Thbs1 (thrombospondin 1) - Rat Genome Database

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Gene: Thbs1 (thrombospondin 1) Mus musculus
Analyze
Symbol: Thbs1
Name: thrombospondin 1
RGD ID: 1615939
MGI Page MGI
Description: Enables extracellular matrix binding activity. Involved in several processes, including behavioral response to pain; positive regulation of macrophage chemotaxis; and positive regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including cellular response to nitric oxide; circulatory system development; and monocyte aggregation. Located in extracellular matrix; extracellular space; and sarcoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; pancreatic ductal carcinoma; and primary open angle glaucoma. Orthologous to human THBS1 (thrombospondin 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: glycoprotein G; tbs; tbsp1; Thbs-; Thbs-1; thrombospondin-1; TS; TSP; TSP-1; TSP1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392117,942,357 - 117,957,614 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2117,942,357 - 117,957,614 (+)EnsemblGRCm39 Ensembl
GRCm382118,111,876 - 118,127,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,111,876 - 118,127,133 (+)EnsemblGRCm38mm10GRCm38
MGSCv372117,937,658 - 117,952,869 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362119,046,897 - 119,061,990 (+)NCBIMGSCv36mm8
MGSCv362117,803,363 - 117,818,574 (+)NCBIMGSCv36mm8
Celera2119,257,347 - 119,271,479 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (EXP)
amphetamine  (ISO)
andrographolide  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP,ISO)
aspartame  (EXP)
atorvastatin calcium  (ISO)
atrazine  (ISO)
axitinib  (ISO)
Azoxymethane  (EXP)
benzalkonium chloride  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP)
boron nitride  (ISO)
busulfan  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
choline  (EXP)
chrysene  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethyl malate  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
diiodine  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (EXP,ISO)
Enterolactone  (ISO)
equol  (ISO)
ethanol  (EXP)
Evodiamine  (ISO)
fenamidone  (EXP)
fenoldopam  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
furosemide  (ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (ISO)
glyphosate  (EXP,ISO)
hydrogen cyanide  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
leflunomide  (ISO)
Licochalcone B  (ISO)
magnesium atom  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
metoprolol  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (EXP)
nitrofen  (ISO)
NORCANTHARIDIN  (ISO)
Nutlin-3  (ISO)
okadaic acid  (EXP,ISO)
organophosphorus compound  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paricalcitol  (ISO)
perfluorononanoic acid  (ISO)
phenformin  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosgene  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phthalaldehyde  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium cyanide  (EXP)
prednisolone  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
Rutecarpine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
senecionine  (EXP,ISO)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
ticlopidine  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
uranium atom  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
apoptotic process  (IEA)
behavioral response to pain  (IMP)
blood vessel morphogenesis  (IGI)
cell migration  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to nitric oxide  (IMP)
cellular response to tumor necrosis factor  (ISO)
chronic inflammatory response  (ISO)
endocardial cushion development  (IGI)
engulfment of apoptotic cell  (ISO)
growth plate cartilage development  (IGI,IMP)
immune response  (ISO)
inflammatory response  (IMP,ISO)
monocyte aggregation  (IMP)
negative regulation of angiogenesis  (IBA,IDA,IMP,ISO)
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell-matrix adhesion  (ISO)
negative regulation of cGMP-mediated signaling  (ISO)
negative regulation of dendritic cell antigen processing and presentation  (ISO)
negative regulation of endothelial cell chemotaxis  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of endothelial cell proliferation  (IMP,ISO)
negative regulation of fibrinolysis  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of interleukin-10 production  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of long-chain fatty acid import across plasma membrane  (ISO)
negative regulation of nitric oxide mediated signal transduction  (ISO)
negative regulation of plasminogen activation  (ISO)
negative regulation of sprouting angiogenesis  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
nitric oxide-cGMP-mediated signaling  (ISO)
outflow tract morphogenesis  (IGI)
peptide cross-linking  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood coagulation  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-substrate adhesion  (IDA)
