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camptothecin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:camptothecin
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Accession:CHEBI:27656 term browser browse the term
Definition:A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Synonyms:exact_synonym: (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
 related_synonym: (S)-(+)-camptothecin;   20(S)-camptothecine;   21,22-Secocamptothecin-21-oic acid lactone;   CPT;   Camptothecine;   D-camptothecin;   Formula=C20H16N2O4;   InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1;   InChIKey=VSJKWCGYPAHWDS-FQEVSTJZSA-N;   SMILES=CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O
 alt_id: CHEBI:22997;   CHEBI:3343
 xref: CAS:7689-03-4;   DrugBank:DB04690;   KEGG:C01897;   KNApSAcK:C00002145;   LINCS:LSM-4611
 xref_mesh: MESH:D002166
 xref: PDBeChem:EHD;   PMID:11024478;   PMID:11549373;   PMID:23344961;   PMID:23474217;   PMID:23676007;   PMID:8965250;   Reaxys:6075662;   Wikipedia:Camptothecin

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camptothecin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions		 ISO Camptothecin results in decreased expression of ABCB1 mRNA; Camptothecin results in decreased expression of ABCB1 protein
Camptothecin inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]		 CTD PMID:10692111 PMID:29356861 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance
multiple interactions		 ISO ABCC1 protein results in decreased susceptibility to Camptothecin analog
Camptothecin inhibits the reaction [ABCC1 results in decreased susceptibility to Daunorubicin]		 CTD PMID:11778547 PMID:12115804 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcg4 ATP binding cassette subfamily G member 4 increases expression ISO Camptothecin results in increased expression of ABCG4 mRNA CTD PMID:38460933 NCBI chr 8:53,508,005...53,525,314
Ensembl chr 8:44,611,187...44,626,881 		JBrowse link
G Acer2 alkaline ceramidase 2 increases expression ISO Camptothecin results in increased expression of ACER2 mRNA CTD PMID:38460933 NCBI chr 5:106,437,773...106,488,572
Ensembl chr 5:101,391,885...101,442,614 		JBrowse link
G Ache acetylcholinesterase increases expression ISO Camptothecin results in increased expression of ACHE mRNA CTD PMID:38460933 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO Camptothecin results in increased expression of ACTA2 mRNA CTD PMID:38460933 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Acvr1b activin A receptor type 1B increases methylation ISO Camptothecin results in increased methylation of ACVR1B gene CTD PMID:30720231 NCBI chr 7:134,164,987...134,208,389
Ensembl chr 7:132,286,275...132,329,673 		JBrowse link
G Adam19 ADAM metallopeptidase domain 19 decreases response to substance ISO ADAM19 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,491,405...30,583,105 		JBrowse link
G Adamts7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 increases expression ISO Camptothecin results in increased expression of ADAMTS7 mRNA CTD PMID:38460933 NCBI chr 8:99,584,529...99,624,132
Ensembl chr 8:90,704,727...90,744,328 		JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression ISO Camptothecin results in increased expression of ADRB2 mRNA CTD PMID:38460933 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 increases methylation ISO Camptothecin results in increased methylation of AGAP1 gene CTD PMID:30720231 NCBI chr 9:97,487,382...97,922,870
Ensembl chr 9:90,039,605...90,470,958 		JBrowse link
G Agrn agrin increases expression ISO Camptothecin results in increased expression of AGRN mRNA CTD PMID:17374387 NCBI chr 5:172,031,528...172,064,429
Ensembl chr 5:166,749,310...166,786,003 		JBrowse link
G Agrp agouti related neuropeptide decreases response to substance ISO AGRP mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr19:50,357,899...50,396,758
Ensembl chr19:33,447,992...33,449,584 		JBrowse link
G Aifm3 AIF family member 3 decreases response to substance ISO AIFM3 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr11:97,009,100...97,030,601
Ensembl chr11:83,504,861...83,521,248 		JBrowse link
G Akap13 A-kinase anchoring protein 13 decreases response to substance ISO AKAP13 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:138,722,445...139,029,401
Ensembl chr 1:129,314,402...129,619,646 		JBrowse link
G Akap8 A-kinase anchoring protein 8 increases expression ISO Camptothecin results in increased expression of AKAP8 mRNA CTD PMID:33770205 NCBI chr 7:11,966,769...11,983,056
Ensembl chr 7:11,316,228...11,332,399 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation
multiple interactions
increases phosphorylation		 ISO Camptothecin affects the phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; Camptothecin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in decreased phosphorylation of AKT1 protein]; Nicotine affects the reaction [Camptothecin affects the phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]		 CTD PMID:24095863 PMID:30851366 PMID:36394428 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin affects binding
multiple interactions		 ISO Camptothecin analog binds to ALB protein; Camptothecin binds to ALB protein
CTSB protein results in increased cleavage of [Camptothecin analog binds to ALB protein]		 CTD PMID:10803926 PMID:17378599 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression ISO Camptothecin results in increased expression of ALDH1L1 mRNA CTD PMID:38460933 NCBI chr 4:124,617,182...124,663,674
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Alms1 ALMS1, centrosome and basal body associated protein decreases methylation ISO Camptothecin results in decreased methylation of ALMS1 gene CTD PMID:30720231 NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:118,125,607...118,226,005 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type increases expression ISO Camptothecin results in increased expression of ALOX12B mRNA CTD PMID:38460933 NCBI chr10:54,361,898...54,373,776
Ensembl chr10:53,863,060...53,874,938 		JBrowse link
G Aloxe3 arachidonate epidermal lipoxygenase 3 increases expression ISO Camptothecin results in increased expression of ALOXE3 mRNA CTD PMID:38460933 NCBI chr10:54,329,224...54,353,167
Ensembl chr10:53,831,264...53,854,328 		JBrowse link
G Als2cl ALS2 C-terminal like increases expression ISO Camptothecin results in increased expression of ALS2CL mRNA CTD PMID:38460933 NCBI chr 8:119,746,498...119,762,824
Ensembl chr 8:110,864,975...110,884,419 		JBrowse link
G Andpro androgen regulated protein increases expression ISO Camptothecin results in increased expression of CST4 mRNA CTD PMID:38460933 NCBI chr 3:157,171,739...157,178,262
Ensembl chr 3:136,718,602...136,724,966 		JBrowse link
G Ankra2 ankyrin repeat family A member 2 increases expression ISO Camptothecin results in increased expression of ANKRA2 mRNA CTD PMID:38460933 NCBI chr 2:31,347,158...31,358,002
Ensembl chr 2:29,612,925...29,623,730 		JBrowse link
G Anxa4 annexin A4 increases expression ISO Camptothecin results in increased expression of ANXA4 mRNA CTD PMID:17374387 NCBI chr 4:120,741,750...120,798,534
Ensembl chr 4:119,184,374...119,241,161 		JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO Camptothecin results in increased expression of AOX1 mRNA CTD PMID:38460933 NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:59,579,649...59,658,770 		JBrowse link
G Apc APC regulator of WNT signaling pathway increases methylation ISO Camptothecin results in increased methylation of APC gene CTD PMID:30720231 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Apod apolipoprotein D increases expression ISO Camptothecin results in increased expression of APOD mRNA CTD PMID:38460933 NCBI chr11:82,936,216...82,957,264
Ensembl chr11:69,431,260...69,452,305 		JBrowse link
G Aqp11 aquaporin 11 increases expression ISO Camptothecin results in increased expression of AQP11 mRNA CTD PMID:38460933 NCBI chr 1:161,457,752...161,467,918
Ensembl chr 1:152,046,517...152,056,725 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO Camptothecin results in increased expression of AQP3 mRNA CTD PMID:38460933 NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Ar androgen receptor multiple interactions ISO Camptothecin binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression ISO Camptothecin results in increased expression of ARC mRNA CTD PMID:38460933 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Arl14 ARF like GTPase 14 increases expression ISO Camptothecin results in increased expression of ARL14 mRNA CTD PMID:38460933 NCBI chr 2:155,778,826...155,780,065
Ensembl chr 2:153,468,977...153,469,555 		JBrowse link
G Armcx1 armadillo repeat containing, X-linked 1 increases expression ISO Camptothecin results in increased expression of ARMCX1 mRNA CTD PMID:38460933 NCBI chr  X:102,192,225...102,196,130
Ensembl chr  X:97,898,883...97,903,299 		JBrowse link
G Artn artemin decreases response to substance ISO ARTN mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 5:136,750,188...136,755,645
Ensembl chr 5:131,464,756...131,468,025 		JBrowse link
G Arvcf ARVCF, delta catenin family member increases expression ISO Camptothecin results in increased expression of ARVCF mRNA CTD PMID:38460933 NCBI chr11:96,092,451...96,150,144
Ensembl chr11:82,587,881...82,645,805 		JBrowse link
G Arx aristaless related homeobox increases expression ISO Camptothecin results in increased expression of ARX mRNA CTD PMID:38460933 NCBI chr  X:62,010,097...62,022,009
Ensembl chr  X:58,016,233...58,028,142 		JBrowse link
G Ass1 argininosuccinate synthase 1 increases expression ISO Camptothecin results in increased expression of ASS1 mRNA CTD PMID:38460933 NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 ISO Glutathione inhibits the reaction [Camptothecin results in increased expression of ATF4 protein]; MYC protein affects the reaction [Camptothecin results in increased expression of ATF4 protein] CTD PMID:30266318 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO ATG5 mutant form inhibits the reaction [Camptothecin results in increased degradation of SQSTM1 protein] CTD PMID:22927544 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression		 ISO Egtazic Acid inhibits the reaction [Camptothecin results in increased expression of ATG7 protein]; EIF2S1 protein affects the reaction [Camptothecin results in increased expression of ATG7 protein]; staurosporine aglycone inhibits the reaction [Camptothecin results in increased expression of ATG7 protein] CTD PMID:30266318 NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Atm ATM serine/threonine kinase decreases expression
multiple interactions
increases expression
increases activity		 ISO
EXP		 Camptothecin results in decreased expression of ATM mRNA
Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]]
camptothecin increases kinase activity in rat cerebellar granule neurons		 CTD
RGD		 PMID:24792648 PMID:30720231 PMID:19151707 RGD:10053571 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atosa atos homolog A increases expression ISO Camptothecin results in increased expression of FAM214A mRNA CTD PMID:38460933 NCBI chr 8:84,575,360...84,653,103
Ensembl chr 8:75,695,022...75,772,549 		JBrowse link
G Atr ATR serine/threonine kinase decreases response to substance
multiple interactions
increases phosphorylation		 ISO ATR mRNA results in decreased susceptibility to Camptothecin; ATR protein results in decreased susceptibility to Camptothecin
3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased phosphorylation of ATR protein]		 CTD PMID:25269479 PMID:30555576 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G B3gnt7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 increases expression ISO Camptothecin results in increased expression of B3GNT7 mRNA CTD PMID:38460933 NCBI chr 9:94,404,197...94,408,148
Ensembl chr 9:86,956,220...86,960,170 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
decreases expression		 ISO Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BAK1 mRNA] CTD PMID:30581319 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Batf2 basic leucine zipper ATF-like transcription factor 2 increases expression ISO Camptothecin results in increased expression of BATF2 mRNA CTD PMID:38460933 NCBI chr 1:212,897,076...212,905,740
Ensembl chr 1:203,468,097...203,475,889 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases activity
increases expression
decreases expression		 ISO
EXP		 [Camptothecin co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in decreased expression of BAX protein; Camptothecin affects the cleavage of and results in decreased expression of BAX protein; Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BAX mRNA]
Camptothecin results in increased activity of BAX protein
Camptothecin results in increased expression of BAX protein
pifithrin inhibits the reaction [Camptothecin results in increased expression of BAX protein]
Camptothecin results in decreased expression of BAX mRNA; Camptothecin results in decreased expression of BAX protein		 CTD PMID:11279278 PMID:15665116 PMID:17555331 PMID:19481069 PMID:30581319 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 affects response to substance
increases expression		 ISO BBC3 protein affects the susceptibility to Camptothecin
Camptothecin results in increased expression of BBC3 mRNA		 CTD PMID:20477944 PMID:38460933 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases response to substance
decreases expression
increases expression		 ISO 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin results in decreased expression of BCL2 protein]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in decreased expression of BCL2 protein]; Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BCL2 mRNA]
BCL2 results in decreased susceptibility to Camptothecin
Camptothecin results in decreased expression of BCL2 mRNA; Camptothecin results in decreased expression of BCL2 protein
Camptothecin results in increased expression of BCL2 mRNA
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BCL2 protein]		 CTD PMID:9664115 PMID:10692111 PMID:10896673 PMID:19481069 PMID:24726431 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance
decreases expression
increases expression
multiple interactions		 EXP
ISO		 BCL2L1 gene mutant form results in decreased susceptibility to Camptothecin
Camptothecin results in decreased expression of BCL2L1 protein alternative form
Camptothecin results in increased expression of BCL2L1 protein
Dexamethasone inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 protein alternative form]; Mifepristone affects the reaction [Dexamethasone inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 protein alternative form]]; Naphthoquinones analog promotes the reaction [Camptothecin results in increased expression of BCL2L1 protein]
BCL2L1 mRNA results in decreased susceptibility to Camptothecin
Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 mRNA]		 CTD PMID:10970895 PMID:19339209 PMID:19497415 PMID:25269479 PMID:30581319 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO [Diethylhexyl Phthalate co-treated with Camptothecin] results in decreased expression of BECN1 protein; Egtazic Acid inhibits the reaction [Camptothecin results in increased expression of BECN1 protein]; EIF2S1 protein affects the reaction [Camptothecin results in increased expression of BECN1 protein]; staurosporine aglycone inhibits the reaction [Camptothecin results in increased expression of BECN1 protein] CTD PMID:30266318 PMID:36394428 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bex1 brain expressed X-linked 1 increases expression ISO Camptothecin results in increased expression of BEX2 mRNA CTD PMID:38460933 NCBI chr  X:104,010,639...104,012,143
Ensembl chr  X:99,219,014...99,220,958 		JBrowse link
G Bex4 brain expressed, X-linked 4 increases expression ISO Camptothecin results in increased expression of BEX4 mRNA CTD PMID:38460933 NCBI chr  X:103,923,609...103,925,041
Ensembl chr  X:99,131,942...99,133,531 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Camptothecin co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in increased cleavage of and results in decreased expression of BID protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of BID protein; Camptothecin results in increased cleavage of and results in decreased expression of BID protein CTD PMID:19481069 PMID:19633536 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bik BCL2-interacting killer increases expression ISO Camptothecin results in increased expression of BIK mRNA CTD PMID:38460933 NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
decreases expression		 ISO [Butyrates co-treated with Camptothecin] results in decreased expression of BIRC5 protein; [Folic Acid co-treated with Camptothecin] results in decreased expression of BIRC5 mRNA
Camptothecin results in increased expression of BIRC5 mRNA
Camptothecin results in decreased expression of BIRC5 mRNA
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BIRC5 protein]		 CTD PMID:16061681 PMID:24726431 PMID:25449198 PMID:30581319 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Blnk B-cell linker increases expression ISO Camptothecin results in increased expression of BLNK mRNA CTD PMID:38460933 NCBI chr 1:249,703,064...249,770,533
Ensembl chr 1:239,753,648...239,821,113 		JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 increases expression ISO Camptothecin results in increased expression of BLOC1S2 mRNA CTD PMID:38460933 NCBI chr 1:252,973,818...252,980,873
Ensembl chr 1:243,024,614...243,031,653 		JBrowse link
