Map2k4 (mitogen-activated protein kinase kinase 4) - Rat Genome Database

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Gene: Map2k4 (mitogen-activated protein kinase kinase 4) Mus musculus
Analyze
Symbol: Map2k4
Name: mitogen-activated protein kinase kinase 4
RGD ID: 1316001
MGI Page MGI
Description: Predicted to enable JUN kinase kinase activity and molecular adaptor activity. Involved in intrinsic apoptotic signaling pathway in response to hydrogen peroxide and smooth muscle cell apoptotic process. Acts upstream of or within MAPK cascade; negative regulation of motor neuron apoptotic process; and response to wounding. Predicted to be located in axon; dendrite cytoplasm; and perikaryon. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-JUN N-terminal kinase kinase 1; dual specificity mitogen-activated protein kinase kinase 4; JNK kinase 1; JNK-activating kinase 1; JNKK; JNKK 1; JNKK1; MAP kinase kinase 4; MAPK/ERK kinase 4; MAPKK 4; MEK 4; MEK4; mitogen activated protein kinase kinase 4, variant 1; MKK4; PRKMK4; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; Sek; Sek1; Ser; Serk1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,579,070 - 65,679,185 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,579,069 - 65,679,123 (-)EnsemblGRCm39 Ensembl
GRCm381165,688,244 - 65,788,359 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,688,243 - 65,788,297 (-)EnsemblGRCm38mm10GRCm38
MGSCv371165,501,746 - 65,601,799 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361165,504,439 - 65,604,492 (-)NCBIMGSCv36mm8
Celera1172,623,125 - 72,726,188 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1140.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
Aciculatin  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
alpha-mangostin  (ISO)
alvocidib  (ISO)
andrographolide  (ISO)
Antimony trioxide  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
auramine O  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bortezomib  (ISO)
butylated hydroxyanisole  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
celecoxib  (EXP)
chlorogenic acid  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP)
cypermethrin  (EXP)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dicrotophos  (ISO)
disodium selenite  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
folic acid  (EXP)
fulvestrant  (ISO)
gallic acid  (ISO)
gingerol  (EXP)
glyphosate  (ISO)
hydrogen cyanide  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
Licochalcone A  (ISO)
lipopolysaccharide  (EXP,ISO)
lycopene  (ISO)
maneb  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
mevinphos  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nickel dichloride  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
picoxystrobin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
scutellarin  (EXP)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sulindac sulfone  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thapsigargin  (EXP)
thiram  (ISO)
topotecan  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zearalenone  (EXP)
zinc dichloride  (EXP)

References

References - curated
# Reference Title Reference Citation
1. Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression. Ahn YH, etal., Mol Cell Biol. 2011 Nov;31(21):4270-85. doi: 10.1128/MCB.05562-11. Epub 2011 Sep 6.
2. Stress- and cell type-dependent regulation of transfected c-Jun N-terminal kinase and mitogen-activated protein kinase kinase isoforms. Butterfield L, etal., Biochem J. 1999 Mar 15;338 ( Pt 3):681-6.
3. Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death. Chang AY J Biomed Sci. 2012 Nov 17;19:96. doi: 10.1186/1423-0127-19-96.
4. Influence of sleep deprivation on expression of MKK4 and c-fos in the mandibular condylar cartilage of rats. Chen J, etal., Br J Oral Maxillofac Surg. 2013 Dec;51(8):e250-5. doi: 10.1016/j.bjoms.2013.06.010. Epub 2013 Jul 13.
5. Toll-like receptor 2-mediated sequential activation of MyD88 and MAPKs contributes to lipopolysaccharide-induced sp-a gene expression in human alveolar epithelial cells. Chuang CY, etal., Immunobiology. 2011 Jun;216(6):707-14. doi: 10.1016/j.imbio.2010.10.009. Epub 2010 Nov 4.
6. The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer. Finegan KG and Tournier C, Cancer Res. 2010 Jul 15;70(14):5797-806. doi: 10.1158/0008-5472.CAN-09-3669. Epub 2010 Jul 7.
7. Increased expression of IRE1alpha and stress-related signal transduction proteins in ischemia-reperfusion injured retina. Hata N, etal., Clin Ophthalmol. 2008 Dec;2(4):743-52.
8. The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma. Hickson JA, etal., Cancer Res. 2006 Feb 15;66(4):2264-70.
9. Genetic variation in the TNF/TRAF2/ASK1/p38 kinase signaling pathway as markers for postoperative pulmonary complications in lung cancer patients. Hildebrandt MA, etal., Sci Rep. 2015 Jul 13;5:12068. doi: 10.1038/srep12068.