positive regulation of chemotaxis  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of macrophage chemotaxis  (IMP)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transforming growth factor beta production  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IMP,ISO)
positive regulation of translation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
response to calcium ion  (ISO)
response to endoplasmic reticulum stress  (IMP)
response to glucose  (ISO)
response to magnesium ion  (ISO)
response to mechanical stimulus  (ISO)
response to testosterone  (ISO)
response to unfolded protein  (IEA)
response to xenobiotic stimulus  (ISO)
sprouting angiogenesis  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal conjunctiva goblet cell number  (IAGP)
abnormal cornea epithelium morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal cystic duct morphology  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal kidney corticomedullary boundary morphology  (IAGP)
abnormal lacrimal gland physiology  (IAGP)
abnormal liver morphology  (IEA)
abnormal lung morphology  (IAGP)
abnormal lung vasculature morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal muscle fiber morphology  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal physiological neovascularization  (IAGP)
abnormal skin condition  (IAGP)
abnormal skin physiology  (IAGP)
abnormal systemic arterial blood pressure  (IAGP)
abnormal tail morphology  (IAGP)
abnormal tumor morphology  (IAGP)
anemia  (IAGP)
bronchial epithelial hyperplasia  (IAGP)
decreased conjunctiva goblet cell number  (IAGP)
decreased heart rate  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased litter size  (IAGP)
decreased pulse pressure  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased renal tubule apoptosis  (IAGP)
decreased sensitivity to skin irradiation  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
delayed wound healing  (IAGP)
dilated gallbladder  (IAGP)
esophagogastric junction metaplasia  (IAGP)
exocrine pancreas hypoplasia  (IAGP)
gastric polyps  (IAGP)
impaired macrophage chemotaxis  (IAGP)
increased adenocarcinoma incidence  (IAGP)
increased adenoma incidence  (IAGP)
increased anti-single stranded DNA antibody level  (IAGP)
increased bleeding time  (IAGP)
increased bone mineral content  (IEA)
increased carcinoma incidence  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased circulating alanine transaminase level  (IEA)
increased club cell number  (IAGP)
increased eosinophil cell number  (IAGP)
increased fibrosarcoma incidence  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased lacrimal gland apoptosis  (IAGP)
increased leukocyte cell number  (IAGP)
increased liver adenocarcinoma incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lymphocyte cell number  (IAGP)
increased lymphoma incidence  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased pancreas tumor incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased sarcoma incidence  (IAGP)
increased small intestine adenocarcinoma incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased tumor incidence  (IAGP)
kyphosis  (IAGP)
lacrimal gland inflammation  (IAGP)
lordosis  (IAGP)
lung inflammation  (IAGP)
microphthalmia  (IAGP)
narrow eye opening  (IAGP)
pancreas inflammation  (IAGP)
pancreatic islet hyperplasia  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
pulmonary alveolar hemorrhage  (IAGP)
reduced fertility  (IAGP)
stomach epithelial hyperplasia  (IAGP)
vascular smooth muscle hyperplasia  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Proteomics analysis of human obesity reveals the epigenetic factor HDAC4 as a potential target for obesity. Abu-Farha M, etal., PLoS One. 2013 Sep 24;8(9):e75342. doi: 10.1371/journal.pone.0075342. eCollection 2013.
2. The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma. Aishima S, etal., Int J Surg Pathol. 2002 Jan;10(1):47-56.
3. A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II. Belmadani S, etal., Am J Pathol. 2007 Sep;171(3):777-89. Epub 2007 Jul 19.
4. Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in vivo. Daniel C, etal., Diabetes. 2007 Dec;56(12):2982-9. Epub 2007 Sep 18.
5. Protection of erythropoietin on experimental spinal cord injury by reducing the expression of thrombospondin-1 and transforming growth factor-beta. Fang XQ, etal., Chin Med J (Engl). 2009 Jul 20;122(14):1631-5.
6. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
7. Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma. Lee S, etal., Am J Pathol. 2002 Sep;161(3):1015-22.
8. Identification and Validation of Stage-Associated Serum Biomarkers in Colorectal Cancer Using MS-Based Procedures. Marín-Vicente C, etal., Proteomics Clin Appl. 2020 Jan;14(1):e1900052. doi: 10.1002/prca.201900052. Epub 2019 Sep 18.
9. Methylation profile of circulating plasma DNA in patients with pancreatic cancer. Melnikov AA, etal., J Surg Oncol. 2009 Feb 1;99(2):119-22.
10. Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma. Ohtani Y, etal., Int J Oncol. 1999 Sep;15(3):453-7.
