Bscl2 (BSCL2 lipid droplet biogenesis associated, seipin)

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Gene: Bscl2 (BSCL2 lipid droplet biogenesis associated, seipin) Rattus norvegicus

Analyze

Symbol:

Bscl2

Name:

BSCL2 lipid droplet biogenesis associated, seipin

RGD ID:

1308135

Description:

Predicted to enable phospholipid binding activity. Predicted to be involved in several processes, including lipid droplet formation; positive regulation of cold-induced thermogenesis; and regulation of lipid metabolic process. Predicted to act upstream of or within several processes, including adipose tissue development; cytosolic lipolysis; and regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction. Predicted to be located in cytosol; endoplasmic reticulum; and lipid droplet. Predicted to be active in endoplasmic reticulum membrane. Used to study azoospermia. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 2; hereditary spastic paraplegia; hereditary spastic paraplegia 17; and lipodystrophy. Orthologous to human BSCL2 (BSCL2 lipid droplet biogenesis associated, seipin); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Berardinelli-Seip congenital lipodystrophy 2 (seipin); Bernardinelli-Seip congenital lipodystrophy 2 homolog; Bernardinelli-Seip congenital lipodystrophy 2 homolog (human); bernardinelli-Seip congenital lipodystrophy type 2 protein homolog; BSCL2, seipin lipid droplet biogenesis associated; LOC361722; MGC109260; seipin

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Allele / Splice:

Bscl2^m1Kyo

Genetic Models:

F344-Bscl2^m1Kyo

Is Marker For:

Strains: F344-Bscl2^m1Kyo

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	205,731,814 - 205,743,430 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	205,733,872 - 205,743,421 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	214,140,405 - 214,151,980 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	221,175,225 - 221,186,823 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	213,868,074 - 213,879,673 (+)	NCBI	Rnor_WKY
Rnor_6.0	1	225,035,956 - 225,046,137 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	225,037,737 - 225,046,040 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	231,972,073 - 231,983,764 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	211,509,675 - 211,518,963 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	211,668,104 - 211,677,392 (+)	NCBI
Celera	1	203,246,734 - 203,256,205 (+)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

Asthenozoospermia (ISO)

azoospermia (IMP)

breast carcinoma (ISO)

Charcot-Marie-Tooth disease (ISO)

Charcot-Marie-Tooth disease type 2 (ISO)

congenital generalized lipodystrophy (ISO)

congenital generalized lipodystrophy type 2 (ISO)

Delayed Hypersensitivity (ISO)

Delayed Puberty (ISO)

diabetes mellitus (ISO)

distal hereditary motor neuronopathy type 5A (ISO)

Distal Hereditary Motor Neuronopathy Type 5C (ISO)

familial partial lipodystrophy type 3 (ISO)

familial temporal lobe epilepsy 8 (ISO)

focal epilepsy (ISO)

genetic disease (ISO)

hereditary spastic paraplegia (ISO)

hereditary spastic paraplegia 17 (ISO)

Insulin Resistance (IMP)

intellectual disability (ISO)

Larsen-like syndrome B3GAT3 type (ISO)

lipodystrophy (ISO)

male infertility (ISS)

neuropathy (ISO)

oligospermia (ISO)

peripheral nervous system disease (ISO)

Progressive Encephalopathy, with or without Lipodystrophy (ISO)

proximal symphalangism (ISO)

type 2 diabetes mellitus (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP,ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4-nitroquinoline N-oxide (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (ISO)

aflatoxin B1 (ISO)

antimycin A (ISO)

aphidicolin (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP)

bleomycin A2 (ISO)

camptothecin (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chrysene (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

cocaine (EXP)

cyclophosphamide (ISO)

cyclosporin A (ISO)

cytarabine (ISO)

dibutyl phthalate (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

etoposide (ISO)

fenthion (ISO)

fonofos (ISO)

hydrogen peroxide (ISO)

