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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69169
Species: Mus musculus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases activityISOPPARG (Homo sapiens)6480464CTDZearalenone results in decreased activity of PPARG proteinPMID:27481073
Ppargdecreases methylationISOPPARG (Homo sapiens)6480464CTDZearalenone results in decreased methylation of PPARG promoterPMID:32119988
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDZearalenone results in increased expression of PPARG mRNA; Zearalenone results in increased expression of PPARG proteinPMID:32119988
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDPPARG inhibits the reaction [Zearalenone results in increased expression of PGR mRNA]; PPARG inhibits the reaction [Zearalenone results in increased expression of TFF1 mRNA]PMID:35588983
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