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Gene: Ercc3 (excision repair cross-complementing rodent repair deficiency, complementation group 3) Mus musculus
Symbol: Ercc3
Name: excision repair cross-complementing rodent repair deficiency, complementation group 3
Description: Exhibits ATPase activity and promoter-specific chromatin binding activity. Predicted to contribute to DNA-dependent ATPase activity and RNA polymerase II CTD heptapeptide repeat kinase activity. Involved in UV protection and transcription elongation from RNA polymerase I promoter. Predicted to colocalize with the transcription factor TFIIH core complex. Used to study xeroderma pigmentosum group B. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group B. Is expressed in several structures, including brain; eye; liver; and trunk. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: basic transcription factor 2 89 kDa subunit; BTF2 p89; BTF2-p89; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; Ercc-3; excision repair 3; general transcription and DNA repair factor IIH helicase subunit XPB; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH subunit XPB; xeroderma pigmentosum group B-complementing protein; XPB
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381832,240,304 - 32,270,151 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371832,399,985 - 32,429,801 (+)NCBIGRCm37mm9NCBIm37
MGSCv361832,383,341 - 32,413,157 (+)NCBImm8
Celera1832,722,096 - 32,752,097 (+)NCBICelera
Cytogenetic Map18 B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ercc3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316157
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.