hydroxyurea (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mifepristone (ISO)

mitomycin C (ISO)

n-propyl gallate (ISO)

paclitaxel (ISO)

paracetamol (ISO)

parathion (ISO)

pirinixic acid (ISO)

quercetin (ISO)

resorcinol (ISO)

resveratrol (ISO)

selenium atom (ISO)

sunitinib (ISO)

temozolomide (ISO)

terbufos (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triptonide (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adipose tissue development (ISO)

biological_process (ND)

cytosolic lipolysis (ISO)

fat cell differentiation (ISO,ISS)

lipid droplet formation (IEA,ISO,ISS)

lipid droplet organization (IBA,ISO,ISS)

lipid metabolic process (IEA)

lipid storage (IBA,ISO,ISS)

maintenance of location in cell (ISO)

negative regulation of catalytic activity (ISO)

negative regulation of lipid catabolic process (ISO,ISS)

positive regulation of cold-induced thermogenesis (ISO,ISS)

regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction (ISO)

regulation of phosphatidic acid biosynthetic process (ISO)

spermatid differentiation (ISO)

Cellular Component

cellular_component (ND)

cytosol (ISO)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IBA,IEA,ISO,ISS)

lipid droplet (ISO)

obsolete integral component of endoplasmic reticulum membrane (ISO)

Molecular Function

molecular_function (ND)

phospholipid binding (ISO)

protein binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal spatial working memory (IMP)

decreased body weight (IMP)

decreased brain weight (IMP)

decreased circulating leptin level (IMP)

decreased testis weight (IMP)

decreased white adipose tissue amount (IMP)

increased circulating cholesterol level (IMP)

increased circulating insulin level (IMP)

increased circulating triglyceride level (IMP)

increased lean body mass (IMP)

increased liver triglyceride level (IMP)

increased liver weight (IMP)

increased oxygen consumption (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode.	Dollet L, etal., Sci Rep. 2016 Oct 17;6:35487. doi: 10.1038/srep35487.
2.	Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.	Ebihara C, etal., Hum Mol Genet. 2015 Aug 1;24(15):4238-49. doi: 10.1093/hmg/ddv156. Epub 2015 May 1.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Localization, cDNA sequence and genomic organization of the rat seipin gene (Bscl2) and sequence analysis in inbred rat models of Type 2 diabetes mellitus.	Kaisaki PJ, etal., Cytogenet Genome Res. 2002;98(1):71-4.
6.	Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13.	Magre J, etal., Nat Genet. 2001 Aug;28(4):365-70.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Refinement of the Silver syndrome locus on chromosome 11q12-q14 in four families and exclusion of eight candidate genes.	Windpassinger C, etal., Hum Genet. 2003 Dec;114(1):99-109. Epub 2003 Sep 16.

Additional References at PubMed

PMID:8889548	PMID:12477932	PMID:14981520	PMID:15489334	PMID:18585921	PMID:19278620	PMID:21551454	PMID:22269949	PMID:23173741	PMID:23458123	PMID:24622797	PMID:24778225
PMID:27564575	PMID:27879284	PMID:30293840	PMID:30901948	PMID:30970241	PMID:31178403	PMID:31708432	PMID:32705147

Genomics

Comparative Map Data

Bscl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	205,731,814 - 205,743,430 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	205,733,872 - 205,743,421 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	214,140,405 - 214,151,980 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	221,175,225 - 221,186,823 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	213,868,074 - 213,879,673 (+)	NCBI	Rnor_WKY
Rnor_6.0	1	225,035,956 - 225,046,137 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	225,037,737 - 225,046,040 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	231,972,073 - 231,983,764 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	211,509,675 - 211,518,963 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	211,668,104 - 211,677,392 (+)	NCBI
Celera	1	203,246,734 - 203,256,205 (+)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

