Gene: Efnb1 (ephrin B1) Rattus norvegicus
Analyze
Symbol:
Efnb1
Name:
ephrin B1
Description:
Predicted to have ephrin receptor binding activity. Involved in presynapse assembly. Localizes to glutamatergic synapse and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in craniofrontonasal syndrome and dysostosis. Orthologous to human EFNB1 (ephrin B1); PARTICIPATES IN altered ephrin - ephrin receptor bidirectional signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
EFL-3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; ephrin-B1; LERK-2; LERK2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
EFNB1 (ephrin B1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):
Efnb1 (ephrin B1) HGNC
EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Efnb1 (ephrin B1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
EFNB1 (ephrin B1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
EFNB1 (ephrin B1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Efnb1 (ephrin B1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
EFNB1 (ephrin B1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
EFNB1 (ephrin B1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Efnb1 (ephrin B1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Efnb1 (ephrin B1)
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Homo sapiens (human):
EFNB1 (ephrin B1)
Alliance
DIOPT (PANTHER|HGNC|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Danio rerio (zebrafish):
efnb1 (ephrin-B1)
Alliance
DIOPT (PANTHER|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Caenorhabditis elegans (roundworm):
efn-2
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
Ephrin
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|OrthoInspector|Hieranoid)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 68,891,227 - 68,904,034 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 68,891,227 - 68,904,038 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 X 69,764,314 - 69,777,121 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 87,163,176 - 87,175,982 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 X 87,236,467 - 87,249,273 (+) NCBI Celera X 64,624,957 - 64,637,749 (+) NCBI Celera Cytogenetic Map X q22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
autistic disorder ISO RGD:737327 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 craniofrontonasal syndrome ISO RGD:737327 8554872 ClinVar Annotator: match by term: Craniofrontonasal dysplasia ClinVar PMID:25741868 , PMID:31837199 craniofrontonasal syndrome ISO RGD:737327 8554872 ClinVar Annotator: match by term: Craniofrontonasal dysplasia ClinVar PMID:28492532 craniofrontonasal syndrome ISO RGD:737327 8554872 ClinVar Annotator: match by term: Craniofrontonasal dysplasia ClinVar PMID:25741868 craniofrontonasal syndrome ISO RGD:737327 8554872 ClinVar Annotator: match by OMIM:304110 ClinVar PMID:23335590 , PMID:6627724 craniofrontonasal syndrome ISO RGD:737327 8554872 ClinVar Annotator: match by OMIM:304110 ClinVar PMID:15124102 craniofrontonasal syndrome ISO RGD:737327 8554872 ClinVar Annotator: match by OMIM:304110 ClinVar PMID:1468459 , PMID:23335590 craniofrontonasal syndrome ISO RGD:737327 8554872 ClinVar Annotator: match by OMIM:304110 ClinVar PMID:15166289 craniofrontonasal syndrome ISO RGD:737327 8554872 ClinVar Annotator: match by OMIM:304110 ClinVar PMID:16685650 craniofrontonasal syndrome ISO RGD:737327 8554872 ClinVar Annotator: match by OMIM:304110 ClinVar craniofrontonasal syndrome ISO RGD:737327 8554872 ClinVar Annotator: match by term: Craniofrontonasal dysplasia ClinVar PMID:16685650 more ... genetic disease ISO RGD:737327 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:15124102 more ... syndromic X-linked intellectual disability Lubs type ISO RGD:737327 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868
Imported Annotations - CTD