11. Stromal thrombospondin-1 expression is a prognostic indicator and a new marker of invasiveness in intraductal papillary-mucinous neoplasm of the pancreas. Okada K, etal., Biomed Res. 2010;31(1):13-9.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Thrombospondin-1 is induced in rat myocardial infarction and its induction is accelerated by ischemia/reperfusion. Sezaki S, etal., Exp Biol Med (Maywood). 2005 Oct;230(9):621-30.
17. Association of angiogenesis related markers with bladder cancer outcomes and other molecular markers. Shariat SF, etal., J Urol. 2010 May;183(5):1744-50. doi: 10.1016/j.juro.2010.01.018. Epub 2010 Mar 17.
18. Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance. Tang D, etal., Oncol Rep. 2006 Mar;15(3):525-32.
19. Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. Tobita K, etal., Int J Oncol. 2002 Dec;21(6):1189-95.
20. Hypermethylation of multiple genes in pancreatic adenocarcinoma. Ueki T, etal., Cancer Res. 2000 Apr 1;60(7):1835-9.
21. Thrombospondins, metallo proteases and thrombospondin receptors messenger RNA and protein expression in different tumour sublines of the Dunning prostate cancer model. Vallbo C and Damber JE, Acta Oncol. 2005;44(3):293-8.
22. [The study of thrombospondin-I (TSP1) expression in the early stages of diabetic retinopathy induced by streptozotocin] Wang JY, etal., Fen Zi Xi Bao Sheng Wu Xue Bao. 2006 Oct;39(5):431-7.
23. Identification of Missense Extracellular Matrix Gene Variants in a Large Glaucoma Pedigree and Investigation of the N700S Thrombospondin-1 Variant in Normal and Glaucomatous Trabecular Meshwork Cells. Wirtz MK, etal., Curr Eye Res. 2022 Jan;47(1):79-90. doi: 10.1080/02713683.2021.1945109. Epub 2021 Jul 6.
24. Expression of angiogenic factors is upregulated in DMBA-induced rat mammary pathologies. Yan M, etal., Pathobiology. 2004;71(5):253-60.
25. Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model. Zhang X, etal., Cancer Lett. 2007 Mar 8;247(1):143-9. Epub 2006 Jun 6.
26. [The role of glucose/TSP-1/TGFbeta1 signal pathways in diabetic cardiomyopathy] Zhong M, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2006 Mar;34(3):217-21.
27. Alteration of thrombospondin-1 and -2 in rat brains following experimental intracerebral hemorrhage. Zhou HJ, etal., J Neurosurg. 2010 Feb 5.
Additional References at PubMed
PMID:1358795   PMID:1371115   PMID:1459996   PMID:1712771   PMID:1774063   PMID:2335352   PMID:2398070   PMID:7499866   PMID:7590978   PMID:7622488   PMID:7633422   PMID:7798257  
PMID:8020965   PMID:8111131   PMID:8126073   PMID:8250913   PMID:8288588   PMID:8350346   PMID:8400410   PMID:8589530   PMID:8617512   PMID:8654563   PMID:8661736   PMID:8950991  
PMID:9373030   PMID:9374397   PMID:9486968   PMID:9653112   PMID:9657149   PMID:9694593   PMID:9889000   PMID:10027393   PMID:10087292   PMID:10349636   PMID:10500044   PMID:10549128  
PMID:10613822   PMID:10849431   PMID:10880440   PMID:10965135   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11606713   PMID:11696456   PMID:11707574   PMID:12213711   PMID:12242711  
PMID:12368264   PMID:12439745   PMID:12466851   PMID:12477932   PMID:12498716   PMID:12535193   PMID:12584168   PMID:12617806   PMID:12912908   PMID:14511656   PMID:14648840   PMID:14962109  
PMID:14981081   PMID:14988590   PMID:15037577   PMID:15325561   PMID:15371459   PMID:15641039   PMID:15652753   PMID:15672414   PMID:15710885   PMID:15728386   PMID:15728547   PMID:15735755  
PMID:15736054   PMID:15890262   PMID:15927970   PMID:15963261   PMID:16009346   PMID:16141072   PMID:16141073   PMID:16150726   PMID:16181801   PMID:16204318   PMID:16227992   PMID:16294224  
PMID:16311602   PMID:16409488   PMID:16418571   PMID:16537572   PMID:16565389   PMID:16569680   PMID:16598380   PMID:16602821   PMID:16624339   PMID:16675960   PMID:16691615   PMID:16705174  
PMID:16835222   PMID:16883596   PMID:17056717   PMID:17082319   PMID:17082620   PMID:17082774   PMID:17133361   PMID:17143334   PMID:17154366   PMID:17293482   PMID:17431190   PMID:17442977  
PMID:17513749   PMID:17583726   PMID:17761938   PMID:17890448   PMID:17916772   PMID:17962514   PMID:18032585   PMID:18171979   PMID:18213587   PMID:18285447   PMID:18287559   PMID:18334835  