G Bnip1 BCL2 interacting protein 1 increases expression ISO Camptothecin results in increased expression of BNIP1 mRNA CTD PMID:33770205 NCBI chr10:16,891,317...16,903,561
Ensembl chr10:16,386,841...16,399,157 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
decreases response to substance		 ISO Camptothecin results in decreased expression of BRCA1 mRNA
BRCA1 mRNA results in decreased susceptibility to Camptothecin		 CTD PMID:10344722 PMID:25269479 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression ISO Camptothecin results in decreased expression of BRCA2 mRNA CTD PMID:10344722 NCBI chr12:4,895,092...4,939,340
Ensembl chr12:59,819...100,567 		JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO Camptothecin results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr 1:215,160,764...215,172,540
Ensembl chr 1:205,733,872...205,743,421 		JBrowse link
G Btbd19 BTB domain containing 19 increases expression ISO Camptothecin results in increased expression of BTBD19 mRNA CTD PMID:38460933 NCBI chr 5:130,596,966...130,605,403
Ensembl chr 5:130,597,684...130,604,335 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Camptothecin results in increased expression of BTG2 mRNA CTD PMID:38460933 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G C13h1orf116 similar to human chromosome 1 open reading frame 116 increases expression ISO Camptothecin results in increased expression of C1ORF116 mRNA CTD PMID:38460933 NCBI chr13:44,739,716...44,753,695
Ensembl chr13:42,188,609...42,201,426 		JBrowse link
G C5ar1 complement C5a receptor 1 increases expression ISO Camptothecin results in increased expression of C5AR1 mRNA CTD PMID:38460933 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G C7h22orf23 similar to human chromosome 22 open reading frame 23 increases expression ISO Camptothecin results in increased expression of C22ORF23 mRNA CTD PMID:38460933 NCBI chr 7:112,585,341...112,592,938
Ensembl chr 7:110,704,894...110,712,487 		JBrowse link
G Cab39 calcium binding protein 39 decreases expression ISO Camptothecin results in decreased expression of CAB39 mRNA CTD PMID:17374387 NCBI chr 9:93,911,099...93,972,542
Ensembl chr 9:86,463,095...86,524,544 		JBrowse link
G Calcoco1 calcium binding and coiled coil domain 1 increases expression ISO Camptothecin results in increased expression of CALCOCO1 mRNA CTD PMID:38460933 NCBI chr 7:135,713,208...135,728,044
Ensembl chr 7:133,834,707...133,849,422 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta increases expression ISO Camptothecin results in increased expression of CAMK2B mRNA CTD PMID:38460933 NCBI chr14:85,059,166...85,148,121
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Casp2 caspase 2 increases splicing
increases expression		 ISO Camptothecin results in increased splicing of CASP2 mRNA
Camptothecin results in increased expression of CASP2 mRNA alternative form		 CTD PMID:14757846 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage		 ISO
EXP		 15-deoxyprostaglandin J2 promotes the reaction [Camptothecin results in increased activity of CASP3 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin results in increased activity of CASP3 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased activity of CASP3 protein]; [Camptothecin co-treated with FAS protein] results in increased activity of CASP3 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; Camptothecin promotes the reaction [15-deoxyprostaglandin J2 results in increased activity of CASP3 protein]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; SMN1 mRNA affects the reaction [Camptothecin results in increased activity of CASP3 protein]; THBS1 protein inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]
Cadmium Chloride inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; Cadmium inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; Dexamethasone inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; Tetrachlorodibenzodioxin promotes the reaction [Camptothecin results in increased cleavage of CASP3 protein]		 CTD PMID:10896673 PMID:15862279 PMID:15958570 PMID:16263807 PMID:16273314 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 increases expression ISO Camptothecin results in increased expression of CASP4 mRNA CTD PMID:38460933 NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
decreases expression		 ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased activity of CASP7 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP7 protein]
Camptothecin results in decreased expression of CASP7 mRNA		 CTD PMID:22302033 PMID:24726431 PMID:30581319 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
affects cleavage
increases activity
increases expression
decreases expression		 ISO
EXP		 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; [Camptothecin co-treated with FAS protein] results in increased activity of CASP8 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP8 protein; Lithium inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP8 protein]
Camptothecin affects the cleavage of CASP8 protein
Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]
Camptothecin results in decreased expression of CASP8 mRNA		 CTD PMID:10896673 PMID:15475000 PMID:15958570 PMID:19497415 PMID:19633536 More... NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases cleavage
increases expression
decreases expression		 ISO
EXP		 [Camptothecin co-treated with FAS protein] results in increased activity of CASP9 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP9 protein; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP9 protein]
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of CASP9 protein]; Cadmium Chloride inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]; Cadmium inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]; Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]
Camptothecin results in decreased expression of CASP9 mRNA		 CTD PMID:10896673 PMID:15958570 PMID:16263807 PMID:19497415 PMID:19633536 More... Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase increases activity
multiple interactions		 EXP Camptothecin results in increased activity of CAT protein
alpha-Tocopherol inhibits the reaction [Camptothecin results in increased activity of CAT protein]		 CTD PMID:25304969 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cav1 caveolin 1 decreases methylation ISO Camptothecin results in decreased methylation of CAV1 gene CTD PMID:30720231 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccdc63 coiled-coil domain containing 63 increases expression ISO Camptothecin results in increased expression of CCDC63 mRNA CTD PMID:38460933 NCBI chr12:40,085,146...40,113,820
Ensembl chr12:34,424,344...34,453,085 		JBrowse link
G Ccdc69 coiled-coil domain containing 69 increases expression ISO Camptothecin results in increased expression of CCDC69 mRNA CTD PMID:38460933 NCBI chr10:39,673,984...39,701,080
Ensembl chr10:39,173,282...39,199,878 		JBrowse link
G Ccdc88b coiled-coil domain containing 88B increases expression ISO Camptothecin results in increased expression of CCDC88B mRNA CTD PMID:38460933 NCBI chr 1:213,466,139...213,482,099
Ensembl chr 1:204,036,918...204,052,970 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Camptothecin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl26 C-C motif chemokine ligand 26 increases expression ISO Camptothecin results in increased expression of CCL26 mRNA CTD PMID:38460933 NCBI chr12:26,745,972...26,750,924
Ensembl chr12:21,109,421...21,114,335 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Camptothecin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Camptothecin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression		 ISO [Folic Acid co-treated with Camptothecin] results in decreased expression of CCNA2 mRNA
Camptothecin results in decreased expression of CCNA2 mRNA		 CTD PMID:30581319 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions
increases expression
decreases expression		 ISO [Butyrates co-treated with Camptothecin] results in decreased expression of CCNB1 protein; CDKN1A protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]
Camptothecin results in decreased expression of CCNB1 protein		 CTD PMID:16061681 PMID:23376119 PMID:30851366 PMID:30885713 PMID:31255635 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 affects localization ISO Camptothecin affects the localization of CCND1 protein CTD PMID:14647467 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO Camptothecin results in increased expression of CCNE1 protein CTD PMID:30851366 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccng2 cyclin G2 increases expression ISO Camptothecin results in increased expression of CCNG2 mRNA CTD PMID:38460933 NCBI chr14:15,088,694...15,097,190
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Cd164l2 CD164 molecule like 2 increases expression ISO Camptothecin results in increased expression of CD164L2 mRNA CTD PMID:38460933 NCBI chr 5:150,698,662...150,711,622
Ensembl chr 5:145,423,892...145,427,720 		JBrowse link
G Cd82 Cd82 molecule increases expression ISO Camptothecin results in increased expression of CD82 mRNA CTD PMID:38460933 NCBI chr 3:99,842,748...99,887,298
Ensembl chr 3:79,385,887...79,431,809 		JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO Camptothecin promotes the reaction [MAD2L1 protein binds to CDC20 protein] CTD PMID:30885713 NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Cdc42bpg CDC42 binding protein kinase gamma increases expression ISO Camptothecin results in increased expression of CDC42BPG mRNA CTD PMID:38460933 NCBI chr 1:213,037,603...213,057,764
Ensembl chr 1:203,608,574...203,628,502 		JBrowse link
G Cdh3 cadherin 3 increases expression ISO Camptothecin results in increased expression of CDH3 mRNA CTD PMID:38460933 NCBI chr19:51,303,414...51,353,900
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Cdip1 cell death-inducing p53 target 1 increases expression ISO Camptothecin results in increased expression of CDIP1 mRNA CTD PMID:38460933 NCBI chr10:11,278,213...11,303,415
Ensembl chr10:10,774,705...10,796,980 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO Camptothecin results in increased expression of and results in increased activity of CDK1 protein; CDKN1A protein affects the reaction [Camptothecin results in increased activity of CDK1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of and results in increased activity of CDK1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CDK1 protein] CTD PMID:30885713 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
increases activity		 ISO
EXP		 Camptothecin results in increased phosphorylation of and results in decreased activity of CDK2 protein
camptothecin increases kinase activity in rat cerebellar granule neurons		 CTD
RGD		 PMID:15141020 PMID:19151707 RGD:10053571 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 increases activity EXP camptothecin increases kinase activity in rat cerebellar granule neurons RGD PMID:19151707 RGD:10053571 NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO Camptothecin results in increased expression of CDK5R1 mRNA CTD PMID:33770205 NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases activity EXP camptothecin increases kinase activity in rat cerebellar granule neurons RGD PMID:19151707 RGD:10053571 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO Aspirin inhibits the reaction [Camptothecin results in increased expression of CDKN1A protein]; Camptothecin results in increased expression of and results in increased phosphorylation of CDKN1A protein; CDKN1A protein affects the reaction [Camptothecin results in increased activity of CDK1 protein]; CDKN1A protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; CDKN1A protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]
Camptothecin results in increased expression of CDKN1A mRNA; Camptothecin results in increased expression of CDKN1A protein		 CTD PMID:9673414 PMID:17555331 PMID:19212664 PMID:24211769 PMID:30022047 More... NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Camptothecin results in increased expression of CEACAM1 mRNA CTD PMID:17374387 PMID:38460933 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Cebpz CCAAT/enhancer binding protein zeta decreases expression ISO Camptothecin results in decreased expression of CEBPZ mRNA CTD PMID:17374387 NCBI chr 6:21,872,071...21,889,755
Ensembl chr 6:16,119,872...16,137,600 		JBrowse link
G Cep85l centrosomal protein 85-like increases methylation ISO Camptothecin results in increased methylation of CEP85L gene CTD PMID:30720231 NCBI chr20:32,568,417...32,739,449
Ensembl chr20:32,572,741...32,739,516 		JBrowse link
G Cfap96 cilia and flagella associated protein 96 increases expression ISO Camptothecin results in increased expression of C4ORF47 mRNA CTD PMID:38460933 NCBI chr16:53,023,623...53,048,176
Ensembl chr16:46,291,311...46,315,625 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein] CTD PMID:25449198 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
increases expression
decreases response to substance		 ISO 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]; Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]
3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form]
CHEK1 mRNA results in decreased susceptibility to Camptothecin		 CTD PMID:21646468 PMID:22403396 PMID:25269479 PMID:30555576 PMID:30720231 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression
increases phosphorylation
multiple interactions		 ISO Camptothecin results in increased expression of CHEK2 protein modified form
Camptothecin results in increased phosphorylation of CHEK2 protein
Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK2 protein modified form]		 CTD PMID:21646468 PMID:25269479 PMID:25977998 PMID:30720231 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Chga chromogranin A increases expression ISO Camptothecin results in increased expression of CHGA mRNA CTD PMID:38460933 NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G Chgb chromogranin B increases expression ISO Camptothecin results in increased expression of CHGB mRNA CTD PMID:38460933 NCBI chr 3:140,496,712...140,510,057
Ensembl chr 3:120,043,738...120,057,166 		JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit increases expression ISO Camptothecin results in increased expression of CHRNA9 mRNA CTD PMID:38460933 NCBI chr14:42,588,948...42,595,669
Ensembl chr14:42,235,226...42,242,192 		JBrowse link
G Chst2 carbohydrate sulfotransferase 2 increases expression ISO Camptothecin results in increased expression of CHST2 mRNA CTD PMID:38460933 NCBI chr 8:104,839,716...104,845,961
Ensembl chr 8:95,959,826...95,966,955 		JBrowse link
G Cimap1c ciliary microtubule associated protein 1C increases expression ISO Camptothecin results in increased expression of ODF3L1 mRNA CTD PMID:38460933 NCBI chr 8:66,144,726...66,176,985
Ensembl chr 8:57,248,746...57,281,004 		JBrowse link
G Clptm1l CLPTM1-like increases response to substance ISO CLPTM1L mutant form results in increased susceptibility to Camptothecin CTD PMID:22675468 NCBI chr 1:31,496,094...31,512,148
Ensembl chr 1:29,667,545...29,683,530 		JBrowse link
G Cltrn collectrin, amino acid transport regulator increases expression ISO Camptothecin results in increased expression of TMEM27 mRNA CTD PMID:38460933 NCBI chr  X:33,993,825...34,027,124
Ensembl chr  X:30,361,967...30,395,349 		JBrowse link
G Cnfn cornifelin increases expression ISO Camptothecin results in increased expression of CNFN mRNA CTD PMID:38460933 NCBI chr 1:80,949,699...80,953,747
Ensembl chr 1:80,951,600...80,953,747 		JBrowse link
G Coil coilin increases expression ISO Camptothecin results in increased expression of COIL mRNA CTD PMID:33770205 NCBI chr10:73,789,077...73,810,378
Ensembl chr10:73,789,488...73,810,393 		JBrowse link
G Col17a1 collagen type XVII alpha 1 chain increases expression ISO Camptothecin results in increased expression of COL17A1 mRNA CTD PMID:38460933 NCBI chr 1:256,472,648...256,518,857
Ensembl chr 1:246,531,367...246,577,632 		JBrowse link
G Col9a2 collagen type IX alpha 2 chain increases expression ISO Camptothecin results in increased expression of COL9A2 mRNA CTD PMID:38460933 NCBI chr 5:139,892,798...139,910,131
Ensembl chr 5:134,607,616...134,624,677 		JBrowse link
G Coro2a coronin 2A increases expression ISO Camptothecin results in increased expression of CORO2A mRNA CTD PMID:38460933 NCBI chr 5:65,623,820...65,677,483
Ensembl chr 5:60,828,247...60,859,035 		JBrowse link
G Cpa4 carboxypeptidase A4 increases expression ISO Camptothecin results in increased expression of CPA4 mRNA CTD PMID:38460933 NCBI chr 4:60,155,675...60,179,644
Ensembl chr 4:59,188,284...59,212,255 		JBrowse link
G Cpe carboxypeptidase E increases expression ISO Camptothecin results in increased expression of CPE mRNA CTD PMID:38460933 NCBI chr16:29,796,707...29,908,647
Ensembl chr16:25,030,276...25,142,233 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 increases expression ISO Camptothecin results in increased expression of CRABP2 mRNA CTD PMID:38460933 NCBI chr 2:175,714,862...175,719,208
Ensembl chr 2:173,416,857...173,421,379 		JBrowse link
G Crebbp CREB binding protein multiple interactions EXP Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]; Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]; pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]] CTD PMID:13679428 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Crx cone-rod homeobox decreases response to substance ISO CRX mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:85,667,971...85,681,852
