Mlh1 (mutL homolog 1) - Rat Genome Database

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Gene: Mlh1 (mutL homolog 1) Mus musculus
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Symbol: Mlh1
Name: mutL homolog 1
RGD ID: 733730
MGI Page MGI
Description: Enables chromatin binding activity and guanine/thymine mispair binding activity. Involved in positive regulation of isotype switching to IgA isotypes and positive regulation of isotype switching to IgG isotypes. Acts upstream of or within several processes, including gamete generation; meiotic nuclear division; and nucleic acid metabolic process. Located in condensed nuclear chromosome and male germ cell nucleus. Part of MutLalpha complex. Is expressed in several structures, including central nervous system; endocrine gland; genitourinary system; oral epithelium; and respiratory system. Used to study Lynch syndrome. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer; mismatch repair cancer syndrome; and sporadic breast cancer. Orthologous to human MLH1 (mutL homolog 1); PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110035C23Rik; AI317206; AI325952; AI561766; colon cancer, nonpolyposis type 2; DNA mismatch repair protein Mlh1; mutL protein homolog 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399111,057,296 - 111,100,854 (-)NCBIGRCm39mm39
GRCm39 Ensembl9111,057,296 - 111,100,859 (-)Ensembl
GRCm389111,228,228 - 111,271,786 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9111,228,228 - 111,271,791 (-)EnsemblGRCm38mm10GRCm38
MGSCv379111,130,732 - 111,174,112 (-)NCBIGRCm37mm9NCBIm37
MGSCv369111,073,071 - 111,116,378 (-)NCBImm8
Celera9110,951,307 - 110,994,774 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map960.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model