Serpinb7 (serpin family B member 7)

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Gene: Serpinb7 (serpin family B member 7) Rattus norvegicus

Analyze

Symbol:

Serpinb7

Name:

serpin family B member 7

RGD ID:

71063

Description:

Predicted to enable serine-type endopeptidase inhibitor activity. Involved in positive regulation of biosynthetic process and positive regulation of glomerular mesangial cell proliferation. Predicted to be active in extracellular space. Biomarker of nephritis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINB7 (serpin family B member 7); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Megsin; serine (or cysteine) peptidase inhibitor, clade B, member 7; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7; serine (or cysteine) proteinase inhibitor, clade B, member 7; serpin B7; serpin peptidase inhibitor, clade B (ovalbumin), member 7

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SERPINB7 (serpin family B member 7)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Serpinb7 (serine (or cysteine) peptidase inhibitor, clade B, member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Serpinb7 (serpin family B member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SERPINB7 (serpin family B member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SERPINB7 (serpin family B member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Serpinb7 (serpin family B member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SERPINB7 (serpin family B member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SERPINB7 (serpin family B member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Serpinb7 (serpin family B member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NIPSNAP2 (nipsnap homolog 2)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Serpinb7 (serine (or cysteine) peptidase inhibitor, clade B, member 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SERPINB7 (serpin family B member 7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-7	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn55B	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	23,369,830 - 23,442,205 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	23,395,671 - 23,442,205 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	23,770,062 - 23,811,605 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	25,054,524 - 25,096,071 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	23,740,244 - 23,781,790 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	27,282,456 - 27,354,775 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	27,312,498 - 27,354,052 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	32,431,704 - 32,503,907 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	13,464,818 - 13,506,372 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	13,464,817 - 13,506,372 (+)	NCBI
Celera	13	23,245,098 - 23,286,663 (+)	NCBI		Celera
Cytogenetic Map	13	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 18q deletion syndrome (ISO)

Diabetic Nephropathies (ISO)

familial encephalopathy with neuroserpin inclusion bodies (ISO)

genetic disease (ISO)

IgA glomerulonephritis (ISO)

multiple congenital anomalies-hypotonia-seizures syndrome 1 (ISO)

nephritis (IEP)

Palmoplantar Keratoderma, Nagashima Type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

4-nitrophenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

CGP 52608 (ISO)

chlorohydrocarbon (EXP)

chlorpyrifos (ISO)

cisplatin (ISO)

Cuprizon (EXP)

dimethylarsinous acid (ISO)

doxorubicin (ISO)

flavonoids (EXP)

formaldehyde (ISO)

fulvestrant (ISO)

gentamycin (EXP)

lipopolysaccharide (ISO)

methimazole (EXP)

methylisothiazolinone (ISO)

methylmercury chloride (EXP)

nickel sulfate (ISO)

paraquat (EXP)

potassium chromate (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

temozolomide (ISO)

trichloroethene (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of collagen biosynthetic process (IMP)

positive regulation of glomerular mesangial cell proliferation (IMP)

positive regulation of platelet-derived growth factor production (IMP)

positive regulation of transforming growth factor beta1 production (IMP)

Cellular Component

extracellular space (IBA)

Molecular Function

serine-type endopeptidase inhibitor activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice.	Inagi R, etal., Diabetes. 2006 Feb;55(2):356-66.
4.	Megsin 2093T-2180C haplotype at the 3' untranslated region is associated with poor renal survival in Korean IgA nephropathy patients.	Lim CS, etal., Clin Nephrol. 2008 Aug;70(2):101-9.
5.	Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.	McDonough CW, etal., Hum Genet. 2009 Dec;126(6):805-17. doi: 10.1007/s00439-009-0732-8.
6.	Gene Data Set	MGD Curation, June 12, 2002
7.	Cloning of rodent megsin revealed its up-regulation in mesangioproliferative nephritis.	Nangaku M, etal., Kidney Int 2001 Aug;60(2):641-52.
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	A rat model of human FENIB (familial encephalopathy with neuroserpin inclusion bodies).	Takano K, etal., Biochem Biophys Res Commun. 2006 Aug 4;346(3):1040-7. Epub 2006 Jun 12.
15.	[Association of single nucleotide polymorphism of megsin gene with IgA nephropathy].	Wang ZH, etal., Zhonghua Yi Xue Za Zhi. 2006 May 23;86(19):1337-41.
16.	Overexpression of megsin induces mesangial cell proliferation and excretion of type IV collagen in vitro.	Xia Y, etal., Cell Immunol. 2011;271(2):413-7. doi: 10.1016/j.cellimm.2011.08.009. Epub 2011 Sep 5.
17.	A family-based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese population.	Xia YF, etal., Clin Nephrol. 2006 Mar;65(3):153-9.