Ensembl chr 1:76,540,141...76,545,818 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO Camptothecin results in increased expression of CRYAB mRNA CTD PMID:38460933 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Csdc2 cold shock domain containing C2 increases expression ISO Camptothecin results in increased expression of CSDC2 mRNA CTD PMID:38460933 NCBI chr 7:115,332,134...115,346,599
Ensembl chr 7:113,451,998...113,466,463 		JBrowse link
G Csta cystatin A increases expression ISO Camptothecin results in increased expression of CSTA mRNA CTD PMID:38460933 NCBI chr11:78,125,813...78,136,818
Ensembl chr11:64,620,483...64,631,488 		JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 increases expression ISO Camptothecin results in increased expression of CTHRC1 mRNA CTD PMID:38460933 NCBI chr 7:72,007,372...72,017,654
Ensembl chr 7:70,122,474...70,132,756 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO CTSB protein results in increased cleavage of [Camptothecin analog binds to ALB protein] CTD PMID:17378599 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsh cathepsin H increases expression ISO Camptothecin results in increased expression of CTSH mRNA CTD PMID:38460933 NCBI chr 8:99,488,756...99,507,639
Ensembl chr 8:90,608,941...90,627,824 		JBrowse link
G Cxxc4 CXXC finger protein 4 increases expression ISO Camptothecin results in increased expression of CXXC4 mRNA CTD PMID:38460933 NCBI chr 2:225,329,044...225,363,347
Ensembl chr 2:222,664,771...222,689,365 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization		 ISO 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin affects the localization of CYCS protein] CTD PMID:19481069 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases response to substance ISO CYP26B1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:118,599,356...118,616,176
Ensembl chr 4:117,041,808...117,058,628 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression
multiple interactions		 ISO Camptothecin results in decreased expression of CYP2B6 mRNA
Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]		 CTD PMID:29356861 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases expression
multiple interactions		 ISO Camptothecin results in decreased expression of CYP2C8 mRNA
Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP2C8 mRNA]		 CTD PMID:29356861
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] CTD PMID:29356861 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
decreases expression		 ISO Folic Acid inhibits the reaction [Camptothecin results in decreased expression of DDIT3 mRNA]; MYC protein affects the reaction [Camptothecin results in increased expression of DDIT3 protein]
Camptothecin results in increased expression of DDIT3 mRNA; Camptothecin results in increased expression of DDIT3 protein		 CTD PMID:30266318 PMID:30581319 PMID:38460933 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO Camptothecin results in increased expression of DDIT4L mRNA CTD PMID:38460933 NCBI chr 2:228,800,831...228,804,478
Ensembl chr 2:226,128,276...226,131,375 		JBrowse link
G Def6 DEF6 guanine nucleotide exchange factor increases expression ISO Camptothecin results in increased expression of DEF6 mRNA CTD PMID:38460933 NCBI chr20:6,270,323...6,291,724
Ensembl chr20:6,268,601...6,289,961 		JBrowse link
G Dgkz diacylglycerol kinase zeta decreases response to substance ISO DGKZ mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 3:98,359,804...98,401,847
Ensembl chr 3:77,904,150...77,946,099 		JBrowse link
G Dnah10 dynein, axonemal, heavy chain 10 increases expression ISO Camptothecin results in increased expression of DNAH10 mRNA CTD PMID:38460933 NCBI chr12:37,484,444...37,607,810
Ensembl chr12:31,822,733...32,007,069 		JBrowse link
G Dnai3 dynein axonemal intermediate chain 3 increases expression ISO Camptothecin results in increased expression of WDR63 mRNA CTD PMID:38460933 NCBI chr 2:237,608,202...237,666,465
Ensembl chr 2:234,929,677...235,006,173 		JBrowse link
G Dock8 dedicator of cytokinesis 8 increases expression ISO Camptothecin results in increased expression of DOCK8 mRNA CTD PMID:38460933 NCBI chr 1:232,075,468...232,268,830
Ensembl chr 1:222,649,309...222,842,474 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions
decreases expression
decreases activity		 ISO Camptothecin inhibits the reaction [Fluorouracil results in increased expression of DPYD mRNA]
Camptothecin results in decreased expression of DPYD mRNA
Camptothecin results in decreased activity of DPYD protein		 CTD PMID:16568373 NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 increases expression ISO Camptothecin results in increased expression of DPYSL4 mRNA CTD PMID:38460933 NCBI chr 1:203,312,646...203,328,523
Ensembl chr 1:193,883,106...193,898,914 		JBrowse link
G Dqx1 DEAQ box RNA-dependent ATPase 1 increases expression ISO Camptothecin results in increased expression of DQX1 mRNA CTD PMID:38460933 NCBI chr 4:117,121,216...117,130,315
Ensembl chr 4:115,563,752...115,572,590 		JBrowse link
G Draxin dorsal inhibitory axon guidance protein increases expression ISO Camptothecin results in increased expression of DRAXIN mRNA CTD PMID:38460933 NCBI chr 5:163,813,308...163,846,609
Ensembl chr 5:158,530,342...158,564,483 		JBrowse link
G Dsc3 desmocollin 3 increases expression ISO Camptothecin results in increased expression of DSC3 mRNA CTD PMID:38460933 NCBI chr18:11,654,833...11,688,871
Ensembl chr18:11,377,347...11,413,797 		JBrowse link
G Dsel dermatan sulfate epimerase-like increases expression ISO Camptothecin results in increased expression of DSEL mRNA CTD PMID:38460933 NCBI chr13:194,738...200,959
Ensembl chr13:175,805...192,647 		JBrowse link
G Dtwd1 DTW domain containing 1 increases expression ISO Camptothecin results in increased expression of DTWD1 mRNA CTD PMID:33770205 NCBI chr 3:133,845,768...133,859,965
Ensembl chr 3:113,392,457...113,408,105 		JBrowse link
G Dusp14 dual specificity phosphatase 14 increases expression ISO Camptothecin results in increased expression of DUSP14 mRNA CTD PMID:38460933 NCBI chr10:69,433,949...69,463,863
Ensembl chr10:68,935,330...68,965,329 		JBrowse link
G Dusp15 dual specificity phosphatase 15 increases expression ISO Camptothecin results in increased expression of DUSP15 mRNA CTD PMID:38460933 NCBI chr 3:161,868,746...161,880,432
Ensembl chr 3:141,408,498...141,418,999 		JBrowse link
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 increases expression ISO Camptothecin results in increased expression of DYRK3 mRNA CTD PMID:38460933 NCBI chr13:45,146,383...45,157,082
Ensembl chr13:42,594,121...42,604,778 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
increases expression		 ISO 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]; E2F1 protein promotes the reaction [Camptothecin results in increased expression of RRM2 protein] CTD PMID:22403396 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Camptothecin results in increased expression of E2F8 mRNA CTD PMID:33770205 NCBI chr 1:107,701,985...107,720,538
Ensembl chr 1:98,565,717...98,584,098 		JBrowse link
G Ebi3 Epstein-Barr virus induced 3 increases expression ISO Camptothecin results in increased expression of EBI3 mRNA CTD PMID:38460933 NCBI chr 9:861,441...874,731
Ensembl chr 9:783,617...787,544 		JBrowse link
G Ecm1 extracellular matrix protein 1 increases expression ISO Camptothecin results in increased expression of ECM1 mRNA CTD PMID:38460933 NCBI chr 2:185,976,439...185,981,656
Ensembl chr 2:183,287,322...183,292,671 		JBrowse link
G Efnb1 ephrin B1 increases expression ISO Camptothecin results in increased expression of EFNB1 mRNA CTD PMID:38460933 NCBI chr  X:68,297,529...68,310,335
Ensembl chr  X:64,257,351...64,270,157 		JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO Camptothecin results in increased expression of EI24 mRNA CTD PMID:17374387 NCBI chr 8:44,683,138...44,699,502
Ensembl chr 8:36,494,289...36,510,571 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation		 ISO Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein] CTD PMID:30266318 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions		 ISO
EXP		 Camptothecin results in increased phosphorylation of EIF2S1 protein
EIF2S1 protein affects the reaction [Camptothecin results in increased expression of ATG7 protein]; EIF2S1 protein affects the reaction [Camptothecin results in increased expression of BECN1 protein]; Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein]
[Camptothecin co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein		 CTD PMID:19046382 PMID:30266318 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 increases expression ISO Camptothecin results in increased expression of ELOVL3 mRNA CTD PMID:38460933 NCBI chr 1:254,938,731...254,942,559
Ensembl chr 1:244,997,287...245,001,115 		JBrowse link
G Enho energy homeostasis associated increases expression ISO Camptothecin results in increased expression of ENHO mRNA CTD PMID:38460933 NCBI chr 5:61,596,860...61,598,657
Ensembl chr 5:56,800,980...56,802,777 		JBrowse link
G Eomes eomesodermin increases expression ISO Camptothecin results in increased expression of EOMES mRNA CTD PMID:38460933 NCBI chr 8:127,059,215...127,067,070
Ensembl chr 8:118,181,777...118,188,316 		JBrowse link
G Ep300 E1A binding protein p300 decreases expression ISO Camptothecin results in decreased expression of EP300 mRNA; Camptothecin results in decreased expression of EP300 protein CTD PMID:10344722 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epm2aip1 EPM2A interacting protein 1 increases expression ISO Camptothecin results in increased expression of EPM2AIP1 mRNA CTD PMID:17374387 NCBI chr 8:120,112,265...120,119,613
Ensembl chr 8:111,233,826...111,241,871 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression		 ISO ERCC1 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]
Camptothecin results in decreased expression of ERCC1 mRNA		 CTD PMID:21227924 PMID:24792648 NCBI chr 1:88,099,308...88,135,966
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit multiple interactions
decreases response to substance		 ISO ERCC4 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]
ERCC4 protein results in decreased susceptibility to Camptothecin		 CTD PMID:21227924 NCBI chr10:2,926,085...2,958,176
Ensembl chr10:2,419,038...2,448,369
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Camptothecin binds to and results in decreased activity of ESR1 protein; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]]; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]] CTD PMID:25752796 PMID:30720231 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Camptothecin binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Exoc3l2 exocyst complex component 3-like 2 increases expression ISO Camptothecin results in increased expression of EXOC3L2 mRNA CTD PMID:38460933 NCBI chr 1:79,113,784...79,145,359
Ensembl chr 1:79,112,506...79,145,465 		JBrowse link
G Fam210b family with sequence similarity 210, member B increases expression ISO Camptothecin results in increased expression of FAM210B mRNA CTD PMID:38460933 NCBI chr 3:181,536,665...181,546,830
Ensembl chr 3:161,118,239...161,128,397 		JBrowse link
G Fam43a family with sequence similarity 43, member A increases expression ISO Camptothecin results in increased expression of FAM43A mRNA CTD PMID:38460933 NCBI chr11:83,633,165...83,636,313
Ensembl chr11:70,128,253...70,131,401 		JBrowse link
G Fam43b family with sequence similarity 43, member B increases expression ISO Camptothecin results in increased expression of FAM43B mRNA CTD PMID:38460933 NCBI chr 5:155,893,961...155,896,359
Ensembl chr 5:150,611,609...150,612,601 		JBrowse link
G Fam83h family with sequence similarity 83, member H increases expression ISO Camptothecin results in increased expression of FAM83H mRNA CTD PMID:38460933 NCBI chr 7:109,597,129...109,605,317
Ensembl chr 7:107,716,431...107,728,672 		JBrowse link
G Fam98c family with sequence similarity 98, member C increases expression ISO Camptothecin results in increased expression of FAM98C mRNA CTD PMID:38460933 NCBI chr 1:84,452,806...84,456,414
Ensembl chr 1:84,452,814...84,456,385 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased expression of and affects the localization of FAS protein]; [Camptothecin co-treated with FAS protein] results in decreased expression of XIAP protein; [Camptothecin co-treated with FAS protein] results in increased activity of CASP3 protein; [Camptothecin co-treated with FAS protein] results in increased activity of CASP8 protein; [Camptothecin co-treated with FAS protein] results in increased activity of CASP9 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of BID protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP3 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP8 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP9 protein; Camptothecin results in increased expression of and affects the localization of FAS protein; Lithium inhibits the reaction [Camptothecin results in increased expression of and affects the localization of FAS protein]
Camptothecin results in increased expression of FAS mRNA		 CTD PMID:15475000 PMID:15958570 PMID:19633536 PMID:38460933 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fbxo2 F-box protein 2 increases expression ISO Camptothecin results in increased expression of FBXO2 mRNA CTD PMID:38460933 NCBI chr 5:163,876,079...163,881,508
Ensembl chr 5:158,592,925...158,598,355 		JBrowse link
G Fdxr ferredoxin reductase increases expression ISO Camptothecin results in increased expression of FDXR mRNA CTD PMID:17374387 NCBI chr10:101,006,845...101,015,582
Ensembl chr10:100,507,865...100,516,658 		JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 increases expression ISO Camptothecin results in increased expression of FEZ1 mRNA CTD PMID:38460933 NCBI chr 8:44,733,288...44,778,519
Ensembl chr 8:36,544,535...36,589,683 		JBrowse link
G Fgd3 FYVE, RhoGEF and PH domain containing 3 increases expression ISO Camptothecin results in increased expression of FGD3 mRNA CTD PMID:38460933 NCBI chr17:15,531,237...15,593,678
Ensembl chr17:15,336,837...15,385,712 		JBrowse link
G Fgfbp3 fibroblast growth factor binding protein 3 increases expression ISO Camptothecin results in increased expression of FGFBP3 mRNA CTD PMID:38460933 NCBI chr 1:244,056,569...244,058,574
Ensembl chr 1:234,644,019...234,646,547 		JBrowse link
G Foxd3 forkhead box D3 increases expression ISO Camptothecin results in increased expression of FOXD3 mRNA CTD PMID:38460933 NCBI chr 5:119,450,532...119,452,898
Ensembl chr 5:114,335,408...114,336,817 		JBrowse link
G Frzb frizzled-related protein increases expression ISO Camptothecin results in increased expression of FRZB mRNA CTD PMID:38460933 NCBI chr 3:85,739,162...85,772,168
Ensembl chr 3:65,332,277...65,365,208 		JBrowse link
G Fxn frataxin increases expression ISO Camptothecin results in increased expression of FXN protein CTD PMID:23418481 NCBI chr 1:231,300,457...231,323,989
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 increases expression ISO Camptothecin results in increased expression of FXYD3 mRNA CTD PMID:38460933 NCBI chr 1:95,432,918...95,440,129 JBrowse link
G Fzd1 frizzled class receptor 1 decreases methylation ISO Camptothecin results in decreased methylation of FZD1 gene CTD PMID:30720231 NCBI chr 4:30,265,074...30,269,472
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643 		JBrowse link
G Fzd8 frizzled class receptor 8 decreases methylation ISO Camptothecin results in decreased methylation of FZD8 gene CTD PMID:30720231 NCBI chr17:62,007,849...62,015,485
Ensembl chr17:57,314,450...57,320,650 		JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 increases expression ISO Camptothecin results in increased expression of GABBR2 mRNA CTD PMID:38460933 NCBI chr 5:65,743,073...66,083,695
Ensembl chr 5:60,947,526...61,288,104 		JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta increases expression ISO Camptothecin results in increased expression of GABRD mRNA CTD PMID:38460933 NCBI chr 5:171,240,813...171,252,709
Ensembl chr 5:165,958,484...165,970,411 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression
multiple interactions
increases expression		 ISO Camptothecin results in decreased expression of GADD45A mRNA
Folic Acid inhibits the reaction [Camptothecin results in decreased expression of GADD45A mRNA]
Camptothecin results in increased expression of GADD45A mRNA		 CTD PMID:24792648 PMID:30581319 PMID:38460933 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO Camptothecin results in increased expression of GADD45G mRNA CTD PMID:24792648 NCBI chr17:13,528,606...13,530,351
Ensembl chr17:13,376,839...13,378,610 		JBrowse link
G Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 increases expression ISO Camptothecin results in increased expression of GALNT5 mRNA CTD PMID:38460933 NCBI chr 3:62,982,465...63,028,724
Ensembl chr 3:42,573,622...42,619,881 		JBrowse link
G Gast gastrin increases expression ISO Camptothecin results in increased expression of GAST mRNA CTD PMID:38460933 NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression ISO Camptothecin results in increased expression of GCH1 mRNA CTD PMID:38460933 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Camptothecin results in increased expression of GDF15 mRNA CTD PMID:38460933 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gdpd1 glycerophosphodiester phosphodiesterase domain containing 1 increases expression ISO Camptothecin results in increased expression of GDPD1 mRNA CTD PMID:38460933 NCBI chr10:72,318,716...72,381,143
Ensembl chr10:71,840,497...71,883,850 		JBrowse link
G Gipr gastric inhibitory polypeptide receptor increases expression ISO Camptothecin results in increased expression of GIPR mRNA CTD PMID:38460933 NCBI chr 1:87,932,316...87,956,084