PMID:18392110   PMID:18420490   PMID:18452614   PMID:18467703   PMID:18594557   PMID:18653767   PMID:18757424   PMID:18757743   PMID:18787106   PMID:18818405   PMID:18946489   PMID:19030180  
PMID:19079608   PMID:19147503   PMID:19181483   PMID:19193867   PMID:19194474   PMID:19284971   PMID:19304944   PMID:19386638   PMID:19411759   PMID:19494207   PMID:19528255   PMID:19672301  
PMID:19700744   PMID:19816943   PMID:19818485   PMID:19826414   PMID:20026598   PMID:20086246   PMID:20091789   PMID:20164378   PMID:20236931   PMID:20370578   PMID:20436479   PMID:20458281  
PMID:20581099   PMID:20610415   PMID:20637190   PMID:20736295   PMID:20844200   PMID:20847111   PMID:20881014   PMID:20923780   PMID:20937270   PMID:20944070   PMID:20971192   PMID:21059996  
PMID:21148423   PMID:21152035   PMID:21168495   PMID:21224474   PMID:21256215   PMID:21267068   PMID:21320502   PMID:21421844   PMID:21536744   PMID:21573017   PMID:21617177   PMID:21622854  
PMID:21641382   PMID:21804139   PMID:21860248   PMID:21873635   PMID:21915269   PMID:22039525   PMID:22067906   PMID:22105716   PMID:22159717   PMID:22169007   PMID:22171010   PMID:22215724  
PMID:22418977   PMID:22509329   PMID:22682248   PMID:22745497   PMID:22803005   PMID:22808089   PMID:22808206   PMID:22930728   PMID:23087362   PMID:23094049   PMID:23117884   PMID:23129809  
PMID:23144964   PMID:23499828   PMID:23591719   PMID:23633432   PMID:23658023   PMID:23677673   PMID:23757408   PMID:23806329   PMID:23863467   PMID:23896411   PMID:23954950   PMID:23963165  
PMID:23983225   PMID:23986549   PMID:24006456   PMID:24018559   PMID:24045574   PMID:24058167   PMID:24081879   PMID:24086667   PMID:24135756   PMID:24140711   PMID:24148348   PMID:24161848  
PMID:24194600   PMID:24300950   PMID:24348274   PMID:24460873   PMID:24485453   PMID:24586749   PMID:24590059   PMID:24668173   PMID:24675658   PMID:24840925   PMID:24983516   PMID:25042340  
PMID:25111226   PMID:25343959   PMID:25492474   PMID:25524772   PMID:25548916   PMID:25554493   PMID:25697354   PMID:25712208   PMID:25803585   PMID:25835637   PMID:25839231   PMID:25940549  
PMID:25943461   PMID:25995382   PMID:26033700   PMID:26241338   PMID:26458493   PMID:26461935   PMID:26463157   PMID:26503986   PMID:26527618   PMID:26668367   PMID:26856994   PMID:26927626  
PMID:27196103   PMID:27283989   PMID:27349907   PMID:27485117   PMID:27492207   PMID:27588705   PMID:27607583   PMID:27626380   PMID:27694478   PMID:27697548   PMID:27742621   PMID:27943541  
PMID:28071719   PMID:28228282   PMID:28330618   PMID:28364044   PMID:28378742   PMID:28535269   PMID:28555642   PMID:28698383   PMID:28729362   PMID:28737660   PMID:28778947   PMID:28924363  
PMID:28970240   PMID:29042481   PMID:29098296   PMID:29206970   PMID:29415890   PMID:29445135   PMID:29844053   PMID:29885454   PMID:30082316   PMID:30136356   PMID:30332778   PMID:30351986  
PMID:30355232   PMID:30389913   PMID:30622267   PMID:30928339   PMID:30939949   PMID:31040226   PMID:31255486   PMID:31550482   PMID:31669249   PMID:31710666   PMID:31793743   PMID:31899207  
PMID:31934850   PMID:31965893   PMID:32098917   PMID:32321834   PMID:32325033   PMID:32366943   PMID:32402278   PMID:32554809   PMID:32580141   PMID:32581705   PMID:32814029   PMID:32866348  
PMID:33028100   PMID:33069367   PMID:33176120   PMID:33232198   PMID:33327743   PMID:33538796   PMID:33619517   PMID:33674464   PMID:33681182   PMID:33824208   PMID:33968943   PMID:33981184  
PMID:34168130   PMID:34321999   PMID:34425286   PMID:34434198   PMID:34653670   PMID:34698361   PMID:34702315   PMID:34769516   PMID:34856120   PMID:34927311   PMID:34986160   PMID:35054863  
PMID:35364055   PMID:35628515   PMID:35858542   PMID:35878760   PMID:36347239   PMID:36453543   PMID:36505365   PMID:36575174   PMID:36715672   PMID:36721988   PMID:36755326   PMID:36901740  
PMID:37252932   PMID:37259865   PMID:37419331   PMID:37591247   PMID:37672887   PMID:37749092   PMID:37957948   PMID:38011284   PMID:38091840   PMID:38147128   PMID:38281553   PMID:38355399  
PMID:38355793   PMID:38439091   PMID:38678560   PMID:38690712   PMID:38780057   PMID:38954467   PMID:38960036   PMID:39078701   PMID:39122122   PMID:39217171   PMID:39305123   PMID:40060904  


Genomics

