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Gene: Ercc3 (excision repair cross-complementing rodent repair deficiency, complementation group 3) Mus musculus
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Symbol: Ercc3
Name: excision repair cross-complementing rodent repair deficiency, complementation group 3
Description: Exhibits ATPase activity and promoter-specific chromatin binding activity. Predicted to contribute to DNA-dependent ATPase activity and RNA polymerase II CTD heptapeptide repeat kinase activity. Involved in UV protection and transcription elongation from RNA polymerase I promoter. Predicted to colocalize with the transcription factor TFIIH core complex. Used to study xeroderma pigmentosum group B. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group B. Is expressed in several structures, including brain; eye; liver; and trunk. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: basic transcription factor 2 89 kDa subunit; BTF2 p89; BTF2-p89; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; Ercc-3; excision repair 3; general transcription and DNA repair factor IIH helicase subunit XPB; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH subunit XPB; xeroderma pigmentosum group B-complementing protein; XPB
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381832,240,304 - 32,270,151 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371832,399,985 - 32,429,801 (+)NCBIGRCm37mm9NCBIm37
MGSCv361832,383,341 - 32,413,157 (+)NCBImm8
Celera1832,722,096 - 32,752,097 (+)NCBICelera
Cytogenetic Map18 B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ercc3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316157
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.