Ensembl chr 1:78,805,593...78,814,462 		JBrowse link
G Git2 GIT ArfGAP 2 decreases response to substance ISO GIT2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr12:47,490,350...47,531,232
Ensembl chr12:41,829,730...41,871,097 		JBrowse link
G Gjb3 gap junction protein, beta 3 increases expression ISO Camptothecin results in increased expression of GJB3 mRNA CTD PMID:38460933 NCBI chr 5:144,933,692...144,939,435
Ensembl chr 5:139,649,195...139,654,980 		JBrowse link
G Gjd3 gap junction protein, delta 3 increases expression ISO Camptothecin results in increased expression of GJD3 mRNA CTD PMID:38460933 NCBI chr10:84,429,923...84,432,011
Ensembl chr10:83,934,135...83,934,971 		JBrowse link
G Gkn2 gastrokine 2 increases expression ISO Camptothecin results in increased expression of GKN2 mRNA CTD PMID:38460933 NCBI chr 4:121,335,642...121,381,680
Ensembl chr 4:119,818,280...119,824,363 		JBrowse link
G Glipr2 GLI pathogenesis-related 2 increases expression ISO Camptothecin results in increased expression of GLIPR2 mRNA CTD PMID:38460933 NCBI chr 5:62,966,163...62,998,016
Ensembl chr 5:58,170,425...58,202,272 		JBrowse link
G Gls2 glutaminase 2 increases expression ISO Camptothecin results in increased expression of GLS2 mRNA CTD PMID:38460933 NCBI chr 7:1,201,757...1,218,014
Ensembl chr 7:617,288...633,426 		JBrowse link
G Gm2a ganglioside GM2 activator increases expression ISO Camptothecin results in increased expression of GM2A mRNA CTD PMID:38460933 NCBI chr10:39,719,919...39,732,452
Ensembl chr10:39,219,243...39,231,757 		JBrowse link
G Gmfg glia maturation factor, gamma increases expression ISO Camptothecin results in increased expression of GMFG mRNA CTD PMID:38460933 NCBI chr 1:92,856,154...92,866,722
Ensembl chr 1:83,728,776...83,739,183 		JBrowse link
G Golt1a golgi transport 1A increases expression ISO Camptothecin results in increased expression of GOLT1A mRNA CTD PMID:38460933 NCBI chr13:47,312,412...47,325,176
Ensembl chr13:44,760,380...44,773,122 		JBrowse link
G Gpr132 G protein-coupled receptor 132 increases expression ISO Camptothecin results in increased expression of GPR132 mRNA CTD PMID:38460933 NCBI chr 6:137,745,142...137,763,037
Ensembl chr 6:131,924,160...131,942,168 		JBrowse link
G Gpr3 G protein-coupled receptor 3 increases expression ISO Camptothecin results in increased expression of GPR3 mRNA CTD PMID:38460933 NCBI chr 5:150,695,406...150,698,526
Ensembl chr 5:145,411,510...145,414,590 		JBrowse link
G Gpr87 G protein-coupled receptor 87 increases expression ISO Camptothecin results in increased expression of GPR87 mRNA CTD PMID:38460933 NCBI chr 2:145,589,630...145,608,094
Ensembl chr 2:143,439,735...143,458,190 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Camptothecin results in increased expression of GPX1 mRNA CTD PMID:38460933 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance ISO GPX4 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gramd2b GRAM domain containing 2B increases expression ISO Camptothecin results in increased expression of GRAMD3 mRNA CTD PMID:38460933 NCBI chr18:52,082,128...52,180,056
Ensembl chr18:49,884,014...49,981,953 		JBrowse link
G Grhl3 grainyhead-like transcription factor 3 increases expression ISO Camptothecin results in increased expression of GRHL3 mRNA CTD PMID:38460933 NCBI chr 5:153,057,760...153,089,890
Ensembl chr 5:147,774,160...147,806,160 		JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B increases expression ISO Camptothecin results in increased expression of GRIN3B mRNA CTD PMID:38460933 NCBI chr 7:10,381,495...10,387,817
Ensembl chr 7:9,730,862...9,737,183 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity		 EXP alpha-Tocopherol inhibits the reaction [Camptothecin results in decreased activity of GSR protein] CTD PMID:25304969 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
decreases response to substance		 ISO Camptothecin results in increased expression of GSTP1 protein
GSTP1 protein polymorphism results in decreased susceptibility to Camptothecin; GSTP1 protein results in decreased susceptibility to Camptothecin		 CTD PMID:14732228 PMID:15500952 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gtf3c6 general transcription factor 3C subunit 6 increases expression ISO Camptothecin results in increased expression of GTF3C6 mRNA CTD PMID:38460933 NCBI chr20:45,210,906...45,222,888
Ensembl chr20:43,655,875...43,667,873 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
increases phosphorylation		 ISO
EXP		 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; [MIR138-1 results in decreased expression of H2AX] which results in increased susceptibility to Camptothecin; [Propyl Gallate results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; ERCC1 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; ERCC4 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]]; H2AX gene mutant form inhibits the reaction [MIR138-1 results in increased susceptibility to Camptothecin]; palbociclib inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; PPP2R2A protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; PPP2R5C protein promotes the reaction [Camptothecin results in increased expression of H2AX protein modified form]; PPP2R5E protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; TDP1 protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; TDP1 protein inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]
Camptothecin results in increased expression of H2AX protein; Camptothecin results in increased expression of H2AX protein modified form
Camptothecin results in increased phosphorylation of H2AX protein		 CTD PMID:17875725 PMID:21227924 PMID:21646468 PMID:21693595 PMID:22302033 More... NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Camptothecin results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hand1 heart and neural crest derivatives expressed 1 increases expression ISO Camptothecin results in increased expression of HAND1 mRNA CTD PMID:38460933 NCBI chr10:42,507,117...42,509,684
Ensembl chr10:42,006,651...42,009,213 		JBrowse link
G Hemk1 HemK methyltransferase family member 1 decreases response to substance ISO HEMK1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 8:116,878,317...116,889,342
Ensembl chr 8:107,999,644...108,010,256 		JBrowse link
G Hes6 hes family bHLH transcription factor 6 increases expression ISO Camptothecin results in increased expression of HES6 mRNA CTD PMID:38460933 NCBI chr 9:99,449,375...99,451,343
Ensembl chr 9:92,001,841...92,003,559 		JBrowse link
G Hic1 HIC ZBTB transcriptional repressor 1 increases expression ISO Camptothecin results in increased expression of HIC1 mRNA CTD PMID:38460933 NCBI chr10:60,512,855...60,517,812
Ensembl chr10:60,011,528...60,019,475 		JBrowse link
G Hist2h2be histone cluster 2 H2B family member E increases expression ISO Camptothecin results in increased expression of HIST2H2BE mRNA CTD PMID:38460933 NCBI chr 2:186,469,452...186,471,899 JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [HNRNPC protein binds to HNRNPC protein alternative form] which results in decreased susceptibility to Camptothecin CTD PMID:16960656 NCBI chr15:27,253,098...27,282,779
Ensembl chr15:24,779,450...24,809,183 		JBrowse link
G Hoxa1 homeobox A1 decreases response to substance
multiple interactions		 ISO HOXA1 mRNA results in decreased susceptibility to Camptothecin
Camptothecin inhibits the reaction [Vitamin A results in increased expression of HOXA1]		 CTD PMID:25269479 PMID:26820057 NCBI chr 4:82,586,505...82,589,209
Ensembl chr 4:81,255,883...81,258,504 		JBrowse link
G Hoxb13 homeo box B13 increases expression ISO Camptothecin results in increased expression of HOXB13 mRNA CTD PMID:38460933 NCBI chr10:81,657,074...81,659,347
Ensembl chr10:81,160,498...81,162,777 		JBrowse link
G Hoxc13 homeobox C13 increases expression ISO Camptothecin results in increased expression of HOXC13 mRNA CTD PMID:38460933 NCBI chr 7:135,937,126...135,943,962
Ensembl chr 7:134,058,640...134,064,800 		JBrowse link
G Hs3st6 heparan sulfate-glucosamine 3-sulfotransferase 6 increases expression ISO Camptothecin results in increased expression of HS3ST6 mRNA CTD PMID:38460933 NCBI chr10:14,286,555...14,292,660
Ensembl chr10:13,781,993...13,788,133 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO Camptothecin results in increased expression of HSPA6 mRNA CTD PMID:38460933 NCBI chr13:85,805,911...85,807,052 JBrowse link
G Hspb8 heat shock protein family B (small) member 8 increases expression ISO Camptothecin results in increased expression of HSPB8 mRNA CTD PMID:38460933 NCBI chr12:45,835,899...45,866,449
Ensembl chr12:40,176,532...40,191,185 		JBrowse link
G Ibsp integrin-binding sialoprotein decreases response to substance ISO IBSP mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr14:5,744,497...5,757,242
Ensembl chr14:5,439,829...5,452,693 		JBrowse link
G Ifi35 interferon-induced protein 35 increases expression ISO Camptothecin results in increased expression of IFI35 mRNA CTD PMID:38460933 NCBI chr10:86,881,270...86,889,523
Ensembl chr10:86,381,010...86,389,952 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 increases expression ISO Camptothecin results in increased expression of IFIH1 mRNA CTD PMID:38460933 NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:47,227,364...47,275,456 		JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression ISO Camptothecin results in increased expression of IFIT2 mRNA CTD PMID:38460933 NCBI chr 1:241,515,735...241,521,799
Ensembl chr 1:232,102,570...232,108,635 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 increases expression ISO Camptothecin results in increased expression of IFIT3 mRNA CTD PMID:38460933 NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:232,114,166...232,119,307 		JBrowse link
G Il1b interleukin 1 beta decreases response to substance ISO IL1B protein results in decreased susceptibility to Camptothecin CTD PMID:16356833 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Camptothecin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Ildr2 immunoglobulin-like domain containing receptor 2 increases expression ISO Camptothecin results in increased expression of ILDR2 mRNA CTD PMID:38460933 NCBI chr13:81,051,723...81,113,590
Ensembl chr13:78,518,802...78,576,924 		JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha increases expression ISO Camptothecin results in increased expression of INA mRNA CTD PMID:38460933 NCBI chr 1:255,838,129...255,849,680
Ensembl chr 1:245,896,775...245,908,330 		JBrowse link
G Inka1 inka box actin regulator 1 increases expression ISO Camptothecin results in increased expression of FAM212A mRNA CTD PMID:38460933 NCBI chr 8:117,552,875...117,554,565
Ensembl chr 8:108,674,263...108,675,953 		JBrowse link
G Inpp1 inositol polyphosphate-1-phosphatase increases expression ISO Camptothecin results in increased expression of INPP1 mRNA CTD PMID:38460933 NCBI chr 9:56,161,816...56,209,774
Ensembl chr 9:48,669,901...48,717,793 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D increases expression ISO Camptothecin results in increased expression of INPP5D mRNA CTD PMID:38460933 NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Insyn2a inhibitory synaptic factor 2A increases expression ISO Camptothecin results in increased expression of INSYN2A mRNA CTD PMID:38460933 NCBI chr 1:199,127,735...199,183,077
Ensembl chr 1:189,697,878...189,752,922 		JBrowse link
G Irf5 interferon regulatory factor 5 increases expression ISO Camptothecin results in increased expression of IRF5 mRNA CTD PMID:38460933 NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:58,127,640...58,139,267 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression ISO Camptothecin results in increased expression of ISG15 mRNA CTD PMID:38460933 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression ISO Camptothecin results in increased expression of ISG20 mRNA CTD PMID:38460933 NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:132,815,123...132,837,027 		JBrowse link
G Itm2a integral membrane protein 2A increases expression ISO Camptothecin results in increased expression of ITM2A mRNA CTD PMID:38460933 NCBI chr  X:76,559,183...76,565,144
Ensembl chr  X:72,486,381...72,492,363 		JBrowse link
G Itpkc inositol-trisphosphate 3-kinase C increases expression ISO Camptothecin results in increased expression of ITPKC mRNA CTD PMID:38460933 NCBI chr 1:91,628,606...91,650,182
Ensembl chr 1:82,500,957...82,522,779 		JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 decreases expression ISO Camptothecin results in decreased expression of JARID2 mRNA CTD PMID:33770205 NCBI chr17:19,983,217...20,163,598
Ensembl chr17:19,777,266...19,955,690 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
multiple interactions		 ISO
EXP		 Camptothecin results in increased expression of JUN protein
Camptothecin results in increased phosphorylation of JUN protein
Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of JUN protein]; MAPK8 protein affects the reaction [Camptothecin results in increased phosphorylation of JUN protein]		 CTD PMID:9751194 PMID:15585644 PMID:30266318 PMID:30885713 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kank3 KN motif and ankyrin repeat domains 3 increases expression ISO Camptothecin results in increased expression of KANK3 mRNA CTD PMID:38460933 NCBI chr 7:15,296,538...15,309,838
Ensembl chr 7:14,594,422...14,607,675 		JBrowse link
G Kcnj12 potassium inwardly-rectifying channel, subfamily J, member 12 increases expression ISO Camptothecin results in increased expression of KCNJ12 mRNA CTD PMID:38460933 NCBI chr10:46,196,110...46,245,008
Ensembl chr10:45,696,849...45,745,492 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 decreases response to substance ISO KCNK2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr13:103,297,387...103,494,686
Ensembl chr13:100,766,113...100,963,435 		JBrowse link
G Kcnk6 potassium two pore domain channel subfamily K member 6 increases expression ISO Camptothecin results in increased expression of KCNK6 mRNA CTD PMID:38460933 NCBI chr 1:93,652,888...93,661,419
Ensembl chr 1:84,525,590...84,534,677 		JBrowse link
G Kcns2 potassium voltage-gated channel, modifier subfamily S, member 2 increases expression ISO Camptothecin results in increased expression of KCNS2 mRNA CTD PMID:38460933 NCBI chr 7:67,907,492...67,913,562
Ensembl chr 7:66,022,352...66,028,422 		JBrowse link
G Kdm6b lysine demethylase 6B increases expression ISO Camptothecin results in increased expression of KDM6B mRNA CTD PMID:38460933 NCBI chr10:54,619,520...54,641,014
Ensembl chr10:54,121,848...54,130,794 		JBrowse link
G Kif17 kinesin family member 17 increases expression ISO Camptothecin results in increased expression of KIF17 mRNA CTD PMID:38460933 NCBI chr 5:155,765,592...155,802,941
Ensembl chr 5:150,481,578...150,519,638 		JBrowse link
G Klc3 kinesin light chain 3 increases expression ISO Camptothecin results in increased expression of KLC3 mRNA CTD PMID:38460933 NCBI chr 1:88,173,842...88,183,806
Ensembl chr 1:79,045,844...79,055,416 		JBrowse link
G Klhdc7a kelch domain containing 7A increases expression ISO Camptothecin results in increased expression of KLHDC7A mRNA CTD PMID:38460933 NCBI chr 5:157,501,740...157,507,843
Ensembl chr 5:152,221,033...152,224,551 		JBrowse link
G Klhl42 kelch-like family, member 42 increases expression ISO Camptothecin results in increased expression of KLHL42 mRNA CTD PMID:33770205 NCBI chr 4:179,999,655...180,027,283
Ensembl chr 4:180,004,580...180,027,283 		JBrowse link
G Klrg2 killer cell lectin like receptor G2 increases expression ISO Camptothecin results in increased expression of KLRG2 mRNA CTD PMID:38460933 NCBI chr 4:68,314,347...68,341,759
Ensembl chr 4:67,363,919...67,374,147 		JBrowse link
G Krt15 keratin 15 increases expression ISO Camptothecin results in increased expression of KRT15 mRNA CTD PMID:38460933 NCBI chr10:85,567,197...85,571,014
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt19 keratin 19 increases expression ISO Camptothecin results in increased expression of KRT19 mRNA CTD PMID:38460933 NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt32 keratin 32 increases expression ISO Camptothecin results in increased expression of KRT32 mRNA CTD PMID:38460933 NCBI chr10:85,513,951...85,520,978
Ensembl chr10:85,013,554...85,020,534 		JBrowse link
G Krtap3-1 keratin associated protein 3-1 increases expression ISO Camptothecin results in increased expression of KRTAP3-1 mRNA CTD PMID:38460933 NCBI chr10:85,023,843...85,024,139
Ensembl chr10:84,527,448...84,528,041 		JBrowse link
G Lacc1 laccase domain containing 1 increases expression ISO Camptothecin results in increased expression of LACC1 mRNA CTD PMID:38460933 NCBI chr15:58,799,477...58,816,840
Ensembl chr15:52,395,183...52,407,545 		JBrowse link
G Lamc3 laminin subunit gamma 3 increases expression ISO Camptothecin results in increased expression of LAMC3 mRNA CTD PMID:38460933 NCBI chr 3:35,562,989...35,624,460
Ensembl chr 3:15,165,220...15,226,697 		JBrowse link
G Lamp3 lysosomal-associated membrane protein 3 increases expression ISO Camptothecin results in increased expression of LAMP3 mRNA CTD PMID:38460933 NCBI chr11:94,657,817...94,726,451
Ensembl chr11:81,193,649...81,221,784 		JBrowse link
G Lce1f late cornified envelope 1F increases expression ISO Camptothecin results in increased expression of LCE1F mRNA CTD PMID:38460933 NCBI chr 2:178,305,786...178,307,372
Ensembl chr 2:178,305,786...178,307,372 		JBrowse link
