Polr2c (polymerase (RNA) II (DNA directed) polypeptide C) - Rat Genome Database
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Gene: Polr2c (polymerase (RNA) II (DNA directed) polypeptide C) Mus musculus
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Symbol: Polr2c
Name: polymerase (RNA) II (DNA directed) polypeptide C
RGD ID: 1315833
Description: Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in transcription by RNA polymerase II. Localizes to cytoplasm and nucleus. Is expressed in 1st branchial arch; alimentary system; limb; and sensory organ. Orthologous to human POLR2C (RNA polymerase II subunit C); PARTICIPATES IN RNA polymerase II transcription pathway; Huntington's disease pathway; purine metabolic pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 33kD; 33kDa; DNA-directed RNA polymerase II 33 kDa polypeptide; DNA-directed RNA polymerase II subunit C; DNA-directed RNA polymerase II subunit RPB3; MGC118242; mRBP; mRBP31; RNA polymerase II 3; RNA polymerase II subunit 3; RNA polymerase II subunit B3; RP; RPB3; RPB31; RPB33; Rpo; Rpo2-3
Orthologs:
Homo sapiens (human) : POLR2C (RNA polymerase II subunit C)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Polr2c (RNA polymerase II subunit C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Polr2c (RNA polymerase II subunit C)
Pan paniscus (bonobo/pygmy chimpanzee) : POLR2C (RNA polymerase II subunit C)
Canis lupus familiaris (dog) : POLR2C (RNA polymerase II subunit C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Polr2c (RNA polymerase II subunit C)
Sus scrofa (pig) : POLR2C (RNA polymerase II subunit C)
Chlorocebus sabaeus (African green monkey) : POLR2C (RNA polymerase II subunit C)
Heterocephalus glaber (naked mole-rat) : Polr2c (RNA polymerase II subunit C)
more info ...
Related Pseudogenes: Gm11993   Gm3815  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,584,078 - 95,590,870 (+)NCBI
GRCm38894,857,450 - 94,864,242 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,857,450 - 94,873,535 (+)EnsemblGRCm38mm10GRCm38
MGSCv37897,381,350 - 97,388,142 (+)NCBIGRCm37mm9NCBIm37
MGSCv36897,746,634 - 97,753,371 (+)NCBImm8
Celera899,182,110 - 99,188,853 (+)NCBICelera
Cytogenetic Map8C5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
infertility  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9034305   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14681479   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:16141233   PMID:16602821   PMID:18799693   PMID:20059953   PMID:20211142   PMID:20362541   PMID:21267068   PMID:21873635   PMID:25131634   PMID:30196744   PMID:31138677  


Genomics

Comparative Map Data
Polr2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,584,078 - 95,590,870 (+)NCBI
GRCm38894,857,450 - 94,864,242 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,857,450 - 94,873,535 (+)EnsemblGRCm38mm10GRCm38
MGSCv37897,381,350 - 97,388,142 (+)NCBIGRCm37mm9NCBIm37
MGSCv36897,746,634 - 97,753,371 (+)NCBImm8
Celera899,182,110 - 99,188,853 (+)NCBICelera
Cytogenetic Map8C5NCBI
POLR2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1657,462,660 - 57,472,009 (+)EnsemblGRCh38hg38GRCh38
GRCh381657,462,679 - 57,472,009 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371657,496,551 - 57,505,921 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361656,054,052 - 56,063,422 (+)NCBINCBI36hg18NCBI36
Build 341656,054,079 - 56,063,416NCBI
Celera1641,997,403 - 42,006,773 (+)NCBI
Cytogenetic Map16q21NCBI
HuRef1643,364,199 - 43,373,569 (+)NCBIHuRef
CHM1_11658,904,605 - 58,913,975 (+)NCBICHM1_1
Polr2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01910,575,060 - 10,581,842 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,575,060 - 10,581,842 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,569,862 - 10,576,644 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,597,288 - 10,604,070 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11910,602,113 - 10,608,896 (-)NCBI
Celera1910,044,762 - 10,051,544 (-)NCBICelera
Cytogenetic Map19p13NCBI
Polr2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,096,324 - 15,111,846 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543315,096,324 - 15,104,435 (+)NCBIChiLan1.0ChiLan1.0
POLR2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11656,871,609 - 56,880,986 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,871,707 - 56,880,102 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01637,738,641 - 37,748,055 (+)NCBIMhudiblu_PPA_v0panPan3
POLR2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl258,950,622 - 58,962,505 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1258,953,568 - 58,962,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Polr2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364759,519,325 - 9,528,121 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLR2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl619,393,597 - 19,401,117 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1619,393,569 - 19,401,119 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,383,885 - 17,391,432 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POLR2C
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl543,394,498 - 43,403,490 (+)Ensembl
ChlSab1.1543,394,294 - 43,403,981 (+)NCBI
Polr2c
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474628,604,098 - 28,612,975 (-)NCBI

