Il1rn (interleukin 1 receptor antagonist) - Rat Genome Database

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Gene: Il1rn (interleukin 1 receptor antagonist) Mus musculus
Analyze
Symbol: Il1rn
Name: interleukin 1 receptor antagonist
RGD ID: 733437
MGI Page MGI
Description: Predicted to enable cytokine receptor binding activity. Acts upstream of or within insulin secretion and lipid metabolic process. Located in extracellular region and vesicle. Is expressed in skin. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: F630041P17Rik; IL; IL-1ra; IL-1RN; IL1 inhibitor; interleukin-1 receptor antagonist protein; IRAP
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,226,872 - 24,241,503 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,226,865 - 24,241,506 (+)EnsemblGRCm39 Ensembl
GRCm38224,336,860 - 24,351,491 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,336,853 - 24,351,494 (+)EnsemblGRCm38mm10GRCm38
MGSCv37224,192,380 - 24,207,011 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36224,158,869 - 24,173,490 (+)NCBIMGSCv36mm8
Celera224,056,294 - 24,070,923 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abscess  (ISO)
acute kidney failure  (IDA,ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (ISO)
adult respiratory distress syndrome  (ISO)
alcohol dependence  (ISO)
allergic conjunctivitis  (ISO)
alopecia areata  (ISO)
Anorexia  (ISO)
anterior uveitis  (ISO)
anthracosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
Arsenic Poisoning  (ISO)
asthma  (ISO)
Atrophy  (ISO)
autistic disorder  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (IMP)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis  (ISO)
bronchiolitis obliterans  (ISO)
bronchopulmonary dysplasia  (ISO)
bronchus carcinoma  (ISO)
Cachexia  (ISO)
calcium oxalate nephrolithiasis  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (ISO)
Cerebral Hemorrhage  (ISO)
cerebrovascular disease  (ISO)
Chediak-Higashi syndrome  (ISO)
Chronic Anterior Uveitis  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis  (ISO)
Chronic Rhinosinusitis  (ISO)
Chronic Uveitis  (ISO)
cicatricial pemphigoid  (ISO)
Colonic Neoplasms  (ISO)
common cold  (ISO)
Corneal Graft Rejection  (ISO)
corneal neovascularization  (IMP,ISO)
COVID-19  (ISO)
crescentic glomerulonephritis  (ISO)
Cryopyrin-Associated Periodic Syndromes  (ISO)
cystic fibrosis  (ISO)
dacryocystitis  (ISO)
depressive disorder  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diarrhea  (ISO)
Drug Hypersensitivity Syndrome  (ISO)
Drug-Induced Agranulocytosis  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
encephalitis  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Endotoxin-Induced Uveitis  (IMP,ISO)
exanthem  (ISO)
Experimental Arthritis  (IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (IMP)
Experimental Autoimmune Uveitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (IDA,IMP,ISO)
Experimental Mammary Neoplasms  (ISO)
Extravasation of Diagnostic and Therapeutic Materials  (ISO)
Eye Manifestations  (ISO)
Febrile Seizures  (ISO)
Fever  (ISO)
fibromyalgia  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
glomerulonephritis  (IEP,ISO)
gout  (ISO)
graft-versus-host disease  (ISO)
Graves ophthalmopathy  (ISO)
hairy cell leukemia  (ISO)
hemolytic-uremic syndrome  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex virus keratitis  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (IMP,ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
interstitial lung disease  (ISO)
interstitial lung disease 2  (ISO)
juvenile rheumatoid arthritis  (ISO)
keratoconus  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IMP,ISO)
learning disability  (ISO)
Leukocytosis  (ISO)
Lichen Sclerosus et Atrophicus  (ISO)
listeriosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Meibomian Gland Dysfunction  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
middle cerebral artery infarction  (ISO)
morbid obesity  (ISO)
Muckle-Wells syndrome  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myositis  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
nephrotic syndrome  (ISO)
obesity  (IAGP,ISO)
Oligoanuria  (ISO)
osteoporosis  (ISO)
Pain  (ISO)
periodontitis  (ISO)
pleural disease  (ISO)
pleural tuberculosis  (ISO)
pleurisy  (ISO)
pneumonia  (IEP,ISO)
Postoperative Cognitive Dysfunction  (ISO)
pre-eclampsia  (ISO)
Proctocolitis  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (IEP)
proteinuria  (ISO)
Pseudomonas Aeruginosa Keratitis  (IDA,IEP)
Pseudomonas Infections  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pustular psoriasis 14  (ISO)
pyelonephritis  (ISO)
renal cell carcinoma  (ISO)
respiratory allergy  (IMP)
rheumatoid arthritis  (IMP,ISO)
rhinitis  (ISO)
Schnitzler syndrome  (ISO)
sciatic neuropathy  (ISO)
Sclerosis  (ISO)
Sepsis  (IEP,ISO)
Serositis  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
Tobacco Use Disorder  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (IMP,ISO)
urinary bladder cancer  (ISO)
Urinary Calculi  (ISO)
vascular disease  (ISO)
Venous Thrombosis  (ISO)
Ventilator-Induced Lung Injury  (ISO)
Viral Bronchiolitis  (ISO)
viral pneumonia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
acetamide  (ISO)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinyl palmitate  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astressin  (ISO)
azathioprine  (ISO)
beclomethasone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-endorphin  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