G Lgals1 galectin 1 decreases expression ISO Camptothecin results in decreased expression of LGALS1 mRNA; Camptothecin results in decreased expression of LGALS1 protein CTD PMID:19483324 NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Lhx3 LIM homeobox 3 increases expression ISO Camptothecin results in increased expression of LHX3 mRNA CTD PMID:38460933 NCBI chr 3:29,424,620...29,432,637
Ensembl chr 3:9,027,425...9,034,480 		JBrowse link
G Lhx6 LIM homeobox 6 increases expression ISO Camptothecin results in increased expression of LHX6 mRNA CTD PMID:38460933 NCBI chr 3:39,829,846...39,853,681
Ensembl chr 3:19,433,494...19,456,061 		JBrowse link
G Lipg lipase G, endothelial type increases expression ISO Camptothecin results in increased expression of LIPG mRNA CTD PMID:38460933 NCBI chr18:70,790,077...70,811,259
Ensembl chr18:68,514,923...68,536,260 		JBrowse link
G Lpin3 lipin 3 increases expression ISO Camptothecin results in increased expression of LPIN3 mRNA CTD PMID:38460933 NCBI chr 3:169,953,479...169,978,034
Ensembl chr 3:149,534,051...149,558,327 		JBrowse link
G Lrch4 leucine rich repeats and calponin homology domain containing 4 decreases response to substance ISO LRCH4 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr12:24,694,364...24,709,354
Ensembl chr12:19,057,587...19,068,577 		JBrowse link
G Lrp1 LDL receptor related protein 1 increases expression ISO Camptothecin results in increased expression of LRP1 mRNA CTD PMID:38460933 NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 multiple interactions
increases expression		 ISO Camptothecin promotes the reaction [MAD2L1 protein binds to CDC20 protein]; CDKN1A protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of and results in increased activity of CDK1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP8 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP9 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]
Camptothecin results in increased expression of MAD2L1 mRNA; Camptothecin results in increased expression of MAD2L1 protein		 CTD PMID:30885713 NCBI chr 4:97,236,419...97,247,603
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Maf MAF bZIP transcription factor increases expression ISO Camptothecin results in increased expression of MAF mRNA CTD PMID:38460933 NCBI chr19:60,259,200...60,622,145
Ensembl chr19:43,360,342...43,712,365 		JBrowse link
G Mafa MAF bZIP transcription factor A increases expression ISO Camptothecin results in increased expression of MAFA mRNA CTD PMID:38460933 NCBI chr 7:109,313,021...109,315,813
Ensembl chr 7:107,433,605...107,434,690 		JBrowse link
G Mageh1 MAGE family member H1 increases expression ISO Camptothecin results in increased expression of MAGEH1 mRNA CTD PMID:38460933 NCBI chr  X:21,725,709...21,726,965
Ensembl chr  X:18,349,774...18,351,516 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases expression ISO Camptothecin results in increased expression of MAP2K3 mRNA CTD PMID:17374387 NCBI chr10:46,107,639...46,128,986
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Camptothecin results in decreased expression of MAP3K5 mRNA CTD PMID:17374387 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases response to substance ISO MAP3K7 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK1 protein CTD PMID:24095863 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK3 protein CTD PMID:24095863 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO Camptothecin results in increased phosphorylation of MAPK8 protein
MAPK8 protein affects the reaction [Camptothecin results in increased activity of SP1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CDK1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased phosphorylation of JUN protein]		 CTD PMID:30885713 PMID:31255635 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Camptothecin results in increased phosphorylation of MAPK9 protein CTD PMID:15585644 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapkbp1 mitogen activated protein kinase binding protein 1 increases expression ISO Camptothecin results in increased expression of MAPKBP1 mRNA CTD PMID:38460933 NCBI chr 3:127,401,612...127,452,152
Ensembl chr 3:106,947,827...106,996,199 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Camptothecin results in decreased expression of MAPT mRNA; Camptothecin results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Marveld3 MARVEL domain containing 3 increases expression ISO Camptothecin results in increased expression of MARVELD3 mRNA CTD PMID:38460933 NCBI chr19:54,818,180...54,832,871
Ensembl chr19:37,905,638...37,923,420 		JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; [Propyl Gallate results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Camptothecin results in increased activity of and affects the localization of MDC1 protein; Propyl Gallate inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 NCBI chr20:2,898,496...2,914,960
Ensembl chr20:2,895,505...2,910,240 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Camptothecin results in increased expression of MDM2 protein CTD PMID:17555331 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Metrnl meteorin-like, glial cell differentiation regulator increases expression ISO Camptothecin results in increased expression of METRNL mRNA CTD PMID:38460933 NCBI chr10:107,462,148...107,476,143
Ensembl chr10:106,963,880...106,977,869 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO Camptothecin results in decreased expression of MGMT mRNA CTD PMID:18492797 NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mib2 MIB E3 ubiquitin protein ligase 2 increases expression ISO Camptothecin results in increased expression of MIB2 mRNA CTD PMID:38460933 NCBI chr 5:171,526,037...171,542,479
Ensembl chr 5:166,243,776...166,259,650 		JBrowse link
G Mir138-1 microRNA 138-1 multiple interactions
increases response to substance		 ISO [MIR138-1 results in decreased expression of H2AX] which results in increased susceptibility to Camptothecin; H2AX gene mutant form inhibits the reaction [MIR138-1 results in increased susceptibility to Camptothecin] CTD PMID:21693595 NCBI chr 8:131,178,434...131,178,532
Ensembl chr 8:122,300,966...122,301,064 		JBrowse link
G Mir145 microRNA 145 increases expression
decreases expression		 ISO Camptothecin results in increased expression of MIR145 mRNA
Camptothecin results in decreased expression of MIR145 mRNA		 CTD PMID:24726431 NCBI chr18:57,369,983...57,370,070
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Mir34a microRNA 34a increases expression ISO Camptothecin results in increased expression of MIR34A mRNA CTD PMID:24726431 NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 increases expression ISO Camptothecin results in increased expression of MKNK2 mRNA CTD PMID:38460933 NCBI chr 7:9,690,385...9,701,527
Ensembl chr 7:9,039,728...9,050,827 		JBrowse link
G Mmp11 matrix metallopeptidase 11 increases expression ISO Camptothecin results in increased expression of MMP11 mRNA CTD PMID:38460933 NCBI chr20:12,730,284...12,739,067
Ensembl chr20:12,730,836...12,739,628 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases response to substance
decreases methylation		 ISO MMP9 mRNA results in decreased susceptibility to Camptothecin
Camptothecin results in decreased methylation of MMP9 gene		 CTD PMID:25269479 PMID:30720231 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mr1 major histocompatibility complex, class I-related increases expression ISO Camptothecin results in increased expression of MR1 mRNA CTD PMID:38460933 NCBI chr13:69,850,420...69,868,302
Ensembl chr13:67,299,585...67,317,970 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO Camptothecin results in decreased expression of MRE11 mRNA CTD PMID:24792648 NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Mrps33 mitochondrial ribosomal protein S33 increases expression ISO Camptothecin results in increased expression of MRPS33 mRNA CTD PMID:38460933 NCBI chr 4:69,563,501...69,572,317
Ensembl chr 4:68,596,729...68,605,428 		JBrowse link
G Mtmr2 myotubularin related protein 2 decreases response to substance ISO MTMR2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 8:18,899,303...18,949,767
Ensembl chr 8:10,617,993...10,668,172 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO Camptothecin results in decreased expression of MTOR protein CTD PMID:31255635 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mx1 MX dynamin like GTPase 1 increases expression ISO Camptothecin results in increased expression of MX1 mRNA CTD PMID:38460933 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:36,799,660...36,823,507 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
affects localization
multiple interactions		 ISO Camptothecin results in increased expression of MYC mRNA
Camptothecin affects the localization of MYC protein
Camptothecin results in increased expression of and results in increased activity of MYC protein; MYC protein affects the reaction [Camptothecin results in increased expression of ATF4 protein]; MYC protein affects the reaction [Camptothecin results in increased expression of DDIT3 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein]; TERT protein affects the reaction [Camptothecin results in increased expression of MYC protein]		 CTD PMID:30266318 PMID:30851366 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myo1e myosin IE decreases expression ISO Camptothecin results in decreased expression of MYO1E mRNA CTD PMID:33770205 NCBI chr 8:79,768,828...79,961,048
Ensembl chr 8:70,887,870...71,080,169 		JBrowse link
G Nadsyn1 NAD synthetase 1 increases expression ISO Camptothecin results in increased expression of NADSYN1 mRNA CTD PMID:38460933 NCBI chr 1:208,410,914...208,439,242
Ensembl chr 1:198,981,604...199,009,869 		JBrowse link
G Nap1l5 nucleosome assembly protein 1-like 5 increases expression ISO Camptothecin results in increased expression of NAP1L5 mRNA CTD PMID:38460933 NCBI chr 4:89,352,834...89,354,704
Ensembl chr 4:88,022,569...88,024,654 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases response to substance ISO NCAM1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Nck2 NCK adaptor protein 2 decreases expression ISO Camptothecin results in decreased expression of NCK2 mRNA CTD PMID:17374387 NCBI chr 9:53,206,006...53,332,417
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Camptothecin inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]] CTD PMID:29356861 NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO Camptothecin inhibits the reaction [NCOR2 protein binds to NR1I2 protein] CTD PMID:29356861 NCBI chr12:37,127,736...37,289,612
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Ncr3lg1 natural killer cell cytotoxicity receptor 3 ligand 1 increases expression ISO Camptothecin results in increased expression of NCR3LG1 mRNA CTD PMID:38460933 NCBI chr 1:105,701,953...105,718,251
Ensembl chr 1:96,574,455...96,580,466 		JBrowse link
G Ndufc1 NADH:ubiquinone oxidoreductase subunit C1 increases expression ISO Camptothecin results in increased expression of NDUFC1 mRNA CTD PMID:38460933 NCBI chr 2:137,597,944...137,601,819
Ensembl chr 2:135,447,119...135,450,874 		JBrowse link
G Nefl neurofilament light chain increases expression ISO Camptothecin results in increased expression of NEFL mRNA CTD PMID:38460933 NCBI chr15:46,477,330...46,481,203
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nefm neurofilament medium chain increases expression ISO Camptothecin results in increased expression of NEFM mRNA CTD PMID:38460933 NCBI chr15:46,535,857...46,541,161
Ensembl chr15:42,360,454...42,365,755 		JBrowse link
G Neurl3 neuralized E3 ubiquitin protein ligase 3 increases expression ISO Camptothecin results in increased expression of NEURL3 mRNA CTD PMID:38460933 NCBI chr 9:45,990,373...45,998,470
Ensembl chr 9:38,494,489...38,502,649 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases activity		 ISO NFE2L2 protein affects the reaction [Camptothecin results in increased expression of TERT mRNA]
Camptothecin results in increased activity of NFE2L2 protein		 CTD PMID:30851366 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ninj1 ninjurin 1 increases expression ISO Camptothecin results in increased expression of NINJ1 mRNA CTD PMID:38460933 NCBI chr17:15,659,208...15,668,115
Ensembl chr17:15,452,813...15,461,704 		JBrowse link
G Nipal1 NIPA-like domain containing 1 increases expression ISO Camptothecin results in increased expression of NIPAL1 mRNA CTD PMID:38460933 NCBI chr14:35,891,645...35,915,658
Ensembl chr14:35,540,324...35,561,659 		JBrowse link
G Nkd2 NKD inhibitor of WNT signaling pathway 2 increases expression ISO Camptothecin results in increased expression of NKD2 mRNA CTD PMID:38460933 NCBI chr 1:31,268,856...31,299,390
Ensembl chr 1:29,441,328...29,470,821 		JBrowse link
G Nkx2-5 NK2 homeobox 5 increases expression ISO Camptothecin results in increased expression of NKX2-5 mRNA CTD PMID:38460933 NCBI chr10:16,844,888...16,851,458
Ensembl chr10:16,344,159...16,346,934 		JBrowse link
G Nlrx1 NLR family member X1 increases expression ISO Camptothecin results in increased expression of NLRX1 mRNA CTD PMID:38460933 NCBI chr 8:53,486,866...53,503,498
Ensembl chr 8:44,590,048...44,606,484 		JBrowse link
G Npas1 neuronal PAS domain protein 1 increases expression ISO Camptothecin results in increased expression of NPAS1 mRNA CTD PMID:38460933 NCBI chr 1:86,295,509...86,316,018
Ensembl chr 1:77,167,381...77,186,762 		JBrowse link
G Npl N-acetylneuraminate pyruvate lyase increases expression ISO Camptothecin results in increased expression of NPL mRNA CTD PMID:38460933 NCBI chr13:68,205,602...68,247,940
Ensembl chr13:65,655,118...65,697,372 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Camptothecin inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Camptothecin inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Camptothecin inhibits the reaction [Rifampin results in increased activity of NR1I2 protein] CTD PMID:29356861 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Camptothecin results in increased expression of NR4A1 mRNA CTD PMID:38460933 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nsg1 neuronal vesicle trafficking associated 1 increases expression ISO Camptothecin results in increased expression of NSG1 mRNA CTD PMID:38460933 NCBI chr14:76,861,079...76,882,822
Ensembl chr14:72,648,741...72,670,514 		JBrowse link
G Ntn1 netrin 1 increases expression ISO Camptothecin results in increased expression of NTN1 mRNA CTD PMID:38460933 NCBI chr10:53,398,852...53,597,595
Ensembl chr10:52,899,934...53,085,326 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A increases expression ISO Camptothecin results in increased expression of OAS1 mRNA CTD PMID:38460933 NCBI chr12:41,330,423...41,341,130
Ensembl chr12:35,669,801...35,680,517 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 increases expression ISO Camptothecin results in increased expression of OPRL1 mRNA CTD PMID:38460933 NCBI chr 3:189,209,495...189,225,406
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Or1a1b olfactory receptor family 1 subfamily A member 1B decreases response to substance ISO OR1A2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr10:59,568,684...59,569,628
Ensembl chr10:59,069,404...59,075,457 		JBrowse link
G Or7c70 olfactory receptor family 7 subfamily C member 70 decreases response to substance ISO OR7C2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 7:11,461,214...11,468,390
Ensembl chr 7:10,799,830...10,813,059 		JBrowse link
G Otulinl OTU deubiquitinase with linear linkage specificity like increases expression ISO Camptothecin results in increased expression of FAM105A mRNA CTD PMID:38460933 NCBI chr 2:80,136,411...80,164,290
Ensembl chr 2:78,408,593...78,433,838 		JBrowse link
G Palmd palmdelphin increases expression ISO Camptothecin results in increased expression of PALMD mRNA CTD PMID:38460933 NCBI chr 2:207,574,413...207,626,239
Ensembl chr 2:204,889,533...204,941,519 		JBrowse link
G Pank1 pantothenate kinase 1 increases expression ISO Camptothecin results in increased expression of PANK1 mRNA CTD PMID:38460933 NCBI chr 1:241,737,371...241,808,126
Ensembl chr 1:232,328,430...232,396,829 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
decreases response to substance
affects response to substance		 ISO
EXP		 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; Camptothecin results in increased ADP-ribosylation of and results in increased degradation of PARP1 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Camptothecin results in increased ADP-ribosylation of and results in increased degradation of PARP1 protein]; Nicotine inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; PARP1 protein promotes the reaction [Camptothecin results in increased abundance of Poly Adenosine Diphosphate Ribose]; RBL2 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; THBS1 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; XRCC1 protein affects the reaction [PARP1 protein affects the susceptibility to Camptothecin]
[Camptothecin co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased cleavage of PARP1 protein; [veliparib results in decreased activity of PARP1 protein] which results in increased susceptibility to Camptothecin
Tetrachlorodibenzodioxin promotes the reaction [Camptothecin results in increased cleavage of PARP1 protein]
PARP1 results in decreased susceptibility to Camptothecin		 CTD PMID:11741290 PMID:15585644 PMID:16962673 PMID:18506790 PMID:19559722 More... NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pax9 paired box 9 increases expression ISO Camptothecin results in increased expression of PAX9 mRNA CTD PMID:38460933 NCBI chr 6:79,917,466...79,938,551
Ensembl chr 6:74,182,568...74,203,506 		JBrowse link
