Rel (reticuloendotheliosis oncogene) - Rat Genome Database

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Gene: Rel (reticuloendotheliosis oncogene) Mus musculus
Analyze
Symbol: Rel
Name: reticuloendotheliosis oncogene
RGD ID: 1322581
MGI Page MGI
Description: Enables DNA-binding transcription factor activity. Acts upstream of or within positive regulation of DNA-templated transcription and positive regulation of interleukin-12 production. Located in cytoplasm and nucleus. Is expressed in central nervous system; eye; genitourinary system; heart; and spleen primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human REL (REL proto-oncogene, NF-kB subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-R; c-Rel; C-Rel proto-oncogene protein; proto-oncogene c-Rel
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391123,686,847 - 23,720,969 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1123,686,847 - 23,720,970 (-)EnsemblGRCm39 Ensembl
GRCm381123,736,847 - 23,770,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1123,736,847 - 23,770,970 (-)EnsemblGRCm38mm10GRCm38
MGSCv371123,641,729 - 23,670,970 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361123,641,990 - 23,670,970 (-)NCBIMGSCv36mm8
Celera1125,863,742 - 25,892,886 (-)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
(R)-noradrenaline  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-tert-butylhydroquinone  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
7,12-dimethyltetraphene  (EXP)
9-cis,11-trans-octadecadienoic acid  (EXP)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amphotericin B  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
bathocuproine disulfonic acid  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP)
buta-1,3-diene  (EXP)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon monoxide  (ISO)
carmustine  (ISO)
CCCP  (EXP)
chlorpyrifos  (EXP)
cisplatin  (EXP,ISO)
cocaine  (ISO)
crocidolite asbestos  (EXP)
curcumin  (ISO)
DDE  (ISO)
deoxynivalenol  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
fluvastatin  (ISO)
formaldehyde  (ISO)
fucoidan  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
hydrogen peroxide  (EXP,ISO)
ionomycin  (ISO)
isotretinoin  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lipoarabinomannan  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
LY294002  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nystatin  (EXP)
o-anisidine  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperine  (ISO)
protein kinase inhibitor  (ISO)
pyrrolidine dithiocarbamate  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
scoparone  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sodium fluoride  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
tacrolimus hydrate  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP)
torcetrapib  (ISO)
trifluoperazine  (EXP)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
tunicamycin  (EXP)
urethane  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)
zearalenone  (EXP)
zidovudine  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive T cell differentiation  (IEA)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal hair follicle placode formation  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal macrophage morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal memory B cell number  (IAGP)
abnormal monocyte differentiation  (IAGP)
abnormal professional antigen presenting cell physiology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal stomach morphology  (IAGP)
abnormal T cell differentiation  (IEA)
abnormal T cell physiology  (IAGP)
abnormal T-helper 1 cell differentiation  (IAGP)
absent vibrissae  (IEA)
decreased alpha-beta T cell number  (IEA)
decreased apoptosis  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1 B cell number  (IEA)
decreased bone marrow cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IEA)
decreased CD8-positive, alpha-beta T cell number  (IEA)
decreased cell proliferation  (IAGP)
decreased central memory CD4-positive, alpha-beta T cell number  (IEA)
decreased common myeloid progenitor cell number  (IAGP)
decreased cytotoxic T cell cytolysis  (IAGP)
decreased DNA replication  (IAGP)
decreased effector memory CD4-positive, alpha-beta T cell number  (IEA)
decreased embryo size  (IAGP)
decreased hair follicle number  (IAGP)
decreased IgE level  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased monocyte cell number  (IEA)
decreased response to antigen  (IEA)
decreased spleen germinal center number  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to parasitic infection  (IAGP)
decreased T cell proliferation  (IAGP)
dermatitis  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
hyperchromasia  (IAGP)
impaired glucose tolerance  (IEA)
impaired hematopoiesis  (IEA)
impaired humoral immune response  (IEA)
impaired macrophage chemotaxis  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IEA)
increased CD8-positive, alpha-beta T cell number  (IEA)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased eosinophil cell number  (IAGP)
increased granulocyte number  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased IgA level  (IAGP)
increased IgG2a level  (IAGP)
increased IgM level  (IAGP)
increased neuron apoptosis  (IAGP)
increased spleen B cell follicle size  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased T cell number  (IEA)
internal hemorrhage  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IEA)
premature death  (IAGP)
thin epidermis  (IAGP)
tremors  (IEA)
underdeveloped hair follicles  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice. Burkitt MD, etal., J Pathol. 2015 Jul;236(3):326-36. doi: 10.1002/path.4527. Epub 2015 Apr 21.
2. Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. Burkitt MD, etal., Oncogene. 2013 Dec 12;32(50):5563-73. doi: 10.1038/onc.2013.334. Epub 2013 Aug 26.
3. Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3. Cogswell PC, etal., Oncogene. 2000 Feb 24;19(9):1123-31.
4. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Abnormalities in the NF-kappaB family and related proteins in endometrial carcinoma. Pallares J, etal., J Pathol. 2004 Dec;204(5):569-77.
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Mouse mammary tumor virus c-rel transgenic mice develop mammary tumors. Romieu-Mourez R, etal., Mol Cell Biol. 2003 Aug;23(16):5738-54.
12. [Expression of NF-kappa B in human bladder cancer and its clinical significance] Xie DH, etal., Ai Zheng. 2002 Jun;21(6):663-7.
Additional References at PubMed
PMID:1319776   PMID:1321343   PMID:1349581   PMID:1533386   PMID:1643310   PMID:1848528   PMID:2023921   PMID:2204017   PMID:2204816   PMID:2567264   PMID:2654811   PMID:2851124  
PMID:3529946   PMID:6296425   PMID:7525452   PMID:7565694   PMID:7590248   PMID:7607087   PMID:7624137   PMID:7649478   PMID:7698769   PMID:7706314   PMID:7767000   PMID:7789972  
PMID:7936653   PMID:8188294   PMID:8199405   PMID:8255175   PMID:8543809   PMID:8563752   PMID:8670867   PMID:8681793   PMID:8751373   PMID:8858144   PMID:8934574   PMID:8976376  
PMID:9003785   PMID:9047238   PMID:9120401   PMID:9162260   PMID:9221757   PMID:9223278   PMID:9317110   PMID:9480976   PMID:9529314   PMID:9799840   PMID:9802878   PMID:9817935  
PMID:9854797   PMID:9862367   PMID:10049356   PMID:10072378   PMID:10077625   PMID:10092097   PMID:10209157   PMID:10221648   PMID:10349636   PMID:10402669   PMID:10464164   PMID:10518539  
PMID:10586083   PMID:10592330   PMID:10602464   PMID:10673281   PMID:10770796   PMID:10822372   PMID:10862795   PMID:10917891   PMID:11034607   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:11602633   PMID:11830667   PMID:11869686   PMID:11884420   PMID:11907083   PMID:11912207   PMID:11930006   PMID:12147627   PMID:12174196   PMID:12235116   PMID:12370384   PMID:12426000  
PMID:12466851   PMID:12477932   PMID:12504005   PMID:12556500   PMID:12646638   PMID:12849986   PMID:12879447   PMID:14568969   PMID:14568984   PMID:14681479   PMID:14755244   PMID:15004174  
PMID:15102909   PMID:15148378   PMID:15199130   PMID:15220916   PMID:15345217   PMID:15618518   PMID:15818410   PMID:15845455   PMID:15858576   PMID:15922711   PMID:16037393   PMID:16081776  
PMID:16141072   PMID:16141073   PMID:16148125   PMID:16166378   PMID:16226509   PMID:16249388   PMID:16277639   PMID:16455974   PMID:16481345   PMID:16602821   PMID:16672661   PMID:16928772  
PMID:17012234   PMID:17167080   PMID:17182554   PMID:17182587   PMID:17227910   PMID:17291992   PMID:17312138   PMID:17431131   PMID:17513724   PMID:17513725   PMID:17513759   PMID:17548587  
PMID:17641044   PMID:17965828   PMID:17982049   PMID:18037997   PMID:18223644   PMID:18287559   PMID:18523276   PMID:18606681   PMID:18626097   PMID:18715197   PMID:18805964   PMID:18832697  
PMID:18927440   PMID:18981423   PMID:19003818   PMID:19454718   PMID:19494297   PMID:19641020   PMID:19710460   PMID:19907075   PMID:19950170   PMID:19995950   PMID:20049877   PMID:20059953  
PMID:20064450   PMID:20082358   PMID:20211142   PMID:20226693   PMID:20228198   PMID:20435892   PMID:20519647   PMID:20610653   PMID:20639489   PMID:20697425   PMID:20740013   PMID:21118906  
PMID:21164518   PMID:21267068   PMID:21343350   PMID:21343618   PMID:21371435   PMID:21402701   PMID:21469108   PMID:21677750   PMID:21873635   PMID:21874024   PMID:21890374   PMID:21915344  
PMID:21940679   PMID:22006976   PMID:22066012   PMID:22210479   PMID:22408080   PMID:22490438   PMID:22860011   PMID:22896637   PMID:23075496   PMID:23114885   PMID:23125425   PMID:23337809  
PMID:23469037   PMID:23562440   PMID:23706741   PMID:23716202   PMID:23982206   PMID:24194600   PMID:24280042   PMID:24591377   PMID:25057006   PMID:25179582   PMID:25180063   PMID:25251667  
PMID:25266721   PMID:25361085   PMID:25681334   PMID:25865065   PMID:26037670   PMID:26084385   PMID:26522720   PMID:26555174   PMID:26694615   PMID:26773039   PMID:26982364   PMID:27132513  
