growth factor-beta 2 and TGF-beta 3 regulate fetal rat cranial suture morphogenesis by regulating rates of cell proliferation and apoptosis. Opperman LA, etal., Dev Dyn. 2000 Oct;219(2):237-47.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. Mouse MP Annotation Import Pipeline RGD automated import pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Transforming growth factor-beta 2 gene silencing with trabedersen (AP 12009) in pancreatic cancer. Schlingensiepen KH, etal., Cancer Sci. 2011 Jun;102(6):1193-200. doi: 10.1111/j.1349-7006.2011.01917.x. Epub 2011 Mar 30.
31. Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells. Sharma K, etal., Am J Physiol Renal Physiol 2003 Dec;285(6):F1258-70.
32. Downregulation of transforming growth factor-beta2 facilitates inflammation in the central nervous system by reciprocal astrocyte/microglia interactions. Siglienti I, etal., J Neuropathol Exp Neurol. 2007 Jan;66(1):47-56.
33. Lesion-associated expression of transforming growth factor-beta-2 in the rat nervous system: evidence for down-regulating the phagocytic activity of microglia and macrophages. Stoll G, etal., Brain Pathol. 2004 Jan;14(1):51-8.
34. The potential role of TGFbeta1, TGFbeta2 and TGFbeta3 protein expression in colorectal carcinomas. Correlation with classic histopathologic factors and patient survival. Tsamandas AC, etal., Strahlenther Onkol. 2004 Apr;180(4):201-8.
35. Differential cytokine activity and morphology during wound healing in the neonatal and adult rat skin. Wagner W and Wehrmann M, J Cell Mol Med. 2007 Nov-Dec;11(6):1342-51.
36. Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3. Wilkes MC, etal., Mol Cell Biol. 2003 Dec;23(23):8878-89.
Additional References at PubMed
PMID:1284245   PMID:1373953   PMID:1375903   PMID:1543915   PMID:1577201   PMID:1638993   PMID:1672660   PMID:1676977   PMID:1707784   PMID:1723948   PMID:1764993   PMID:1879607  
PMID:1955457   PMID:1970330   PMID:2015789   PMID:2040369   PMID:2226202   PMID:2375595   PMID:2401212   PMID:2481605   PMID:2797004   PMID:3226728   PMID:7485998   PMID:7493021  
PMID:7574296   PMID:7601910   PMID:7627810   PMID:7687212   PMID:7774812   PMID:7813789   PMID:7819129   PMID:7819439   PMID:7842167   PMID:7883868   PMID:8002998   PMID:8050368  
PMID:8075820   PMID:8119140   PMID:8125201   PMID:8148154   PMID:8164195   PMID:8206089   PMID:8358866   PMID:8530024   PMID:8541216   PMID:8565825   PMID:8726224   PMID:8916368  
PMID:9010342   PMID:9169087   PMID:9177772   PMID:9184209   PMID:9203584   PMID:9217007   PMID:9427478   PMID:9525700   PMID:9768360   PMID:9839358   PMID:9921650   PMID:10030593  
PMID:10349630   PMID:10349636   PMID:10433821   PMID:10446266   PMID:10521784   PMID:10588868   PMID:10725249   PMID:10848613   PMID:10922068   PMID:10976050   PMID:10984614   PMID:11042159  
PMID:11076861   PMID:11084649   PMID:11092979   PMID:11106407   PMID:11109025   PMID:11159184   PMID:11180952   PMID:11217851   PMID:11390347   PMID:11404017   PMID:11526486   PMID:11675471  
PMID:11677049   PMID:11784073   PMID:11829488   PMID:11830573   PMID:11850179   PMID:11854453   PMID:11857453   PMID:11882017   PMID:11960699   PMID:11984523   PMID:12091349   PMID:12114535  
PMID:12141444   PMID:12142029   PMID:12192060   PMID:12217325   PMID:12220125   PMID:12381922   PMID:12393102   PMID:12466851   PMID:12477932   PMID:12478370   PMID:12588999   PMID:12617806  
PMID:12666199   PMID:12666204   PMID:12773577   PMID:12805272   PMID:12815630   PMID:12838410   PMID:14550911   PMID:14701881   PMID:14707111   PMID:14973287   PMID:14985127   PMID:15031101  
PMID:15206957   PMID:15226263   PMID:15248063   PMID:15294963   PMID:15305298   PMID:15342483   PMID:15478122   PMID:15528466   PMID:15531369   PMID:15582152   PMID:15615879   PMID:15724248  
PMID:15744664   PMID:15896309   PMID:15911702   PMID:15923624   PMID:15929941   PMID:15963767   PMID:16026545   PMID:16026622   PMID:16141072   PMID:16141073   PMID:16192636   PMID:16257223  
PMID:16282338   PMID:16314491   PMID:16466398   PMID:16598383   PMID:16602821   PMID:16632597   PMID:16702235   PMID:16741229   PMID:16787918   PMID:16879310   PMID:16887829   PMID:16919269  