carvedilol  (ISO)
celastrol  (ISO)
ceric oxide  (ISO)
cholesterol  (ISO)
choline  (EXP)
cisplatin  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
delta-tocotrienol  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (EXP)
dichloromethane  (EXP)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
folic acid  (EXP)
fructose  (EXP)
fumonisin B1  (EXP)
gedunin  (ISO)
Genipin  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
glycidol  (ISO)
graphene oxide  (EXP)
graphite  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
ionomycin  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoliquiritigenin  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
lenalidomide  (EXP)
lipopolysaccharide  (EXP,ISO)
malonaldehyde  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (ISO)
metformin  (EXP)
methacholine chloride  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methyltestosterone  (ISO)
microcystin-LR  (EXP)
Mofezolac (TN)  (ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
potassium dichromate  (EXP)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
prostaglandin E2  (ISO)
purine-6-thiol  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
rofecoxib  (ISO)
rotenone  (EXP)
scopolamine  (EXP)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (EXP)
sulfasalazine  (ISO)
tacrolimus hydrate  (EXP)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP)
thalidomide  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
tremolite asbestos  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (EXP)
trimethyltin  (EXP)
triphenyl phosphate  (ISO)
urethane  (ISO)
wortmannin  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA,ISO)
cytoplasm  (IEA)
cytosol  (IEA,ISO)
extracellular region  (IDA)
extracellular space  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
vesicle  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aorta elastic tissue morphology  (IAGP)
abnormal body temperature homeostasis  (IAGP)
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal dendritic cell differentiation  (IAGP)
abnormal dendritic cell number  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal keratinocyte physiology  (IAGP)
abnormal macrophage chemotaxis  (IAGP)
abnormal T-helper 1 cell morphology  (IAGP)
abnormal T-helper 2 cell morphology  (IAGP)
abnormal vascular wound healing  (IAGP)
aneurysm  (IAGP)
aortitis  (IAGP)
artery stenosis  (IAGP)
chronic inflammation  (IAGP)
decreased body weight  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating interleukin-1 level  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
epidermal desquamation  (IAGP)
granulomatous inflammation  (IAGP)
increased acute inflammation  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating serum amyloid protein level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased T cell proliferation  (IAGP)
parakeratosis  (IAGP)
pathological neovascularization  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
psoriasis  (IAGP)
reduced fertility  (IAGP)
rheumatoid arthritis  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
thick dermal layer  (IAGP)
thick epidermis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans. null
2. Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma. Abazis-Stamboulieh D, etal., Leuk Lymphoma. 2007 Nov;48(11):2196-203.
3. Association of low-grade inflammation with nephropathy in type 2 diabetic patients: role of elevated CRP-levels and 2 different gene-polymorphisms of proinflammatory cytokines. Abrahamian H, etal., Exp Clin Endocrinol Diabetes. 2007 Jan;115(1):38-41.
4. Genetic association of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86 bp repeat) polymorphisms with Type 2 diabetes mellitus in North Indians. Achyut BR, etal., Clin Chim Acta. 2007 Feb;377(1-2):163-9. Epub 2006 Oct 27.
5. Cytokine gene polymorphisms are associated with risk of urinary bladder cancer and recurrence after BCG immunotherapy. Ahirwar DK, etal., Biomarkers. 2009 Jun;14(4):213-8.
6. ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. Aki K, etal., Am J Physiol Renal Physiol. 2010 Apr;298(4):F870-82. Epub 2010 Jan 13.
7. Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice. Amin A, etal., J Pathol. 2012 Jun;227(2):165-74. doi: 10.1002/path.3960. Epub 2012 Feb 17.
8. Interleukin 1 receptor antagonist gene polymorphism is associated with severe renal involvement and renal sequelae in Henoch-Schonlein purpura. Amoli MM, etal., J Rheumatol. 2002 Jul;29(7):1404-7.
9. Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease. Antin JH, etal., Blood. 1994 Aug 15;84(4):1342-8.
10. Interleukin-1 receptor antagonist gene polymorphism and mortality in patients with severe sepsis. Arnalich F, etal., Clin Exp Immunol. 2002 Feb;127(2):331-6.
11. Cytokine mRNA in the joints and draining lymph nodes of rats with adjuvant arthritis and effects of cyclosporin A. Ayer LM, etal., Inflammation. 2000 Oct;24(5):447-61.
12. Regulation of proinflammatory cytokines in seasonal allergic rhinitis. Bachert C, etal., Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):375-9.
13. Multiplex immunoassay analysis of cytokines in idiopathic inflammatory myopathy. Baird GS and Montine TJ, Arch Pathol Lab Med. 2008 Feb;132(2):232-8. doi: 10.1043/1543-2165(2008)132[232:MIAOCI]2.0.CO;2.
14. Correlation of serum levels of interleukin-1 family members with disease activity and response to treatment in hairy cell leukemia. Barak V, etal., Eur Cytokine Netw. 1998 Mar;9(1):33-9.