PMID:27217485   PMID:27224262   PMID:27481129   PMID:27626380   PMID:27649781   PMID:27663963   PMID:28202908   PMID:28385374   PMID:28652399   PMID:28726772   PMID:28769786   PMID:28886380  
PMID:28889947   PMID:28889989   PMID:30037996   PMID:30683700   PMID:30850343   PMID:31147458   PMID:31787981   PMID:32062419   PMID:32098801   PMID:32191641   PMID:32294437   PMID:32554809  
PMID:32580933   PMID:32610126   PMID:32725139   PMID:33168981   PMID:33446811   PMID:33458695   PMID:33960413   PMID:33995369   PMID:34140389   PMID:34168080   PMID:34175279   PMID:34529751  
PMID:34707143   PMID:34867937   PMID:35139355   PMID:35694784   PMID:36089330   PMID:36240066   PMID:37392737   PMID:38355793   PMID:38483906   PMID:38563819   PMID:39024115  


Genomics

Comparative Map Data
Rel
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391123,686,847 - 23,720,969 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1123,686,847 - 23,720,970 (-)EnsemblGRCm39 Ensembl
GRCm381123,736,847 - 23,770,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1123,736,847 - 23,770,970 (-)EnsemblGRCm38mm10GRCm38
MGSCv371123,641,729 - 23,670,970 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361123,641,990 - 23,670,970 (-)NCBIMGSCv36mm8
Celera1125,863,742 - 25,892,886 (-)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.36NCBI
REL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38260,881,574 - 60,931,612 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl260,881,491 - 60,931,612 (+)EnsemblGRCh38hg38GRCh38
GRCh37261,108,709 - 61,158,747 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36260,962,256 - 61,003,682 (+)NCBINCBI36Build 36hg18NCBI36
Build 34261,020,402 - 61,061,829NCBI
Celera260,952,347 - 60,993,771 (+)NCBICelera
Cytogenetic Map2p16.1NCBI
HuRef260,850,654 - 60,892,025 (+)NCBIHuRef
CHM1_1261,039,153 - 61,080,572 (+)NCBICHM1_1
T2T-CHM13v2.0260,887,420 - 60,937,448 (+)NCBIT2T-CHM13v2.0
Rel
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,891,238 - 101,922,324 (-)NCBIGRCr8
mRatBN7.21497,690,105 - 97,721,194 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1497,695,161 - 97,720,892 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.014108,490,794 - 108,517,582 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14108,491,069 - 108,509,892 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014108,212,714 - 108,238,553 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414104,645,370 - 104,671,275 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114104,664,855 - 104,689,687 (-)NCBI
Celera1496,671,067 - 96,689,938 (-)NCBICelera
Cytogenetic Map14q22NCBI
Rel
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542422,911,541 - 22,939,651 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542422,909,035 - 22,939,651 (-)NCBIChiLan1.0ChiLan1.0
REL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21265,446,373 - 65,496,842 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A65,458,688 - 65,500,793 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A60,972,022 - 61,013,562 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A62,113,581 - 62,155,241 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A62,113,581 - 62,155,241 (+)Ensemblpanpan1.1panPan2
REL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11060,990,264 - 61,030,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1060,990,197 - 61,023,663 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1060,878,772 - 60,922,447 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01061,997,356 - 62,041,015 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1061,997,563 - 62,030,500 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11061,697,560 - 61,740,683 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01061,984,931 - 62,028,604 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01062,277,508 - 62,321,170 (+)NCBIUU_Cfam_GSD_1.0
Rel