BSCL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	62,690,262 - 62,709,537 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	11	62,689,289 - 62,709,845 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	62,457,734 - 62,477,009 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	62,214,323 - 62,231,395 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	62,214,322 - 62,231,395	NCBI
Celera	11	59,786,117 - 59,805,403 (-)	NCBI		Celera
Cytogenetic Map	11	q12.3	NCBI
HuRef	11	58,786,515 - 58,805,891 (-)	NCBI		HuRef
CHM1_1	11	62,340,845 - 62,360,176 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	62,679,681 - 62,698,954 (-)	NCBI		T2T-CHM13v2.0

Bscl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	8,814,831 - 8,826,047 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	8,814,831 - 8,826,047 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	8,837,467 - 8,848,683 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	8,837,467 - 8,848,683 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	8,911,957 - 8,923,173 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	8,906,548 - 8,915,712 (+)	NCBI		MGSCv36	mm8
Celera	19	8,597,278 - 8,608,494 (+)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	5.76	NCBI

Bscl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955599	507,501 - 514,151 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955599	505,725 - 514,225 (+)	NCBI	ChiLan1.0	ChiLan1.0

BSCL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	61,399,314 - 61,416,494 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	61,399,314 - 61,416,494 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	58,046,842 - 58,064,219 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

BSCL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	53,958,380 - 53,971,120 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	53,958,475 - 53,971,119 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	52,563,744 - 52,576,469 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	55,010,452 - 55,023,323 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	55,010,741 - 55,023,896 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	54,106,793 - 54,119,570 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	53,681,289 - 53,694,035 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	54,477,585 - 54,490,344 (+)	NCBI		UU_Cfam_GSD_1.0

Bscl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	10,453,683 - 10,463,113 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936581	567,662 - 578,267 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936581	567,426 - 576,859 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BSCL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	9,052,070 - 9,064,886 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	9,052,676 - 9,064,890 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	8,400,731 - 8,410,537 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BSCL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	11,198,033 - 11,216,709 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	11,200,356 - 11,216,622 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	108,534,784 - 108,555,013 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bscl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624926	1,190,072 - 1,196,076 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624926	1,189,990 - 1,197,220 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Bscl2
54 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	43
Count of miRNA genes:	38
Interacting mature miRNAs:	43
Transcripts:	ENSRNOT00000065977
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642722	214537671	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	213533942	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164747424	209747424	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	164747424	209747424	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	167909849	212909849	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169537671	214537671	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	169537671	214537671	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	171310381	216310381	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	171629477	216629477	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	171629477	216629477	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	171629477	216629477	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	171629477	216629477	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	171629477	216629477	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	171629477	216629477	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	172609619	217609619	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	173108781	218108781	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	174133260	219133260	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	176550523	221550523	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	176869060	221869060	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	178784622	223784622	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1302787	Stl25	Serum triglyceride level QTL 25	2.7	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	180359209	210702199	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	180359209	218108781	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	181133855	226133855	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	181759564	214537555	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	181829673	224569684	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	182623426	219932796	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	184550676	229550676	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	185145134	221264292	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	188377360	224054420	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	191019702	246062233	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	191033875	236033875	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	192825253	243914732	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	193113876	238113876	Rat
634338	Hcar4	Hepatocarcinoma resistance QTL 4	4.6		liver integrity trait (VT:0010547)	liver tumorous lesion number to liver area ratio (CMO:0001210)	1	193422268	214537671	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	196248093	241248093	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	0.00000081	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	196248093	241248093	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	197670404	242670404	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	197697768	238755659	Rat
2302375	Bw83	Body weight QTL 83	4.87	0.0002	body mass (VT:0001259)	body weight (CMO:0000012)	1	197697768	242697768	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	197814409	242814409	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	197814409	242814409	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	197814409	242814409	Rat
1331790	Bp201	Blood pressure QTL 201	3.127		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	198211513	225126682	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	199050459	259647894	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	199368955	224569684	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	201554356	246554356	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	201554356	246554356	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	201554356	246554356	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	201554356	246554356	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	201554356	246554356	Rat
10059587	Bw173	Body weight QTL 173	3.23	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	1	202069611	247069611	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	203995416	244113296	Rat

