Map2k4 Mouse 1,2-dimethylhydrazine decreases expression EXP 6480464 1 and 2-Dimethylhydrazine results in decreased expression of MAP2K4 mRNA CTD PMID:22206623 Map2k4 Mouse 17beta-estradiol increases expression ISO MAP2K4 (Homo sapiens) 6480464 Estradiol results in increased expression of MAP2K4 mRNA CTD PMID:23094148 Map2k4 Mouse 17beta-estradiol multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAP2K4 mRNA] CTD PMID:23094148 Map2k4 Mouse 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO MAP2K4 (Homo sapiens) 6480464 Dihydrotestosterone results in increased expression of MAP2K4 mRNA CTD PMID:29581250 Map2k4 Mouse 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO MAP2K4 (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 Map2k4 Mouse 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of MAP2K4 mRNA CTD PMID:21570461 Map2k4 Mouse 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Map2k4 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of MAP2K4 mRNA CTD PMID:32109520 Map2k4 Mouse 2,4,6-tribromophenol decreases expression ISO MAP2K4 (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 Map2k4 Mouse 3,3',5,5'-tetrabromobisphenol A decreases expression ISO MAP2K4 (Homo sapiens) 6480464 tetrabromobisphenol A results in decreased expression of MAP2K4 protein CTD PMID:31675489 Map2k4 Mouse 4,4'-sulfonyldiphenol multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 [bisphenol S co-treated with Fulvestrant] results in increased methylation of MAP2K4 gene CTD PMID:31601247 Map2k4 Mouse 4-hydroxyphenyl retinamide multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased phosphorylation of MAP2K4 protein] CTD PMID:16407847 Map2k4 Mouse 4-hydroxyphenyl retinamide increases phosphorylation ISO MAP2K4 (Homo sapiens) 6480464 Fenretinide results in increased phosphorylation of MAP2K4 protein CTD PMID:16407847 Map2k4 Mouse 6-propyl-2-thiouracil decreases expression ISO Map2k4 (Rattus norvegicus) 6480464 Propylthiouracil results in decreased expression of MAP2K4 mRNA CTD PMID:24780913 Map2k4 Mouse acetamide decreases expression ISO Map2k4 (Rattus norvegicus) 6480464 acetamide results in decreased expression of MAP2K4 mRNA CTD PMID:31881176 Map2k4 Mouse Aciculatin multiple interactions EXP 6480464 aciculatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein] CTD PMID:21548916 Map2k4 Mouse acrylamide increases expression ISO MAP2K4 (Homo sapiens) 6480464 Acrylamide results in increased expression of MAP2K4 mRNA CTD PMID:32763439 Map2k4 Mouse actinomycin D decreases expression ISO MAP2K4 (Homo sapiens) 6480464 Dactinomycin results in decreased expression of MAP2K4 mRNA CTD PMID:16001973 Map2k4 Mouse afimoxifene decreases response to substance ISO MAP2K4 (Homo sapiens) 6480464 MAP2K4 results in decreased susceptibility to afimoxifene CTD PMID:21233418 Map2k4 Mouse aflatoxin B1 decreases methylation ISO MAP2K4 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of MAP2K4 gene CTD PMID:27153756 Map2k4 Mouse aflatoxin B1 increases expression ISO MAP2K4 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of MAP2K4 mRNA CTD PMID:27153756 Map2k4 Mouse alpha-mangostin increases phosphorylation ISO MAP2K4 (Homo sapiens) 6480464 mangostin analog results in increased phosphorylation of MAP2K4 protein CTD PMID:28722351 Map2k4 Mouse alvocidib multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 alvocidib promotes the reaction [Bortezomib results in increased phosphorylation of and results in increased activity of MAP2K4 protein] CTD PMID:15039284 Map2k4 Mouse andrographolide multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K4 protein] CTD PMID:24814888 Map2k4 Mouse Antimony trioxide multiple interactions EXP 6480464 MAP2K4 protein affects the reaction [antimony trioxide results in increased activity of MAPK8 protein] CTD PMID:16112521 Map2k4 Mouse antimycin A decreases expression ISO MAP2K4 (Homo sapiens) 6480464 Antimycin A results in decreased expression of MAP2K4 mRNA