Additional References at PubMed

PMID:18580857

Genomics

Comparative Map Data

Serpinb7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	23,369,830 - 23,442,205 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	23,395,671 - 23,442,205 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	23,770,062 - 23,811,605 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	25,054,524 - 25,096,071 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	23,740,244 - 23,781,790 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	27,282,456 - 27,354,775 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	27,312,498 - 27,354,052 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	32,431,704 - 32,503,907 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	13,464,818 - 13,506,372 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	13,464,817 - 13,506,372 (+)	NCBI
Celera	13	23,245,098 - 23,286,663 (+)	NCBI		Celera
Cytogenetic Map	13	p11	NCBI

SERPINB7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	63,753,057 - 63,805,370 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	63,752,935 - 63,805,376 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	61,420,291 - 61,472,604 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	59,571,257 - 59,623,584 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	59,593,623 - 59,623,590	NCBI
Celera	18	58,140,787 - 58,193,062 (+)	NCBI		Celera
Cytogenetic Map	18	q21.33	NCBI
HuRef	18	58,121,598 - 58,173,856 (+)	NCBI		HuRef
CHM1_1	18	61,416,473 - 61,468,833 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	63,958,110 - 64,010,475 (+)	NCBI		T2T-CHM13v2.0

Serpinb7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	107,350,418 - 107,380,419 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	107,327,385 - 107,380,419 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	107,422,689 - 107,452,689 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	107,399,655 - 107,452,689 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	109,319,266 - 109,349,266 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	109,250,236 - 109,280,235 (+)	NCBI		MGSCv36	mm8
Celera	1	110,260,443 - 110,291,388 (+)	NCBI		Celera
Cytogenetic Map	1	E2.1	NCBI
cM Map	1	50.34	NCBI

Serpinb7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	47,599,150 - 47,649,885 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	47,599,503 - 47,649,537 (+)	NCBI	ChiLan1.0	ChiLan1.0

SERPINB7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	18	66,956,410 - 67,008,506 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	57,112,242 - 57,164,213 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	60,423,119 - 60,475,171 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	60,445,135 - 60,475,165 (+)	Ensembl	panpan1.1		panPan2

SERPINB7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	13,336,067 - 13,392,674 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	13,336,837 - 13,358,125 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	14,296,781 - 14,353,408 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	13,191,171 - 13,247,792 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	13,191,169 - 13,218,577 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	13,229,696 - 13,286,210 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	13,158,947 - 13,215,544 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	13,408,033 - 13,464,630 (-)	NCBI		UU_Cfam_GSD_1.0

Serpinb7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	26,626,496 - 26,678,824 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936497	1,866,166 - 1,887,690 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936497	1,865,540 - 1,887,695 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SERPINB7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	157,953,877 - 157,998,842 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	157,953,872 - 157,999,242 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	175,390,325 - 175,435,317 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SERPINB7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	15,992,154 - 16,020,001 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	15,992,186 - 16,044,650 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666060	9,672,358 - 9,700,689 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Serpinb7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624792	9,730,223 - 9,794,673 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Serpinb7
506 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	18
Count of miRNA genes:	13
Interacting mature miRNAs:	18
Transcripts:	ENSRNOT00000003466
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317027	Aia22	Adjuvant induced arthritis QTL 22	2.29		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	13	1	34266636	Rat
738036	Lnnr4	Liver neoplastic nodule remodeling QTL 4	3.64		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	1	42356786	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
631672	Iddm12	Insulin dependent diabetes mellitus QTL 12	2.2	0.0032	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	5994668	34535351	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	5994668	44807491	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317034	Aia9	Adjuvant induced arthritis QTL 9	4.62		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	11766535	32331607	Rat
2317044	Aia23	Adjuvant induced arthritis QTL 23	2.3		joint integrity trait (VT:0010548)	ankle joint diameter (CMO:0002148)	13	11766535	32331607	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	11929449	45417941	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	11929449	46193066	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low			4		9						7	11
Below cutoff	2	15	28	16	10	16	3	3	17	18	23		3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_130404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249629	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC103453	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF105329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228843	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000003466 ⟹ ENSRNOP00000003466