Markers in Region

RH129317

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	205,732,176 - 205,732,348 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	225,034,261 - 225,034,432	NCBI	Rnor6.0
Rnor_5.0	1	231,972,426 - 231,972,597	UniSTS	Rnor5.0
RGSC_v3.4	1	211,507,980 - 211,508,151	UniSTS	RGSC3.4
Celera	1	203,245,039 - 203,245,210	UniSTS
RH 3.4 Map	1	1510.5	UniSTS
Cytogenetic Map	1	q43	UniSTS

RH142166

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	205,732,412 - 205,732,609 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	225,034,497 - 225,034,693	NCBI	Rnor6.0
Rnor_5.0	1	231,972,662 - 231,972,858	UniSTS	Rnor5.0
RGSC_v3.4	1	211,508,216 - 211,508,412	UniSTS	RGSC3.4
Celera	1	203,245,275 - 203,245,471	UniSTS
RH 3.4 Map	1	1510.5	UniSTS
Cytogenetic Map	1	q43	UniSTS

BG381397

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	205,734,426 - 205,734,537 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	225,036,511 - 225,036,621	NCBI	Rnor6.0
Rnor_5.0	1	231,974,676 - 231,974,786	UniSTS	Rnor5.0
RGSC_v3.4	1	211,510,230 - 211,510,340	UniSTS	RGSC3.4
Celera	1	203,247,289 - 203,247,399	UniSTS
RH 3.4 Map	1	1510.5	UniSTS
Cytogenetic Map	1	q43	UniSTS

UniSTS:498224

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	205,735,581 - 205,735,832 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	225,037,665 - 225,037,915	NCBI	Rnor6.0
Rnor_5.0	1	231,975,830 - 231,976,080	UniSTS	Rnor5.0
RGSC_v3.4	1	211,511,384 - 211,511,634	UniSTS	RGSC3.4
Celera	1	203,248,443 - 203,248,693	UniSTS
Cytogenetic Map	1	q43	UniSTS

Related Rat Strains

The following Strains have been annotated to Bscl2

F344-Bscl2^m1Kyo

Genetic Models

This gene Bscl2 is modified in the following models/strains

F344-Bscl2^m1Kyo

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	35	57	41	19	41	1	4	74	35	41	11	1
Low		8					7	7					7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084125	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC099294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC089942	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BF393055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220723	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000077959 ⟹ ENSRNOP00000069562

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	205,734,985 - 205,743,401 (+)	Ensembl
Rnor_6.0 Ensembl	1	225,037,737 - 225,046,040 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098204 ⟹ ENSRNOP00000095921

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	205,734,985 - 205,743,401 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000106351 ⟹ ENSRNOP00000077692

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	205,733,872 - 205,743,421 (+)	Ensembl

RefSeq Acc Id:

NM_001012171 ⟹ NP_001012171

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	205,733,872 - 205,743,422 (+)	NCBI
Rnor_6.0	1	225,035,956 - 225,046,137 (+)	NCBI
Rnor_5.0	1	231,972,073 - 231,983,764 (+)	NCBI
RGSC_v3.4	1	211,509,675 - 211,518,963 (+)	RGD
Celera	1	203,246,734 - 203,256,205 (+)	RGD

