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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736867
Species: Mus musculus
RGD Object: Gene
Symbol: Abcc3
Name: ATP-binding cassette, sub-family C member 3
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc3affects expressionISOAbcc3 (Rattus norvegicus)6480464CTDZearalenone affects the expression of ABCC3 mRNA; Zearalenone affects the expression of ABCC3 proteinPMID:22521637
Abcc3decreases expressionISOABCC3 (Homo sapiens)6480464CTDZearalenone results in decreased expression of ABCC3 mRNAPMID:19371625
Abcc3multiple interactionsISOABCC3 (Homo sapiens)6480464CTDZearalenone inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]PMID:19647055
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