15. Comparison of cytokine gene polymorphism in drug-induced maculopapular eruption, urticaria and drug reaction with eosinophilia and systemic symptoms (DRESS). Barbaud A, etal., J Eur Acad Dermatol Venereol. 2014 Apr;28(4):491-9. doi: 10.1111/jdv.12130. Epub 2013 Mar 6.
16. Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats. Barrientos RM, etal., J Neurosci. 2012 Oct 17;32(42):14641-8. doi: 10.1523/JNEUROSCI.2173-12.2012.
17. Soluble interleukin-1 receptor antagonist concentration in patients with Graves' ophthalmopathy is neither related to cigarette smoking nor predictive of subsequent response to glucocorticoids. Bartalena L, etal., Clin Endocrinol (Oxf). 2000 May;52(5):647-51.
18. Interleukin-1 receptor antagonist as a biomarker for bronchiolitis obliterans syndrome in lung transplant recipients. Belperio JA, etal., Transplantation. 2002 Feb 27;73(4):591-9.
19. Blood serum interleukin-1 receptor antagonist in pars planitis and ocular Behcet disease. Benezra D, etal., Am J Ophthalmol. 1997 May;123(5):593-8.
20. Nucleotide variation, haplotype structure, and association with end-stage renal disease of the human interleukin-1 gene cluster. Bensen JT, etal., Genomics. 2003 Aug;82(2):194-217.
21. Altered levels of the soluble IL-1, IL-4 and TNF receptors, as well as the IL-1 receptor antagonist, in intermittent allergic rhinitis. Benson M, etal., Int Arch Allergy Immunol. 2004 Jul;134(3):227-32. Epub 2004 Jun 1.
22. Host adaptive immunity deficiency in severe pandemic influenza. Bermejo-Martin JF, etal., Crit Care. 2010 Sep 14;14(5):R167.
23. Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain. Betz AL, etal., J Cereb Blood Flow Metab. 1995 Jul;15(4):547-51.
24. Association of interleukin-1Ra gene polymorphism in patients with bladder cancer: case control study from North India. Bid HK, etal., Urology. 2006 May;67(5):1099-104.
25. Counteracting corneal immunoinflammatory lesion with interleukin-1 receptor antagonist protein. Biswas PS, etal., J Leukoc Biol. 2004 Oct;76(4):868-75. Epub 2004 Jul 16.
26. Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus. Blakemore AI, etal., Hum Genet. 1996 Mar;97(3):369-74.
27. Targeted systemic radiotherapy with scVEGF/177Lu leads to sustained disruption of the tumor vasculature and intratumoral apoptosis. Blankenberg FG, etal., J Nucl Med. 2011 Oct;52(10):1630-7. Epub 2011 Sep 2.
28. Acute bacterial inflammation of the mouse prostate. Boehm BJ, etal., Prostate. 2012 Feb;72(3):307-17. doi: 10.1002/pros.21433. Epub 2011 Jun 16.
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183. Association of interleukin-1beta and interleukin-1 receptor antagonist genes with disease severity in MS. Schrijver HM, etal., Neurology 1999 Feb;52(3):595-9.
184. Regulatory effects of endogenous interleukin-1 receptor antagonist protein in immunoglobulin G immune complex-induced lung injury. Shanley TP, etal., J Clin Invest. 1996 Feb 15;97(4):963-70.
185. Interleukin 1 receptor blockade reduces tumor necrosis factor production, tissue injury, and mortality after hepatic ischemia-reperfusion in the rat. Shito M, etal., Transplantation. 1997 Jan 15;63(1):143-8.
186. Impact of interleukin-1 receptor antagonist and tumor necrosis factor-alpha gene polymorphism on IgA nephropathy. Shu KH, etal., Kidney Int. 2000 Aug;58(2):783-9.
187. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. Siezen CL, etal., Pediatr Infect Dis J. 2009 Apr;28(4):333-5.
188. The IL-1 family: regulators of immunity. Sims JE and Smith DE, Nat Rev Immunol. 2010 Feb;10(2):89-102. Epub 2010 Jan 18.
189. Production of interleukin-10 by human bronchogenic carcinoma. Smith DR, etal., Am J Pathol. 1994 Jul;145(1):18-25.
190. Increased interleukin-1 receptor antagonist in idiopathic pulmonary fibrosis. A compartmental analysis. Smith DR, etal., Am J Respir Crit Care Med. 1995 Jun;151(6):1965-73.
191. Genetic variability in the severity and outcome of community-acquired pneumonia. Sole-Violan J, etal., Respir Med. 2010 Mar;104(3):440-7. Epub 2009 Nov 8.
192. Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Solomon A, etal., Invest Ophthalmol Vis Sci. 2001 Sep;42(10):2283-92.
193. The role of cytokines in the behavioral responses to endotoxin and influenza virus infection in mice: effects of acute and chronic administration of the interleukin-1-receptor antagonist (IL-1ra). Swiergiel AH, etal., Brain Res. 1997 Nov 21;776(1-2):96-104.
194. Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array. Szarka A, etal., BMC Immunol. 2010 Dec 2;11:59.
195. Interleukin-1 receptor antagonist modifies the changes in vital organs induced by acute necrotizing pancreatitis in a rat experimental model. Tanaka N, etal., Crit Care Med. 1995 May;23(5):901-8.
196. Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene. Tarlow JK, etal., J Invest Dermatol. 1994 Sep;103(3):387-90.
197. Adenoviral overproduction of interleukin-1 receptor antagonist increases beta cell replication and mass in syngeneically transplanted islets, and improves metabolic outcome. Tellez N, etal., Diabetologia. 2007 Mar;50(3):602-11. Epub 2007 Jan 13.
198. Tobacco smoking associated with the increases of the bronchoalveolar levels of interleukin-5 and interleukin-1 receptor antagonist in acute eosinophilic pneumonia. Teng Y and Gao Y, Eur Rev Med Pharmacol Sci. 2014;18(6):887-93.
199. The detrimental effects of IFN-alpha on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction. Thacker SG, etal., J Immunol. 2010 Oct 1;185(7):4457-69. Epub 2010 Aug 30.
200. Balance of pro- and anti-inflammatory cytokines correlates with outcome of acute experimental Pseudomonas aeruginosa keratitis. Thakur A, etal., Infect Immun. 2002 Apr;70(4):2187-97.
201. Evolution of gene expression changes in newborn rats after mechanical ventilation with reversible intubation. Trummer-Menzi E, etal., Pediatr Pulmonol. 2012 Jul 10. doi: 10.1002/ppul.22613.
202. The different expression patterns of interleukin-1 receptor antagonist in systemic lupus erythematosus. Tsai LJ, etal., Tissue Antigens. 2006 Dec;68(6):493-501.
203. Suppression of experimental uveitis by a recombinant adeno-associated virus vector encoding interleukin-1 receptor antagonist. Tsai ML, etal., Mol Vis. 2009 Aug 8;15:1542-52.
204. Imbalances between tumor necrosis factor-alpha and its soluble receptor forms, and interleukin-1beta and interleukin-1 receptor antagonist in BAL fluid of cavitary pulmonary tuberculosis. Tsao TC, etal., Chest. 2000 Jan;117(1):103-9.
205. Soluble TNF-alpha receptor and IL-1 receptor antagonist elevation in BAL in active pulmonary TB. Tsao TC, etal., Eur Respir J. 1999 Sep;14(3):490-5.
206. Interleukin-1 alpha and interleukin-1 receptor antagonist in the urine of children with acute pyelonephritis and relation to renal scarring. Tullus K, etal., Acta Paediatr. 1996 Feb;85(2):158-62.
207. Endotoxin-induced cytokine gene expression in vivo. IV. Expression of interleukin-1 alpha/beta and interleukin-1 receptor antagonist mRNA during endotoxemia and during endotoxin-initiated local acute inflammation. Ulich TR, etal., Am J Pathol. 1992 Jul;141(1):61-8.
208. Haplotypes of IL1B, IL1RN, IL1R1, and IL1R2 and the risk of venous thrombosis. van Minkelen R, etal., Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1486-91. Epub 2007 Apr 5.
209. Cytokine gene polymorphisms and high-resolution-computed tomography score in idiopathic pulmonary fibrosis. Vasakova M, etal., Respir Med. 2007 May;101(5):944-50. Epub 2006 Oct 23.
210. Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases. Vidal-Vanaclocha F, etal., Cancer Res. 1994 May 15;54(10):2667-72.
211. Topical administration of interleukin-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease. Vijmasi T, etal., Mol Vis. 2013 Sep 19;19:1957-65. eCollection 2013.
212. Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline. Voelkel NF, etal., Am J Respir Cell Mol Biol. 1994 Dec;11(6):664-75.
213. Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma. Wang CC, etal., Gene Ther. 2006 Oct;13(19):1414-21. Epub 2006 May 25.
214. Interleukin-1 beta induction of neuron apoptosis depends on p38 mitogen-activated protein kinase activity after spinal cord injury. Wang XJ, etal., Acta Pharmacol Sin. 2005 Aug;26(8):934-42.
215. Association of interleukin-1 receptor antagonist gene polymorphism with IgA nephropathy. Watanabe M, etal., Nephron. 2002 Aug;91(4):744-6.
216. Altered levels of interleukin-1 beta and interleukin-1 receptor antagonist in chronic myelogenous leukemia: clinical and prognostic correlates. Wetzler M, etal., Blood. 1994 Nov 1;84(9):3142-7.
217. Induction of pituitary cytokine transcripts by peripheral lipopolysaccharide. Whiteside MB, etal., J Neuroendocrinol. 1999 Feb;11(2):115-20.
218. Increased risk of fibrosing alveolitis associated with interleukin-1 receptor antagonist and tumor necrosis factor-alpha gene polymorphisms. Whyte M, etal., Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):755-8.
219. Influence of polymorphism in the genes for the interleukin (IL)-1 receptor antagonist and IL-1beta on tuberculosis. Wilkinson RJ, etal., J Exp Med. 1999 Jun 21;189(12):1863-74.