Comparative Map Data
Thbs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392117,942,357 - 117,957,614 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2117,942,357 - 117,957,614 (+)EnsemblGRCm39 Ensembl
GRCm382118,111,876 - 118,127,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,111,876 - 118,127,133 (+)EnsemblGRCm38mm10GRCm38
MGSCv372117,937,658 - 117,952,869 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362119,046,897 - 119,061,990 (+)NCBIMGSCv36mm8
MGSCv362117,803,363 - 117,818,574 (+)NCBIMGSCv36mm8
Celera2119,257,347 - 119,271,479 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.34NCBI
THBS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381539,581,079 - 39,599,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1539,581,079 - 39,599,466 (+)EnsemblGRCh38hg38GRCh38
GRCh371539,873,280 - 39,891,667 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361537,660,572 - 37,676,960 (+)NCBINCBI36Build 36hg18NCBI36
Build 341537,660,571 - 37,676,959NCBI
Celera1516,636,119 - 16,652,508 (+)NCBICelera
Cytogenetic Map15q14NCBI
HuRef1516,716,691 - 16,733,080 (+)NCBIHuRef
CHM1_11539,992,660 - 40,009,050 (+)NCBICHM1_1
T2T-CHM13v2.01537,385,886 - 37,404,273 (+)NCBIT2T-CHM13v2.0
Thbs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83125,510,250 - 125,525,402 (+)NCBIGRCr8
mRatBN7.23105,056,293 - 105,071,445 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,056,292 - 105,071,440 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3108,721,861 - 108,736,913 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,317,382 - 117,332,433 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03114,977,769 - 114,992,820 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03109,862,120 - 109,873,466 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3109,862,117 - 109,873,466 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,411,045 - 116,422,101 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3103,978,436 - 103,990,486 (+)NCBICelera
Cytogenetic Map3q35NCBI
Thbs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554166,489,451 - 6,506,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554166,490,034 - 6,506,419 (+)NCBIChiLan1.0ChiLan1.0
THBS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21628,821,736 - 28,838,123 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11532,972,998 - 32,987,997 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01518,521,802 - 18,538,172 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11536,776,756 - 36,793,469 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1536,776,756 - 36,793,170 (+)Ensemblpanpan1.1panPan2
THBS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1306,770,212 - 6,786,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl306,769,470 - 6,784,915 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha306,824,809 - 6,841,468 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0306,896,290 - 6,912,963 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl306,895,539 - 6,911,152 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1306,820,232 - 6,836,894 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0306,926,083 - 6,942,777 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,055,241 - 7,071,904 (+)NCBIUU_Cfam_GSD_1.0
Thbs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,216,385 - 85,233,062 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,064,422 - 3,081,949 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364713,064,466 - 3,081,125 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THBS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,728,784 - 131,746,115 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,728,781 - 131,746,098 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,905,998 - 146,923,315 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THBS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12643,410,693 - 43,427,816 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2643,410,580 - 43,427,812 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604897,515,387 - 97,532,504 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thbs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248046,849,670 - 6,867,684 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248046,849,660 - 6,866,164 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Thbs1