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	23,395,671 - 23,442,205 (+)	Ensembl
Rnor_6.0 Ensembl	13	27,312,498 - 27,354,052 (+)	Ensembl

RefSeq Acc Id:

NM_130404 ⟹ NP_569088

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	23,395,670 - 23,442,205 (+)	NCBI
Rnor_6.0	13	27,312,498 - 27,354,052 (+)	NCBI
Rnor_5.0	13	32,431,704 - 32,503,907 (+)	NCBI
RGSC_v3.4	13	13,464,818 - 13,506,372 (+)	RGD
Celera	13	23,245,098 - 23,286,663 (+)	RGD

Sequence:

show sequence

ATGGCCTCCCTTGCTGCAGCAAATGCAGAATTTGGCTTCGACTTATTCAGAGAGATGGATAGTA
GTCAAGGAAACGGAAATGTATTCTTCTCTTCCCTGAGCATCTTCACTGCCCTGAGCCTAATCCG
TTTGGGTGCTCGAGGTGACTGTGCACGTCAGATTGACAAGGCCCTGCACTTTATCTCCCCATCA
AGACAAGGGAATTCATCGAACAGTCAGCTAGGACTGCAATATCAATTGAAAAGAGTTCTTGCTG
ACATAAACTCATCTCATAAGGATTATGAACTCAGCATTGCCAATGGAGTTTTTGCAGAGAAAGT
ATTTGATTTTCATAAGAGCTATATGGAGTGTGCTGAAAACTTATACAATGCTAAAGTGGAAAGA
GTTGATTTTACAAATGATATACAAGAAACCAGATTTAAAATTAATAAATGGATTGAAAATGAAA
CACATGGCAAAATCAAGAAGGTGTTGGGGGACAGCAGCCTCAGCTCATCAGCTGTCATGGTGCT
AGTGAATGCTGTTTACTTCAAAGGCAAGTGGAAATCGGCCTTCACCAAGAGTGATACCCTCAGT
TGCCATTTCAGGTCTCCCAGCGGTCCTGGAAAAGCAGTTAATATGATGCATCAAGAACGGAGGT
TCAATTTGTCTACCATTCAGGAGCCACCAATGCAGATTCTTGAGCTACAATATCATGGTGGCAT
AAGCATGTACATCATGTTGCCCGAGGATGACCTATCCGAAATTGAAAGCAAGCTGAGTTTCCAG
AATCTAATGGACTGGACAAATAGCAGGAAGATGAAATCTCAGTATGTGAATGTGTTTCTCCCCC
AGTTCAAGATAGAGAAAGATTATGAAATGAGGAGCCACTTGAAATCTGTAGGCTTGGAAGACAT
CTTTGTTGAGTCCAGGGCTGATCTGTCTGGAATTGCCTCTGGAGGTCGTCTCTATGTATCAAAG
CTAATGCACAAGTCCCTCATAGAGGTCTCAGAAGAAGGCACCGAGGCAACTGCTGCCACAGAAA
GTAACATCGTTGAAAAGCTACTTCCTGAATCCACGGTGTTCAGAGCTGACCGCCCCTTTCTGTT
TGTCATTAGGAAGAATGGCATCATCTTATTTACTGGCAAAGTCTCGTGTCCTTGA

hide sequence

RefSeq Acc Id:

XM_006249629 ⟹ XP_006249691

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	23,369,830 - 23,442,205 (+)	NCBI
Rnor_6.0	13	27,282,456 - 27,354,775 (+)	NCBI
Rnor_5.0	13	32,431,704 - 32,503,907 (+)	NCBI

