![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Dyrk3 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of DYRK3 mRNA] | CTD | PMID:31150632 | Dyrk3 | Rat | 1,1-dichloroethene | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of DYRK3 mRNA | CTD | PMID:26682919 | Dyrk3 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of DYRK3 mRNA | CTD | PMID:22206623 | Dyrk3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Dyrk3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of DYRK3 mRNA | CTD | PMID:21570461 | Dyrk3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of DYRK3 mRNA | CTD | PMID:27913140 and PMID:33387578 | Dyrk3 | Rat | 2-palmitoylglycerol | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of DYRK3 mRNA | CTD | PMID:37199045 | Dyrk3 | Rat | 4,4'-diaminodiphenylmethane | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of DYRK3 mRNA | CTD | PMID:18648102 | Dyrk3 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | Fenretinide results in increased expression of DYRK3 mRNA | CTD | PMID:28973697 | Dyrk3 | Rat | 5-iodotubercidin | decreases activity | ISO | DYRK3 (Homo sapiens) | 6480464 | 5-iodotubercidin results in decreased activity of DYRK3 protein | CTD | PMID:26953159 | Dyrk3 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of DYRK3 mRNA | CTD | PMID:24780913 | Dyrk3 | Rat | 7,12-dimethyltetraphene | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | 9 more ... | CTD | PMID:32553695 | Dyrk3 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of DYRK3 mRNA | CTD | PMID:31881176 | Dyrk3 | Rat | aflatoxin B1 | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of DYRK3 mRNA | CTD | PMID:19770486 | Dyrk3 | Rat | aflatoxin B1 | decreases methylation | ISO | DYRK3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of DYRK3 gene | CTD | PMID:27153756 | Dyrk3 | Rat | all-trans-retinoic acid | decreases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of DYRK3 mRNA | CTD | PMID:33167477 | Dyrk3 | Rat | atrazine | decreases expression | EXP | | 6480464 | Atrazine results in decreased expression of DYRK3 mRNA | CTD | PMID:36841081 | Dyrk3 | Rat | benzo[a]pyrene | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | Benzo(a)pyrene metabolite results in increased expression of DYRK3 mRNA and Benzo(a)pyrene results in increased expression of DYRK3 mRNA | CTD | PMID:19770486 and PMID:32553695 | Dyrk3 | Rat | benzo[a]pyrene | decreases methylation | ISO | DYRK3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of DYRK3 promoter | CTD | PMID:27901495 | Dyrk3 | Rat | benzo[a]pyrene | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of DYRK3 mRNA | CTD | PMID:20064835 and PMID:22316170 | Dyrk3 | Rat | benzo[a]pyrene diol epoxide I | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20382639 | Dyrk3 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of DYRK3 mRNA | CTD | PMID:31163220 | Dyrk3 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of DYRK3 mRNA | CTD | PMID:25181051 | Dyrk3 | Rat | bisphenol A | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of DYRK3 mRNA | CTD | PMID:32156529 | Dyrk3 | Rat | bisphenol A | increases methylation | ISO | DYRK3 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of DYRK3 gene | CTD | PMID:31601247 | Dyrk3 | Rat | bisphenol A | multiple interactions | ISO | DYRK3 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of DYRK3 gene | CTD | PMID:31601247 | Dyrk3 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of DYRK3 mRNA | CTD | PMID:32145629 and PMID:34973380 | Dyrk3 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of DYRK3 gene | CTD | PMID:28505145 | Dyrk3 | Rat | bisphenol A | decreases methylation | ISO | Dyrk3 (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of DYRK3 promoter | CTD | PMID:27312807 | Dyrk3 | Rat | butyric acid | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Butyric Acid results in increased expression of DYRK3 mRNA | CTD | PMID:33770205 | Dyrk3 | Rat | cadmium dichloride | decreases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of DYRK3 mRNA | CTD | PMID:33770205 | Dyrk3 | Rat | camptothecin | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Camptothecin results in increased expression of DYRK3 mRNA | CTD | PMID:38460933 | Dyrk3 | Rat | carbamazepine | affects expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of DYRK3 mRNA | CTD | PMID:25979313 | Dyrk3 | Rat | CGP 52608 | multiple interactions | ISO | DYRK3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to DYRK3 gene] | CTD | PMID:28238834 | Dyrk3 | Rat | chloroprene | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | Chloroprene results in increased expression of DYRK3 mRNA | CTD | PMID:23125180 | Dyrk3 | Rat | chlorpyrifos | decreases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of DYRK3 mRNA | CTD | PMID:37019170 | Dyrk3 | Rat | choline | multiple interactions | ISO | Dyrk3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DYRK3 gene | CTD | PMID:20938992 | Dyrk3 | Rat | chromium(6+) | multiple interactions | ISO | DYRK3 (Homo sapiens) | 6480464 | [zinc chromate results in increased abundance of chromium hexavalent ion] which results in increased expression of DYRK3 mRNA | CTD | PMID:38479592 | Dyrk3 | Rat | cisplatin | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of DYRK3 mRNA | CTD | PMID:19561079 more ... | Dyrk3 | Rat | copper atom | multiple interactions | ISO | DYRK3 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of DYRK3 mRNA | CTD | PMID:20971185 | Dyrk3 | Rat | copper(0) | multiple interactions | ISO | DYRK3 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of DYRK3 mRNA | CTD | PMID:20971185 | Dyrk3 | Rat | copper(II) sulfate | decreases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of DYRK3 mRNA | CTD | PMID:19549813 | Dyrk3 | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of DYRK3 mRNA | CTD | PMID:26577399 | Dyrk3 | Rat | deguelin | decreases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | deguelin results in decreased expression of DYRK3 mRNA | CTD | PMID:33512557 | Dyrk3 | Rat | dibenz[a,h]anthracene | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:26377693 | Dyrk3 | Rat | dioxygen | multiple interactions | ISO | Dyrk3 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of DYRK3 mRNA | CTD | PMID:30529165 | Dyrk3 | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of DYRK3 mRNA | CTD | PMID:29391264 | Dyrk3 | Rat | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of DYRK3 mRNA | CTD | PMID:31078653 | Dyrk3 | Rat | ethylparaben | decreases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | ethyl-p-hydroxybenzoate results in decreased expression of DYRK3 mRNA | CTD | PMID:37690743 | Dyrk3 | Rat | folic acid | multiple interactions | ISO | Dyrk3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DYRK3 gene | CTD | PMID:20938992 | Dyrk3 | Rat | folic acid | decreases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of DYRK3 mRNA | CTD | PMID:25629700 | Dyrk3 | Rat | folic acid | multiple interactions | ISO | DYRK3 (Homo sapiens) | 6480464 | [Folic Acid deficiency co-treated with Methotrexate] results in increased expression of DYRK3 mRNA | CTD | PMID:24657277 | Dyrk3 | Rat | folpet | decreases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | folpet results in decreased expression of DYRK3 mRNA | CTD | PMID:31558096 | Dyrk3 | Rat | fulvestrant | multiple interactions | ISO | DYRK3 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of DYRK3 gene | CTD | PMID:31601247 | Dyrk3 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of DYRK3 mRNA | CTD | PMID:22061828 | Dyrk3 | Rat | L-methionine | multiple interactions | ISO | Dyrk3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DYRK3 gene | CTD | PMID:20938992 | Dyrk3 | Rat | leflunomide | decreases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | leflunomide results in decreased expression of DYRK3 mRNA | CTD | PMID:28988120 | Dyrk3 | Rat | lipopolysaccharide | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of DYRK3 mRNA | CTD | PMID:35811015 | Dyrk3 | Rat | lipopolysaccharide | multiple interactions | ISO | DYRK3 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of DYRK3 mRNA] | CTD | PMID:35811015 | Dyrk3 | Rat | methotrexate | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Methotrexate results in increased expression of DYRK3 mRNA | CTD | PMID:24657277 | Dyrk3 | Rat | methotrexate | multiple interactions | ISO | DYRK3 (Homo sapiens) | 6480464 | [Folic Acid deficiency co-treated with Methotrexate] results in increased expression of DYRK3 mRNA | CTD | PMID:24657277 | Dyrk3 | Rat | methoxyacetic acid | affects expression | EXP | | 6480464 | methoxyacetic acid affects the expression of DYRK3 mRNA | CTD | PMID:20864626 | Dyrk3 | Rat | N-nitrosodiethylamine | multiple interactions | ISO | Dyrk3 (Mus musculus) | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of DYRK3 mRNA | CTD | PMID:24535843 | Dyrk3 | Rat | nitrofen | decreases expression | EXP | | 6480464 | nitrofen results in decreased expression of DYRK3 mRNA | CTD | PMID:26720608 | Dyrk3 | Rat | nitrofen | increases expression | EXP | | 6480464 | nitrofen results in increased expression of DYRK3 mRNA | CTD | PMID:33484710 | Dyrk3 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of DYRK3 mRNA | CTD | PMID:25729387 | Dyrk3 | Rat | oxaliplatin | decreases expression | EXP | | 6480464 | oxaliplatin results in decreased expression of DYRK3 mRNA | CTD | PMID:25729387 | Dyrk3 | Rat | ozone | multiple interactions | ISO | Dyrk3 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of DYRK3 mRNA | CTD | PMID:34911549 | Dyrk3 | Rat | ozone | multiple interactions | ISO | DYRK3 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of DYRK3 mRNA | CTD | PMID:35430440 | Dyrk3 | Rat | panobinostat | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Panobinostat results in increased expression of DYRK3 mRNA | CTD | PMID:33770205 | Dyrk3 | Rat | paracetamol | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of DYRK3 mRNA | CTD | PMID:21420995 | Dyrk3 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of DYRK3 mRNA | CTD | PMID:33387578 | Dyrk3 | Rat | phenobarbital | multiple interactions | ISO | Dyrk3 (Mus musculus) | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of DYRK3 mRNA and NR1I3 protein affects the reaction [Phenobarbital results in increased expression of DYRK3 mRNA] | CTD | PMID:19482888 and PMID:24535843 | Dyrk3 | Rat | phenobarbital | affects expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of DYRK3 mRNA | CTD | PMID:19159669 | Dyrk3 | Rat | phenobarbital | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of DYRK3 mRNA | CTD | PMID:19482888 | Dyrk3 | Rat | picoxystrobin | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | picoxystrobin results in increased expression of DYRK3 mRNA | CTD | PMID:33512557 | Dyrk3 | Rat | resveratrol | multiple interactions | ISO | DYRK3 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of DYRK3 mRNA | CTD | PMID:23557933 | Dyrk3 | Rat | rotenone | decreases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Rotenone results in decreased expression of DYRK3 mRNA | CTD | PMID:33512557 | Dyrk3 | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | DYRK3 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of DYRK3 mRNA] | CTD | PMID:35811015 | Dyrk3 | Rat | silicon dioxide | decreases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of DYRK3 mRNA | CTD | PMID:19073995 | Dyrk3 | Rat | sodium arsenite | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of DYRK3 mRNA | CTD | PMID:38568856 | Dyrk3 | Rat | sodium arsenite | decreases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of DYRK3 mRNA | CTD | PMID:34032870 | Dyrk3 | Rat | sodium dichromate | affects expression | EXP | | 6480464 | sodium bichromate affects the expression of DYRK3 mRNA | CTD | PMID:22110744 | Dyrk3 | Rat | sunitinib | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of DYRK3 mRNA | CTD | PMID:31533062 | Dyrk3 | Rat | temozolomide | decreases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of DYRK3 mRNA | CTD | PMID:31758290 | Dyrk3 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of DYRK3 mRNA] | CTD | PMID:31150632 | Dyrk3 | Rat | tetrachloromethane | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of DYRK3 mRNA | CTD | PMID:31919559 | Dyrk3 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of DYRK3 mRNA | CTD | PMID:30723492 and PMID:31150632 | Dyrk3 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of DYRK3 mRNA | CTD | PMID:23411599 and PMID:34492290 | Dyrk3 | Rat | titanium dioxide | decreases methylation | ISO | Dyrk3 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of DYRK3 gene | CTD | PMID:35295148 | Dyrk3 | Rat | titanium dioxide | increases methylation | ISO | Dyrk3 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of DYRK3 gene | CTD | PMID:35295148 | Dyrk3 | Rat | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of DYRK3 mRNA | CTD | PMID:25729387 | Dyrk3 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of DYRK3 mRNA | CTD | PMID:25729387 | Dyrk3 | Rat | trichloroethene | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | Trichloroethylene results in increased expression of DYRK3 mRNA | CTD | PMID:25549359 | Dyrk3 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of DYRK3 mRNA | CTD | PMID:33387578 | Dyrk3 | Rat | trichostatin A | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of DYRK3 mRNA | CTD | PMID:28542535 | Dyrk3 | Rat | troglitazone | decreases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | troglitazone results in decreased expression of DYRK3 mRNA | CTD | PMID:28973697 | Dyrk3 | Rat | trovafloxacin | increases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | trovafloxacin results in increased expression of DYRK3 mRNA | CTD | PMID:35537566 | Dyrk3 | Rat | urethane | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Urethane results in increased expression of DYRK3 mRNA | CTD | PMID:28818685 | Dyrk3 | Rat | valproic acid | decreases expression | ISO | Dyrk3 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of DYRK3 mRNA | CTD | PMID:21427059 | Dyrk3 | Rat | valproic acid | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of DYRK3 mRNA | CTD | PMID:29154799 and PMID:33770205 | Dyrk3 | Rat | valproic acid | affects expression | ISO | DYRK3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of DYRK3 mRNA | CTD | PMID:25979313 | Dyrk3 | Rat | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of DYRK3 mRNA | CTD | PMID:18042343 | Dyrk3 | Rat | vorinostat | increases expression | ISO | DYRK3 (Homo sapiens) | 6480464 | vorinostat results in increased expression of DYRK3 mRNA | CTD | PMID:27188386 | |