CTD PMID:33512557 Map2k4 Mouse antirheumatic drug increases expression ISO MAP2K4 (Homo sapiens) 6480464 Antirheumatic Agents results in increased expression of MAP2K4 mRNA CTD PMID:24449571 Map2k4 Mouse aristolochic acid A decreases expression ISO MAP2K4 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of MAP2K4 mRNA CTD PMID:33212167 Map2k4 Mouse arsenite(3-) multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 arsenite inhibits the reaction [G3BP1 protein binds to MAP2K4 mRNA] CTD PMID:32406909 Map2k4 Mouse arsenous acid multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 MAP2K4 gene mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of MAPK8 protein] more ... CTD PMID:14701702 and PMID:15978632 Map2k4 Mouse arsenous acid increases response to substance ISO MAP2K4 (Homo sapiens) 6480464 MAP2K4 protein results in increased susceptibility to Arsenic Trioxide and MAP2K4 results in increased susceptibility to Arsenic Trioxide CTD PMID:14701702 and PMID:18633430 Map2k4 Mouse arsenous acid increases response to substance EXP 6480464 MAP2K4 protein results in increased susceptibility to Arsenic Trioxide CTD PMID:16184197 Map2k4 Mouse auramine O increases expression ISO MAP2K4 (Homo sapiens) 6480464 Benzophenoneidum results in increased expression of MAP2K4 protein CTD PMID:28722353 Map2k4 Mouse benzo[a]pyrene increases phosphorylation ISO MAP2K4 (Homo sapiens) 6480464 Benzo(a)pyrene analog results in increased phosphorylation of MAP2K4 protein CTD PMID:24910982 Map2k4 Mouse benzo[a]pyrene increases methylation ISO MAP2K4 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of MAP2K4 promoter CTD PMID:27901495 Map2k4 Mouse benzo[a]pyrene diol epoxide I decreases expression ISO MAP2K4 (Homo sapiens) 6480464 7 more ... CTD PMID:19150397 Map2k4 Mouse benzo[a]pyrene diol epoxide I increases expression ISO MAP2K4 (Homo sapiens) 6480464 7 more ... CTD PMID:26238291 Map2k4 Mouse benzo[a]pyrene diol epoxide I multiple interactions EXP 6480464 AG 1879 inhibits the reaction [7 more ... CTD PMID:21501596 Map2k4 Mouse benzo[a]pyrene diol epoxide I increases phosphorylation EXP 6480464 7 more ... CTD PMID:21501596 Map2k4 Mouse bis(2-chloroethyl) sulfide increases phosphorylation EXP 6480464 Mustard Gas results in increased phosphorylation of MAP2K4 protein CTD PMID:18200059 Map2k4 Mouse bisphenol A affects expression ISO Map2k4 (Rattus norvegicus) 6480464 bisphenol A affects the expression of MAP2K4 mRNA CTD PMID:25181051 Map2k4 Mouse bisphenol A decreases expression ISO MAP2K4 (Homo sapiens) 6480464 bisphenol A results in decreased expression of MAP2K4 protein CTD PMID:31675489 Map2k4 Mouse bisphenol A increases methylation ISO MAP2K4 (Homo sapiens) 6480464 bisphenol A results in increased methylation of MAP2K4 gene CTD PMID:31601247 Map2k4 Mouse bortezomib multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 alvocidib promotes the reaction [Bortezomib results in increased phosphorylation of and results in increased activity of MAP2K4 protein] and Bortezomib results in increased phosphorylation of and results in increased activity of MAP2K4 protein CTD PMID:15039284 Map2k4 Mouse butylated hydroxyanisole multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased phosphorylation of MAP2K4 protein] CTD PMID:16407847 Map2k4 Mouse cadmium dichloride increases phosphorylation ISO MAP2K4 (Homo sapiens) 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K4 protein CTD PMID:18703135 Map2k4 Mouse cadmium dichloride multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein] CTD PMID:18703135 Map2k4 Mouse cadmium dichloride increases phosphorylation ISO Map2k4 (Rattus norvegicus) 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K4 protein CTD PMID:18021293 and PMID:18703135 Map2k4 Mouse cadmium dichloride multiple interactions ISO Map2k4 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein] CTD PMID:18703135 Map2k4 Mouse cadmium dichloride multiple interactions EXP 6480464 [MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased expression of HSPA1A protein] more ... CTD PMID:18348256 Map2k4 Mouse caffeine increases phosphorylation ISO MAP2K4 (Homo sapiens) 6480464 Caffeine results in increased phosphorylation of MAP2K4 protein CTD PMID:35688186 Map2k4 Mouse celecoxib multiple interactions EXP 6480464 Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP2K4 protein] CTD PMID:32416088 Map2k4 Mouse chlorogenic acid multiple interactions EXP 6480464 Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K4 protein] CTD PMID:15944151 Map2k4 Mouse chromium(6+) multiple interactions EXP 6480464 MAP2K4 protein promotes the reaction [chromium hexavalent ion results in increased phosphorylation of ATF2 protein] more ... CTD PMID:19654923 Map2k4 Mouse chromium(6+) increases response to substance EXP 6480464 MAP2K4 protein results in increased susceptibility to chromium hexavalent ion CTD PMID:19654923 Map2k4 Mouse cisplatin multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 [Cisplatin co-treated with Quercetin] results in increased expression of MAP2K4 mRNA CTD PMID:27514524 Map2k4 Mouse cobalt dichloride increases expression ISO MAP2K4 (Homo sapiens) 6480464 cobaltous chloride results in increased expression of MAP2K4 mRNA CTD PMID:19376846 Map2k4 Mouse cocaine increases expression EXP 6480464 Cocaine results in increased expression of MAP2K4 mRNA CTD PMID:18355967 Map2k4 Mouse copper atom multiple interactions ISO Map2k4 (Rattus norvegicus) 6480464 [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein and Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein] CTD PMID:22085843 Map2k4 Mouse copper atom multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of MAP2K4 mRNA CTD PMID:30911355 Map2k4 Mouse copper(0) multiple interactions ISO Map2k4 (Rattus norvegicus) 6480464 [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein and Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein] CTD PMID:22085843 Map2k4 Mouse copper(0) multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of MAP2K4 mRNA CTD PMID:30911355 Map2k4 Mouse crocidolite asbestos decreases phosphorylation ISO MAP2K4 (Homo sapiens) 6480464 Asbestos and Crocidolite results in decreased phosphorylation of MAP2K4 protein CTD PMID:17191120 Map2k4 Mouse curcumin decreases expression ISO MAP2K4 (Homo sapiens) 6480464 Curcumin results in decreased expression of MAP2K4 mRNA CTD PMID:15713895 Map2k4 Mouse curcumin increases phosphorylation ISO MAP2K4 (Homo sapiens) 150429751 Curcumin increases phosphorylation of MAP2K4 protein in uterine cervix RGD Map2k4 Mouse cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of MAP2K4 mRNA CTD PMID:19770486 Map2k4 Mouse cypermethrin multiple interactions EXP 6480464 [[[cypermethrin results in decreased expression of MIR155 mRNA] which results in increased expression of BCL6 mRNA] which results in decreased expression of MAP2K4 protein] which results in decreased phosphorylation of and results in decreased activity of MAPK8 protein more ... CTD PMID:29471534 Map2k4 Mouse decabromodiphenyl ether decreases expression ISO MAP2K4 (Homo sapiens) 6480464 decabromobiphenyl ether results in decreased expression of MAP2K4 protein CTD PMID:31675489 Map2k4 Mouse deoxynivalenol multiple interactions EXP 6480464 Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP2K4 protein] CTD PMID:32416088 Map2k4 Mouse deoxynivalenol increases phosphorylation EXP 6480464 deoxynivalenol results in increased phosphorylation of MAP2K4 protein CTD PMID:32416088 Map2k4 Mouse diallyl trisulfide multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 MAP2K4 protein affects the reaction [diallyl trisulfide results in increased abundance of Reactive Oxygen Species] and MAP2K4 protein affects the reaction [diallyl trisulfide results in increased degradation of FTL protein] CTD PMID:16707465 Map2k4 Mouse diarsenic trioxide multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 MAP2K4 