G Pde2a phosphodiesterase 2A increases expression ISO Camptothecin results in increased expression of PDE2A mRNA CTD PMID:38460933 NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Pgf placental growth factor increases expression ISO Camptothecin results in increased expression of PGF mRNA CTD PMID:38460933 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:104,816,104...104,826,685 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Camptothecin binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pi4k2a phosphatidylinositol 4-kinase type 2 alpha increases expression ISO Camptothecin results in increased expression of PI4K2A mRNA CTD PMID:38460933 NCBI chr 1:250,850,440...250,878,399
Ensembl chr 1:240,902,855...240,929,337 		JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 increases expression ISO Camptothecin results in increased expression of PIK3AP1 mRNA CTD PMID:38460933 NCBI chr 1:250,040,250...250,194,364
Ensembl chr 1:240,093,065...240,204,828 		JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 increases expression ISO Camptothecin results in increased expression of PIK3IP1 mRNA CTD PMID:38460933 NCBI chr14:82,428,315...82,440,261
Ensembl chr14:78,204,053...78,216,608 		JBrowse link
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase increases expression ISO Camptothecin results in increased expression of PIM2 mRNA CTD PMID:38460933 NCBI chr  X:17,289,509...17,294,778
Ensembl chr  X:14,617,582...14,622,851 		JBrowse link
G Pla2g4c phospholipase A2 group IVC increases expression ISO Camptothecin results in increased expression of PLA2G4C mRNA CTD PMID:38460933 NCBI chr 1:83,315,017...83,411,342
Ensembl chr 1:74,236,211...74,274,656 		JBrowse link
G Plcd1 phospholipase C, delta 1 increases expression ISO Camptothecin results in increased expression of PLCD1 mRNA CTD PMID:38460933 NCBI chr 8:127,672,955...127,695,939
Ensembl chr 8:118,795,201...118,818,186 		JBrowse link
G Plekha4 pleckstrin homology domain containing A4 increases expression ISO Camptothecin results in increased expression of PLEKHA4 mRNA CTD PMID:38460933 NCBI chr 1:105,142,296...105,165,297
Ensembl chr 1:96,006,000...96,028,826 		JBrowse link
G Plekhb1 pleckstrin homology domain containing B1 increases expression ISO Camptothecin results in increased expression of PLEKHB1 mRNA CTD PMID:38460933 NCBI chr 1:164,410,901...164,425,216
Ensembl chr 1:154,998,800...155,016,142 		JBrowse link
G Plin2 perilipin 2 increases expression ISO Camptothecin results in increased expression of PLIN2 mRNA CTD PMID:38460933 NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO Camptothecin results in increased expression of PLK3 mRNA CTD PMID:17374387 PMID:38460933 NCBI chr 5:135,843,725...135,848,900
Ensembl chr 5:130,607,142...130,612,317 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Camptothecin results in increased expression of PMAIP1 mRNA CTD PMID:38460933 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Podnl1 podocan-like 1 increases expression ISO Camptothecin results in increased expression of PODNL1 mRNA CTD PMID:38460933 NCBI chr19:40,932,026...40,938,760
Ensembl chr19:24,027,297...24,033,846 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO Camptothecin results in increased expression of PPM1D mRNA CTD PMID:38460933 NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,172,603...70,208,607 		JBrowse link
G Ppp1r14c protein phosphatase 1, regulatory (inhibitor) subunit 14c increases expression ISO Camptothecin results in increased expression of PPP1R14C mRNA CTD PMID:38460933 NCBI chr 1:42,177,977...42,358,654
Ensembl chr 1:39,773,403...39,886,956 		JBrowse link
G Ppp1r16b protein phosphatase 1, regulatory subunit 16B decreases response to substance ISO PPP1R16B mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 3:167,743,518...167,839,511
Ensembl chr 3:147,324,126...147,418,937 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B decreases response to substance ISO PPP1R1B protein alternative form results in decreased susceptibility to Camptothecin; PPP1R1B protein results in decreased susceptibility to Camptothecin CTD PMID:16061638 NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C increases expression ISO Camptothecin results in increased expression of PPP1R3C mRNA CTD PMID:38460933 NCBI chr 1:243,873,524...243,878,527
Ensembl chr 1:234,460,652...234,465,961 		JBrowse link
G Ppp1r3g protein phosphatase 1, regulatory subunit 3G increases expression ISO Camptothecin results in increased expression of PPP1R3G mRNA CTD PMID:38460933 NCBI chr17:29,080,407...29,083,739
Ensembl chr17:28,876,482...28,877,525 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha multiple interactions ISO Camptothecin affects the localization of [PPP2R5E protein binds to PPP2CA protein] CTD PMID:25772433 NCBI chr10:36,856,534...36,878,789
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha affects localization
decreases response to substance		 ISO Camptothecin affects the localization of PPP2R1A protein
PPP2R1A mRNA results in decreased susceptibility to Camptothecin		 CTD PMID:25269479 PMID:25772433 NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha multiple interactions
decreases response to substance		 ISO PPP2R2A protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]
PPP2R2A protein results in decreased susceptibility to Camptothecin		 CTD PMID:25772433 NCBI chr15:45,380,142...45,439,428
Ensembl chr15:41,204,200...41,263,924 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma multiple interactions
increases response to substance		 ISO PPP2R5C protein promotes the reaction [Camptothecin results in increased expression of H2AX protein modified form]
PPP2R5C protein results in increased susceptibility to Camptothecin		 CTD PMID:25772433 NCBI chr 6:135,282,947...135,419,591
Ensembl chr 6:129,461,648...129,598,346 		JBrowse link
G Ppp2r5e protein phosphatase 2 regulatory subunit B', epsilon multiple interactions
decreases response to substance		 ISO Camptothecin affects the localization of [PPP2R5E protein binds to PPP2CA protein]; PPP2R5E protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]
PPP2R5E protein results in decreased susceptibility to Camptothecin		 CTD PMID:25772433 NCBI chr 6:99,904,569...100,053,672
Ensembl chr 6:94,168,846...94,317,872 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Camptothecin results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 1:143,659,312...143,681,019
Ensembl chr 1:134,250,081...134,271,765 		JBrowse link
G Prdm13 PR/SET domain 13 increases expression ISO Camptothecin results in increased expression of PRDM13 mRNA CTD PMID:38460933 NCBI chr 5:40,017,607...40,029,658
Ensembl chr 5:35,225,435...35,232,881 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 increases expression ISO Camptothecin results in increased expression of PRKAB1 mRNA CTD PMID:38460933 NCBI chr12:46,248,971...46,259,487
Ensembl chr12:40,588,211...40,598,661 		JBrowse link
G Prodh proline dehydrogenase increases expression ISO Camptothecin results in increased expression of PRODH mRNA CTD PMID:38460933 NCBI chr11:96,414,275...96,431,604
Ensembl chr11:82,910,137...82,927,305 		JBrowse link
G Prrt1 proline-rich transmembrane protein 1 increases expression ISO Camptothecin results in increased expression of PRRT1 mRNA CTD PMID:38460933 NCBI chr20:4,122,565...4,126,386
Ensembl chr20:4,117,957...4,121,600 		JBrowse link
G Prss27 serine protease 27 increases expression ISO Camptothecin results in increased expression of PRSS27 mRNA CTD PMID:38460933 NCBI chr10:13,574,526...13,581,887
Ensembl chr10:13,069,959...13,077,322 		JBrowse link
G Prss35 serine protease 35 increases expression ISO Camptothecin results in increased expression of PRSS35 mRNA CTD PMID:38460933 NCBI chr 8:96,594,460...96,610,992
Ensembl chr 8:87,714,966...87,731,009 		JBrowse link
G Prss57 serine protease 57 increases expression ISO Camptothecin results in increased expression of PRSS57 mRNA CTD PMID:38460933 NCBI chr 7:10,563,477...10,573,617
Ensembl chr 7:9,917,484...9,922,922 		JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 decreases expression ISO Camptothecin results in decreased expression of PSD3 mRNA CTD PMID:33770205 NCBI chr16:26,238,595...26,802,535
Ensembl chr16:21,465,639...22,034,547 		JBrowse link
G Ptafr platelet-activating factor receptor increases expression ISO Camptothecin results in increased expression of PTAFR mRNA CTD PMID:38460933 NCBI chr 5:150,049,322...150,079,060
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Ptar1 protein prenyltransferase alpha subunit repeat containing 1 decreases response to substance ISO PTAR1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:230,709,731...230,753,380
Ensembl chr 1:221,283,415...221,327,073 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Camptothecin results in decreased expression of and results in decreased phosphorylation of PTEN protein CTD PMID:30885713 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Camptothecin results in increased expression of PTGS2 mRNA CTD PMID:38460933 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptp4a3 protein tyrosine phosphatase 4A3 increases expression ISO Camptothecin results in increased expression of PTP4A3 mRNA CTD PMID:38460933 NCBI chr 7:107,518,220...107,549,949
Ensembl chr 7:105,628,029...105,660,919 		JBrowse link
G Ptpro protein tyrosine phosphatase, receptor type, O decreases response to substance ISO PTPRO mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:171,895,104...172,105,911
Ensembl chr 4:170,164,431...170,374,771 		JBrowse link
G Rab37 RAB37, member RAS oncogene family increases expression ISO Camptothecin results in increased expression of RAB37 mRNA CTD PMID:38460933 NCBI chr10:100,833,240...100,900,950
Ensembl chr10:100,334,216...100,401,474 		JBrowse link
G Rad50 RAD50 double strand break repair protein decreases expression ISO Camptothecin results in decreased expression of RAD50 mRNA CTD PMID:24792648 NCBI chr10:38,310,147...38,362,100
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Rad51 RAD51 recombinase decreases expression ISO Camptothecin results in decreased expression of RAD51 mRNA; Camptothecin results in decreased expression of RAD51 protein CTD PMID:10344722 PMID:24792648 NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rad51c RAD51 paralog C increases response to substance ISO RAD51C gene mutant form results in increased susceptibility to Camptothecin CTD PMID:20400963 NCBI chr10:72,702,299...72,728,980
Ensembl chr10:72,205,032...72,231,248 		JBrowse link
G Rara retinoic acid receptor, alpha increases methylation ISO Camptothecin results in increased methylation of RARA gene CTD PMID:30720231 NCBI chr10:84,379,780...84,424,371
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rasal1 RAS protein activator like 1 increases expression ISO Camptothecin results in increased expression of RASAL1 mRNA CTD PMID:38460933 NCBI chr12:41,541,865...41,574,957
Ensembl chr12:35,881,270...35,913,727 		JBrowse link
G Rasd1 ras related dexamethasone induced 1 increases expression ISO Camptothecin results in increased expression of RASD1 mRNA CTD PMID:38460933 NCBI chr10:45,265,975...45,275,279
Ensembl chr10:44,766,455...44,768,186 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation
affects response to substance		 ISO Camptothecin results in increased phosphorylation of RB1 protein
RB1 protein affects the susceptibility to Camptothecin		 CTD PMID:14647467 PMID:14704340 PMID:15064736 PMID:15585644 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO Camptothecin results in decreased expression of RBL1 protein CTD PMID:15585644 NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:145,807,095...145,869,330 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions
decreases response to substance		 ISO RBL2 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]
RBL2 protein results in decreased susceptibility to Camptothecin		 CTD PMID:15585644 NCBI chr19:32,049,690...32,096,467
Ensembl chr19:15,876,853...15,923,572 		JBrowse link
G Rcor2 REST corepressor 2 increases expression ISO Camptothecin results in increased expression of RCOR2 mRNA CTD PMID:38460933 NCBI chr 1:213,882,585...213,890,022
Ensembl chr 1:204,454,360...204,460,838 		JBrowse link
G Reep2 receptor accessory protein 2 increases expression ISO Camptothecin results in increased expression of REEP2 mRNA CTD PMID:38460933 NCBI chr18:26,712,236...26,721,275
Ensembl chr18:26,438,346...26,447,161 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases response to substance
multiple interactions		 ISO
EXP		 RELA results in increased susceptibility to Camptothecin
Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]; pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] affects the localization of and results in increased phosphorylation of RELA protein]
Camptothecin results in increased expression of and results in decreased phosphorylation of RELA protein; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in decreased phosphorylation of RELA protein]; Diethylhexyl Phthalate promotes the reaction [Camptothecin results in increased expression of RELA protein]		 CTD PMID:13679428 PMID:21737676 PMID:25449198 PMID:36394428 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ret ret proto-oncogene decreases expression EXP Camptothecin results in decreased expression of RET protein CTD PMID:17555550 NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G Retsat retinol saturase increases expression ISO Camptothecin results in increased expression of RETSAT mRNA CTD PMID:38460933 NCBI chr 4:106,211,459...106,220,222
Ensembl chr 4:104,653,155...104,668,310 		JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a increases expression ISO Camptothecin results in increased expression of RGMA mRNA CTD PMID:38460933 NCBI chr 1:136,538,782...136,582,763
Ensembl chr 1:127,128,934...127,172,918 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO Camptothecin results in increased expression of RGS16 mRNA CTD PMID:38460933 NCBI chr13:68,421,480...68,443,312
Ensembl chr13:65,887,530...65,892,857 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Camptothecin results in increased expression of RGS2 mRNA CTD PMID:38460933 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rhoc ras homolog family member C increases expression ISO Camptothecin results in increased expression of RHOC mRNA CTD PMID:38460933 NCBI chr 2:194,975,586...194,981,637
Ensembl chr 2:192,287,130...192,295,306 		JBrowse link
G Rhod ras homolog family member D increases expression ISO Camptothecin results in increased expression of RHOD mRNA CTD PMID:38460933 NCBI chr 1:211,138,126...211,153,953
Ensembl chr 1:201,708,699...201,722,632 		JBrowse link
G Rinl Ras and Rab interactor-like increases expression ISO Camptothecin results in increased expression of RINL mRNA CTD PMID:38460933 NCBI chr 1:93,204,543...93,215,851
Ensembl chr 1:84,077,265...84,088,330 		JBrowse link
G Rnasel ribonuclease L increases expression ISO Camptothecin results in increased expression of RNASEL mRNA CTD PMID:38460933 NCBI chr13:68,446,641...68,460,804
Ensembl chr13:65,901,459...65,908,704 		JBrowse link
G Rnf144b ring finger protein 144B increases expression ISO Camptothecin results in increased expression of RNF144B mRNA CTD PMID:38460933 NCBI chr17:17,637,564...17,786,685
Ensembl chr17:17,432,786...17,562,760 		JBrowse link
G Rnf31 ring finger protein 31 decreases response to substance ISO RNF31 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr15:33,053,450...33,065,285
Ensembl chr15:29,083,631...29,101,915 		JBrowse link
G Rom1 retinal outer segment membrane protein 1 increases expression ISO Camptothecin results in increased expression of ROM1 mRNA CTD PMID:38460933 NCBI chr 1:215,253,155...215,255,163
Ensembl chr 1:205,824,052...205,826,175 		JBrowse link
G Rpgrip1 RPGR interacting protein 1 increases expression ISO Camptothecin results in increased expression of RPGRIP1 mRNA CTD PMID:38460933 NCBI chr15:27,282,997...27,341,021
Ensembl chr15:24,814,614...24,868,605 		JBrowse link
G Rpl13a ribosomal protein L13A increases expression ISO Camptothecin results in increased expression of RPL13A mRNA CTD PMID:38460933 NCBI chr 1:104,746,223...104,748,975
Ensembl chr 1:95,609,370...95,620,463 		JBrowse link
G Rps4x ribosomal protein S4, X-linked increases expression ISO Camptothecin results in increased expression of RPS4X mRNA CTD PMID:38460933 NCBI chr  X:71,338,478...71,342,921
Ensembl chr  X:67,298,525...67,303,019
Ensembl chr 4:67,298,525...67,303,019 		JBrowse link
G Rps6 ribosomal protein S6 increases expression ISO Camptothecin results in increased expression of RPS6 protein modified form CTD PMID:29384525 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator increases expression ISO Camptothecin results in increased expression of RRAD mRNA CTD PMID:38460933 NCBI chr19:360,581...363,874
Ensembl chr19:354,198...357,417 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions
increases expression		 ISO 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]; Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]; E2F1 protein promotes the reaction [Camptothecin results in increased expression of RRM2 protein]
Camptothecin results in increased expression of RRM2 mRNA; Camptothecin results in increased expression of RRM2 protein		 CTD PMID:22403396 NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO Camptothecin results in increased expression of RRM2B mRNA CTD PMID:38460933 NCBI chr 7:70,962,008...70,993,726
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Rsph1 radial spoke head component 1 increases expression ISO Camptothecin results in increased expression of RSPH1 mRNA CTD PMID:38460933 NCBI chr20:9,343,258...9,361,988