220. Genetically modified bone marrow-derived vehicle cells site specifically deliver an anti-inflammatory cytokine to inflamed interstitium of obstructive nephropathy. Yamagishi H, etal., J Immunol. 2001 Jan 1;166(1):609-16.
221. Mesenchymal Stem Cell: Does it Work in an Experimental Model with Acute Respiratory Distress Syndrome? Yilmaz S, etal., Stem Cell Rev. 2012 Jul 19.
222. Prophylaxis of antibody-induced acute glomerulonephritis with genetically modified bone marrow-derived vehicle cells. Yokoo T, etal., Hum Gene Ther. 1999 Nov 1;10(16):2673-8.
223. Rhinovirus regulation of IL-1 receptor antagonist in vivo and in vitro: a potential mechanism of symptom resolution. Yoon HJ, etal., J Immunol. 1999 Jun 15;162(12):7461-9.
224. IL-1 up-regulates osteopontin expression in experimental crescentic glomerulonephritis in the rat. Yu XQ, etal., Am J Pathol. 1999 Mar;154(3):833-41.
225. The experimental treatment of corneal graft rejection with the interleukin-1 receptor antagonist (IL-1ra) gene. Yuan J, etal., PLoS One. 2013 May 28;8(5):e60714. doi: 10.1371/journal.pone.0060714. Print 2013.
226. Association of tumor necrosis factor-alpha and interleukin-1 gene polymorphisms with silicosis. Yucesoy B, etal., Toxicol Appl Pharmacol. 2001 Apr 1;172(1):75-82.
227. Interleukin-1 receptor antagonist gene polymorphism increases susceptibility to septic shock in children with acute lymphoblastic leukemia. Zapata-Tarres M, etal., Pediatr Infect Dis J. 2013 Feb;32(2):136-9. doi: 10.1097/INF.0b013e31827566dd.
228. Association of interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Turkish children with atopic asthma. Zeyrek D, etal., Allergy Asthma Proc. 2008 Sep-Oct;29(5):468-74.
229. Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1 beta expression in a rat model. Zhang RX, etal., Anesth Analg. 2007 Nov;105(5):1482-8, table of contents.
230. Therapeutic effect of exogenous bone marrowderived mesenchymal stem cell transplantation on silicosis via paracrine mechanisms in rats. Zhao MM, etal., Mol Med Rep. 2013 Sep;8(3):741-6. doi: 10.3892/mmr.2013.1580. Epub 2013 Jul 10.
231. Interleukin 6, tumour necrosis factor alpha, interleukin 1beta and interleukin 1 receptor antagonist promoter or coding gene polymorphisms in multiple myeloma. Zheng C, etal., Br J Haematol. 2000 Apr;109(1):39-45.
232. Amniotic-fluid-derived mesenchymal stem cells overexpressing interleukin-1 receptor antagonist improve fulminant hepatic failure. Zheng YB, etal., PLoS One. 2012;7(7):e41392. Epub 2012 Jul 23.
233. Expression of cell adhesion molecules on limbal and neovascular endothelium in corneal inflammatory neovascularization. Zhu SN and Dana MR, Invest Ophthalmol Vis Sci. 1999 Jun;40(7):1427-34.
234. Roles of central interleukin-1 on stress-induced-hypertension and footshock-induced-analgesia in rats. Zou CJ, etal., Neurosci Lett. 2001 Sep 21;311(1):41-4.
235. [Prognostic values of serum concentration and urinary excretion of interleukin-1 receptor antagonist and tumor necrosis factor receptors type I and II in patients with IGA nephropathy]. Zwiech R, etal., Pol Arch Med Wewn. 2005 Apr;113(4):326-33.