Sequence:

show sequence

AGGAAGGAGGCAGGAAGAACTGGAGCCCAGCAGCGAAGCCCTCAGAGCTGCACTGGGAGGAGGA
GACACTTGGTTTCAAAATGGCCTCCCTTGCTGCAGCAAATGCAGAATTTGGCTTCGACTTATTC
AGAGAGATGGATAGTAGTCAAGGAAACGGAAATGTATTCTTCTCTTCCCTGAGCATCTTCACTG
CCCTGAGCCTAATCCGTTTGGGTGCTCGAGGTGACTGTGCACGTCAGATTGACAAGGCCCTGCA
CTTTATCTCCCCATCAAGACAAGGGAATTCATCGAACAGTCAGCTAGGACTGCAATATCAATTG
AAAAGAGTTCTTGCTGACATAAACTCATCTCATAAGGATTATGAACTCAGCATTGCCAATGGAG
TTTTTGCAGAGAAAGTATTTGATTTTCATAAGAGCTATATGGAGTGTGCTGAAAACTTATACAA
TGCTAAAGTGGAAAGAGTTGACTTTACAAATGATATACAAGAAACCAGATTTAAAATTAATAAA
TGGATTGAAAATGAAACACATGGCAAAATCAAGAAGGTGTTGGGGGACAGCAGCCTCAGCTCAT
CAGCTGTCATGGTGCTAGTGAATGCTGTTTACTTCAAAGGCAAGTGGAAATCGGCCTTCACCAA
GAGTGATACCCTCAGTTGCCATTTCAGGTCTCCCACGTGTCCTGGAAAAGCAGTTAATATGATG
CATCAAGAACGGAGGTTCAATTTGTCTACCATTCAGGAGCCACCAATGCAGATTCTTGAGCTAC
AATATCATGGTGGCATAAGCATGTACATCATGTTGCCCGAGGATGACCTATCCGAAATTGAAAG
CAAGCTGAGTTTCCAGAATCTAATGGACTGGACAAATAGCAGGAAGATGAAATCTCAGTATGTG
AATGTGTTTCTCCCCCAGTTCAAGATAGAGAAAGATTATGAAATGAGGAGCCACTTGAAATCTG
TAGGCTTGGAAGACATCTTTGTTGAGTCCAGGGCTGATCTGTCTGGAATTGCCTCTGGAGGTCG
TCTCTATGTATCAAAGCTAATGCACAAGTCCCTCATAGAGGTCTCAGAAGAAGGCACCGAGGCA
ACTGCTGCCACAGAAAGTAACATCGTTGAAAAGCTACTTCCTGAATCCACGGTGTTCAGAGCTG
ACCGCCCCTTTCTGTTTGTCATTAGGAAGAATGGCATCATCTTATTTACTGGCAAAGTCTCGTG
TCCTTGAAATTCTATTTGGTTTTCCATACACTAACAGGCATGAAGAAACATCATAAGTGAATAG
AATTGTAATTGGAAGTACATGGGTTTGCTTTGATTTGTTTCAGTTCATTGGTGGTCAGCAAATT
ATTTTGGTGACTTAACCTTTTTCACTCCCTGGTTGGTAGTCTCAATCCCTGCTCTCATCATTTT
TACTCCCATTTACTTCCCTTCATCTTATATTATTGGCTTTCCCTCCATGTTCTACTCTTCCATT
CTTTCCGAAGGCCCATCTGGAAACATGGATTCTGATTCTCTCATGAAAGAATGCATGGGCTGCC
TGTGGAAACTTTCACATTTGAATTCCTTAGTTTTCAGAGACATTCCTGCTTCATGATTCAATGA
TCTAAAAAGTAAGCCCATTTTTTCCCAGAAATCAAAATGAAGGCTAACTCATTCTTGACAACCA
AGAAGATGCTAGAATTTCCTTTAGAACACTTGACTTCCCAATCACTGTATAATCCAGGGACTCA
AAATACAGAATTAAGATTGGTAAGCAAGCAAAGTGTTTCATTAATACCTTCAAATTTATAGCCT
TTTGCTTACTTGGTAAGACTTAATATATACATAATTTTCAAATATTAAGTGCTTTTTAAATGTT
GGCAGTTATTTACAAAAAAGTATTTCATATTCTTATGAGATTGTGTTTCTCATATTTCTCATAA
TAAAGATGTATAACACCTGTACAGTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_569088	(Get FASTA)	NCBI Sequence Viewer
	XP_006249691	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAL16769	(Get FASTA)	NCBI Sequence Viewer
	EDL91756	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_569088 ⟸ NM_130404

- UniProtKB:

G3V6B5 (UniProtKB/TrEMBL), A6JSV8 (UniProtKB/TrEMBL), Q920J5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASLAAANAEFGFDLFREMDSSQGNGNVFFSSLSIFTALSLIRLGARGDCARQIDKALHFISPS
RQGNSSNSQLGLQYQLKRVLADINSSHKDYELSIANGVFAEKVFDFHKSYMECAENLYNAKVER
VDFTNDIQETRFKINKWIENETHGKIKKVLGDSSLSSSAVMVLVNAVYFKGKWKSAFTKSDTLS
CHFRSPSGPGKAVNMMHQERRFNLSTIQEPPMQILELQYHGGISMYIMLPEDDLSEIESKLSFQ
NLMDWTNSRKMKSQYVNVFLPQFKIEKDYEMRSHLKSVGLEDIFVESRADLSGIASGGRLYVSK
LMHKSLIEVSEEGTEATAATESNIVEKLLPESTVFRADRPFLFVIRKNGIILFTGKVSCP

hide sequence

RefSeq Acc Id:	XP_006249691 ⟸ XM_006249629
- Peptide Label:	isoform X1
- UniProtKB:	G3V6B5 (UniProtKB/TrEMBL), A6JSV8 (UniProtKB/TrEMBL), Q920J5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASLAAANAEFGFDLFREMDSSQGNGNVFFSSLSIFTALSLIRLGARGDCARQIDKALHFISPS RQGNSSNSQLGLQYQLKRVLADINSSHKDYELSIANGVFAEKVFDFHKSYMECAENLYNAKVER VDFTNDIQETRFKINKWIENETHGKIKKVLGDSSLSSSAVMVLVNAVYFKGKWKSAFTKSDTLS CHFRSPTCPGKAVNMMHQERRFNLSTIQEPPMQILELQYHGGISMYIMLPEDDLSEIESKLSFQ NLMDWTNSRKMKSQYVNVFLPQFKIEKDYEMRSHLKSVGLEDIFVESRADLSGIASGGRLYVSK LMHKSLIEVSEEGTEATAATESNIVEKLLPESTVFRADRPFLFVIRKNGIILFTGKVSCP hide sequence

RefSeq Acc Id:

ENSRNOP00000003466 ⟸ ENSRNOT00000003466

Protein Domains

SERPIN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V6B5-F1-model_v2	AlphaFold	G3V6B5	1-380	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:71063	AgrOrtholog
BioCyc Gene	G2FUF-18582	BioCyc
Ensembl Genes	ENSRNOG00000002555	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000003466	ENTREZGENE
	ENSRNOP00000003466.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003466	ENTREZGENE
	ENSRNOT00000003466.5	UniProtKB/TrEMBL
Gene3D-CATH	2.30.39.10	UniProtKB/TrEMBL
	3.30.497.10	UniProtKB/TrEMBL
InterPro	Protease_inhib_I4_serpin	UniProtKB/TrEMBL
	Protease_inhib_I4_serpin_CS	UniProtKB/TrEMBL
	Sepin_dom	UniProtKB/TrEMBL
	Serpin_sf	UniProtKB/TrEMBL
	Serpin_sf_1	UniProtKB/TrEMBL
	Serpin_sf_2	UniProtKB/TrEMBL
KEGG Report	rno:117092	UniProtKB/TrEMBL
NCBI Gene	117092	ENTREZGENE
PANTHER	Prot_inh_serpin	UniProtKB/TrEMBL
	SERPIN B7	UniProtKB/TrEMBL
Pfam	Serpin	UniProtKB/TrEMBL
PhenoGen	Serpinb7	PhenoGen
PROSITE	SERPIN	UniProtKB/TrEMBL
SMART	SERPIN	UniProtKB/TrEMBL
Superfamily-SCOP	Prot_inh_serpin	UniProtKB/TrEMBL
UniProt	A6JSV8	ENTREZGENE, UniProtKB/TrEMBL
	G3V6B5	ENTREZGENE, UniProtKB/TrEMBL
	Q920J5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-13	Serpinb7	serpin family B member 7	Serpinb7	serpin peptidase inhibitor, clade B (ovalbumin), member 7	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-01-19	Serpinb7	serpin peptidase inhibitor, clade B (ovalbumin), member 7	Serpinb7	serine (or cysteine) peptidase inhibitor, clade B, member 7	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-18	Serpinb7	serine (or cysteine) peptidase inhibitor, clade B, member 7	Serpinb7	serine (or cysteine) proteinase inhibitor, clade B, member 7	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Serpinb7	serine (or cysteine) proteinase inhibitor, clade B, member 7			Name updated	1299863	APPROVED
2002-07-09	Serpinb7	serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	expression upregulated in mesangial cells during proliferative stage in the nephron	70611

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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