craniofrontonasal syndrome ISO RGD:737327 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15124102 more ... craniosynostosis ISO RGD:737327 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15166289 Frontonasal Dysplasia ISO RGD:737327 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15166289 Hypertelorism ISO RGD:737327 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15166289 Inflammation ISO RGD:737327 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24098442 obesity ISO RGD:737327 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24098442 Imported Annotations - OMIM
craniofrontonasal syndrome ISO RGD:737327 7240710 OMIM
17alpha-ethynylestradiol affects expression ISO RGD:10508 6480464 Ethinyl Estradiol affects the expression of EFNB1 mRNA CTD PMID:17555576 17beta-estradiol affects expression ISO RGD:10508 6480464 Estradiol affects the expression of EFNB1 mRNA CTD PMID:15598610 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of EFNB1 mRNA CTD PMID:21602191 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10508 6480464 Tetrachlorodibenzodioxin affects the expression of EFNB1 mRNA CTD PMID:21570461 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:23196670 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:737327 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EFNB1 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EFNB1 mRNA CTD PMID:28628672 3-methylcholanthrene increases expression ISO RGD:10508 6480464 Methylcholanthrene results in increased expression of EFNB1 mRNA CTD PMID:20713471 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of EFNB1 mRNA CTD PMID:24780913 aflatoxin B1 increases expression ISO RGD:737327 6480464 Aflatoxin B1 results in increased expression of EFNB1 mRNA CTD PMID:21641981 , PMID:22100608 aflatoxin B1 decreases methylation ISO RGD:737327 6480464 Aflatoxin B1 results in decreased methylation of EFNB1 gene CTD PMID:27153756 all-trans-retinoic acid increases expression ISO RGD:10508 6480464 Tretinoin results in increased expression of EFNB1 mRNA CTD PMID:16604517 all-trans-retinoic acid decreases expression ISO RGD:737327 6480464 Tretinoin results in decreased expression of EFNB1 mRNA CTD PMID:23724009 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of EFNB1 mRNA CTD PMID:16483693 arsane increases expression ISO RGD:10508 6480464 Arsenic results in increased expression of EFNB1 mRNA CTD PMID:24019935 arsenic atom increases expression ISO RGD:10508 6480464 Arsenic results in increased expression of EFNB1 mRNA CTD PMID:24019935 atrazine increases expression ISO RGD:737327 6480464 Atrazine results in increased expression of EFNB1 mRNA CTD PMID:22378314 benzo[a]pyrene increases expression ISO RGD:737327 6480464 Benzo(a)pyrene results in increased expression of EFNB1 mRNA CTD PMID:22316170 , PMID:32234424 benzo[a]pyrene multiple interactions ISO RGD:10508 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of EFNB1 mRNA CTD PMID:27858113 benzo[b]fluoranthene decreases expression ISO RGD:10508 6480464 benzo(b)fluoranthene results in decreased expression of EFNB1 mRNA CTD PMID:26377693 benzo[b]fluoranthene multiple interactions ISO RGD:10508 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of EFNB1 mRNA CTD PMID:27858113 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of EFNB1 mRNA CTD PMID:25181051 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of EFNB1 mRNA CTD PMID:30816183 bisphenol A multiple interactions ISO RGD:737327 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EFNB1 mRNA CTD PMID:28628672 bisphenol F multiple interactions ISO RGD:737327 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EFNB1 mRNA CTD PMID:28628672 cadmium atom decreases expression ISO RGD:10508 6480464 Cadmium results in decreased expression of EFNB1 mRNA CTD PMID:24067728 cadmium dichloride decreases expression ISO RGD:737327 6480464 Cadmium Chloride results in decreased expression of EFNB1 mRNA CTD PMID:26472689 carbon nanotube decreases expression ISO RGD:737327 6480464 Nanotubes, Carbon results in decreased expression of EFNB1 mRNA CTD PMID:25511174 carbon nanotube decreases expression ISO RGD:10508 6480464 Nanotubes, Carbon analog results in decreased expression of EFNB1 mRNA, Nanotubes, Carbon results in decreased expression of EFNB1 mRNA CTD PMID:25554681 chlorpyrifos decreases expression