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629222,137,080 - 22,165,823 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364916,405,515 - 6,436,510 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364916,405,493 - 6,435,096 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl380,872,255 - 80,911,939 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1380,861,862 - 80,912,233 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2384,966,717 - 85,003,490 (-)NCBISscrofa10.2Sscrofa10.2susScr3
REL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11446,068,212 - 46,097,226 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1446,068,014 - 46,096,802 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604565,685,304 - 65,731,499 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rel
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248331,022,656 - 1,053,342 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248331,016,330 - 1,053,514 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rel
906 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:138
Interacting mature miRNAs:141
Transcripts:ENSMUST00000102864
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
10412216Eae44_mexperimental allergic encephalomyelitis susceptibility 44 (mouse)Not determined111226863739950840Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
1357518Tgyl1_mtriglyceride level 1 (mouse)Not determined11688027733916219Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
Rel  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381123,745,464 - 23,745,636UniSTSGRCm38
MGSCv371123,645,464 - 23,645,636UniSTSGRCm37
Celera1125,867,381 - 25,867,553UniSTS
Cytogenetic Map11A3.2UniSTS
cM Map1113.0UniSTS
Rel  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A3.2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000102864   ⟹   ENSMUSP00000099928
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1123,686,847 - 23,720,970 (-)Ensembl
GRCm38.p6 Ensembl1123,736,847 - 23,770,970 (-)Ensembl
RefSeq Acc Id: NM_009044   ⟹   NP_033070
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391123,686,847 - 23,720,969 (-)NCBI
GRCm381123,736,847 - 23,770,969 (-)NCBI
MGSCv371123,641,729 - 23,670,970 (-)RGD
Celera1125,863,742 - 25,892,886 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033070   ⟸   NM_009044
- UniProtKB: P15307 (UniProtKB/Swiss-Prot),   A4QPD3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000099928   ⟸   ENSMUST00000102864
Protein Domains
RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15307-F1-model_v2 AlphaFold P15307 1-587 view protein structure

Promoters
RGD ID:6821720
Promoter ID:MM_KWN:6695
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000011787
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361123,670,726 - 23,671,502 (-)MPROMDB
RGD ID:8674128
Promoter ID:EPDNEW_M15095
Type:initiation region
Name:Rel_2
Description:Mus musculus reticuloendotheliosis oncogene , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15096  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381123,770,767 - 23,770,827EPDNEW
RGD ID:8674130
Promoter ID:EPDNEW_M15096
Type:initiation region
Name:Rel_1
Description:Mus musculus reticuloendotheliosis oncogene , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15095  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381123,770,969 - 23,771,029EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97897 AgrOrtholog
Ensembl Genes ENSMUSG00000020275 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000102864 ENTREZGENE
  ENSMUST00000102864.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IPT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IPT_NFkappaB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NFkB/Dor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD-n_c-Rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19696 UniProtKB/TrEMBL
MGD MGI:97897 ENTREZGENE
NCBI Gene 19696 ENTREZGENE
PANTHER PTHR24169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24169:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RHD_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rel PhenoGen
PRINTS NFKBTNSCPFCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE REL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A4QPD3 ENTREZGENE, UniProtKB/TrEMBL
  P15307 ENTREZGENE, UniProtKB/Swiss-Prot