10. Overexpression of mitogen-activated protein kinase kinase 4 and nuclear factor-kappaB in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis. Huang C, etal., Oncol Rep. 2009 Jul;22(1):89-95.
11. [The relationship between expression of mitogen-activated protein kinase kinase 4 and metastasis in oral squamous cell carcinoma]. Jiang N, etal., Hua Xi Kou Qiang Yi Xue Za Zhi. 2011 Oct;29(5):555-8.
12. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
13. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
14. Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers. Kim HL, etal., Cancer Res. 2001 Apr 1;61(7):2833-7.
15. High-density single nucleotide polymorphism array defines novel stage and location-dependent allelic imbalances in human bladder tumors. Koed K, etal., Cancer Res. 2005 Jan 1;65(1):34-45.
16. 7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. Lee DE, etal., J Biol Chem. 2011 Apr 22;286(16):14246-56. doi: 10.1074/jbc.M110.147348. Epub 2011 Mar 4.
17. Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer. Lee HY, etal., Clin Cancer Res. 2002 Sep;8(9):2970-5.
18. Curcumin induced human gastric cancer BGC-823 cells apoptosis by ROS-mediated ASK1-MKK4-JNK stress signaling pathway. Liang T, etal., Int J Mol Sci. 2014 Sep 5;15(9):15754-65. doi: 10.3390/ijms150915754.
19. A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity. Liu B, etal., Carcinogenesis. 2010 Aug;31(8):1405-11. doi: 10.1093/carcin/bgq126. Epub 2010 Jun 16.
20. Up-regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia. Lotan TL, etal., J Pathol. 2007 Aug;212(4):386-94.
21. [Association between MKK4 promoter-1304T/G polymorphism and genetic susceptibility in sporadic nasopharyngeal carcinoma]. Lu M, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Feb;30(4):287-90.
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. MGD IEA MGD IEA
24. A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion. Mizukami Y, etal., J Biol Chem. 1997 Jun 27;272(26):16657-62.
25. Homozygous deletion of MKK4 in ovarian serous carcinoma. Nakayama K, etal., Cancer Biol Ther. 2006 Jun;5(6):630-4. Epub 2006 Jun 9.
26. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
30. Mouse MP Annotation Import Pipeline RGD automated import pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. The Similar Effects of miR-512-3p and miR-519a-2-5p on the Promotion of Hepatocellular Carcinoma: Different Tunes Sung With Equal Skill. Rui T, etal., Front Oncol. 2020 Aug 7;10:1244. doi: 10.3389/fonc.2020.01244. eCollection 2020.
34. Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. Stark AM, etal., J Cancer Res Clin Oncol. 2005 Mar;131(3):191-8. Epub 2004 Dec 8.
35. Increased adipose tissue expression of proinflammatory CD40, MKK4 and JNK in patients with very severe chronic obstructive pulmonary disease. Tkacova R, etal., Respiration. 2011;81(5):386-93. Epub 2010 Aug 12.
36. Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7. Vander Griend DJ, etal., Cancer Res. 2005 Dec 1;65(23):10984-91.
37. Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. Wang R, etal., J Neurochem. 2006 Dec;99(6):1543-54. Epub 2006 Oct 25.
38. Association of genetic variation in mitotic kinases with breast cancer risk. Wang X, etal., Breast Cancer Res Treat. 2010 Jan;119(2):453-62. doi: 10.1007/s10549-009-0404-3. Epub 2009 Apr 30.
39. The association between -1304T>G polymorphism in the promoter of MKK4 gene and the risk of sporadic colorectal cancer in southern Chinese population. Wei Y, etal., Int J Cancer. 2009 Oct 15;125(8):1876-83. doi: 10.1002/ijc.24575.
40. Human gastric cancer kinase profile and prognostic significance of MKK4 kinase. Wu CW, etal., Am J Pathol. 2000 Jun;156(6):2007-15. doi: 10.1016/s0002-9440(10)65073-0.
41. MicroRNA-802 plays a tumour suppressive role in tongue squamous cell carcinoma through directly targeting MAP2K4. Wu X, etal., Cell Prolif. 2017 Jun;50(3). doi: 10.1111/cpr.12336. Epub 2017 Mar 20.
42. The protective role of polymorphism MKK4-1304 T>G in nasopharyngeal carcinoma is modulated by Epstein-Barr virus' infection status. Zheng J, etal., Int J Cancer. 2012 May 1;130(9):1981-90. doi: 10.1002/ijc.26253. Epub 2011 Aug 25.
43. Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 reduction and couples hypertrophic signals to ventricular arrhythmogenesis. Zi M, etal., J Biol Chem. 2011 May 20;286(20):17821-30. doi: 10.1074/jbc.M111.228791. Epub 2011 Mar 28.
Additional References at PubMed
PMID:7997269   PMID:8631303   PMID:8706895   PMID:8786147   PMID:8889548   PMID:9002521   PMID:9096336   PMID:9135144   PMID:9294148   PMID:9339368   PMID:9524273   PMID:9618507  
PMID:9620683   PMID:9661668   PMID:9759859   PMID:9876179   PMID:9891090   PMID:10095085   PMID:10100631   PMID:10198162   PMID:10349636   PMID:10366447   PMID:10523642   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:11544199   PMID:11920199   PMID:12368275   PMID:12376107   PMID:12391307   PMID:12477932   PMID:12520002   PMID:12556533   PMID:12624093   PMID:12893778  
PMID:12897243   PMID:12904583   PMID:14500727   PMID:14681479   PMID:15122334   PMID:15218018   PMID:15731347   PMID:15782199   PMID:15908922   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:17110930   PMID:17158870   PMID:17187786   PMID:17214902   PMID:17449011   PMID:17526490   PMID:17568772   PMID:17641059   PMID:17679097   PMID:17681137   PMID:17699753   PMID:17875933  
PMID:18049864   PMID:18287559   PMID:18348256   PMID:18635759   PMID:18757346   PMID:19265040   PMID:19737936   PMID:19753101   PMID:19898473   PMID:20588253   PMID:21267068   PMID:21351092  
PMID:21664343   PMID:21873635   PMID:22031940   PMID:22090513   PMID:22114267   PMID:22130668   PMID:22411628   PMID:22753496   PMID:23041440   PMID:23355465   PMID:23582328   PMID:24095980  
PMID:24487067   PMID:24705900   PMID:24713432   PMID:24721794   PMID:25100604   PMID:26947074   PMID:28641113   PMID:28661486   PMID:28671696   PMID:28733031   PMID:30367030   PMID:32016794  
PMID:32325033   PMID:32659913   PMID:33175451   PMID:34502275   PMID:34502457   PMID:36417873   PMID:36656864   PMID:37142655  


Genomics

Comparative Map Data
Map2k4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,579,070 - 65,679,185 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,579,069 - 65,679,123 (-)EnsemblGRCm39 Ensembl
GRCm381165,688,244 - 65,788,359 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,688,243 - 65,788,297 (-)EnsemblGRCm38mm10GRCm38
MGSCv371165,501,746 - 65,601,799 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361165,504,439 - 65,604,492 (-)NCBIMGSCv36mm8
Celera1172,623,125 - 72,726,188 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1140.53NCBI
MAP2K4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381712,020,877 - 12,143,828 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1712,020,829 - 12,143,830 (+)EnsemblGRCh38hg38GRCh38
GRCh371711,924,194 - 12,047,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361711,864,860 - 11,987,776 (+)NCBINCBI36Build 36hg18NCBI36
Build 341711,864,859 - 11,987,775NCBI
Celera1711,954,698 - 12,077,624 (+)NCBICelera
Cytogenetic Map17p12ENTREZGENE
HuRef1711,825,033 - 11,947,931 (+)NCBIHuRef
CHM1_11711,933,251 - 12,056,267 (+)NCBICHM1_1
T2T-CHM13v2.01711,928,859 - 12,051,837 (+)NCBIT2T-CHM13v2.0
Map2k4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81050,842,348 - 50,947,063 (-)NCBIGRCr8
mRatBN7.21050,343,227 - 50,447,956 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1050,344,915 - 50,447,993 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1055,014,269 - 55,116,147 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01054,504,259 - 54,606,140 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01050,012,148 - 50,114,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01052,196,121 - 52,301,887 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1052,196,124 - 52,290,657 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01051,951,707 - 52,054,098 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41052,009,149 - 52,041,599 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11052,020,408 - 52,055,249 (-)NCBI
Celera1049,553,065 - 49,624,419 (-)NCBICelera
Cytogenetic Map10q24NCBI
Map2k4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554675,187,356 - 5,307,692 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554675,188,036 - 5,295,570 (-)NCBIChiLan1.0ChiLan1.0
MAP2K4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21961,596,659 - 61,721,974 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11766,403,318 - 66,528,369 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01739,497,105 - 39,622,331 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11744,246,301 - 44,359,906 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1744,248,857 - 44,359,909 (-)Ensemblpanpan1.1panPan2
MAP2K4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1536,142,610 - 36,243,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl536,118,388 - 36,241,296 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha536,246,628 - 36,382,182 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0536,216,260 - 36,351,866 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl536,216,250 - 36,351,818 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1536,183,407 - 36,318,935 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0536,137,113 - 36,272,679 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0536,321,228 - 36,456,796 (+)NCBIUU_Cfam_GSD_1.0
