Cyp4f18 (cytochrome P450, family 4, subfamily f, polypeptide 18) - Rat Genome Database
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Gene: Cyp4f18 (cytochrome P450, family 4, subfamily f, polypeptide 18) Mus musculus
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Symbol: Cyp4f18
Name: cytochrome P450, family 4, subfamily f, polypeptide 18
RGD ID: 1313186
MGI Page MGI
Description: Predicted to have monooxygenase activity. Predicted to be involved in several processes, including fatty acid metabolic process; quinone catabolic process; and regulation of icosanoid secretion. Predicted to localize to apical plasma membrane; cytoplasm; and intracellular membrane-bounded organelle. Orthologous to human CYP4F3 (cytochrome P450 family 4 subfamily F member 3); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3; cytochrome P450 4F3; cytochrome P450 CYP4F18; cytochrome P450, 4f18; cytochrome P450-LTB-omega; leukotriene-B(4) 20-monooxygenase 2; leukotriene-B(4) omega-1/omega-2 hydroxylase; leukotriene-B(4) omega-hydroxylase 2
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,742,326 - 72,763,512 (-)NCBIGRCm39mm39
GRCm38871,988,482 - 72,009,668 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,988,482 - 72,009,626 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,512,381 - 74,533,525 (-)NCBIGRCm37mm9NCBIm37
MGSCv36874,917,471 - 74,938,606 (-)NCBImm8
Celera876,344,833 - 76,358,866 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Poisoning  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14681479   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16380383   PMID:17081494   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:24632148   PMID:26613087   PMID:32325033  


Genomics

Comparative Map Data
Cyp4f18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,742,326 - 72,763,512 (-)NCBIGRCm39mm39
GRCm38871,988,482 - 72,009,668 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,988,482 - 72,009,626 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,512,381 - 74,533,525 (-)NCBIGRCm37mm9NCBIm37
MGSCv36874,917,471 - 74,938,606 (-)NCBImm8
Celera876,344,833 - 76,358,866 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
CYP4F3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1915,640,897 - 15,662,825 (+)EnsemblGRCh38hg38GRCh38
GRCh381915,640,897 - 15,662,825 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371915,751,701 - 15,771,570 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361915,612,707 - 15,632,570 (+)NCBINCBI36hg18NCBI36
Build 341915,612,706 - 15,634,634NCBI
Celera1915,648,618 - 15,668,477 (+)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1915,320,174 - 15,340,137 (+)NCBIHuRef
CHM1_11915,751,200 - 15,771,063 (+)NCBICHM1_1
Cyp4f18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,501,680 - 19,528,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,410,810 - 19,528,999 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,358,299 - 19,385,553 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,183,761 - 18,225,158 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11618,197,585 - 18,224,006 (+)NCBI
Celera1617,986,320 - 18,013,579 (+)NCBICelera
Cytogenetic Map16p14NCBI
CYP4F3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11916,146,664 - 16,165,869 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1916,146,664 - 16,165,869 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01915,162,886 - 15,182,334 (+)NCBIMhudiblu_PPA_v0panPan3
LOC484867
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2046,458,620 - 46,705,789 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12046,611,799 - 46,664,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC110259329
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl261,864,575 - 61,984,903 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1261,863,378 - 61,884,717 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP4F3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl614,241,409 - 14,263,494 (+)Ensembl
ChlSab1.1614,241,352 - 14,260,799 (+)NCBI

Position Markers
Cyp4f18  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C1UniSTS
cM Map834.67UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:458
Count of miRNA genes:361
Interacting mature miRNAs:397
Transcripts:ENSMUST00000003574, ENSMUST00000125448, ENSMUST00000141975
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000003574   ⟹   ENSMUSP00000003574
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,988,482 - 72,009,626 (-)Ensembl
RefSeq Acc Id: ENSMUST00000125448
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,989,554 - 71,993,231 (-)Ensembl
RefSeq Acc Id: ENSMUST00000141975   ⟹   ENSMUSP00000148315
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,988,483 - 71,992,915 (-)Ensembl
RefSeq Acc Id: NM_024444   ⟹   NP_077764
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,742,326 - 72,763,470 (-)NCBI
GRCm38871,988,482 - 72,009,626 (-)NCBI
MGSCv37874,512,381 - 74,533,525 (-)RGD
Celera876,344,833 - 76,358,866 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509748   ⟹   XP_006509811
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,742,326 - 72,763,466 (-)NCBI
GRCm38871,988,482 - 72,009,622 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509749   ⟹   XP_006509812
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,742,326 - 72,762,979 (-)NCBI
GRCm38871,988,482 - 72,009,622 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242327   ⟹   XP_011240629
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,742,326 - 72,763,512 (-)NCBI
GRCm38871,988,482 - 72,009,668 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243782   ⟹   XP_030099642
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,742,326 - 72,761,041 (-)NCBI
GRCm38871,988,482 - 72,007,197 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_077764   ⟸   NM_024444
- Peptide Label: precursor
- UniProtKB: Q99N16 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509811   ⟸   XM_006509748
- Peptide Label: isoform X1
- UniProtKB: Q99N16 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509812   ⟸   XM_006509749
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011240629   ⟸   XM_011242327
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030099642   ⟸   XM_030243782
- Peptide Label: isoform X3
RefSeq Acc Id: ENSMUSP00000003574   ⟸   ENSMUST00000003574
RefSeq Acc Id: ENSMUSP00000148315   ⟸   ENSMUST00000141975

Promoters
RGD ID:8667447
Promoter ID:EPDNEW_M11755
Type:single initiation site
Name:Cyp4f18_1
Description:Mus musculus cytochrome P450, family 4, subfamily f, polypeptide18 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38872,009,626 - 72,009,686EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919304 AgrOrtholog
Ensembl Genes ENSMUSG00000003484 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000003574 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148315 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000003574 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000141975 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:72054 UniProtKB/Swiss-Prot
MGD MGI:1919304 ENTREZGENE
NCBI Gene 72054 ENTREZGENE
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp4f18 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450IV UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.160020 ENTREZGENE
UniProt A0A1D5RLD0_MOUSE UniProtKB/TrEMBL
  CP4F3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary E9QLZ3 UniProtKB/Swiss-Prot
  Q9D8N4 UniProtKB/Swiss-Prot