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Gene: Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1) Mus musculus
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Symbol: Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
Description: Exhibits 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity. Involved in lung development. Predicted to localize to apical part of cell; nuclear membrane; and rough endoplasmic reticulum. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study cortisone reductase deficiency 2. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 2; and obesity. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (S)-nicotine; 11-dehydrocorticosterone; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 11-beta-HSD1; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11beta-HSD-1; 11beta-HSD1A; 11beta-hydroxysteroid dehydrogenase type 1; corticosteroid 11-beta-dehydrogenase isozyme 1; Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta-HSD1A)
Orthologs:
Homo sapiens (human) : HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)
Canis lupus familiaris (dog) : HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1)
Sus scrofa (pig) : HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)
Chlorocebus sabaeus (African green monkey) : HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)
Heterocephalus glaber (naked mole-rat) : Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1193,221,634 - 193,264,075 (-)EnsemblGRCm38mm10GRCm38
GRCm381193,221,640 - 193,264,045 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371195,047,834 - 195,090,239 (-)NCBIGRCm37mm9NCBIm37
MGSCv361194,922,413 - 194,964,769 (-)NCBImm8
Celera1200,096,784 - 200,141,189 (-)NCBICelera
Cytogenetic Map1H6NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hsd11b1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10734
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.