Map2k4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560251,288,135 - 51,356,168 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365954,727,108 - 4,830,662 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365954,762,327 - 4,828,433 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1256,402,075 - 56,516,238 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11256,402,029 - 56,516,217 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21259,330,511 - 59,409,571 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11611,366,610 - 11,485,411 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1611,366,751 - 11,486,125 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660599,768,762 - 9,889,281 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478614,457,452 - 14,597,027 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478614,457,382 - 14,597,027 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map2k4
3576 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1218
Count of miRNA genes:645
Interacting mature miRNAs:765
Transcripts:ENSMUST00000046963, ENSMUST00000125598, ENSMUST00000130009, ENSMUST00000138093, ENSMUST00000140301, ENSMUST00000140740, ENSMUST00000152096
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115925661769482699Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115406567067078411Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
4141642Ltxs2_mlethal factor toxin susceptibility 2 (mouse)Not determined116304211368500330Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
C86896  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381165,714,246 - 65,714,483UniSTSGRCm38
MGSCv371165,527,748 - 65,527,985UniSTSGRCm37
Celera1172,649,090 - 72,649,327UniSTS
Cytogenetic Map11B3UniSTS
cM Map1133.0UniSTS
Whitehead/MRC_RH11857.88UniSTS
9_15_91.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381165,710,249 - 65,710,403UniSTSGRCm38
MGSCv371165,523,751 - 65,523,905UniSTSGRCm37
Celera1172,645,093 - 72,645,247UniSTS
Cytogenetic Map11B3UniSTS
cM Map1133.0UniSTS
Whitehead_YAC11 UniSTS
U18310  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381165,690,434 - 65,690,612UniSTSGRCm38
MGSCv371165,503,936 - 65,504,114UniSTSGRCm37
Celera1172,625,315 - 72,625,493UniSTS
Cytogenetic Map11B3UniSTS
cM Map1133.0UniSTS
Whitehead_YAC11 UniSTS
UniSTS:225260  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381165,709,712 - 65,709,863UniSTSGRCm38
MGSCv371165,523,214 - 65,523,365UniSTSGRCm37
Celera1172,644,556 - 72,644,707UniSTS
Cytogenetic Map11B3UniSTS
cM Map1133.0UniSTS
Map2k4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381165,688,541 - 65,689,528UniSTSGRCm38
MGSCv371165,502,043 - 65,503,030UniSTSGRCm37
Celera1172,623,422 - 72,624,409UniSTS
Cytogenetic Map11B3UniSTS
cM Map1133.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001316367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001316368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001316369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001362739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001362740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK036928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL663069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY244326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY277234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB723868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U18310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000046963   ⟹   ENSMUSP00000041282
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1165,579,069 - 65,679,123 (-)Ensembl
GRCm38.p6 Ensembl1165,688,243 - 65,788,297 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125598   ⟹   ENSMUSP00000137656
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1165,581,159 - 65,610,429 (-)Ensembl
GRCm38.p6 Ensembl1165,690,333 - 65,719,603 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130009   ⟹   ENSMUSP00000137819
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1165,603,046 - 65,679,111 (-)Ensembl
GRCm38.p6 Ensembl1165,712,220 - 65,788,285 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138093   ⟹   ENSMUSP00000154113
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1165,610,365 - 65,636,664 (-)Ensembl
GRCm38.p6 Ensembl1165,719,539 - 65,745,838 (-)Ensembl
Ensembl Acc Id: ENSMUST00000140301   ⟹   ENSMUSP00000137955
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1165,587,114 - 65,679,111 (-)Ensembl
GRCm38.p6 Ensembl1165,696,288 - 65,788,285 (-)Ensembl
Ensembl Acc Id: ENSMUST00000140740
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1165,582,554 - 65,587,840 (-)Ensembl
GRCm38.p6 Ensembl1165,691,728 - 65,697,014 (-)Ensembl
Ensembl Acc Id: ENSMUST00000152096   ⟹   ENSMUSP00000114219
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1165,603,045 - 65,679,112 (-)Ensembl