Position Markers
D83999  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38119,149,572 - 9,149,720UniSTSGRCm38
GRCm38894,863,654 - 94,863,802UniSTSGRCm38
MGSCv37119,049,575 - 9,049,723UniSTSGRCm37
MGSCv37897,387,554 - 97,387,702UniSTSGRCm37
Celera119,583,291 - 9,583,439UniSTS
Celera899,188,265 - 99,188,413UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map8D1UniSTS
Whitehead/MRC_RH1163.03UniSTS
MARC_4899-4900:991938840:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38894,863,918 - 94,864,214UniSTSGRCm38
MGSCv37897,387,818 - 97,388,114UniSTSGRCm37
Celera899,188,529 - 99,188,825UniSTS
Cytogenetic Map8D1UniSTS
MARC_6240-6241:992007189:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38894,863,916 - 94,864,216UniSTSGRCm38
MGSCv37897,387,816 - 97,388,116UniSTSGRCm37
Celera899,188,527 - 99,188,827UniSTS
Cytogenetic Map8D1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined885716921119717069Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined885716921119717069Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined885716921119717069Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889000000130800000Mouse
14696809Rbcn3_mrod bipolar cell number 3 (mouse)894330000102130000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:218
Count of miRNA genes:183
Interacting mature miRNAs:199
Transcripts:ENSMUST00000109521
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000109521   ⟹   ENSMUSP00000105147
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl894,857,450 - 94,864,242 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211939   ⟹   ENSMUSP00000148830
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl894,857,518 - 94,873,535 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211957
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl894,861,385 - 94,863,555 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212120
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl894,857,583 - 94,862,620 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212124   ⟹   ENSMUSP00000148321
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl894,857,632 - 94,863,541 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212744
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl894,857,501 - 94,861,826 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212848   ⟹   ENSMUSP00000148434
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl894,861,716 - 94,863,741 (+)Ensembl
RefSeq Acc Id: NM_009090   ⟹   NP_033116
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39895,584,078 - 95,590,870 (+)NCBI
GRCm38894,857,450 - 94,864,242 (+)ENTREZGENE
MGSCv37897,381,350 - 97,388,142 (+)RGD
Celera899,182,110 - 99,188,853 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033116   ⟸   NM_009090
- UniProtKB: P97760 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000148830   ⟸   ENSMUST00000211939
RefSeq Acc Id: ENSMUSP00000105147   ⟸   ENSMUST00000109521
RefSeq Acc Id: ENSMUSP00000148434   ⟸   ENSMUST00000212848
RefSeq Acc Id: ENSMUSP00000148321   ⟸   ENSMUST00000212124
Protein Domains
RPOLD

Promoters
RGD ID:8667925
Promoter ID:EPDNEW_M11994
Type:initiation region
Name:Polr2c_1
Description:Mus musculus polymerase II polypeptide C , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38894,857,537 - 94,857,597EPDNEW
RGD ID:6843625
Promoter ID:MM_KWN:55361
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4
Transcripts:ENSMUST00000034235,   UC009MXE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36897,381,236 - 97,381,736 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109299 AgrOrtholog
Ensembl Genes ENSMUSG00000031783 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000105147 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148321 UniProtKB/TrEMBL
  ENSMUSP00000148434 UniProtKB/TrEMBL
  ENSMUSP00000148830 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000109521 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000211939 UniProtKB/TrEMBL
  ENSMUST00000212124 UniProtKB/TrEMBL
  ENSMUST00000212848 UniProtKB/TrEMBL
Gene3D-CATH 2.170.120.12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1360.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNA-dir_RNA_pol_30-40kDasu_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-dir_RNA_pol_insert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-dir_RNA_pol_RpoA/D/Rpb3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBP11-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNApol_insert_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20021 UniProtKB/Swiss-Prot
MGD MGI:109299 ENTREZGENE
NCBI Gene 20021 ENTREZGENE
Pfam RNA_pol_A_bac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_pol_L UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Polr2c PhenoGen
PROSITE RNA_POL_D_30KD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RPOLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55257 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56553 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.292492 ENTREZGENE
UniProt A0A1D5RLD4_MOUSE UniProtKB/TrEMBL
  A0A1D5RLM9_MOUSE UniProtKB/TrEMBL
  A0A1D5RML8_MOUSE UniProtKB/TrEMBL
  P97760 ENTREZGENE
  Q3UUX3_MOUSE UniProtKB/TrEMBL
  RPB3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q99M46 UniProtKB/Swiss-Prot