ISO RGD:10508 6480464 Chlorpyrifos results in decreased expression of EFNB1 mRNA CTD PMID:20350560 chrysene decreases expression ISO RGD:10508 6480464 chrysene results in decreased expression of EFNB1 mRNA CTD PMID:26377693 chrysene multiple interactions ISO RGD:10508 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of EFNB1 mRNA CTD PMID:27858113 cisplatin multiple interactions ISO RGD:737327 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of EFNB1 mRNA CTD PMID:27392435 cisplatin increases expression ISO RGD:737327 6480464 Cisplatin results in increased expression of EFNB1 mRNA CTD PMID:27392435 , PMID:27594783 cocaine increases expression EXP 6480464 Cocaine results in increased expression of EFNB1 mRNA CTD PMID:15691709 , PMID:17898221 dexamethasone multiple interactions ISO RGD:737327 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EFNB1 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EFNB1 mRNA CTD PMID:28628672 dibutyl phthalate decreases expression ISO RGD:10508 6480464 Dibutyl Phthalate results in decreased expression of EFNB1 mRNA CTD PMID:21266533 doxorubicin increases expression ISO RGD:737327 6480464 Doxorubicin results in increased expression of EFNB1 mRNA CTD PMID:29803840 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of EFNB1 mRNA CTD PMID:29391264 furan increases methylation EXP 6480464 furan results in increased methylation of EFNB1 gene CTD PMID:22079235 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of EFNB1 mRNA CTD PMID:22061828 indometacin multiple interactions ISO RGD:737327 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EFNB1 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EFNB1 mRNA CTD PMID:28628672 isobutanol multiple interactions ISO RGD:737327 6480464 [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of EFNB1 mRNA CTD PMID:29432896 leflunomide decreases expression ISO RGD:737327 6480464 leflunomide results in decreased expression of EFNB1 mRNA CTD PMID:28988120 maneb multiple interactions ISO RGD:10508 6480464 [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of EFNB1 mRNA CTD PMID:23017109 mercury atom increases expression ISO RGD:737327 6480464 Mercury results in increased expression of EFNB1 mRNA CTD PMID:16823088 mercury(0) increases expression ISO RGD:737327 6480464 Mercury results in increased expression of EFNB1 mRNA CTD PMID:16823088 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of EFNB1 mRNA CTD PMID:19564919 methotrexate affects expression ISO RGD:10508 6480464 Methotrexate affects the expression of EFNB1 mRNA CTD PMID:18502557 paraquat multiple interactions ISO RGD:10508 6480464 [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of EFNB1 mRNA CTD PMID:23017109 pentachlorophenol increases expression ISO RGD:10508 6480464 Pentachlorophenol results in increased expression of EFNB1 mRNA CTD PMID:23892564 phenobarbital affects expression ISO RGD:737327 6480464 Phenobarbital affects the expression of EFNB1 mRNA CTD PMID:19159669 phenobarbital affects expression ISO RGD:10508 6480464 Phenobarbital affects the expression of EFNB1 mRNA CTD PMID:23091169 pirinixic acid increases expression ISO RGD:10508 6480464 pirinixic acid results in increased expression of EFNB1 mRNA CTD PMID:18301758 potassium dichromate increases expression ISO RGD:737327 6480464 Potassium Dichromate results in increased expression of EFNB1 protein CTD PMID:23718831 propiconazole decreases expression ISO RGD:10508 6480464 propiconazole results in decreased expression of EFNB1 mRNA CTD PMID:21278054 SCH 23390 increases expression EXP 6480464 SCH 23390 results in increased expression of EFNB1 mRNA CTD PMID:19564919 sodium arsenite decreases expression ISO RGD:10508 6480464 sodium arsenite results in decreased expression of EFNB1 mRNA CTD PMID:16014739 Soman increases expression EXP 6480464 Soman results in increased expression of EFNB1 mRNA CTD PMID:19281266 tetraphene multiple interactions ISO RGD:10508 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of EFNB1 mRNA CTD PMID:27858113 trichloroethene increases expression ISO RGD:10508 6480464 Trichloroethylene results in increased expression of EFNB1 mRNA CTD PMID:15363585 urethane increases expression ISO RGD:737327 6480464 Urethane results in increased expression of EFNB1 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:10508 6480464 Valproic Acid affects the expression of EFNB1 mRNA CTD PMID:17292431 valproic acid increases methylation ISO RGD:737327 6480464 Valproic Acid results in increased methylation of EFNB1 gene CTD PMID:29154799 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of EFNB1 mRNA CTD PMID:18042343