Additional References at PubMed
PMID:1358808   PMID:1828262   PMID:1830498   PMID:1834470   PMID:2137200   PMID:2137201   PMID:7850809   PMID:7989596   PMID:8003626   PMID:8100556   PMID:8176222   PMID:8216424  
PMID:8299552   PMID:8464923   PMID:8630372   PMID:8639177   PMID:8751373   PMID:9049629   PMID:9153551   PMID:9292778   PMID:9550387   PMID:9565638   PMID:9778220   PMID:10349636  
PMID:10637274   PMID:10744718   PMID:10749768   PMID:10780854   PMID:10890909   PMID:11017920   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11418636   PMID:11792572   PMID:11810022  
PMID:11899425   PMID:11933077   PMID:11983917   PMID:11988319   PMID:11991723   PMID:12077269   PMID:12477932   PMID:12667655   PMID:12721360   PMID:12799211   PMID:12874179   PMID:12878687  
PMID:12958152   PMID:14583241   PMID:15004178   PMID:15059807   PMID:15086551   PMID:15218058   PMID:15240711   PMID:15388329   PMID:15578092   PMID:15749858   PMID:15914123   PMID:15939811  
PMID:16081819   PMID:16129814   PMID:16141072   PMID:16141073   PMID:16306368   PMID:16320323   PMID:16374779   PMID:16385385   PMID:16415102   PMID:16569679   PMID:16602821   PMID:16622029  
PMID:16622035   PMID:17021861   PMID:17283139   PMID:17429444   PMID:17823985   PMID:17942936   PMID:17967442   PMID:17982084   PMID:18060042   PMID:18279308   PMID:18282478   PMID:18594791  
PMID:18606706   PMID:19002106   PMID:19144317   PMID:19213834   PMID:19261929   PMID:19458323   PMID:19559408   PMID:19571816   PMID:19656856   PMID:19922413   PMID:20110570   PMID:20112392  
PMID:20181656   PMID:20357263   PMID:20545758   PMID:20610641   PMID:20639493   PMID:20727895   PMID:20844479   PMID:20920427   PMID:21267068   PMID:21300825   PMID:21309947   PMID:21414240  
PMID:21525884   PMID:21722710   PMID:21873635   PMID:22096246   PMID:22117073   PMID:22140485   PMID:22245214   PMID:22290145   PMID:22331066   PMID:22539301   PMID:22567084   PMID:22592923  
PMID:22942082   PMID:22980031   PMID:23209411   PMID:23308180   PMID:23396662   PMID:23475218   PMID:23671185   PMID:23689131   PMID:23840826   PMID:23845567   PMID:24431229   PMID:24558360  
PMID:24566623   PMID:24603878   PMID:25156255   PMID:25209981   PMID:25244011   PMID:25479427   PMID:25725107   PMID:25839897   PMID:25909959   PMID:26002078   PMID:26042735   PMID:26108163  
PMID:26209680   PMID:26276675   PMID:26413013   PMID:26474296   PMID:26661518   PMID:26873573   PMID:26951334   PMID:26972847   PMID:27109611   PMID:27476761   PMID:27480124   PMID:27482635  
PMID:28159904   PMID:28645307   PMID:29444430   PMID:29481574   PMID:29540618   PMID:29662944   PMID:29891552   PMID:30070147   PMID:30354247   PMID:31002437   PMID:31283798   PMID:31505254  
PMID:31611644   PMID:31745167   PMID:31865314   PMID:31932497   PMID:31972159   PMID:32471111   PMID:33064141   PMID:33493267   PMID:33924148   PMID:34437647   PMID:35191758   PMID:35332327  
PMID:35412062   PMID:36304082   PMID:36314682   PMID:36596811   PMID:36929654   PMID:37478856   PMID:37945820   PMID:38019303   PMID:38022496   PMID:38875998  


Genomics

Comparative Map Data
Il1rn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,226,872 - 24,241,503 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,226,865 - 24,241,506 (+)EnsemblGRCm39 Ensembl
GRCm38224,336,860 - 24,351,491 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,336,853 - 24,351,494 (+)EnsemblGRCm38mm10GRCm38
MGSCv37224,192,380 - 24,207,011 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36224,158,869 - 24,173,490 (+)NCBIMGSCv36mm8
Celera224,056,294 - 24,070,923 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.36NCBI
IL1RN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,099,360 - 113,134,014 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2113,099,315 - 113,134,016 (+)EnsemblGRCh38hg38GRCh38
GRCh372113,875,548 - 113,891,591 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,591,941 - 113,608,064 (+)NCBINCBI36Build 36hg18NCBI36
Build 342113,591,700 - 113,607,823NCBI
Celera2107,260,159 - 107,276,191 (+)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,329,950 - 106,345,897 (+)NCBIHuRef
CHM1_12113,879,899 - 113,896,017 (+)NCBICHM1_1
T2T-CHM13v2.02113,544,556 - 113,560,594 (+)NCBIT2T-CHM13v2.0
Il1rn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8327,509,836 - 27,525,738 (+)NCBIGRCr8
mRatBN7.237,111,567 - 7,127,451 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,111,550 - 7,127,445 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,225,656 - 10,231,090 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0318,811,887 - 18,817,327 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,001,698 - 17,007,132 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.031,449,778 - 1,468,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,452,644 - 1,468,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.031,445,598 - 1,461,452 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,607,800 - 2,613,216 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.132,607,803 - 2,611,842 (+)NCBI
Celera31,959,290 - 1,964,693 (+)NCBICelera
Cytogenetic Map3p13NCBI
Il1rn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,144,810 - 1,159,471 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,145,022 - 1,159,413 (-)NCBIChiLan1.0ChiLan1.0
IL1RN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21215,056,807 - 15,073,265 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A15,059,572 - 15,065,747 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A88,991,646 - 89,008,013 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A114,061,182 - 114,077,048 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A114,061,182 - 114,078,839 (+)Ensemblpanpan1.1panPan2
IL1RN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,236,690 - 37,250,424 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,212,751 - 37,249,329 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,014,575 - 37,019,617 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01738,014,380 - 38,028,164 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1738,014,324 - 38,027,492 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11737,157,832 - 37,162,873 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01737,214,332 - 37,219,374 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01737,426,795 - 37,431,843 (+)NCBIUU_Cfam_GSD_1.0
Il1rn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,552,650 - 82,571,860 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367831,447,106 - 1,466,340 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367831,447,158 - 1,466,331 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1RN
(Sus scrofa - pig)		 No map positions available.
