Gm266 (predicted gene 266) - Rat Genome Database

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Gene: Gm266 (predicted gene 266) Mus musculus
Analyze
Symbol: Gm266
Name: predicted gene 266
RGD ID: 1619015
MGI Page MGI
Description: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Rap protein signal transduction and negative regulation of cell migration. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC212539; uncharacterized protein LOC212539
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912111,451,043 - 111,452,257 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12111,451,043 - 111,452,257 (-)EnsemblGRCm39 Ensembl
GRCm3812111,484,609 - 111,485,823 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12111,484,609 - 111,485,823 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712112,722,820 - 112,724,034 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612111,932,419 - 111,933,604 (-)NCBIMGSCv36mm8
Celera12112,674,808 - 112,676,022 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gm266Mouseintellectual disability  ISORGD:13436158554872ClinVar Annotator: match by term: Intellectual disability, severeClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gm266Mousehepatocellular carcinoma  ISORGD:134361511554173CTD Direct Evidence: marker/mechanismCTDPMID:28284560

1 to 20 of 49 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gm266Mouse17beta-estradiol affects expressionISORGD:13436156480464Estradiol affects the expression of DIRAS3 mRNACTDPMID:20106945
Gm266Mouse17beta-estradiol increases expressionISORGD:13436156480464Estradiol results in increased expression of DIRAS3 mRNACTDPMID:36828454
Gm266Mouse2-palmitoylglycerol increases expressionISORGD:134361564804642-palmitoylglycerol results in increased expression of DIRAS3 mRNACTDPMID:37199045
Gm266Mouseaflatoxin B1 affects expressionISORGD:13436156480464Aflatoxin B1 affects the expression of DIRAS3 proteinCTDPMID:20106945
Gm266Mousealpha-Zearalanol multiple interactionsISORGD:15651686480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of DIRAS3 mRNACTDPMID:35163327
Gm266MouseArchazolid B decreases expressionISORGD:13436156480464archazolid B results in decreased expression of DIRAS3 mRNACTDPMID:25218289
Gm266Mousearistolochic acid A decreases expressionISORGD:13436156480464aristolochic acid I results in decreased expression of DIRAS3 mRNACTDPMID:33212167
Gm266Mousearsenite(3-) increases methylationISORGD:13436156480464arsenite results in increased methylation of DIRAS3 promoterCTDPMID:23974009
Gm266Mousearsenous acid decreases expressionISORGD:13436156480464Arsenic Trioxide results in decreased expression of DIRAS3 mRNACTDPMID:26705709
Gm266Mousebenzo[a]pyrene decreases methylationISORGD:13436156480464Benzo(a)pyrene results in decreased methylation of DIRAS3 exonCTDPMID:27901495
Gm266Mousebenzo[a]pyrene decreases expressionISORGD:13436156480464Benzo(a)pyrene results in decreased expression of DIRAS3 mRNACTDPMID:32234424
Gm266Mousebenzo[a]pyrene affects methylationISORGD:13436156480464Benzo(a)pyrene affects the methylation of DIRAS3 5' UTR; Benzo(a)pyrene affects the methylation of DIRAS3 promoterCTDPMID:27901495
Gm266Mousebisphenol A increases expressionISORGD:13436156480464bisphenol A results in increased expression of DIRAS3 mRNACTDPMID:27685785|PMID:36828454
Gm266Mousebutanal decreases expressionISORGD:13436156480464butyraldehyde results in decreased expression of DIRAS3 mRNACTDPMID:26079696
Gm266MouseCGP 52608 multiple interactionsISORGD:13436156480464CGP 52608 promotes the reaction [RORA protein binds to DIRAS3 gene]CTDPMID:28238834
Gm266MouseCuprizon decreases expressionISORGD:15651686480464Cuprizone results in decreased expression of DIRAS3 mRNACTDPMID:26577399|PMID:27523638
Gm266Mousecyclosporin A decreases expressionISORGD:13436156480464Cyclosporine results in decreased expression of DIRAS3 mRNACTDPMID:20106945
Gm266Mousediarsenic trioxide decreases expressionISORGD:13436156480464Arsenic Trioxide results in decreased expression of DIRAS3 mRNACTDPMID:26705709
Gm266Mousedorsomorphin multiple interactionsISORGD:13436156480464[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...CTDPMID:27188386
Gm266Mousedoxorubicin decreases expressionISORGD:15651686480464Doxorubicin results in decreased expression of DIRAS3 mRNACTDPMID:32289291