PMID:17141511   PMID:17272814   PMID:17303760   PMID:17325033   PMID:17350578   PMID:17391645   PMID:17418116   PMID:17460765   PMID:17519332   PMID:17526730   PMID:17559664   PMID:17634193  
PMID:17673674   PMID:17767158   PMID:17804598   PMID:17881772   PMID:17997227   PMID:18038450   PMID:18159948   PMID:18213583   PMID:18287057   PMID:18287559   PMID:18317401   PMID:18358466  
PMID:18498095   PMID:18498113   PMID:18508041   PMID:18723448   PMID:18790002   PMID:18796538   PMID:18804458   PMID:18854036   PMID:18941179   PMID:18945958   PMID:19084512   PMID:19109099  
PMID:19123128   PMID:19141644   PMID:19161227   PMID:19164472   PMID:19304887   PMID:19403103   PMID:19449303   PMID:19465598   PMID:19509472   PMID:19587023   PMID:19705113   PMID:19757385  
PMID:19846762   PMID:19864318   PMID:19906978   PMID:19965872   PMID:20007998   PMID:20184861   PMID:20200502   PMID:20207738   PMID:20230754   PMID:20299672   PMID:20300191   PMID:20346356  
PMID:20421479   PMID:20427645   PMID:20501701   PMID:20530870   PMID:20565961   PMID:20603020   PMID:20633555   PMID:20858897   PMID:20875417   PMID:20890042   PMID:20970343   PMID:21087928  
PMID:21181942   PMID:21266196   PMID:21300867   PMID:21352545   PMID:21356372   PMID:21436291   PMID:21512031   PMID:21533152   PMID:21593251   PMID:21597012   PMID:21780244   PMID:21839733  
PMID:21873635   PMID:21880664   PMID:21909369   PMID:21959449   PMID:21967974   PMID:21983003   PMID:21984612   PMID:22130515   PMID:22186728   PMID:22235033   PMID:22326956   PMID:22331429  
PMID:22437311   PMID:22485132   PMID:22560297   PMID:22573381   PMID:22674610   PMID:22682244   PMID:22696295   PMID:22739237   PMID:22772368   PMID:22847922   PMID:22899851   PMID:22995554  
PMID:23041440   PMID:23193168   PMID:23303681   PMID:23319608   PMID:23342175   PMID:23525041   PMID:23560082   PMID:23584732   PMID:23603491   PMID:23824573   PMID:23946447   PMID:23963447  
PMID:24006456   PMID:24045946   PMID:24131868   PMID:24157418   PMID:24161934   PMID:24278323   PMID:24279395   PMID:24356956   PMID:24449835   PMID:24472616   PMID:24474796   PMID:24550112  
PMID:24623077   PMID:24680892   PMID:24741061   PMID:24760528   PMID:24831012   PMID:24859004   PMID:24895296   PMID:24906856   PMID:24917498   PMID:24952961   PMID:24990151   PMID:24996922  
PMID:25053429   PMID:25082703   PMID:25249460   PMID:25274628   PMID:25318679   PMID:25332192   PMID:25336743   PMID:25382630   PMID:25428587   PMID:25448845   PMID:25450421   PMID:25456500  
PMID:25467979   PMID:25520397   PMID:25575930   PMID:25715398   PMID:25759071   PMID:25766329   PMID:25963716   PMID:26100917   PMID:26120030   PMID:26284554   PMID:26315405   PMID:26324903  
PMID:26457758   PMID:26458493   PMID:26472242   PMID:26607280   PMID:26799667   PMID:26837596   PMID:26878215   PMID:26930384   PMID:26952977   PMID:27056911   PMID:27180663   PMID:27215389  
PMID:27224923   PMID:27348588   PMID:27358050   PMID:27377816   PMID:27465829   PMID:27605619   PMID:27771509   PMID:27913639   PMID:27922003   PMID:27939132   PMID:28009292   PMID:28159809  
PMID:28329690   PMID:28538179   PMID:28558017   PMID:28568893   PMID:28621467   PMID:28640846   PMID:28675425   PMID:28700594   PMID:28771943   PMID:28807903   PMID:28809397   PMID:28945200  
PMID:29031500   PMID:29038307   PMID:29416028   PMID:29438518   PMID:29540665   PMID:29593116   PMID:29618843   PMID:29686677   PMID:29689292   PMID:29743238   PMID:29853617   PMID:29869452  
PMID:29945868   PMID:30201295   PMID:30228991   PMID:30598510   PMID:30659114   PMID:30731284   PMID:30922407   PMID:31028279   PMID:31118233   PMID:31311865   PMID:31399471   PMID:31719045  
PMID:32001436   PMID:32212902   PMID:32219603   PMID:32655758   PMID:32794350   PMID:32938678   PMID:33147210   PMID:33227706   PMID:33510480   PMID:33798452   PMID:33846290   PMID:34108685  
PMID:34321999   PMID:34359856   PMID:34622152   PMID:34815802   PMID:34830390   PMID:35069536   PMID:35157852   PMID:35247391   PMID:35364055   PMID:35525525   PMID:35894043   PMID:36128893  
PMID:36227576   PMID:36314682   PMID:36497119   PMID:36543770   PMID:36610224   PMID:36691035   PMID:36762637   PMID:37017267   PMID:37217119   PMID:37497597  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391186,354,984 - 186,441,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1186,354,989 - 186,438,186 (-)EnsemblGRCm39 Ensembl