IL1RN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11416,136,667 - 16,152,451 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1416,146,333 - 16,151,326 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660803,528,175 - 3,543,946 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il1rn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474913,210,476 - 13,225,890 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474913,210,365 - 13,224,471 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il1rn
414 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1406
Count of miRNA genes:572
Interacting mature miRNAs:660
Transcripts:ENSMUST00000114482, ENSMUST00000114485, ENSMUST00000114486, ENSMUST00000114487, ENSMUST00000142093, ENSMUST00000143423
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
4142333Tgq10_mtriglyceride QTL 10 (mouse)Not determined125324559Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301838Sluc16_msusceptibility to lung cancer 16 (mouse)Not determined2126529589Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
4141836Tgq11_mtriglyceride QTL 11 (mouse)Not determined125324559Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967669127022642Mouse

Markers in Region
M64404  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38224,349,891 - 24,350,030UniSTSGRCm38
MGSCv37224,205,411 - 24,205,550UniSTSGRCm37
Celera224,069,325 - 24,069,464UniSTS
Cytogenetic Map2A3UniSTS
cM Map210.0UniSTS
Whitehead/MRC_RH2412.23UniSTS
UniSTS:224661  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38224,349,764 - 24,349,925UniSTSGRCm38
MGSCv37224,205,284 - 24,205,445UniSTSGRCm37
Celera224,069,198 - 24,069,359UniSTS
Cytogenetic Map2A3UniSTS
cM Map210.0UniSTS
Il1rn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38224,350,674 - 24,350,851UniSTSGRCm38
MGSCv37224,206,194 - 24,206,371UniSTSGRCm37
Celera224,070,108 - 24,070,283UniSTS
Cytogenetic Map2A3UniSTS
cM Map210.0UniSTS
Il1rn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38224,349,640 - 24,350,396UniSTSGRCm38
MGSCv37224,205,160 - 24,205,916UniSTSGRCm37
Celera224,069,074 - 24,069,830UniSTS
Cytogenetic Map2A3UniSTS
cM Map210.0UniSTS
Il1rn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
cM Map210.0UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001039701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001159562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006497727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF001795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL732528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY206809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ383807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ383808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI656439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L32838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S64082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000114482   ⟹   ENSMUSP00000110126
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,235,322 - 24,240,948 (+)Ensembl
GRCm38.p6 Ensembl224,345,310 - 24,350,936 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114485   ⟹   ENSMUSP00000110129
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,235,300 - 24,239,819 (+)Ensembl
GRCm38.p6 Ensembl224,345,288 - 24,349,807 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114486
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,226,868 - 24,229,421 (+)Ensembl
GRCm38.p6 Ensembl224,336,856 - 24,339,409 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114487   ⟹   ENSMUSP00000110131
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,226,865 - 24,241,506 (+)Ensembl
GRCm38.p6 Ensembl224,336,853 - 24,351,494 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142093   ⟹   ENSMUSP00000141269
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,226,868 - 24,239,469 (+)Ensembl
GRCm38.p6 Ensembl224,336,856 - 24,349,457 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143423
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,235,360 - 24,236,366 (+)Ensembl
GRCm38.p6 Ensembl224,345,348 - 24,346,354 (+)Ensembl
RefSeq Acc Id: NM_001039701   ⟹   NP_001034790
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39224,235,383 - 24,241,503 (+)NCBI
GRCm38224,345,371 - 24,351,491 (+)NCBI
MGSCv37224,192,380 - 24,207,011 (+)RGD
Celera224,056,294 - 24,070,923 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001159562   ⟹   NP_001153034
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39224,235,303 - 24,241,503 (+)NCBI
GRCm38224,345,291 - 24,351,491 (+)NCBI
MGSCv37224,192,380 - 24,207,011 (+)RGD
Celera224,056,294 - 24,070,923 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_031167   ⟹   NP_112444
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39224,226,872 - 24,241,503 (+)NCBI
GRCm38224,336,860 - 24,351,491 (+)ENTREZGENE
MGSCv37224,192,380 - 24,207,011 (+)RGD
Celera224,056,294 - 24,070,923 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006497727   ⟹   XP_006497790
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39224,235,126 - 24,241,497 (+)NCBI