712 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:923
Count of miRNA genes:538
Interacting mature miRNAs:665
Transcripts:ENSMUST00000039559, ENSMUST00000142588
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
13506762Tbvq2_mtrabecular bone volume QTL 2 (mouse)2115430481124741920Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
1301909Smdq2_msegregation of mitochondrial DNA QTL 2 (mouse)Not determined292778465126778607Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297210364131210364Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111173704145173821Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1300798Actre3_mactivity response to ethanol 3 (mouse)Not determined2112024987128173821Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88143423122143570Mouse
1301415Actre4_mactivity response to ethanol 4 (mouse)Not determined2112024987128173821Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114288075132714157Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297210364131210364Mouse
1558825Aabpr_maberrant activation of B cell proliferation (mouse)Not determined2116033229122207534Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286095716120095823Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286095716120095823Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111551028145551163Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112212746146213005Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112212746146213005Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297123370131123532Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297123370131123532Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110489658144489807Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287440643121440778Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111173704145173821Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103095716129213005Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284008488118008593Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286095716120095823Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111173704145173821Mouse
10449390Actre14_mactivity response to ethanol 14 (mouse)2114123370117943090Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286095716120095823Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291089974125090104Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse

Markers in Region
RH129576  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382118,126,708 - 118,126,900UniSTSGRCm38
MGSCv372117,952,444 - 117,952,636UniSTSGRCm37
Celera2119,271,054 - 119,271,246UniSTS
Cytogenetic Map2F1-F3UniSTS
Cytogenetic Map10B4UniSTS
M87276  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382118,125,171 - 118,125,340UniSTSGRCm38
MGSCv372117,950,907 - 117,951,076UniSTSGRCm37
Celera2119,269,511 - 119,269,680UniSTS
Cytogenetic Map2F1-F3UniSTS
Whitehead_YAC2 UniSTS
D2Mit62  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382118,112,449 - 118,112,609UniSTSGRCm38
MGSCv372117,938,185 - 117,938,345UniSTSGRCm37
Cytogenetic Map2F1-F3UniSTS
cM Map265.0UniSTS
Whitehead Genetic254.6UniSTS
Whitehead/MRC_RH21505.98UniSTS
Whitehead_YAC2 UniSTS
PMC152639P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382118,123,352 - 118,123,427UniSTSGRCm38
MGSCv372117,949,088 - 117,949,163UniSTSGRCm37
Celera2119,267,693 - 119,267,768UniSTS
Cytogenetic Map2F1-F3UniSTS
Thbs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv372117,944,515 - 117,944,852UniSTSGRCm37
MGSCv372117,938,408 - 117,938,626UniSTSGRCm37
Celera2119,263,123 - 119,263,460UniSTS
Cytogenetic Map2F1-F3UniSTS
cM Map265.0UniSTS
Thbs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382118,112,672 - 118,112,890UniSTSGRCm38
MGSCv372117,938,408 - 117,938,626UniSTSGRCm37
Cytogenetic Map2F1-F3UniSTS
cM Map265.0UniSTS
Thbs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382118,118,779 - 118,119,116UniSTSGRCm38
MGSCv372117,944,515 - 117,944,852UniSTSGRCm37
Celera2119,263,123 - 119,263,460UniSTS
Cytogenetic Map2F1-F3UniSTS
Thbs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F1-F3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000039559   ⟹   ENSMUSP00000044903