GRCm381186,622,787 - 186,709,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,622,792 - 186,705,989 (-)EnsemblGRCm38mm10GRCm38
MGSCv371188,447,065 - 188,529,871 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361188,324,430 - 188,406,777 (-)NCBIMGSCv36mm8
Celera1193,563,609 - 193,649,724 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map189.95NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381218,345,336 - 218,444,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1218,345,336 - 218,444,619 (+)EnsemblGRCh38hg38GRCh38
GRCh371218,518,678 - 218,617,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361216,586,491 - 216,681,596 (+)NCBINCBI36Build 36hg18NCBI36
Build 341214,908,262 - 215,003,365NCBI
Celera1191,735,848 - 191,834,418 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1189,186,842 - 189,286,057 (+)NCBIHuRef
CHM1_11219,791,024 - 219,890,484 (+)NCBICHM1_1
T2T-CHM13v2.01217,580,100 - 217,679,392 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21398,160,075 - 98,261,771 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1398,160,087 - 98,261,405 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13100,678,931 - 100,778,632 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013102,066,560 - 102,165,910 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01399,261,239 - 99,360,947 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013105,039,639 - 105,142,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13105,039,853 - 105,141,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013109,679,866 - 109,792,609 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413102,718,703 - 102,818,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113102,907,748 - 103,007,811 (-)NCBI
Celera1397,669,691 - 97,769,426 (-)NCBICelera
Cytogenetic Map13q26NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955406172,814 - 249,248 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955406174,949 - 249,248 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1130,925,280 - 31,023,656 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01193,907,398 - 194,005,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11198,758,718 - 198,856,853 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1198,758,751 - 198,859,041 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13813,430,832 - 13,511,655 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3813,429,148 - 13,510,242 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3813,472,728 - 13,552,654 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03813,464,207 - 13,544,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3813,464,807 - 13,545,256 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13813,473,487 - 13,553,481 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03813,819,811 - 13,899,809 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03814,128,921 - 14,209,014 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934458,300,141 - 58,383,975 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936628308,691 - 394,007 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936628310,720 - 394,002 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl108,305,539 - 8,390,341 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1108,306,136 - 8,435,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21010,353,794 - 10,476,143 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap10p16NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12511,163,651 - 11,259,868 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2511,163,100 - 11,258,470 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605511,574,533 - 11,672,282 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248352,363,139 - 2,437,643 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248352,363,059 - 2,436,536 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Tgfb2
2935 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:633
Count of miRNA genes:437
Interacting mature miRNAs:496
