Prdm14 (PR domain containing 14) - Rat Genome Database

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Gene: Prdm14 (PR domain containing 14) Mus musculus
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Symbol: Prdm14
Name: PR domain containing 14
RGD ID: 1614007
MGI Page MGI
Description: Exhibits RNA binding activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in several processes, including histone H3-R26 methylation; inner cell mass cell fate commitment; and regulation of nucleobase-containing compound metabolic process. Localizes to nucleus. Is expressed in several structures, including hemolymphoid system; intestine; liver; lung; and yolk sac. Orthologous to human PRDM14 (PR/SET domain 14); PARTICIPATES IN DNA modification pathway; INTERACTS WITH bisphenol A; diethyl maleate; lead diacetate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: PR domain zinc finger protein 14; PR domain-containing 14; PR domain-containing protein 14
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm4263  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,183,652 - 13,197,387 (-)NCBIGRCm39mm39
GRCm39 Ensembl113,183,681 - 13,197,387 (-)Ensembl
GRCm38113,113,428 - 13,127,163 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,113,457 - 13,127,163 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,103,509 - 13,117,244 (-)NCBIGRCm37mm9NCBIm37
MGSCv36113,098,642 - 13,112,377 (-)NCBImm8
MGSCv36113,198,671 - 13,212,167 (-)NCBImm8
Celera113,077,505 - 13,091,214 (-)NCBICelera
Cytogenetic Map1A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:14610273   PMID:14681479   PMID:16141072   PMID:16141073   PMID:18622394   PMID:18799693   PMID:19001867  
PMID:19043588   PMID:19050759   PMID:21183938   PMID:21267068   PMID:21339739   PMID:21677750   PMID:21873635   PMID:22482507   PMID:23333148   PMID:23670199   PMID:23851488   PMID:24046360  
PMID:24183668   PMID:24268575   PMID:24335252   PMID:24552707   PMID:25993097   PMID:26325469   PMID:26523391   PMID:26523946   PMID:27281218   PMID:27626380   PMID:27866876   PMID:28423353  
PMID:29320730   PMID:29471045   PMID:30630825   PMID:31015254   PMID:31221220   PMID:32001439   PMID:33637711  


Genomics

Comparative Map Data
Prdm14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,183,652 - 13,197,387 (-)NCBIGRCm39mm39
GRCm39 Ensembl113,183,681 - 13,197,387 (-)Ensembl
GRCm38113,113,428 - 13,127,163 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,113,457 - 13,127,163 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,103,509 - 13,117,244 (-)NCBIGRCm37mm9NCBIm37
MGSCv36113,098,642 - 13,112,377 (-)NCBImm8
MGSCv36113,198,671 - 13,212,167 (-)NCBImm8
Celera113,077,505 - 13,091,214 (-)NCBICelera
Cytogenetic Map1A3NCBI
PRDM14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl870,051,651 - 70,071,693 (-)EnsemblGRCh38hg38GRCh38
GRCh38870,051,613 - 70,071,252 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37870,963,886 - 70,983,487 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36871,126,575 - 71,146,116 (-)NCBINCBI36hg18NCBI36
Build 34871,126,578 - 71,146,116NCBI
Celera866,961,694 - 66,981,231 (-)NCBI
Cytogenetic Map8q13.3NCBI
HuRef866,457,068 - 66,476,744 (-)NCBIHuRef
CHM1_1871,019,399 - 71,039,074 (-)NCBICHM1_1
Prdm14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.256,082,163 - 6,092,712 (+)NCBI
Rnor_6.0 Ensembl55,710,392 - 5,730,560 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.055,710,076 - 5,730,560 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0510,550,222 - 10,570,255 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera55,665,056 - 5,674,368 (+)NCBICelera
Cytogenetic Map5q11NCBI
Prdm14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554449,612,059 - 9,626,817 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554449,606,310 - 9,626,772 (+)NCBIChiLan1.0ChiLan1.0
PRDM14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1868,240,111 - 68,261,039 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl868,240,741 - 68,260,263 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0866,578,674 - 66,599,360 (-)NCBIMhudiblu_PPA_v0panPan3
PRDM14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12919,203,798 - 19,220,149 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2919,203,807 - 19,220,518 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2919,420,735 - 19,479,950 (-)NCBI
ROS_Cfam_1.02919,300,801 - 19,317,150 (-)NCBI
UMICH_Zoey_3.12919,340,296 - 19,356,663 (-)NCBI
UNSW_CanFamBas_1.02919,406,772 - 19,423,122 (-)NCBI
UU_Cfam_GSD_1.02919,687,457 - 19,703,818 (-)NCBI
Prdm14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530359,964,384 - 59,979,219 (+)NCBI
SpeTri2.0NW_00493649614,789,443 - 14,820,967 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRDM14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl465,274,003 - 65,295,600 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1465,273,988 - 65,295,362 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2470,938,499 - 70,962,240 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRDM14
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1865,800,454 - 65,820,190 (-)NCBI
ChlSab1.1 Ensembl865,800,923 - 65,819,456 (-)Ensembl
Prdm14
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474421,092,091 - 21,121,313 (+)NCBI

