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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732738
Species: Mus musculus
RGD Object: Gene
Symbol: Ncoa2
Name: nuclear receptor coactivator 2
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncoa2multiple interactionsISONCOA2 (Homo sapiens)6480464CTDZearalenone analog promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone analog promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone promotes the reaction [NCOA2 protein binds to ESR1 protein]PMID:15084758 PMID:28807876
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