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152794822186438620Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153675990187676105Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153712853187712853Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154410512188410512Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155002940189002940Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155002940189002940Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155002940189002940Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155525623189527533Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155716221189716369Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155716221189716369Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155716221189716369Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155721528189722608Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1155831765189831892Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined155831765189831892Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1155831765189831892Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1155831765189831892Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156602037189303617Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156602037189303617Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162145207194111528Mouse
1300888Berr1_mberghei resistance locus 1 (mouse)Not determined1164143227190534272Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1165873675195154279Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167462514195154279Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167462514195154279Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167462514195154279Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167586086191225397Mouse
1301333Mop3_mmorphine preference 3 (mouse)Not determined1167756737189303617Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170379500195154279Mouse
4142389Scfr1_mstem cell frequency regulator 1 (mouse)Not determined171632048189303617Mouse
1300727Mptp1_mMPTP sensitivity 1 (mouse)Not determined1171632048192681050Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1171983110195154279Mouse
11049575Lmr8b_mleishmaniasis resistance 8b (mouse)1172303451195154279Mouse
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172303451195154279Mouse
10043863Swrl5_mSWR lupus locus 5 (mouse)Not determined1172303451195154279Mouse
12880426V25Dq2_mvitamin D inactive form serum level QTL 2 (mouse)1172532197195154279Mouse
12880429V25Dq1_mvitamin D inactive form serum level QTL 1 (mouse)1172632197195154279Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175211318195154279Mouse
11532690Sluc37_msusceptibility to lung cancer 37 (mouse)1175468817194111528Mouse
1357692Axtq1_manxiety QTL 1 (mouse)Not determined1180832317191851043Mouse
1357620Aaj1_manxiety in A/J 1 (mouse)Not determined1180832317191851043Mouse
4141034Bmd1c_mbone mineral density 1c (mouse)Not determined185909790189303617Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381186,622,909 - 186,622,989UniSTSGRCm38
MGSCv371188,446,788 - 188,446,868UniSTSGRCm37
Celera1193,563,332 - 193,563,412UniSTS
Cytogenetic Map1H5UniSTS
cM Map1101.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371188,448,693 - 188,448,895UniSTSGRCm37
Celera1193,565,237 - 193,565,439UniSTS
Cytogenetic Map1H5UniSTS
cM Map1101.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381186,625,202 - 186,625,399UniSTSGRCm38
MGSCv371188,449,081 - 188,449,278UniSTSGRCm37
Celera1193,565,625 - 193,565,822UniSTS
Cytogenetic Map1H5UniSTS
cM Map1101.5UniSTS
Whitehead_YAC1 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381186,706,303 - 186,706,423UniSTSGRCm38
MGSCv371188,530,182 - 188,530,302UniSTSGRCm37
Celera1193,650,035 - 193,650,158UniSTS
Cytogenetic Map1H5UniSTS
cM Map1102.0UniSTS
Whitehead Genetic1104.9UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381186,704,985 - 186,705,138UniSTSGRCm38
MGSCv371188,528,864 - 188,529,017UniSTSGRCm37
Celera1193,648,717 - 193,648,870UniSTS
Celera1193,648,673 - 193,648,870UniSTS
Cytogenetic Map1H5UniSTS
cM Map1101.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381186,624,814 - 186,625,016UniSTSGRCm38
