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Gene: Chek2 (checkpoint kinase 2) Mus musculus
Symbol: Chek2
Name: checkpoint kinase 2
Description: ENCODES a protein that exhibits protein kinase activity; identical protein binding (ortholog); kinase activity (ortholog); INVOLVED IN apoptotic process; cellular response to gamma radiation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; PARTICIPATES IN p53 signaling pathway; cell cycle pathway, mitotic; ASSOCIATED WITH abnormal cell cycle; abnormal cell cycle checkpoint function; abnormal cell physiology; ASSOCIATED WITH astrocytoma (ortholog); breast cancer (ortholog); Breast Cancer, Familial (ortholog); FOUND IN chromosome, telomeric region (ortholog); Golgi apparatus (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cds1; Cds1 homolog; CHK2; CHK2 checkpoint homolog; HUCDS1; protein kinase Chk2; Rad53; Rad53 homolog; serine/threonine-protein kinase Chk2
Homo sapiens (human) : CHEK2 (checkpoint kinase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Chek2 (checkpoint kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chek2 (checkpoint kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CHEK2 (checkpoint kinase 2)
Canis lupus familiaris (dog) : CHEK2 (checkpoint kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chek2 (checkpoint kinase 2)
Sus scrofa (pig) : CHEK2 (checkpoint kinase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm385110,839,800 - 110,874,140 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375111,269,036 - 111,303,152 (+)NCBIGRCm37mm9NCBIm37
MGSCv365111,080,319 - 111,114,435 (+)NCBImm8
Celera5107,972,108 - 108,006,794 (+)NCBICelera
Cytogenetic Map5 FNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Chek2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732862
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.