Ensembl chr20:9,341,913...9,360,640 		JBrowse link
G Rundc3a RUN domain containing 3A increases expression ISO Camptothecin results in increased expression of RUNDC3A mRNA CTD PMID:38460933 NCBI chr10:87,852,746...87,861,903
Ensembl chr10:87,352,646...87,361,765 		JBrowse link
G Rwdd3 RWD domain containing 3 increases expression ISO Camptothecin results in increased expression of RWDD3 mRNA CTD PMID:33770205 NCBI chr 2:211,918,361...211,933,644
Ensembl chr 2:209,233,622...209,248,853 		JBrowse link
G Sbk1 SH3 domain binding kinase 1 increases expression ISO Camptothecin results in increased expression of SBK1 mRNA CTD PMID:38460933 NCBI chr 1:190,237,677...190,282,494
Ensembl chr 1:180,807,099...180,851,885 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 increases expression ISO Camptothecin results in increased expression of SCN3B mRNA CTD PMID:38460933 NCBI chr 8:49,527,529...49,550,019
Ensembl chr 8:40,630,455...40,652,868 		JBrowse link
G Sdc1 syndecan 1 increases expression ISO Camptothecin results in increased expression of SDC1 mRNA CTD PMID:17374387 NCBI chr 6:37,282,041...37,304,503
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
G Sel1l SEL1L adaptor subunit of SYVN1 ubiquitin ligase decreases response to substance ISO SEL1L mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 6:116,466,163...116,510,436
Ensembl chr 6:110,735,450...110,779,648 		JBrowse link
G Septin4 septin 4 increases expression ISO Camptothecin results in increased expression of SEPT4 mRNA CTD PMID:38460933 NCBI chr10:72,863,969...72,888,018
Ensembl chr10:72,366,873...72,390,768 		JBrowse link
G Serpinb5 serpin family B member 5 increases expression ISO Camptothecin results in increased expression of SERPINB5 mRNA CTD PMID:38460933 NCBI chr13:23,500,203...23,520,401
Ensembl chr13:22,985,557...23,005,756 		JBrowse link
G Serpinb7 serpin family B member 7 increases expression ISO Camptothecin results in increased expression of SERPINB7 mRNA CTD PMID:38460933 NCBI chr13:23,884,466...23,956,834
Ensembl chr13:23,395,671...23,442,205 		JBrowse link
G Sertad1 SERTA domain containing 1 increases expression ISO Camptothecin results in increased expression of SERTAD1 mRNA CTD PMID:38460933 NCBI chr 1:91,903,297...91,906,565
Ensembl chr 1:82,775,252...82,779,091 		JBrowse link
G Sesn2 sestrin 2 increases expression ISO Camptothecin results in increased expression of SESN2 mRNA CTD PMID:38460933 NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Sfn stratifin increases expression ISO Camptothecin results in increased expression of SFN mRNA CTD PMID:38460933 NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sgtb small glutamine rich tetratricopeptide repeat co-chaperone beta decreases expression ISO Camptothecin results in decreased expression of SGTB mRNA CTD PMID:33770205 NCBI chr 2:36,966,840...37,003,318
Ensembl chr 2:35,233,042...35,269,518 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 ISO [SIRT1 mutant form co-treated with Camptothecin] results in increased acetylation of TP53 protein; Camptothecin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of SIRT1 protein]
Camptothecin results in decreased expression of SIRT1 protein		 CTD PMID:24726431 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 increases expression ISO Camptothecin results in increased expression of SIRT2 mRNA CTD PMID:38460933 NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt4 sirtuin 4 increases expression ISO Camptothecin results in increased expression of SIRT4 mRNA CTD PMID:38460933 NCBI chr12:46,785,852...46,800,179
Ensembl chr12:41,131,262...41,139,439 		JBrowse link
G Slamf7 SLAM family member 7 increases expression ISO Camptothecin results in increased expression of SLAMF7 mRNA CTD PMID:38460933 NCBI chr13:86,668,060...86,688,222
Ensembl chr13:84,136,899...84,154,105 		JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression ISO Camptothecin results in increased expression of SLC17A7 mRNA CTD PMID:38460933 NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:95,649,745...95,661,588 		JBrowse link
G Slc2a12 solute carrier family 2 member 12 increases methylation ISO Camptothecin results in increased methylation of SLC2A12 gene CTD PMID:30720231 NCBI chr 1:24,623,558...24,683,577
Ensembl chr 1:22,804,418...22,860,971 		JBrowse link
G Slc45a4 solute carrier family 45, member 4 increases expression ISO Camptothecin results in increased expression of SLC45A4 mRNA CTD PMID:38460933 NCBI chr 7:107,370,826...107,459,163
Ensembl chr 7:105,481,792...105,550,170 		JBrowse link
G Slc4a11 solute carrier family 4 member 11 increases expression ISO Camptothecin results in increased expression of SLC4A11 mRNA CTD PMID:38460933 NCBI chr 3:138,353,305...138,365,983
Ensembl chr 3:117,900,223...117,912,674 		JBrowse link
G Slfn5 schlafen family member 5 increases expression ISO Camptothecin results in increased expression of SLFN5 mRNA CTD PMID:38460933 NCBI chr10:68,378,440...68,392,515
Ensembl chr10:67,880,009...67,893,109 		JBrowse link
G Smn1 survival of motor neuron 1, telomeric multiple interactions
increases response to substance		 ISO SMN1 mRNA affects the reaction [Camptothecin results in increased activity of CASP3 protein]
SMN1 protein results in increased susceptibility to Camptothecin		 CTD PMID:15862279 NCBI chr 2:33,224,115...33,235,162
Ensembl chr 2:31,490,015...31,501,060 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 increases expression ISO Camptothecin results in increased expression of SMPD3 mRNA CTD PMID:19698806 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B increases expression ISO Camptothecin results in increased expression of SMPDL3B mRNA CTD PMID:38460933 NCBI chr 5:150,228,607...150,250,688
Ensembl chr 5:144,944,636...144,966,720 		JBrowse link
G Smtnl2 smoothelin-like 2 increases expression ISO Camptothecin results in increased expression of SMTNL2 mRNA CTD PMID:38460933 NCBI chr10:57,506,873...57,528,050
Ensembl chr10:57,008,327...57,029,505 		JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO Camptothecin results in increased expression of SNAI2 mRNA CTD PMID:38460933 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Snai3 snail family transcriptional repressor 3 increases expression ISO Camptothecin results in increased expression of SNAI3 mRNA CTD PMID:38460933 NCBI chr19:67,425,311...67,437,830
Ensembl chr19:50,516,771...50,523,486 		JBrowse link
G Snx22 sorting nexin 22 increases expression ISO Camptothecin results in increased expression of SNX22 mRNA CTD PMID:38460933 NCBI chr 8:75,503,297...75,509,271
Ensembl chr 8:66,609,970...66,612,850 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression ISO Camptothecin results in increased expression of SOCS1 mRNA CTD PMID:38460933 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions		 ISO Camptothecin results in increased expression of SOD1 protein
Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of SOD1 protein]		 CTD PMID:30720231 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression		 ISO Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of SOD2 protein] CTD PMID:30720231 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 increases expression ISO Camptothecin results in increased expression of SORBS1 mRNA CTD PMID:38460933 NCBI chr 1:249,057,324...249,279,703
Ensembl chr 1:239,108,777...239,330,169 		JBrowse link
G Sox11 SRY-box transcription factor 11 increases methylation ISO Camptothecin results in increased methylation of SOX11 gene CTD PMID:30720231 NCBI chr 6:49,736,773...49,738,794
Ensembl chr 6:44,008,340...44,010,354 		JBrowse link
G Sox12 SRY-box transcription factor 12 increases methylation ISO Camptothecin results in increased methylation of SOX12 gene CTD PMID:30720231 NCBI chr 3:161,319,800...161,320,819
Ensembl chr 3:140,856,579...140,860,975 		JBrowse link
G Sox17 SRY-box transcription factor 17 increases methylation ISO Camptothecin results in increased methylation of SOX17 gene CTD PMID:30720231 NCBI chr 5:19,814,345...19,819,859
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
G Sox3 SRY-box transcription factor 3 increases methylation ISO Camptothecin results in increased methylation of SOX3 gene CTD PMID:30720231 NCBI chr  X:144,344,892...144,346,971
Ensembl chr  X:139,309,329...139,310,678 		JBrowse link
G Sox4 SRY-box transcription factor 4 increases methylation ISO Camptothecin results in increased methylation of SOX4 gene CTD PMID:30720231 NCBI chr17:35,876,298...35,881,004
Ensembl chr17:35,667,537...35,673,665 		JBrowse link
G Sox8 SRY-box transcription factor 8 increases methylation ISO Camptothecin results in increased methylation of SOX8 gene CTD PMID:30720231 NCBI chr10:15,089,357...15,094,345
Ensembl chr10:14,584,829...14,589,818 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
increases activity
increases expression		 ISO Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of SP1 mRNA]; Camptothecin results in increased activity of and affects the localization of SP1 protein; Camptothecin results in increased expression of and results in increased activity of SP1 protein; MAPK8 protein affects the reaction [Camptothecin results in increased activity of SP1 protein]; mithramycin A inhibits the reaction [Camptothecin results in increased activity of SP1 protein]; TERT protein affects the reaction [Camptothecin results in increased expression of SP1 protein] CTD PMID:11261509 PMID:30851366 PMID:30885713 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sp3 Sp3 transcription factor increases activity
multiple interactions		 ISO Camptothecin results in increased activity of SP3 protein
mithramycin A inhibits the reaction [Camptothecin results in increased activity of SP3 protein]		 CTD PMID:11261509 NCBI chr 3:78,219,421...78,272,318
Ensembl chr 3:57,812,075...57,860,342 		JBrowse link
G Spata18 spermatogenesis associated 18 increases expression ISO Camptothecin results in increased expression of SPATA18 mRNA CTD PMID:38460933 NCBI chr14:34,885,995...34,912,704
Ensembl chr14:34,531,061...34,558,687 		JBrowse link
G Spata20 spermatogenesis associated 20 increases expression ISO Camptothecin results in increased expression of SPATA20 mRNA CTD PMID:38460933 NCBI chr10:79,924,407...79,932,351
Ensembl chr10:79,427,528...79,434,368 		JBrowse link
G Spint1 serine peptidase inhibitor, Kunitz type 1 increases expression ISO Camptothecin results in increased expression of SPINT1 mRNA CTD PMID:38460933 NCBI chr 3:126,685,017...126,697,957
Ensembl chr 3:106,231,444...106,244,119 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 increases expression ISO Camptothecin results in increased expression of SPRY1 mRNA CTD PMID:38460933 NCBI chr 2:122,484,995...122,490,008
Ensembl chr 2:120,556,706...120,566,189 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases degradation		 ISO ATG5 mutant form inhibits the reaction [Camptothecin results in increased degradation of SQSTM1 protein]; Camptothecin inhibits the reaction [Cannabidiol results in increased expression of SQSTM1 mRNA] CTD PMID:22927544 PMID:34302491 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srgap3 SLIT-ROBO Rho GTPase activating protein 3 decreases expression ISO Camptothecin results in decreased expression of SRGAP3 mRNA CTD PMID:33770205 NCBI chr 4:147,391,082...147,626,407
Ensembl chr 4:145,840,078...146,070,575 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Camptothecin results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Sstr5 somatostatin receptor 5 increases expression ISO Camptothecin results in increased expression of SSTR5 mRNA CTD PMID:38460933 NCBI chr10:15,010,209...15,017,469
Ensembl chr10:14,506,868...14,512,946 		JBrowse link
G Stambpl1 STAM binding protein-like 1 increases methylation ISO Camptothecin results in increased methylation of STAMBPL1 gene CTD PMID:30720231 NCBI chr 1:241,095,695...241,158,225
Ensembl chr 1:231,699,995...231,745,032 		JBrowse link
G Stc1 stanniocalcin 1 increases expression ISO Camptothecin results in increased expression of STC1 mRNA CTD PMID:38460933 NCBI chr15:50,709,439...50,720,093
Ensembl chr15:44,299,621...44,310,264 		JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 decreases response to substance ISO STYXL1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr12:26,544,059...26,576,365
Ensembl chr12:20,907,435...20,939,752 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase increases expression ISO Camptothecin results in increased expression of SUV39H1 mRNA CTD PMID:33770205 NCBI chr  X:17,093,059...17,105,942
Ensembl chr  X:14,421,109...14,433,982 		JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 increases expression ISO Camptothecin results in increased expression of SUV39H1 mRNA CTD PMID:33770205 NCBI chr  X:146,828,818...146,831,485 JBrowse link
G Syk spleen associated tyrosine kinase increases expression ISO Camptothecin results in increased expression of SYK mRNA CTD PMID:38460933 NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Synpo2 synaptopodin 2 increases expression ISO Camptothecin results in increased expression of SYNPO2 mRNA CTD PMID:38460933 NCBI chr 2:213,901,685...214,055,844
Ensembl chr 2:211,216,783...211,371,267 		JBrowse link
G Sytl1 synaptotagmin-like 1 increases expression ISO Camptothecin results in increased expression of SYTL1 mRNA CTD PMID:38460933 NCBI chr 5:145,452,524...145,462,940
Ensembl chr 5:145,422,669...145,462,940 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 decreases response to substance ISO TAB2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:4,195,400...4,245,485
Ensembl chr 1:2,375,490...2,424,756 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Camptothecin results in increased expression of TAP1 mRNA CTD PMID:17374387 PMID:38460933 NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,656,263...4,666,901 		JBrowse link
G Tax1bp3 Tax1 binding protein 3 increases expression ISO Camptothecin results in increased expression of TAX1BP3 mRNA CTD PMID:17374387 NCBI chr10:58,294,357...58,298,875
Ensembl chr10:57,795,382...57,800,363 		JBrowse link
G Tbc1d16 TBC1 domain family, member 16 decreases expression ISO Camptothecin results in decreased expression of TBC1D16 mRNA CTD PMID:33770205 NCBI chr10:104,899,507...104,985,233
Ensembl chr10:104,402,398...104,486,670 		JBrowse link
G Tbxa2r thromboxane A2 receptor increases expression ISO Camptothecin results in increased expression of TBXA2R mRNA CTD PMID:38460933 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:8,383,378...8,388,176 		JBrowse link
G Tcea3 transcription elongation factor A3 increases expression ISO Camptothecin results in increased expression of TCEA3 mRNA CTD PMID:38460933 NCBI chr 5:153,760,401...153,792,934
Ensembl chr 5:148,476,941...148,509,448 		JBrowse link
G Tcp11l2 t-complex 11 like 2 increases expression ISO Camptothecin results in increased expression of TCP11L2 mRNA CTD PMID:38460933 NCBI chr 7:21,037,955...21,072,857
Ensembl chr 7:19,150,252...19,185,095 		JBrowse link
G Tdp1 tyrosyl-DNA phosphodiesterase 1 multiple interactions ISO TDP1 protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; TDP1 protein inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]] CTD PMID:21227924 NCBI chr 6:124,892,821...124,960,646
Ensembl chr 6:119,163,166...119,231,021 		JBrowse link
G Tent5a terminal nucleotidyltransferase 5A increases expression ISO Camptothecin results in increased expression of FAM46A mRNA CTD PMID:38460933 NCBI chr 8:95,102,349...95,109,100
Ensembl chr 8:86,225,357...86,229,045 		JBrowse link
G Tert telomerase reverse transcriptase increases expression
multiple interactions		 ISO Camptothecin results in increased expression of TERT mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein]; Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of TERT protein]; Camptothecin results in increased expression of and results in increased phosphorylation of TERT protein; Glutathione inhibits the reaction [Camptothecin results in increased expression of TERT protein]; NFE2L2 protein affects the reaction [Camptothecin results in increased expression of TERT mRNA]; TERT protein affects the reaction [Camptothecin results in increased expression of MYC protein]; TERT protein affects the reaction [Camptothecin results in increased expression of SP1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein]		 CTD PMID:30851366 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO Camptothecin results in increased expression of TFF1 mRNA CTD PMID:38460933 NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Thbs1 thrombospondin 1 decreases expression
multiple interactions
decreases secretion		 ISO Camptothecin results in decreased expression of THBS1 mRNA
THBS1 protein inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; THBS1 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]
Camptothecin results in decreased secretion of THBS1 protein		 CTD PMID:16962673 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Camptothecin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Camptothecin binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Thsd1 thrombospondin type 1 domain containing 1 increases expression ISO Camptothecin results in increased expression of THSD1 mRNA CTD PMID:38460933 NCBI chr16:76,473,026...76,507,404
Ensembl chr16:69,771,408...69,801,504 		JBrowse link
G Tincr TINCR ubiquitin domain containing increases expression ISO Camptothecin results in increased expression of TINCR mRNA CTD PMID:38460933 NCBI chr 9:1,476,770...1,477,039
NCBI chr 9:1,474,238...1,476,470 		JBrowse link
G Tle6 TLE family member 6, subcortical maternal complex member increases expression ISO Camptothecin results in increased expression of TLE6 mRNA CTD PMID:38460933 NCBI chr 7:8,757,846...8,769,405