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2117,942,357 - 117,957,614 (+)Ensembl
GRCm38.p6 Ensembl2118,111,876 - 118,127,133 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142588
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2117,953,421 - 117,954,245 (+)Ensembl
GRCm38.p6 Ensembl2118,122,940 - 118,123,764 (+)Ensembl
RefSeq Acc Id: NM_001313914   ⟹   NP_001300843
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392117,942,357 - 117,957,614 (+)NCBI
GRCm382118,111,876 - 118,127,133 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011580   ⟹   NP_035710
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392117,942,357 - 117,957,614 (+)NCBI
GRCm382118,111,876 - 118,127,133 (+)NCBI
MGSCv372117,937,658 - 117,952,869 (+)RGD
Celera2119,257,347 - 119,271,479 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035710   ⟸   NM_011580
- Peptide Label: isoform 1 precursor
- UniProtKB: Q80YQ1 (UniProtKB/TrEMBL),   Q8CGB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300843   ⟸   NM_001313914
- Peptide Label: isoform 2 precursor
- UniProtKB: P35441 (UniProtKB/Swiss-Prot),   Q3TR40 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000044903   ⟸   ENSMUST00000039559
Protein Domains
EGF-like   Laminin G-like   TSP C-terminal   TSP type-1   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35441-F1-model_v2 AlphaFold P35441 1-1170 view protein structure

Promoters
RGD ID:6832937
Promoter ID:MM_KWN:31154
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000036100,   UC008LRR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362117,936,996 - 117,937,792 (+)MPROMDB
RGD ID:6832936
Promoter ID:MM_KWN:31155
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_4Hour,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000036101
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362117,948,251 - 117,949,157 (+)MPROMDB
RGD ID:6878280
Promoter ID:EPDNEW_M2591
Type:multiple initiation site
Name:Thbs1_1
Description:Mus musculus thrombospondin 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2592  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382118,111,893 - 118,111,953EPDNEW
RGD ID:6878282
Promoter ID:EPDNEW_M2592
Type:single initiation site
Name:Thbs1_2
Description:Mus musculus thrombospondin 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2591  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382118,112,282 - 118,112,342EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98737 AgrOrtholog
Ensembl Genes ENSMUSG00000040152 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000039559 ENTREZGENE
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot
  2.60.120.200 UniProtKB/Swiss-Prot
  4.10.1080.10 UniProtKB/Swiss-Prot
  6.20.200.20 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  Laminin_G UniProtKB/Swiss-Prot
  Thrombospondin_3-like_rpt UniProtKB/Swiss-Prot
  Thrombospondin_3_rpt UniProtKB/Swiss-Prot
  Thrombospondin_C UniProtKB/Swiss-Prot
  TSP1_rpt UniProtKB/Swiss-Prot
  TSP1_rpt_sf UniProtKB/Swiss-Prot
  TSP_type-3_rpt UniProtKB/Swiss-Prot
  TSPN-like_N UniProtKB/Swiss-Prot
  VWF_dom UniProtKB/Swiss-Prot
MGD MGI:98737 ENTREZGENE
NCBI Gene 21825 ENTREZGENE
PANTHER PTHR10199:SF78 UniProtKB/Swiss-Prot
  THROMBOSPONDIN UniProtKB/Swiss-Prot
Pfam Laminin_G_2 UniProtKB/Swiss-Prot
  TSP_1 UniProtKB/Swiss-Prot
  TSP_3 UniProtKB/Swiss-Prot
  TSP_C UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
PhenoGen Thbs1 PhenoGen
PRINTS TSP1REPEAT UniProtKB/Swiss-Prot
PROSITE EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  TSP1 UniProtKB/Swiss-Prot
  TSP3 UniProtKB/Swiss-Prot
  TSP_CTER UniProtKB/Swiss-Prot
  VWFC_1 UniProtKB/Swiss-Prot
  VWFC_2 UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  TSP1 UniProtKB/Swiss-Prot
  TSPN UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  FnI-like domain UniProtKB/Swiss-Prot
  SSF103647 UniProtKB/Swiss-Prot
  SSF49899 UniProtKB/Swiss-Prot
  SSF82895 UniProtKB/Swiss-Prot
UniProt P35441 ENTREZGENE
  Q3TP59_MOUSE UniProtKB/TrEMBL
  Q3TPD3_MOUSE UniProtKB/TrEMBL
  Q3TR40 ENTREZGENE, UniProtKB/TrEMBL
  Q80YQ1 ENTREZGENE, UniProtKB/TrEMBL
  Q8CGB2 ENTREZGENE, UniProtKB/TrEMBL
  TSP1_MOUSE UniProtKB/Swiss-Prot