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Gene: Prkaa2 (protein kinase, AMP-activated, alpha 2 catalytic subunit) Mus musculus
Symbol: Prkaa2
Name: protein kinase, AMP-activated, alpha 2 catalytic subunit
Description: Exhibits AMP-activated protein kinase activity; chromatin binding activity; and histone serine kinase activity. Involved in several processes, including regulation of autophagy; regulation of organelle organization; and regulation of protein modification process. Localizes to several cellular components, including cytoplasmic stress granule; dendrite; and neuronal cell body. Is expressed in several structures, including brain; future brain; heart; lung; and spinal cord. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; vascular endothelial growth factor signaling pathway; autophagy pathway; INTERACTS WITH (S)-nicotine; 1,1-dichloroethene; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310008I11Rik; 5'-AMP-activated protein kinase catalytic subunit alpha-2; A830082D05; ACACA kinase; acetyl-CoA carboxylase kinase; AMP-activated protein kinase alpha-2 variant B; AMPK subunit alpha-2; AMPKalpha2; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl4105,029,874 - 105,109,890 (-)EnsemblGRCm38mm10GRCm38
GRCm384105,029,649 - 105,109,898 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374104,702,255 - 104,782,503 (-)NCBIGRCm37mm9NCBIm37
MGSCv364104,532,922 - 104,607,801 (-)NCBImm8
Celera4103,380,658 - 103,460,821 (-)NCBICelera
Cytogenetic Map4C6NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Prkaa2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730889
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.