GRCm38.p6 Ensembl1165,712,219 - 65,788,286 (-)Ensembl
RefSeq Acc Id: NM_001316367   ⟹   NP_001303296
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391165,579,070 - 65,679,185 (-)NCBI
GRCm381165,688,244 - 65,788,359 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001316368   ⟹   NP_001303297
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391165,579,070 - 65,679,185 (-)NCBI
GRCm381165,688,244 - 65,788,359 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001316369   ⟹   NP_001303298
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391165,579,070 - 65,679,185 (-)NCBI
GRCm381165,688,244 - 65,788,359 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001362739   ⟹   NP_001349668
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391165,579,070 - 65,636,682 (-)NCBI
GRCm381165,688,244 - 65,745,856 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001362740   ⟹   NP_001349669
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391165,579,070 - 65,636,682 (-)NCBI
GRCm381165,688,244 - 65,745,856 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009157   ⟹   NP_033183
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391165,579,070 - 65,679,185 (-)NCBI
GRCm381165,688,244 - 65,788,359 (-)NCBI
MGSCv371165,501,746 - 65,601,799 (-)RGD
Celera1172,623,125 - 72,726,188 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011249033   ⟹   XP_011247335
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391165,579,094 - 65,679,139 (-)NCBI
GRCm381165,688,268 - 65,788,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030246018   ⟹   XP_030101878
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391165,579,094 - 65,679,180 (-)NCBI
GRCm381165,688,268 - 65,788,354 (-)NCBI
Sequence:
RefSeq Acc Id: NP_033183   ⟸   NM_009157
- Peptide Label: isoform b
- UniProtKB: P47809 (UniProtKB/Swiss-Prot),   Q543X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011247335   ⟸   XM_011249033
- Peptide Label: isoform X1
- UniProtKB: Q8K2U0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001303298   ⟸   NM_001316369
- Peptide Label: isoform c
- UniProtKB: Q543X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001303297   ⟸   NM_001316368
- Peptide Label: isoform c
- UniProtKB: Q543X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001303296   ⟸   NM_001316367
- Peptide Label: isoform a
- UniProtKB: Q543X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001349669   ⟸   NM_001362740
- Peptide Label: isoform d
- UniProtKB: Q8K2U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001349668   ⟸   NM_001362739
- Peptide Label: isoform d
- UniProtKB: Q8K2U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030101878   ⟸   XM_030246018
- Peptide Label: isoform X1
- UniProtKB: Q8K2U0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000137656   ⟸   ENSMUST00000125598
Ensembl Acc Id: ENSMUSP00000137819   ⟸   ENSMUST00000130009
Ensembl Acc Id: ENSMUSP00000041282   ⟸   ENSMUST00000046963
Ensembl Acc Id: ENSMUSP00000154113   ⟸   ENSMUST00000138093
Ensembl Acc Id: ENSMUSP00000114219   ⟸   ENSMUST00000152096
Ensembl Acc Id: ENSMUSP00000137955   ⟸   ENSMUST00000140301
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47809-F1-model_v2 AlphaFold P47809 1-397 view protein structure

Promoters
RGD ID:6821221
Promoter ID:MM_KWN:7905
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000013145
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361165,559,246 - 65,559,746 (-)MPROMDB
RGD ID:6821219
Promoter ID:MM_KWN:7906
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000108693,   ENSMUST00000108694,   OTTMUST00000013142,   OTTMUST00000013143,   OTTMUST00000013144,   OTTMUST00000013146
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361165,601,581 - 65,602,081 (-)MPROMDB
RGD ID:8675042
Promoter ID:EPDNEW_M15552
Type:initiation region
Name:Map2k4_1
Description:Mus musculus mitogen-activated protein kinase kinase 4 , transcriptvariant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381165,788,254 - 65,788,314EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346869 AgrOrtholog
Ensembl Genes ENSMUSG00000033352 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000046963 ENTREZGENE
  ENSMUST00000046963.10 UniProtKB/Swiss-Prot
  ENSMUST00000125598.8 UniProtKB/TrEMBL
  ENSMUST00000130009.2 UniProtKB/TrEMBL
  ENSMUST00000138093.2 UniProtKB/TrEMBL
  ENSMUST00000140301.8 UniProtKB/TrEMBL
  ENSMUST00000152096.8 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.2120 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26398 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1346869 ENTREZGENE
NCBI Gene 26398 ENTREZGENE
PANTHER DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Map2k4 PhenoGen
PIRSF Integrin-linked_kinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BQK8_MOUSE UniProtKB/TrEMBL
  B1ATL6_MOUSE UniProtKB/TrEMBL
  M0QW52_MOUSE UniProtKB/TrEMBL
  M0QWG5_MOUSE UniProtKB/TrEMBL
  M0QWR0_MOUSE UniProtKB/TrEMBL
  MP2K4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q543X6 ENTREZGENE, UniProtKB/TrEMBL
  Q8K2U0 ENTREZGENE, UniProtKB/TrEMBL