1 to 20 of 49 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gm266Mousenegative regulation of cell migration involved_inIBAPANTHER:PTN000631627|MGI:1921262|MGI:1919315|MGI:978552290270 GO_CentralGO_REF:0000033
Gm266MouseRap protein signal transduction involved_inIBAPANTHER:PTN000631627|MGI:1919315|MGI:1921262|MGI:978552290270 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gm266Mouseplasma membrane is_active_inIBAPANTHER:PTN000631348|UniProtKB:P11233|CGD:CAL0000199219|UniProtKB:O95057|FB:FBgn0003205|RGD:620590|UniProtKB:P01116|UniProtKB:P01112|dictyBase:DDB_G0292998|UniProtKB:P62070|SGD:S000005042|RGD:2827|SGD:S000003384|MGI:108053|CGD:CAL0000184093|SGD:S000005627|FB:FBgn0015286|RGD:619851|UniProtKB:P61225|UniProtKB:P11234|dictyBase:DDB_G0293434|UniProtKB:E9QX28|UniProtKB:Q9Y3L5|UniProtKB:Q99578|UniProtKB:P10114|dictyBase:DDB_G0291237|MGI:97852|MGI:108054|PomBase:SPAC17H9.09c|UniProtKB:Q96HU82290270 GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gm266MouseGDP binding enablesIBAPANTHER:PTN000631348|PomBase:SPAC17H9.09c|RGD:621840|UniProtKB:P10301|UniProtKB:P10114|RGD:2981|UniProtKB:Q9Y3L5|UniProtKB:P01112|PomBase:SPBC428.16c|UniProtKB:Q15382|UniProtKB:P11234|UniProtKB:P61225|UniProtKB:P61224|UniProtKB:P112332290270 GO_CentralGO_REF:0000033
Gm266MouseGTP binding enablesIBAPANTHER:PTN000631348|UniProtKB:P01112|dictyBase:DDB_G0281385|SGD:S000005042|UniProtKB:P61224|UniProtKB:O95057|UniProtKB:P11233|MGI:97912|UniProtKB:Q15382|MGI:96224|MGI:108053|WB:WBGene00002335|RGD:1359694|RGD:621840|UniProtKB:Q92963|dictyBase:DDB_G0293434|UniProtKB:Q9Y3L5|UniProtKB:P61225|UniProtKB:P11234|PomBase:SPBC428.16c|UniProtKB:Q8TAI7|UniProtKB:Q96HU8|UniProtKB:P10114|dictyBase:DDB_G0291237|PomBase:SPAC17H9.09c|MGI:1080542290270 GO_CentralGO_REF:0000033
Gm266MouseGTPase activity enablesIBAPANTHER:PTN000631348|UniProtKB:Q96A58|MGI:96680|UniProtKB:Q92963|PomBase:SPBC428.16c|CGD:CAL0000181665|UniProtKB:P11234|FB:FBgn0015286|SGD:S000005627|UniProtKB:Q96HU8|PomBase:SPAC17H9.09c|MGI:108054|UniProtKB:Q12526|MGI:97852|UniProtKB:P10114|SGD:S000005042|UniProtKB:P62070|UniProtKB:P01112|UniProtKB:P01116|UniProtKB:Q15382|UniProtKB:P61224|UniProtKB:P01111|FB:FBgn0003205|UniProtKB:O95057|CGD:CAL0000199219|UniProtKB:P11233|CGD:CAL0000184093|UniProtKB:O14807|FB:FBgn0041191|SGD:S000003384|FB:FBgn0004636|RGD:621840|MGI:1927243|UniProtKB:P103012290270 GO_CentralGO_REF:0000033
Gm266Mouseprotein binding enablesISOUniProtKB:Q6FHY59068941 PMID:32296183IntActPMID:32296183
Gm266Mouseprotein binding enablesISOUniProtKB:P407639068941 PMID:21643014IntActPMID:21643014