Biological Process axon guidance TAS 727396 RGD axon guidance IBA FB:FBgn0040324 more ... 13792537 PMID:21873635 GO_Central axon guidance IEA UniProtKB:P52795 , ensembl:ENSMUSP000000507161600115 GO_REF:0000107 Ensembl GO_REF:0000107 axon guidance ISO RGD:10508 1624291 (MGI:MGI:2153438, PMID:11731465) RGD MGI:MGI:2153438 , PMID:11731465 embryonic pattern specification ISO RGD:10508 1624291 MGI:MGI:3039289 (MGI:MGI:3037600 , PMID:15037550) RGD MGI:MGI:3037600 , PMID:15037550 embryonic pattern specification IEA UniProtKB:P52795 , ensembl:ENSMUSP000000507161600115 GO_REF:0000107 Ensembl GO_REF:0000107 ephrin receptor signaling pathway TAS 727396 RGD ephrin receptor signaling pathway IBA MGI:MGI:102707 more ... 13792537 PMID:21873635 GO_Central ephrin receptor signaling pathway IEA InterPro:IPR034255 1600115 GO_REF:0000002 InterPro GO_REF:0000002 nervous system development IMP 727396 RGD neural crest cell migration ISO RGD:10508 1624291 MGI:MGI:3039290 (MGI:MGI:3037600 , PMID:15037550) RGD MGI:MGI:3037600 , PMID:15037550 neural crest cell migration IEA UniProtKB:P52795 , ensembl:ENSMUSP000000507161600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of T cell proliferation ISO RGD:10508 1624291 (MGI:MGI:3522541, PMID:15502157) RGD MGI:MGI:3522541 , PMID:15502157 positive regulation of T cell proliferation IEA UniProtKB:P52795 , ensembl:ENSMUSP000000507161600115 GO_REF:0000107 Ensembl GO_REF:0000107 presynapse assembly IDA 13702172 PMID:19915143 SynGO presynapse assembly IMP 13702172 PMID:19915143 SynGO T cell costimulation ISO RGD:10508 1624291 (MGI:MGI:3513714, PMID:15599401) RGD MGI:MGI:3513714 , PMID:15599401 T cell costimulation IEA UniProtKB:P52795 , ensembl:ENSMUSP000000507161600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cytoplasm ISO RGD:10508 1624291 (MGI:MGI:3849211, PMID:19515908) RGD MGI:MGI:3849211 , PMID:19515908 cytoplasm IEA UniProtKB:P52795 , ensembl:ENSMUSP000000507161600115 GO_REF:0000107 Ensembl GO_REF:0000107 glutamatergic synapse IDA 13702172 PMID:19915143 SynGO glutamatergic synapse IMP 13702172 PMID:19915143 SynGO integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000043 UniProt GO_REF:0000043 integral component of presynaptic membrane IDA 13702172 PMID:19915143 SynGO membrane raft ISO RGD:10508 1624291 (MGI:MGI:1334095, PMID:10197531) RGD MGI:MGI:1334095 , PMID:10197531 membrane raft IEA UniProtKB:P52795 , ensembl:ENSMUSP000000507161600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:10508 1624291 (MGI:MGI:3849211, PMID:19515908) RGD MGI:MGI:3849211 , PMID:19515908 nucleus IEA UniProtKB:P52795 , ensembl:ENSMUSP000000507161600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane IEA UniProtKB:P98172 , ensembl:ENSP000002049611600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane IBA MGI:MGI:105097 more ... 13792537 PMID:21873635 GO_Central plasma membrane ISO RGD:737327 1624291 RGD GO_REF:0000052 synapse IDA 8554504 PMID:9883737 UniProt Molecular Function ephrin receptor binding TAS 727396 RGD ephrin receptor binding IBA FB:FBgn0040324 more ... 13792537 PMID:21873635 GO_Central ephrin receptor binding IEA UniProtKB:P52795 , ensembl:ENSMUSP000000507161600115 GO_REF:0000107 Ensembl GO_REF:0000107 ephrin receptor binding ISO RGD:10508 1624291 PR:Q03145 more ... RGD MGI:MGI:3037383 , PMID:14988728 protein binding ISO RGD:10508 1624291 PR:P52801 more ... RGD MGI:MGI:3037383 more ... protein binding ISO RGD:737327 1624291 UniProtKB:P04626 more ... RGD PMID:22279592 more ... protein binding IPI UniProtKB:P54763 8554504 PMID:9883737 UniProt
Gene-Chemical Interaction Annotations