gene mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of MAPK8 protein] more ... CTD PMID:14701702 and PMID:15978632 Map2k4 Mouse diarsenic trioxide increases response to substance EXP 6480464 MAP2K4 protein results in increased susceptibility to Arsenic Trioxide CTD PMID:16184197 Map2k4 Mouse diarsenic trioxide increases response to substance ISO MAP2K4 (Homo sapiens) 6480464 MAP2K4 protein results in increased susceptibility to Arsenic Trioxide and MAP2K4 results in increased susceptibility to Arsenic Trioxide CTD PMID:14701702 and PMID:18633430 Map2k4 Mouse dicrotophos decreases expression ISO MAP2K4 (Homo sapiens) 6480464 dicrotophos results in decreased expression of MAP2K4 mRNA CTD PMID:28302478 Map2k4 Mouse disodium selenite multiple interactions EXP 6480464 Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP2K4 protein] CTD PMID:26522834 Map2k4 Mouse doxorubicin affects activity ISO MAP2K4 (Homo sapiens) 6480464 Doxorubicin affects the activity of MAP2K4 protein CTD PMID:15870702 Map2k4 Mouse doxorubicin decreases response to substance ISO MAP2K4 (Homo sapiens) 6480464 MAP2K4 protein results in decreased susceptibility to Doxorubicin CTD PMID:14701702 Map2k4 Mouse doxorubicin increases expression ISO MAP2K4 (Homo sapiens) 6480464 Doxorubicin results in increased expression of MAP2K4 mRNA CTD PMID:16001973 Map2k4 Mouse endosulfan decreases expression ISO MAP2K4 (Homo sapiens) 6480464 Endosulfan results in decreased expression of MAP2K4 mRNA CTD PMID:28108160 Map2k4 Mouse ethanol affects splicing EXP 6480464 Ethanol affects the splicing of MAP2K4 mRNA CTD PMID:30319688 Map2k4 Mouse folic acid decreases expression EXP 6480464 Folic Acid results in decreased expression of MAP2K4 mRNA CTD PMID:25629700 Map2k4 Mouse fulvestrant multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 [bisphenol S co-treated with Fulvestrant] results in increased methylation of MAP2K4 gene CTD PMID:31601247 Map2k4 Mouse gallic acid increases expression ISO MAP2K4 (Homo sapiens) 6480464 Gallic Acid results in increased expression of MAP2K4 mRNA CTD PMID:34408198 Map2k4 Mouse gingerol multiple interactions EXP 6480464 gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein] CTD PMID:18577375 Map2k4 Mouse glyphosate affects methylation ISO MAP2K4 (Homo sapiens) 6480464 Glyphosate affects the methylation of MAP2K4 gene CTD PMID:35377194 Map2k4 Mouse glyphosate decreases expression ISO MAP2K4 (Homo sapiens) 6480464 Glyphosate results in decreased expression of MAP2K4 mRNA CTD PMID:31295307 Map2k4 Mouse hydrogen cyanide decreases expression EXP 6480464 Hydrogen Cyanide results in decreased expression of MKK4 mRNA CTD PMID:33914522 Map2k4 Mouse hydrogen peroxide multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 MAP2K4 protein affects the reaction [Hydrogen Peroxide results in increased degradation of FTL protein] CTD PMID:16707465 Map2k4 Mouse indometacin increases expression ISO MAP2K4 (Homo sapiens) 6480464 Indomethacin results in increased expression of MAP2K4 protein CTD PMID:15804060 Map2k4 Mouse isoprenaline multiple interactions ISO Map2k4 (Rattus norvegicus) 6480464 [Isoproterenol co-treated with POSTN protein] results in decreased expression of MAP2K4 mRNA CTD PMID:30303030 Map2k4 Mouse ivermectin decreases expression ISO MAP2K4 (Homo sapiens) 6480464 Ivermectin results in decreased expression of MAP2K4 protein CTD PMID:32959892 Map2k4 Mouse Licochalcone A decreases phosphorylation ISO MAP2K4 (Homo sapiens) 6480464 licochalcone A results in decreased phosphorylation of MAP2K4 protein CTD PMID:30187994 Map2k4 Mouse Licochalcone A multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 licochalcone A promotes the reaction [Sorafenib results in decreased phosphorylation of MAP2K4 protein] and Sorafenib promotes the reaction [licochalcone A results in decreased phosphorylation of MAP2K4 protein] CTD PMID:30187994 Map2k4 Mouse lipopolysaccharide increases phosphorylation ISO MAP2K4 (Homo sapiens) 150429951 lipopolysaccharide increases phosphorylation of MAP2K4 protein in the pulmonary alveolus epithelium RGD Map2k4 Mouse lipopolysaccharide increases phosphorylation EXP 6480464 Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein CTD PMID:21548916 Map2k4 Mouse lipopolysaccharide increases activity EXP 6480464 Lipopolysaccharides results in increased activity of MAP2K4 protein CTD PMID:20589745 Map2k4 Mouse lipopolysaccharide multiple interactions EXP 6480464 [Manganese co-treated with Lipopolysaccharides] results in increased activity of and results in increased phosphorylation of MAP2K4 protein more ... CTD PMID:20589745 and PMID:21548916 Map2k4 Mouse lipopolysaccharide multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 MYD88 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein] and TLR2 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein] CTD PMID:21112663 Map2k4 Mouse lipopolysaccharide increases phosphorylation ISO MAP2K4 (Homo sapiens) 6480464 Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein CTD PMID:21112663 Map2k4 Mouse lycopene decreases expression ISO MAP2K4 (Homo sapiens) 6480464 lycopene results in decreased expression of MAP2K4 protein CTD PMID:17337101 Map2k4 Mouse maneb multiple interactions EXP 6480464 [Maneb co-treated with Paraquat] results in decreased expression of MAP2K4 mRNA CTD PMID:36117858 Map2k4 Mouse manganese atom multiple interactions EXP 6480464 [Manganese co-treated with Lipopolysaccharides] results in increased activity of and results in increased phosphorylation of MAP2K4 protein more ... CTD PMID:20589745 Map2k4 Mouse manganese atom decreases phosphorylation EXP 6480464 Manganese results in decreased phosphorylation of MAP2K4 protein CTD PMID:20589745 Map2k4 Mouse manganese(0) multiple interactions EXP 6480464 [Manganese co-treated with Lipopolysaccharides] results in increased activity of and results in increased phosphorylation of MAP2K4 protein more ... CTD PMID:20589745 Map2k4 Mouse manganese(0) decreases phosphorylation EXP 6480464 Manganese results in decreased phosphorylation of MAP2K4 protein CTD PMID:20589745 Map2k4 Mouse manganese(II) chloride increases phosphorylation ISO Map2k4 (Rattus norvegicus) 6480464 manganese chloride results in increased phosphorylation of MAP2K4 protein CTD PMID:15342272 and PMID:9751194 Map2k4 Mouse methidathion affects expression EXP 6480464 methidathion affects the expression of MAP2K4 mRNA CTD PMID:34813904 Map2k4 Mouse methotrexate increases expression ISO MAP2K4 (Homo sapiens) 6480464 Methotrexate results in increased expression of MAP2K4 mRNA CTD PMID:21678067 Map2k4 Mouse mevinphos increases phosphorylation ISO Map2k4 (Rattus norvegicus) 6480464 Mevinphos results in increased phosphorylation of MAP2K4 protein CTD PMID:23157661 Map2k4 Mouse monosodium L-glutamate decreases expression ISO Map2k4 (Rattus norvegicus) 6480464 Sodium Glutamate results in decreased expression of MAP2K4 mRNA CTD PMID:28954212 Map2k4 Mouse N-acetyl-L-cysteine multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein] CTD PMID:18703135 Map2k4 Mouse N-acetyl-L-cysteine multiple interactions ISO MAP2K4 (Homo sapiens) 150429751 N-acetyl-L-cysteine inhibits the reaction [Curcumin increases phosphorylation of MAP2K4 protein in uterine cervix] RGD Map2k4 Mouse N-acetyl-L-cysteine multiple interactions ISO Map2k4 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein] and Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein] CTD PMID:18703135 and PMID:22085843 Map2k4 Mouse N-nitrosodiethylamine multiple interactions EXP 6480464 Diethylnitrosamine results in increased phosphorylation of and results in increased activity of MAP2K4 protein and MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of MAP2K4 protein] CTD PMID:18691550 Map2k4 Mouse N-nitrosodimethylamine multiple interactions ISO Map2k4 (Rattus norvegicus) 6480464 [GJB1 protein affects the susceptibility to [Dietary Fats co-treated