#
Reference Title
Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:19501082   PMID:21873635  



Gm266
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912111,451,043 - 111,452,257 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12111,451,043 - 111,452,257 (-)EnsemblGRCm39 Ensembl
GRCm3812111,484,609 - 111,485,823 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12111,484,609 - 111,485,823 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712112,722,820 - 112,724,034 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612111,932,419 - 111,933,604 (-)NCBIMGSCv36mm8
Celera12112,674,808 - 112,676,022 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.01NCBI
DIRAS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38168,045,962 - 68,050,627 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl168,045,886 - 68,051,717 (-)EnsemblGRCh38hg38GRCh38
GRCh37168,511,645 - 68,516,310 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36168,284,233 - 68,289,048 (-)NCBINCBI36Build 36hg18NCBI36
Build 34168,223,667 - 68,228,481NCBI
Celera166,802,348 - 66,807,163 (-)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef166,621,747 - 66,626,564 (-)NCBIHuRef
CHM1_1168,627,001 - 68,631,820 (-)NCBICHM1_1
T2T-CHM13v2.0167,923,423 - 67,928,086 (-)NCBIT2T-CHM13v2.0
Diras3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,346,157 - 136,347,371 (-)NCBIGRCr8
mRatBN7.26130,524,972 - 130,526,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,524,742 - 130,530,825 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.06135,938,345 - 135,940,205 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6135,938,935 - 135,939,534 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,475,515 - 144,477,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,245,520 - 136,247,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6128,080,876 - 128,082,770 (-)NCBICelera
Cytogenetic Map6q32NCBI
DIRAS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21158,813,884 - 158,825,676 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11157,979,647 - 157,985,477 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0167,283,556 - 67,288,561 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1169,239,462 - 69,244,436 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl169,240,117 - 69,240,806 (-)Ensemblpanpan1.1panPan2
LOC480441
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1871,032,087 - 71,033,379 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha870,544,283 - 70,545,574 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0871,309,047 - 71,310,337 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1870,972,635 - 70,973,926 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0871,037,280 - 71,038,571 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0871,437,437 - 71,438,728 (-)NCBIUU_Cfam_GSD_1.0
Diras3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505880,798,207 - 80,800,867 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365913,688,774 - 3,691,342 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIRAS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6144,576,342 - 144,578,818 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16144,576,342 - 144,578,820 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26133,865,007 - 133,867,486 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DIRAS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12065,060,391 - 65,065,165 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2065,063,822 - 65,064,511 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603352,548,119 - 52,553,856 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Gm266
34 total Variants

Predicted Target Of
Summary Value
Count of predictions:203
Count of miRNA genes:168
Interacting mature miRNAs:187
Transcripts:ENSMUST00000010673
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 29 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
4141297Plyid_mPolymeric IgA dominance (mouse)Not determined109183385115885122Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse

1 to 10 of 29 rows






Ensembl Acc Id: ENSMUST00000010673   ⟹   ENSMUSP00000010673
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12111,451,043 - 111,452,257 (-)Ensembl
GRCm38.p6 Ensembl12111,484,609 - 111,485,823 (-)Ensembl
RefSeq Acc Id: NM_001033248   ⟹   NP_001028420
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,451,043 - 111,452,257 (-)NCBI
GRCm3812111,484,609 - 111,485,823 (-)ENTREZGENE
MGSCv3712112,722,820 - 112,724,034 (-)RGD
Celera12112,674,808 - 112,676,022 (-)RGD
cM Map12 ENTREZGENE
Sequence:
Protein RefSeqs NP_001028420 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI45737 (Get FASTA)   NCBI Sequence Viewer  
  AAI45763 (Get FASTA)   NCBI Sequence Viewer  
  BAE38750 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000010673
  ENSMUSP00000010673.6
RefSeq Acc Id: NP_001028420   ⟸   NM_001033248
- UniProtKB: A6H634 (UniProtKB/TrEMBL),   Q3TLP2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000010673   ⟸   ENSMUST00000010673

Name Modeler Protein Id AA Range Protein Structure
AF-A6H634-F1-model_v2 AlphaFold A6H634 1-200 view protein structure

RGD ID:8679328
Promoter ID:EPDNEW_M17695
Type:multiple initiation site
Name:Gm266_1
Description:Mus musculus predicted gene 266 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812111,485,796 - 111,485,856EPDNEW
RGD ID:6822979
Promoter ID:MM_KWN:12829
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:NM_001033248
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612112,723,741 - 112,724,292 (-)MPROMDB


1 to 23 of 23 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000010529 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000010673 ENTREZGENE
  ENSMUST00000010673.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Ras UniProtKB/TrEMBL
KEGG Report mmu:212539 UniProtKB/TrEMBL
MGD MGI:2685112 ENTREZGENE
NCBI Gene 212539 ENTREZGENE
PANTHER PTHR24070 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PhenoGen Gm266 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A6H634 ENTREZGENE, UniProtKB/TrEMBL
  Q3TLP2 ENTREZGENE, UniProtKB/TrEMBL
1 to 23 of 23 rows