MGSCv371188,448,693 - 188,448,895UniSTSGRCm37
Celera1193,565,237 - 193,565,439UniSTS
Cytogenetic Map1H5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H5UniSTS



RefSeq Acc Id: ENSMUST00000045288   ⟹   ENSMUSP00000043849
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1186,354,989 - 186,438,186 (-)Ensembl
GRCm38.p6 Ensembl1186,622,792 - 186,705,989 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191766
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1186,357,777 - 186,382,187 (-)Ensembl
GRCm38.p6 Ensembl1186,625,580 - 186,649,990 (-)Ensembl
RefSeq Acc Id: ENSMUST00000193640
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1186,422,921 - 186,436,530 (-)Ensembl
GRCm38.p6 Ensembl1186,690,724 - 186,704,333 (-)Ensembl
RefSeq Acc Id: ENSMUST00000194593
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1186,364,964 - 186,400,352 (-)Ensembl
GRCm38.p6 Ensembl1186,632,767 - 186,668,155 (-)Ensembl
RefSeq Acc Id: ENSMUST00000194960
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1186,361,080 - 186,382,253 (-)Ensembl
GRCm38.p6 Ensembl1186,628,883 - 186,650,056 (-)Ensembl
RefSeq Acc Id: ENSMUST00000195201   ⟹   ENSMUSP00000142149
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1186,356,415 - 186,437,897 (-)Ensembl
GRCm38.p6 Ensembl1186,624,218 - 186,705,700 (-)Ensembl
RefSeq Acc Id: NM_001329107   ⟹   NP_001316036
RefSeq Status: REVIEWED
Mouse AssemblyChrPosition (strand)Source
GRCm391186,354,989 - 186,438,186 (-)NCBI
GRCm381186,622,792 - 186,705,989 (-)NCBI
RefSeq Acc Id: NM_009367   ⟹   NP_033393
RefSeq Status: REVIEWED
Mouse AssemblyChrPosition (strand)Source
GRCm391186,354,989 - 186,438,186 (-)NCBI
GRCm381186,622,792 - 186,705,989 (-)NCBI
MGSCv371188,447,065 - 188,529,871 (-)RGD
Celera1193,563,609 - 193,649,724 (-)RGD
RefSeq Acc Id: XM_006497136   ⟹   XP_006497199
Mouse AssemblyChrPosition (strand)Source
GRCm391186,354,984 - 186,441,504 (-)NCBI
GRCm381186,622,787 - 186,709,697 (-)NCBI
RefSeq Acc Id: XM_030252968   ⟹   XP_030108828
Mouse AssemblyChrPosition (strand)Source
GRCm391186,354,984 - 186,441,504 (-)NCBI
GRCm381186,622,787 - 186,709,683 (-)NCBI
RefSeq Acc Id: NP_033393   ⟸   NM_009367
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q91VP5 (UniProtKB/Swiss-Prot),   P27090 (UniProtKB/Swiss-Prot),   Q3TWH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006497199   ⟸   XM_006497136
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030108828   ⟸   XM_030252968
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001316036   ⟸   NM_001329107
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A0A6YXU9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000043849   ⟸   ENSMUST00000045288
RefSeq Acc Id: ENSMUSP00000142149   ⟸   ENSMUST00000195201
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27090-F1-model_v2 AlphaFold P27090 1-414 view protein structure

RGD ID:6876040
Promoter ID:EPDNEW_M1471
Type:initiation region
Description:Mus musculus transforming growth factor, beta 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M1472  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381186,705,274 - 186,705,334EPDNEW
RGD ID:6876042
Promoter ID:EPDNEW_M1472
Type:multiple initiation site
Description:Mus musculus transforming growth factor, beta 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M1471  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381186,705,989 - 186,706,049EPDNEW
RGD ID:6818578
Promoter ID:MM_KWN:3236
SO ACC ID:SO:0000170
Tissues & Cell Lines:Brain,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_009367,   UC007DZP.1
Mouse AssemblyChrPosition (strand)Source
MGSCv361188,528,636 - 188,529,917 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98726 AgrOrtholog
Ensembl Genes ENSMUSG00000039239 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000045288 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000195201.2 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21808 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgfb2 PhenoGen
PIRSF TGF-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFBETA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFB2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q91VP5 UniProtKB/Swiss-Prot