with Dimethylnitrosamine]] which affects the phosphorylation of MAP2K4 protein CTD PMID:32833043 Map2k4 Mouse nickel dichloride multiple interactions EXP 6480464 GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K4 protein] CTD PMID:23536762 Map2k4 Mouse p-menthan-3-ol increases expression ISO MAP2K4 (Homo sapiens) 6480464 Menthol results in increased expression of MAP2K4 mRNA CTD PMID:26760959 Map2k4 Mouse paclitaxel multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 MAP2K4 protein affects the reaction [Paclitaxel results in increased activity of CASP3 protein] and MAP2K4 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein] CTD PMID:10075725 Map2k4 Mouse paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of MAP2K4 mRNA CTD PMID:17562736 Map2k4 Mouse paracetamol increases expression ISO Map2k4 (Rattus norvegicus) 6480464 Acetaminophen results in increased expression of MAP2K4 mRNA CTD PMID:33387578 Map2k4 Mouse paracetamol multiple interactions EXP 6480464 [RIPK1 protein affects the susceptibility to Acetaminophen] which affects the phosphorylation of MAP2K4 protein more ... CTD PMID:22687999 more ... Map2k4 Mouse paracetamol increases phosphorylation EXP 6480464 Acetaminophen results in increased phosphorylation of MAP2K4 protein CTD PMID:22687999 more ... Map2k4 Mouse paracetamol increases response to substance ISO Map2k4 (Rattus norvegicus) 6480464 MAP2K4 results in increased susceptibility to Acetaminophen CTD PMID:11562448 Map2k4 Mouse paracetamol multiple interactions ISO Map2k4 (Rattus norvegicus) 6480464 Acetaminophen results in increased phosphorylation of and results in increased activity of MAP2K4 protein and MAP2K4 mutant form inhibits the reaction [Acetaminophen results in increased activity of MAPK8 protein] CTD PMID:11562448 Map2k4 Mouse paraquat multiple interactions EXP 6480464 [Maneb co-treated with Paraquat] results in decreased expression of MAP2K4 mRNA CTD PMID:36117858 Map2k4 Mouse perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of MAP2K4 protein CTD PMID:26178269 Map2k4 Mouse phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K4 protein] CTD PMID:15944151 Map2k4 Mouse picoxystrobin decreases expression ISO MAP2K4 (Homo sapiens) 6480464 picoxystrobin results in decreased expression of MAP2K4 mRNA CTD PMID:33512557 Map2k4 Mouse pyrrolidine dithiocarbamate multiple interactions ISO Map2k4 (Rattus norvegicus) 6480464 [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein and Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein] CTD PMID:22085843 Map2k4 Mouse quercetin increases expression ISO MAP2K4 (Homo sapiens) 6480464 Quercetin results in increased expression of MAP2K4 mRNA CTD PMID:23727915 Map2k4 Mouse quercetin increases expression ISO Map2k4 (Rattus norvegicus) 6480464 Quercetin results in increased expression of MAP2K4 mRNA CTD PMID:17103110 Map2k4 Mouse quercetin decreases expression ISO MAP2K4 (Homo sapiens) 6480464 Quercetin results in decreased expression of MAP2K4 mRNA CTD PMID:15309432 Map2k4 Mouse quercetin multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 [Cisplatin co-treated with Quercetin] results in increased expression of MAP2K4 mRNA and Quercetin inhibits the reaction [[CYP2E1 protein results in increased susceptibility to Docosahexaenoic Acids] which results in increased phosphorylation of MAP2K4 protein] CTD PMID:16963249 and PMID:27514524 Map2k4 Mouse reactive oxygen species multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 MAP2K4 protein affects the reaction [diallyl trisulfide results in increased abundance of Reactive Oxygen Species] CTD PMID:16707465 Map2k4 Mouse scutellarin multiple interactions EXP 6480464 scutellarin inhibits the reaction [Zearalenone results in increased expression of MAP2K4 protein] CTD PMID:36252740 Map2k4 Mouse sodium arsenite increases expression ISO MAP2K4 (Homo sapiens) 6480464 sodium arsenite results in increased expression of MAP2K4 mRNA CTD PMID:12760830 