Ensembl chr 7:8,107,207...8,118,639 		JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 increases expression ISO Camptothecin results in increased expression of TMCC3 mRNA CTD PMID:38460933 NCBI chr 7:30,781,452...31,058,888
Ensembl chr 7:28,893,967...29,171,926 		JBrowse link
G Tmem151a transmembrane protein 151A increases expression ISO Camptothecin results in increased expression of TMEM151A mRNA CTD PMID:38460933 NCBI chr 1:211,816,773...211,821,558
Ensembl chr 1:202,388,240...202,392,182 		JBrowse link
G Tmem250 transmembrane protein 250 increases expression ISO Camptothecin results in increased expression of TMEM250 mRNA CTD PMID:33770205 NCBI chr 3:29,360,770...29,364,756
Ensembl chr 3:8,962,657...8,966,349 		JBrowse link
G Tmem40 transmembrane protein 40 increases expression ISO Camptothecin results in increased expression of TMEM40 mRNA CTD PMID:38460933 NCBI chr 4:150,464,123...150,491,895
Ensembl chr 4:148,791,505...148,823,665 		JBrowse link
G Tmem47 transmembrane protein 47 increases expression ISO Camptothecin results in increased expression of TMEM47 mRNA CTD PMID:38460933 NCBI chr  X:45,421,405...45,447,900
Ensembl chr  X:45,421,405...45,447,900 		JBrowse link
G Tmem52 transmembrane protein 52 increases expression ISO Camptothecin results in increased expression of TMEM52 mRNA CTD PMID:38460933 NCBI chr 5:171,330,948...171,332,704
Ensembl chr 5:166,046,565...166,050,433 		JBrowse link
G Tmem63b transmembrane protein 63B increases expression ISO Camptothecin results in increased expression of TMEM63B mRNA CTD PMID:38460933 NCBI chr 9:22,810,753...22,838,163
Ensembl chr 9:15,320,432...15,340,720 		JBrowse link
G Tmod2 tropomodulin 2 increases expression ISO Camptothecin results in increased expression of TMOD2 mRNA CTD PMID:38460933 NCBI chr 8:85,197,222...85,250,627
Ensembl chr 8:76,325,667...76,365,720 		JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 increases expression ISO Camptothecin results in increased expression of TNFRSF14 mRNA CTD PMID:38460933 NCBI chr 5:170,768,413...170,776,749
Ensembl chr 5:165,484,262...165,493,703 		JBrowse link
G Tnfrsf22 tumor necrosis factor receptor superfamily, member 22 increases expression ISO Camptothecin results in increased expression of TNFRSF10C mRNA CTD PMID:38460933 NCBI chr 1:208,269,844...208,285,823
Ensembl chr 1:198,840,453...198,856,309 		JBrowse link
G Tnfsf15 TNF superfamily member 15 increases expression ISO Camptothecin results in increased expression of TNFSF15 mRNA CTD PMID:38460933 NCBI chr 5:82,150,376...82,171,743
Ensembl chr 5:77,139,878...77,156,228 		JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO Camptothecin results in increased expression of TNFSF9 mRNA CTD PMID:17374387 NCBI chr 9:2,031,011...2,033,345
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
G Top1 DNA topoisomerase I multiple interactions
decreases response to substance
decreases activity		 ISO
EXP		 [Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein; [moxifloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein
TOP1 protein mutant form results in decreased susceptibility to Camptothecin
Camptothecin analog results in decreased activity of TOP1 protein; Camptothecin results in decreased activity of TOP1 protein		 CTD PMID:12097280 PMID:18191106 PMID:20600288 PMID:21056033 PMID:21227924 More... NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:149,293,403...149,376,623 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases glutathionylation
increases activity
increases phosphorylation
increases response to substance
increases expression
decreases acetylation
affects response to substance
decreases response to substance		 ISO
EXP		 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin results in increased expression of TP53 protein]; [SIRT1 mutant form co-treated with Camptothecin] results in increased acetylation of TP53 protein; Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of TP53 protein modified form]; Camptothecin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased acetylation of TP53 protein]; Camptothecin results in increased stability of and results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein; nutlin 3 inhibits the reaction [Camptothecin results in increased expression of TP53 protein]; S-ethyl glutathione inhibits the reaction [Camptothecin results in increased expression of TP53 protein modified form]
Camptothecin results in increased glutathionylation of TP53 protein
Camptothecin results in increased activity of TP53 protein
Camptothecin results in increased phosphorylation of TP53 protein
Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin results in increased activity of TP53 protein]
TP53 protein results in increased susceptibility to Camptothecin
Camptothecin results in decreased acetylation of TP53 protein
TRP53 protein affects the susceptibility to Camptothecin
TP53 mutant form results in decreased susceptibility to Camptothecin; TP53 protein mutant form results in decreased susceptibility to Camptothecin; TP53 protein results in decreased susceptibility to Camptothecin		 CTD PMID:9673414 PMID:10692111 PMID:11279278 PMID:11741290 PMID:12082016 More... NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53i11 tumor protein p53 inducible protein 11 increases expression ISO Camptothecin results in increased expression of TP53I11 mRNA CTD PMID:38460933 NCBI chr 3:99,600,213...99,615,462
Ensembl chr 3:79,144,895...79,160,050 		JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Camptothecin results in increased expression of TP53I3 mRNA CTD PMID:17374387 NCBI chr 6:33,537,779...33,545,204 JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Camptothecin results in increased expression of TP53INP1 mRNA CTD PMID:38460933 NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:24,260,568...24,267,968 		JBrowse link
G Tp53inp2 tumor protein p53 inducible nuclear protein 2 increases expression ISO Camptothecin results in increased expression of TP53INP2 mRNA CTD PMID:38460933 NCBI chr 3:164,341,618...164,350,270
Ensembl chr 3:143,882,021...143,890,097 		JBrowse link
G Tp63 tumor protein p63 decreases expression ISO Camptothecin results in decreased expression of TP63 protein alternative form CTD PMID:23376119 NCBI chr11:88,343,647...88,554,543
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Traf6 TNF receptor associated factor 6 decreases response to substance ISO TRAF6 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Trank1 tetratricopeptide repeat and ankyrin repeat containing 1 increases expression ISO Camptothecin results in increased expression of TRANK1 mRNA CTD PMID:38460933 NCBI chr 8:120,153,381...120,233,879
Ensembl chr 8:111,276,354...111,355,092 		JBrowse link
G Trim28 tripartite motif-containing 28 increases expression ISO Camptothecin results in increased expression of TRIM28 protein modified form CTD PMID:25977998 NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:73,652,709...73,659,380 		JBrowse link
G Trim29 tripartite motif-containing 29 increases expression ISO Camptothecin results in increased expression of TRIM29 mRNA CTD PMID:38460933 NCBI chr 8:52,579,175...52,603,919
Ensembl chr 8:43,682,221...43,706,992 		JBrowse link
G Trim3 tripartite motif-containing 3 increases expression ISO Camptothecin results in increased expression of TRIM3 mRNA CTD PMID:38460933 NCBI chr 1:169,362,751...169,385,430
Ensembl chr 1:159,944,908...159,973,600 		JBrowse link
G Trim31 tripartite motif-containing 31 increases expression ISO Camptothecin results in increased expression of TRIM31 mRNA CTD PMID:38460933 NCBI chr20:1,658,386...1,671,711
Ensembl chr20:1,653,165...1,666,494 		JBrowse link
G Trim67 tripartite motif-containing 67 increases expression ISO Camptothecin results in increased expression of TRIM67 mRNA CTD PMID:38460933 NCBI chr19:69,659,857...69,703,290
Ensembl chr19:52,764,387...52,800,422 		JBrowse link
G Trim8 tripartite motif-containing 8 increases expression ISO Camptothecin results in increased expression of TRIM8 mRNA CTD PMID:38460933 NCBI chr 1:255,311,039...255,325,937
Ensembl chr 1:245,369,632...245,384,513 		JBrowse link
G Tro trophinin increases expression ISO Camptothecin results in increased expression of TRO mRNA CTD PMID:38460933 NCBI chr  X:22,990,922...23,001,955
Ensembl chr  X:19,563,517...19,572,953 		JBrowse link
G Tsg101 tumor susceptibility 101 decreases response to substance ISO TSG101 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:106,549,035...106,578,859
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Tspan1 tetraspanin 1 increases expression ISO Camptothecin results in increased expression of TSPAN1 mRNA CTD PMID:38460933 NCBI chr 5:134,883,704...134,896,083
Ensembl chr 5:129,646,993...129,652,017 		JBrowse link
G Tspan12 tetraspanin 12 increases expression ISO Camptothecin results in increased expression of TSPAN12 mRNA CTD PMID:38460933 NCBI chr 4:51,279,562...51,355,030
Ensembl chr 4:50,313,772...50,389,246 		JBrowse link
G Tulp4 TUB like protein 4 decreases expression ISO Camptothecin results in decreased expression of TULP4 mRNA CTD PMID:33770205 NCBI chr 1:49,082,492...49,218,262
Ensembl chr 1:46,682,863...46,809,688 		JBrowse link
G Twf1 twinfilin actin-binding protein 1 decreases response to substance ISO TWF1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 7:127,595,210...127,607,821
Ensembl chr 7:125,716,015...125,727,894 		JBrowse link
G Tyms thymidylate synthetase increases expression ISO Camptothecin results in increased expression of TYMS mRNA CTD PMID:16568373 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Tysnd1 trypsin like peroxisomal matrix peptidase 1 increases expression ISO Camptothecin results in increased expression of TYSND1 mRNA CTD PMID:38460933 NCBI chr20:30,180,878...30,188,239
Ensembl chr20:29,638,277...29,643,995 		JBrowse link
G Uap1l1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 increases expression ISO Camptothecin results in increased expression of UAP1L1 mRNA CTD PMID:38460933 NCBI chr 3:28,570,854...28,579,766
Ensembl chr 3:8,173,216...8,180,443 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases methylation ISO Camptothecin results in decreased methylation of UGT1A6 gene CTD PMID:30720231 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Unc5b unc-5 netrin receptor B increases expression ISO Camptothecin results in increased expression of UNC5B mRNA CTD PMID:38460933 NCBI chr20:29,240,639...29,307,270
Ensembl chr20:28,697,726...28,764,537 		JBrowse link
G Upf1 UPF1, RNA helicase and ATPase decreases response to substance ISO UPF1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr16:19,110,531...19,131,327
Ensembl chr16:19,076,322...19,096,568 		JBrowse link
G Usp5 ubiquitin specific peptidase 5 decreases response to substance ISO USP5 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:159,305,927...159,321,345
Ensembl chr 4:157,619,643...157,634,711 		JBrowse link
G Vamp8 vesicle-associated membrane protein 8 increases expression ISO Camptothecin results in increased expression of VAMP8 mRNA CTD PMID:38460933 NCBI chr 4:106,000,570...106,011,081
Ensembl chr 4:104,442,393...104,452,897 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 increases expression ISO Camptothecin results in increased expression of VANGL2 mRNA CTD PMID:38460933 NCBI chr13:86,995,124...87,021,770
Ensembl chr13:84,465,527...84,489,378 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
decreases response to substance		 ISO Camptothecin results in decreased expression of VEGFA protein
VEGFA protein results in decreased susceptibility to Camptothecin		 CTD PMID:16356833 PMID:20116850 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vmo1 vitelline membrane outer layer 1 homolog increases expression ISO Camptothecin results in increased expression of VMO1 mRNA CTD PMID:38460933 NCBI chr10:55,726,572...55,733,432
Ensembl chr10:55,227,944...55,229,289 		JBrowse link
G Vpreb3 V-set pre-B cell surrogate light chain 3 increases expression ISO Camptothecin results in increased expression of VPREB3 mRNA CTD PMID:38460933 NCBI chr20:12,716,862...12,720,108
Ensembl chr20:12,716,779...12,719,520 		JBrowse link
G Vps37d VPS37D subunit of ESCRT-I increases expression ISO Camptothecin results in increased expression of VPS37D mRNA CTD PMID:38460933 NCBI chr12:21,609,210...21,614,669
Ensembl chr12:21,609,182...21,614,659 		JBrowse link
G Vsig1 V-set and immunoglobulin domain containing 1 increases expression ISO Camptothecin results in increased expression of VSIG1 mRNA CTD PMID:38460933 NCBI chr  X:109,395,406...109,428,612
Ensembl chr  X:104,607,031...104,639,249 		JBrowse link
G Wfdc2 WAP four-disulfide core domain 2 increases expression ISO Camptothecin results in increased expression of WFDC2 mRNA CTD PMID:38460933 NCBI chr 3:173,706,091...173,735,055
Ensembl chr 3:153,286,131...153,292,807 		JBrowse link
G Wnt4 Wnt family member 4 increases expression ISO Camptothecin results in increased expression of WNT4 mRNA CTD PMID:38460933 NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases response to substance		 ISO [Butyrates co-treated with Camptothecin] results in decreased expression of XIAP protein; [Camptothecin co-treated with FAS protein] results in decreased expression of XIAP protein
XIAP protein results in decreased susceptibility to Camptothecin
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein]		 CTD PMID:16061681 PMID:16211302 PMID:19633536 PMID:25449198 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 affects response to substance
multiple interactions		 ISO XRCC1 protein affects the susceptibility to Camptothecin
[XRCC1 protein affects the susceptibility to Camptothecin] which affects the abundance of NAD; olaparib affects the reaction [[XRCC1 protein affects the susceptibility to Camptothecin] which affects the abundance of NAD]; veliparib affects the reaction [[XRCC1 protein affects the susceptibility to Camptothecin] which affects the abundance of NAD]; XRCC1 protein affects the reaction [PARP1 protein affects the susceptibility to Camptothecin]		 CTD PMID:35778544 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 decreases expression ISO Camptothecin results in decreased expression of XRCC3 mRNA CTD PMID:24792648 NCBI chr 6:136,684,558...136,694,822
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases response to substance
increases methylation		 ISO XRCC4 results in decreased susceptibility to Camptothecin
Camptothecin results in increased methylation of XRCC4 gene		 CTD PMID:21785230 PMID:30720231 NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
G Yars2 tyrosyl-tRNA synthetase 2 increases expression ISO Camptothecin results in increased expression of YARS2 mRNA CTD PMID:33770205 NCBI chr11:98,136,530...98,142,320
Ensembl chr11:84,624,369...84,638,125 		JBrowse link
G Ypel3 yippee-like 3 increases expression ISO Camptothecin results in increased expression of YPEL3 mRNA CTD PMID:38460933 NCBI chr 1:190,814,920...190,818,248
Ensembl chr 1:181,384,357...181,387,705 		JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 decreases response to substance ISO ZAP70 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 9:46,485,605...46,507,552
Ensembl chr 9:38,989,750...39,011,700 		JBrowse link
G Zc3hc1 zinc finger, C3HC-type containing 1 decreases response to substance ISO ZC3HC1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:59,957,402...59,979,336
Ensembl chr 4:58,989,987...59,011,933 		JBrowse link
G Zfp282 zinc finger protein 282 increases expression ISO Camptothecin results in increased expression of ZNF282 mRNA CTD PMID:33770205 NCBI chr 4:76,884,996...76,910,250
Ensembl chr 4:76,884,924...76,911,370 		JBrowse link
G Zfp35 zinc finger protein 35 increases expression ISO Camptothecin results in increased expression of ZNF79 mRNA CTD PMID:38460933 NCBI chr18:15,543,604...15,559,084
Ensembl chr18:15,268,814...15,285,088 		JBrowse link
G Zfp385a zinc finger protein 385A increases expression ISO Camptothecin results in increased expression of ZNF385A mRNA CTD PMID:38460933 NCBI chr 7:136,327,393...136,354,017
Ensembl chr 7:134,448,921...134,475,548 		JBrowse link
G Zfp398 zinc finger protein 398 increases expression ISO Camptothecin results in increased expression of ZNF398 mRNA CTD PMID:38460933 NCBI chr 4:78,180,620...78,214,367
Ensembl chr 4:76,849,681...76,876,243 		JBrowse link
G Zfyve1 zinc finger FYVE-type containing 1 increases expression ISO Camptothecin results in increased expression of ZFYVE1 mRNA CTD PMID:38460933 NCBI chr 6:108,916,062...108,965,231
Ensembl chr 6:103,184,938...103,234,039 		JBrowse link
G Zg16b zymogen granule protein 16B increases expression ISO Camptothecin results in increased expression of ZG16B mRNA CTD PMID:38460933 NCBI chr10:13,484,327...13,488,745
Ensembl chr10:12,979,020...12,983,572 		JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO Camptothecin results in increased expression of ZMAT3 mRNA CTD PMID:38460933 NCBI chr 2:117,034,517...117,066,141
Ensembl chr 2:115,106,966...115,136,863 		JBrowse link
G Znrd2 zinc ribbon domain containing 2 increases expression ISO Camptothecin results in increased expression of SSSCA1 mRNA CTD PMID:38460933 NCBI chr 1:212,447,010...212,448,793
Ensembl chr 1:203,017,682...203,019,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        aetiopathogenetic role 19224
          genotoxin 17672
            camptothecin 560
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  ester 17562
                                    carboxylic ester 16963
                                      lactone 13299
                                        delta-lactone 4210
                                          camptothecin 560
paths to the root