GRCm38224,345,111 - 24,351,485 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001034790 (Get FASTA)   NCBI Sequence Viewer  
  NP_001153034 (Get FASTA)   NCBI Sequence Viewer  
  NP_112444 (Get FASTA)   NCBI Sequence Viewer  
  XP_006497790 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA20576 (Get FASTA)   NCBI Sequence Viewer  
  AAA39277 (Get FASTA)   NCBI Sequence Viewer  
  AAA39278 (Get FASTA)   NCBI Sequence Viewer  
  AAA39309 (Get FASTA)   NCBI Sequence Viewer  
  AAA39310 (Get FASTA)   NCBI Sequence Viewer  
  AAB20265 (Get FASTA)   NCBI Sequence Viewer  
  AAC15251 (Get FASTA)   NCBI Sequence Viewer  
  AAH42532 (Get FASTA)   NCBI Sequence Viewer  
  ABD43196 (Get FASTA)   NCBI Sequence Viewer  
  ABD43197 (Get FASTA)   NCBI Sequence Viewer  
  ABD43198 (Get FASTA)   NCBI Sequence Viewer  
  ABD43199 (Get FASTA)   NCBI Sequence Viewer  
  BAC36291 (Get FASTA)   NCBI Sequence Viewer  
  BAC40797 (Get FASTA)   NCBI Sequence Viewer  
  BAE32704 (Get FASTA)   NCBI Sequence Viewer  
  BAE33152 (Get FASTA)   NCBI Sequence Viewer  
  BAE33361 (Get FASTA)   NCBI Sequence Viewer  
  BAE33421 (Get FASTA)   NCBI Sequence Viewer  
  BAE33438 (Get FASTA)   NCBI Sequence Viewer  
  BAE33460 (Get FASTA)   NCBI Sequence Viewer  
  BAE33484 (Get FASTA)   NCBI Sequence Viewer  
  BAE33497 (Get FASTA)   NCBI Sequence Viewer  
  BAE33984 (Get FASTA)   NCBI Sequence Viewer  
  BAE41757 (Get FASTA)   NCBI Sequence Viewer  
  BAE42202 (Get FASTA)   NCBI Sequence Viewer  
  BAE42426 (Get FASTA)   NCBI Sequence Viewer  
  CBY45190 (Get FASTA)   NCBI Sequence Viewer  
  EDL08170 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000110126
  ENSMUSP00000110126.2
  ENSMUSP00000110129
  ENSMUSP00000110129.3
  ENSMUSP00000110131
  ENSMUSP00000110131.3
  ENSMUSP00000141269.2
GenBank Protein P25085 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112444   ⟸   NM_031167
- Peptide Label: isoform 1
- UniProtKB: Q542W1 (UniProtKB/TrEMBL),   Q8CGA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001034790   ⟸   NM_001039701
- Peptide Label: isoform 2 precursor
- UniProtKB: O70207 (UniProtKB/Swiss-Prot),   P25085 (UniProtKB/Swiss-Prot),   Q542C7 (UniProtKB/TrEMBL),   Q8CGA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153034   ⟸   NM_001159562
- Peptide Label: isoform 3
- UniProtKB: Q3TBV5 (UniProtKB/TrEMBL),   Q8CGA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006497790   ⟸   XM_006497727
- Peptide Label: isoform X1
- UniProtKB: Q8CGA1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000110131   ⟸   ENSMUST00000114487
Ensembl Acc Id: ENSMUSP00000110129   ⟸   ENSMUST00000114485
Ensembl Acc Id: ENSMUSP00000110126   ⟸   ENSMUST00000114482
Ensembl Acc Id: ENSMUSP00000141269   ⟸   ENSMUST00000142093

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25085-F1-model_v2 AlphaFold P25085 1-178 view protein structure

Promoters
RGD ID:6831617
Promoter ID:MM_KWN:28037
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B4,   MEF_B6
Transcripts:OTTMUST00000028283,   OTTMUST00000028286
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36224,192,234 - 24,192,734 (+)MPROMDB
RGD ID:6831616
Promoter ID:MM_KWN:28038
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B4,   MEF_B6
Transcripts:ENSMUST00000114486
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36224,192,951 - 24,193,667 (+)MPROMDB
RGD ID:6831618
Promoter ID:MM_KWN:28039
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   MEF_B6
Transcripts:ENSMUST00000114482,   OTTMUST00000028287,   OTTMUST00000028288
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36224,200,416 - 24,201,022 (+)MPROMDB
RGD ID:6876514
Promoter ID:EPDNEW_M1707
Type:initiation region
Name:Il1rn_1
Description:Mus musculus interleukin 1 receptor antagonist , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38224,345,417 - 24,345,477EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96547 AgrOrtholog
Ensembl Genes ENSMUSG00000026981 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000114482 ENTREZGENE
  ENSMUST00000114482.3 UniProtKB/Swiss-Prot
  ENSMUST00000114485 ENTREZGENE
  ENSMUST00000114485.9 UniProtKB/TrEMBL
  ENSMUST00000114487 ENTREZGENE
  ENSMUST00000114487.9 UniProtKB/Swiss-Prot
  ENSMUST00000142093.7 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IL-1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1RA/IL-36 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16181 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96547 ENTREZGENE
NCBI Gene 16181 ENTREZGENE
PANTHER PTHR10078 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10078:SF28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il1rn PhenoGen
PRINTS INTERLEUKIN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLEUKIN1X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A6YVU4_MOUSE UniProtKB/TrEMBL
  IL1RA_MOUSE UniProtKB/Swiss-Prot
  O70207 ENTREZGENE
  P25085 ENTREZGENE
  Q3TBV5 ENTREZGENE, UniProtKB/TrEMBL
  Q542C7 ENTREZGENE, UniProtKB/TrEMBL
  Q542W1 ENTREZGENE, UniProtKB/TrEMBL
  Q8CGA1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O70207 UniProtKB/Swiss-Prot