Map2k4 Mouse sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of MAP2K4 mRNA CTD PMID:31233874 Map2k4 Mouse sodium arsenite multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 MAP2K4 mutant form affects the reaction [sodium arsenite results in increased expression of TP53 protein] and MAP2K4 mutant form inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein] CTD PMID:15734884 Map2k4 Mouse sodium arsenite multiple interactions EXP 6480464 CDKN1B protein inhibits the reaction [sodium arsenite results in increased activity of MAP2K4 protein] CTD PMID:20566634 Map2k4 Mouse sorafenib decreases phosphorylation ISO MAP2K4 (Homo sapiens) 6480464 Sorafenib results in decreased phosphorylation of MAP2K4 protein CTD PMID:30187994 Map2k4 Mouse sorafenib multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 licochalcone A promotes the reaction [Sorafenib results in decreased phosphorylation of MAP2K4 protein] and Sorafenib promotes the reaction [licochalcone A results in decreased phosphorylation of MAP2K4 protein] CTD PMID:30187994 Map2k4 Mouse streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP2K4 protein and Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP2K4 protein] CTD PMID:26522834 Map2k4 Mouse sulforaphane increases expression ISO MAP2K4 (Homo sapiens) 6480464 sulforaphane results in increased expression of MAP2K4 mRNA CTD PMID:31838189 Map2k4 Mouse sulindac sulfone multiple interactions ISO MAP2K4 (Homo sapiens) 6480464 sulindac sulfone results in increased phosphorylation of and results in increased activity of MAP2K4 protein CTD PMID:11051267 Map2k4 Mouse tamoxifen increases expression ISO MAP2K4 (Homo sapiens) 6480464 Tamoxifen results in increased expression of MAP2K4 mRNA CTD PMID:15590111 Map2k4 Mouse tebufenpyrad decreases expression ISO MAP2K4 (Homo sapiens) 6480464 4-chloro-N-((4-(1 and 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in decreased expression of MAP2K4 mRNA CTD PMID:33512557 Map2k4 Mouse tert-butyl hydroperoxide increases phosphorylation ISO MAP2K4 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased phosphorylation of MAP2K4 protein CTD PMID:17003459 Map2k4 Mouse testosterone decreases expression ISO MAP2K4 (Homo sapiens) 6480464 Testosterone results in decreased expression of MAP2K4 mRNA CTD PMID:33359661 Map2k4 Mouse thapsigargin decreases expression EXP 6480464 Thapsigargin results in decreased expression of MAP2K4 protein CTD PMID:24648495 Map2k4 Mouse thiram increases expression ISO MAP2K4 (Homo sapiens) 6480464 Thiram results in increased expression of MAP2K4 mRNA CTD PMID:38568856 Map2k4 Mouse topotecan decreases expression ISO Map2k4 (Rattus norvegicus) 6480464 Topotecan results in decreased expression of MAP2K4 mRNA CTD PMID:25729387 Map2k4 Mouse triphenyl phosphate affects expression ISO MAP2K4 (Homo sapiens) 6480464 triphenyl phosphate affects the expression of MAP2K4 mRNA CTD PMID:37042841 Map2k4 Mouse valproic acid decreases expression ISO MAP2K4 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of MAP2K4 mRNA CTD PMID:23179753 Map2k4 Mouse valproic acid affects expression ISO MAP2K4 (Homo sapiens) 6480464 Valproic Acid affects the expression of MAP2K4 mRNA CTD PMID:25979313 Map2k4 Mouse vinclozolin increases expression ISO Map2k4 (Rattus norvegicus) 6480464 vinclozolin results in increased expression of MAP2K4 mRNA CTD PMID:23555832 Map2k4 Mouse zearalenone decreases expression EXP 6480464 Zearalenone results in decreased expression of MAP2K4 protein CTD PMID:36252740 Map2k4 Mouse zearalenone multiple interactions EXP 6480464 scutellarin inhibits the reaction [Zearalenone results in increased expression of MAP2K4 protein] CTD PMID:36252740 Map2k4 Mouse zearalenone increases expression EXP 6480464 Zearalenone results in increased expression of MAP2K4 protein CTD PMID:36252740 Map2k4 Mouse zinc dichloride increases activity EXP 6480464 zinc chloride results in increased activity of MAP2K4 protein CTD PMID:11306679