Sequence:

show sequence

AGCTGGACTGCTACACCCCCCCCCCAACCCTGACACAGCACTTAGTACCTGAATCTTCATTTCT
TTCAGTGACCCTCCATTCTTCAGATCTAGGAAGATGTGACACTCTACAGGTGATCAGCTTCTAG
ATCACCACTTTGTACCCACAAGTGATTTGAGTTGGGGATCCAGGGGCAGCAGAGGTAACCATCA
GGAAGATATTTAAAGAAATGATACATCACAGACGAGAAGCTGGGGGGAAAGAGACATGCAGAGA
CCCGGTCAAAGGATCAGACAAAGAGGAGGAACCTTCAGCTGCCCTACCCCATGGCCAAGTGTAT
CGTCCCAGTGGAAGACCAGCCAGGAACTCAAGGCCTGAAACTGGGGCCAGATCCCCTGCTGTCC
CCATCATGGTCAATGACCCACCAGTCCCTGCCTTGCTGTGGGCCCAGGAAGTGGGCCATGTGTT
GGCAGGCCGCGCCCGCAGGCTGATGCTGCAGTTTGGGGTGCTCTTTTGTACCATCCTCCTTTTG
CTTTGGGTGTCTGTGTTCCTCTACGGTTCTTTCTACTACTCCTACATGCCGACCGTCAGCCACC
TCAGCCCTGTGCATTTCTATTACAGGACAGACTGTGATTCCTCTACTGCTTCGCTCTGCTCTTT
CCCTGTTGCCAATGTCTCGCTGACTAAGAGTGGACGTGACCGGGTGCTGATGTATGGACAGCCA
TATCGAGTCACCTTAGAGCTTGAGCTGCCAGAATCCCCTGTGAATCAAGACTTGGGCATGTTCT
TAGTCACCGTTTCGTGCTATACCAGAGGTGGCCGAATCATCTCCACTTCTTCACGCTCGGTGAT
GCTTCATTACCGCTCTCAGCTGCTACAGATGCTCGACACGCTGGTGTTCTCCAGCCTGCTGCTG
TTTGGCTTTGCAGAACAGAAGCAGCTCCTGGAAGTAGAACTCTACTCTGACTATAGGGAGAATT
CGTATGTACCAACAACTGGGGCAATTATCGAAGTCCACAGCAAGCGTGTCCAGATGTATGGAGC
TTACCTCCGCATCCATGCCCACTTCACTGGACTCAGGTACCTGCTATACAACTTCCCCATGACC
TGCGCCTTCGTGGGTGTGGCCAGCAACTTCACATTCCTCAGTGTCATCGCGCTCTTCAGCTATA
TGCAGTGGGTGTGGGGTGCTGTCTGGCCCCGACACCGCTTCTCTTTGCAGGTTAATATCCGACA
AAGGGATAATTCAGGACACGGGGCCCAGCGTCGGATCTCTCGCCATCAGCCAGGTCAGGCGTCT
ACCCAGCAGTCAGATGTGACAGAGGATGGCGAGAGCCCTGAGGATCCCTCAGGAACAGAGGGTC
AGCTGTCTGAGGAAGAGAAACCAGAGAAGCAGCCTCTGAATGGAGAAGGGGAGCAGGAGCCAGA
GGCTAGTGACGGCTCCTGGGAAGATGCTGCTTTGCTGACCGAAGCCTCAACGTCTGCCCTCGCC
CCTGAGACTCTGGGCAGCCTCAGGCAACGCCAGACCTGCTCCAGTTCCTGAACAAAAGGGTGGA
GTCTTCACATTCCAGCACTTTCCCATAGGGCACCTCTTCCCTTGTTCCCTTAATAAACTATTTT
GTGTCAGCTGCTAGTATGGAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039084117 ⟹ XP_038940045

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	205,734,847 - 205,743,430 (+)	NCBI

RefSeq Acc Id:

XM_039084125 ⟹ XP_038940053

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	205,731,814 - 205,743,430 (+)	NCBI

RefSeq Acc Id:

XM_039084128 ⟹ XP_038940056

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	205,734,952 - 205,743,430 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012171	(Get FASTA)	NCBI Sequence Viewer
	XP_038940045	(Get FASTA)	NCBI Sequence Viewer
	XP_038940053	(Get FASTA)	NCBI Sequence Viewer
	XP_038940056	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89942	(Get FASTA)	NCBI Sequence Viewer
	EDM12733	(Get FASTA)	NCBI Sequence Viewer
	EDM12734	(Get FASTA)	NCBI Sequence Viewer
	EDM12735	(Get FASTA)	NCBI Sequence Viewer
	EDM12736	(Get FASTA)	NCBI Sequence Viewer
	EDM12737	(Get FASTA)	NCBI Sequence Viewer
	Q5FVJ6	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001012171 ⟸ NM_001012171

- UniProtKB:

A0A8I5Y6M7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVNDPPVPALLWAQEVGHVLAGRARRLMLQFGVLFCTILLLLWVSVFLYGSFYYSYMPTVSHLS
PVHFYYRTDCDSSTASLCSFPVANVSLTKSGRDRVLMYGQPYRVTLELELPESPVNQDLGMFLV
TVSCYTRGGRIISTSSRSVMLHYRSQLLQMLDTLVFSSLLLFGFAEQKQLLEVELYSDYRENSY
VPTTGAIIEVHSKRVQMYGAYLRIHAHFTGLRYLLYNFPMTCAFVGVASNFTFLSVIALFSYMQ
WVWGAVWPRHRFSLQVNIRQRDNSGHGAQRRISRHQPGQASTQQSDVTEDGESPEDPSGTEGQL
SEEEKPEKQPLNGEGEQEPEASDGSWEDAALLTEASTSALAPETLGSLRQRQTCSSS

hide sequence

RefSeq Acc Id:

ENSRNOP00000069562 ⟸ ENSRNOT00000077959

RefSeq Acc Id:	XP_038940053 ⟸ XM_039084125
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038940045 ⟸ XM_039084117
- Peptide Label:	isoform X1
- UniProtKB:	Q5FVJ6 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038940056 ⟸ XM_039084128
- Peptide Label:	isoform X1
- UniProtKB:	Q5FVJ6 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:

ENSRNOP00000095921 ⟸ ENSRNOT00000098204

RefSeq Acc Id:

ENSRNOP00000077692 ⟸ ENSRNOT00000106351

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5FVJ6-F1-model_v2	AlphaFold	Q5FVJ6	1-377	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308135	AgrOrtholog
BioCyc Gene	G2FUF-56492	BioCyc
Ensembl Genes	ENSRNOG00000052393	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000069562.2	UniProtKB/TrEMBL
	ENSRNOP00000077692	ENTREZGENE
	ENSRNOP00000077692.1	UniProtKB/TrEMBL
	ENSRNOP00000095921	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000077959.2	UniProtKB/TrEMBL
	ENSRNOT00000098204	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000106351	ENTREZGENE
	ENSRNOT00000106351.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7311394	IMAGE-MGC_LOAD
InterPro	Seipin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:361722	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109260	IMAGE-MGC_LOAD
NCBI Gene	361722	ENTREZGENE
PANTHER	PTHR21212	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Seipin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Bscl2	PhenoGen
UniProt	A0A0G2JVP0_RAT	UniProtKB/TrEMBL
	A0A8I5Y6M7	ENTREZGENE, UniProtKB/TrEMBL
	BSCL2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-01	Bscl2	BSCL2, seipin lipid droplet biogenesis associated	Bscl2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-01-06	Bscl2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	Bscl2	Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-03-30	Bscl2	Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)	Bscl2_predicted	Bernardinelli-Seip congenital lipodystrophy 2 homolog (predicted)	Symbol and name updated to reflect update of predicted to known gene	1331545	APPROVED
2005-01-12	Bscl2_predicted	Bernardinelli-Seip congenital lipodystrophy 2 homolog (predicted)			Symbol and Name status set to approved	70820	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	excluded as a candidate gene for a glucose intolerance QTL in the Goto-Kakizaki (GK) rat model	1600600

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Mammalian Phenotype