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Gene: Chek2 (checkpoint kinase 2) Mus musculus
Symbol: Chek2
Name: checkpoint kinase 2
RGD ID: 732862
Description: Exhibits protein kinase activity. Involved in several processes, including cellular response to gamma radiation; mitotic G2 phase; and signal transduction by p53 class mediator. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including central nervous system; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Orthologous to human CHEK2 (checkpoint kinase 2); PARTICIPATES IN p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cds1; Cds1 homolog; CHK2; CHK2 checkpoint homolog; HUCDS1; protein kinase Chk2; Rad; Rad53; Rad53 homolog; serine/threonine-protein kinase Chk2
Homo sapiens (human) : CHEK2 (checkpoint kinase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Chek2 (checkpoint kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chek2 (checkpoint kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CHEK2 (checkpoint kinase 2)
Canis lupus familiaris (dog) : CHEK2 (checkpoint kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chek2 (checkpoint kinase 2)
Sus scrofa (pig) : CHEK2 (checkpoint kinase 2)
Chlorocebus sabaeus (African green monkey) : CHEK2 (checkpoint kinase 2)
Heterocephalus glaber (naked mole-rat) : Chek2 (checkpoint kinase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395110,987,668 - 111,022,006 (+)NCBI
GRCm385110,839,800 - 110,874,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,839,979 - 110,874,145 (+)EnsemblGRCm38mm10GRCm38
MGSCv375111,269,036 - 111,303,152 (+)NCBIGRCm37mm9NCBIm37
MGSCv365111,080,319 - 111,114,435 (+)NCBImm8
Celera5107,972,108 - 108,006,794 (+)NCBICelera
Cytogenetic Map5FNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Chek2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732862
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.