Position Markers
Prdm14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1A3UniSTS
cM Map14.1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412226Alpq4_malcohol preference QTL 4 (mouse)Not determined1122906465Mouse
1301891Alcp25_malcohol preference locus 25 (mouse)Not determined1125132961Mouse
1300834Cia20_mcollagen induced arthritis 20 (mouse)Not determined1125132961Mouse
1301482Morph1_mmorphine antinociception 1 (mouse)Not determined1130297523Mouse
1301275Sle10_msystematic lupus erythematosus susceptibility 10 (mouse)Not determined1281197036812128Mouse
1301370Adip1_madiposity 1 (mouse)Not determined1281197036812128Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1301471Obq2_mobesity QTL 2 (mouse)Not determined1387139637871663Mouse
10043970Obq23_mobesity QTL 23 (mouse)Not determined1494244138942441Mouse
1301011Cplaq4_mcircadian period of locomotor activity 4 (mouse)Not determined1963436143634520Mouse
14700685Civq2_mcerebral infarct volume QTL 2 (mouse)11130140145301401Mouse
38501065Nociq4_mnociceptive sensitivity QTL 4 (mouse)11195484515072061Mouse
4141646Fecq3_mfecundity QTL 3 (mouse)Not determined11284669626478604Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:242
Count of miRNA genes:213
Interacting mature miRNAs:220
Transcripts:ENSMUST00000047577
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000047577   ⟹   ENSMUSP00000044245
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl113,113,457 - 13,127,163 (-)Ensembl
RefSeq Acc Id: NM_001081209   ⟹   NP_001074678
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,183,652 - 13,197,387 (-)NCBI
GRCm38113,113,428 - 13,127,163 (-)NCBI
MGSCv37113,103,509 - 13,117,244 (-)RGD
Celera113,077,505 - 13,091,214 (-)RGD
cM Map1 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001074678 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AHX99431 (Get FASTA)   NCBI Sequence Viewer  
  BAE24596 (Get FASTA)   NCBI Sequence Viewer  
  E9Q3T6 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001074678   ⟸   NM_001081209
- UniProtKB: E9Q3T6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000044245   ⟸   ENSMUST00000047577
Protein Domains
SET

Promoters
RGD ID:6818279
Promoter ID:MM_KWN:142
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:UC007AIJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36113,115,606 - 13,116,106 (-)MPROMDB
RGD ID:6818278
Promoter ID:MM_KWN:143
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Lung,   Spleen
Transcripts:ENSMUST00000115400,   NM_001081209
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36113,117,401 - 13,117,901 (-)MPROMDB
RGD ID:6873198
Promoter ID:EPDNEW_M50
Type:multiple initiation site
Name:Prdm14_1
Description:Mus musculus PR domain containing 14 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38113,127,238 - 13,127,298EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3588194 AgrOrtholog
Ensembl Genes ENSMUSG00000042414 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000044245 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000047577 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro PRDM14_PR-SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:383491 UniProtKB/Swiss-Prot
MGD MGI:3588194 ENTREZGENE
NCBI Gene 383491 ENTREZGENE
Pfam SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prdm14 PhenoGen
PROSITE SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A023UED4_MOUSE UniProtKB/TrEMBL
  E9Q3T6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3URU1 UniProtKB/Swiss-Prot