Slc4a11 (solute carrier family 4 member 11)

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Gene: Slc4a11 (solute carrier family 4 member 11) Rattus norvegicus

Analyze

Symbol:

Slc4a11

Name:

solute carrier family 4 member 11

RGD ID:

1310188

Description:

Predicted to enable several functions, including active borate transmembrane transporter activity; proton channel activity; and salt transmembrane transporter activity. Predicted to be involved in several processes, including bicarbonate transport; cellular hypotonic response; and monoatomic cation transport. Located in basolateral plasma membrane and vesicle membrane. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; congenital hereditary endothelial dystrophy of cornea; and corneal dystrophy-perceptive deafness syndrome. Orthologous to human SLC4A11 (solute carrier family 4 member 11); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC311423; sodium bicarbonate transporter-like protein 11; solute carrier family 4, sodium bicarbonate transporter-like, member 11; solute carrier family 4, sodium borate transporter, member 11

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC4A11 (solute carrier family 4 member 11)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Slc4a11 (solute carrier family 4, sodium bicarbonate transporter-like, member 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc4a11 (solute carrier family 4 member 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC4A11 (solute carrier family 4 member 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC4A11 (solute carrier family 4 member 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc4a11 (solute carrier family 4 member 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC4A11 (solute carrier family 4 member 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC4A11 (solute carrier family 4 member 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc4a11 (solute carrier family 4 member 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	HSPA9 (heat shock protein family A (Hsp70) member 9)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SLC4A11 (solute carrier family 4 member 11)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc4a11 (solute carrier family 4, sodium bicarbonate transporter-like, member 11)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc4a11 (solute carrier family 4 member 11)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BOR1	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	abts-2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	abts-3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc4a11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pcyt1b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	117,900,223 - 117,912,787 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	117,900,223 - 117,912,674 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	121,794,589 - 121,806,946 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	130,392,225 - 130,404,562 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	128,050,725 - 128,063,082 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	123,224,242 - 123,236,535 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	123,224,242 - 123,236,535 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	129,722,370 - 129,734,676 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	118,313,086 - 118,325,392 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	118,218,975 - 118,239,305 (-)	NCBI
Celera	3	116,711,040 - 116,723,436 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital hereditary endothelial dystrophy of cornea (ISO,ISS)

corneal dystrophy (ISO)

Corneal Dystrophy, Fuchs Endothelial, 4 (ISO)

corneal dystrophy-perceptive deafness syndrome (ISO)

genetic disease (ISO)

Huntington's disease-like 1 (ISO)

Inosine Triphosphatase Deficiency (ISO)

pantothenate kinase-associated neurodegeneration (ISO)

posterior polymorphous corneal dystrophy 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

butanal (ISO)

calcitriol (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diquat (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

etoposide (ISO)

folic acid (ISO)

gentamycin (EXP)

L-methionine (ISO)

methimazole (EXP)

nickel sulfate (ISO)

O-methyleugenol (ISO)

paracetamol (EXP)

paraquat (EXP)

phenylmercury acetate (ISO)

progesterone (ISO)

propanal (ISO)

quercetin (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

thioacetamide (EXP)

trametinib (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

troglitazone (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bicarbonate transport (ISO)

borate transmembrane transport (IEA)

borate transport (ISO)

cellular hypotonic response (ISO)

cellular response to oxidative stress (ISO)

fluid transport (ISO)

intracellular monoatomic cation homeostasis (ISO)

monoatomic anion transport (IEA)

monoatomic ion homeostasis (IBA,ISO)

proton transmembrane transport (ISO)

regulation of mesenchymal stem cell differentiation (ISO)

regulation of mitochondrial membrane potential (ISO)

sodium ion transmembrane transport (IEA)

sodium ion transport (ISO)

transmembrane transport (IBA)

water transport (IEA)

Cellular Component

apical plasma membrane (ISO)

basolateral plasma membrane (IBA,IDA,ISO)

plasma membrane (IBA,IDA)

vesicle membrane (IDA)

Molecular Function

active borate transmembrane transporter activity (ISO)

bicarbonate transmembrane transporter activity (ISO)

protein dimerization activity (ISO)

proton channel activity (ISO)

proton transmembrane transporter activity (ISO)

sodium channel activity (ISO)

solute:inorganic anion antiporter activity (IEA)

transmembrane transporter activity (IBA)

water transmembrane transporter activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues.	Damkier HH, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R2136-46. doi: 10.1152/ajpregu.00356.2007. Epub 2007 Aug 22.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15525507	PMID:20185830	PMID:22072594	PMID:26582474	PMID:31124301

Genomics

Comparative Map Data

Slc4a11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	117,900,223 - 117,912,787 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	117,900,223 - 117,912,674 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	121,794,589 - 121,806,946 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	130,392,225 - 130,404,562 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	128,050,725 - 128,063,082 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	123,224,242 - 123,236,535 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	123,224,242 - 123,236,535 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	129,722,370 - 129,734,676 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	118,313,086 - 118,325,392 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	118,218,975 - 118,239,305 (-)	NCBI
Celera	3	116,711,040 - 116,723,436 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

SLC4A11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	3,227,417 - 3,239,559 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	3,227,417 - 3,239,559 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	3,208,063 - 3,220,205 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	3,156,063 - 3,166,373 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	3,156,063 - 3,166,373	NCBI
Celera	20	3,270,026 - 3,281,861 (-)	NCBI		Celera
Cytogenetic Map	20	p13	NCBI
HuRef	20	3,156,372 - 3,168,190 (-)	NCBI		HuRef
CHM1_1	20	3,208,125 - 3,219,949 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	3,258,367 - 3,270,505 (-)	NCBI		T2T-CHM13v2.0

Slc4a11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	130,526,027 - 130,539,439 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	130,526,033 - 130,539,439 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	130,684,107 - 130,697,519 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	130,684,113 - 130,697,519 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	130,509,844 - 130,523,255 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	130,375,549 - 130,388,960 (-)	NCBI		MGSCv36	mm8
Celera	2	131,908,906 - 131,922,301 (-)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	63.24	NCBI

Slc4a11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	14,120,301 - 14,131,989 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	14,123,021 - 14,133,437 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC4A11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	20	4,188,361 - 4,208,785 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	3,311,640 - 3,324,966 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	3,074,434 - 3,086,445 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	3,074,804 - 3,086,157 (-)	Ensembl	panpan1.1		panPan2

SLC4A11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	18,057,437 - 18,068,420 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	18,057,517 - 18,068,425 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	17,885,917 - 17,896,861 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	18,476,201 - 18,487,134 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	18,475,793 - 18,487,130 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	18,069,908 - 18,080,840 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	18,182,276 - 18,193,225 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	18,509,870 - 18,520,803 (+)	NCBI		UU_Cfam_GSD_1.0

Slc4a11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	167,055,165 - 167,066,274 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	15,486,372 - 15,497,673 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936485	15,486,565 - 15,497,638 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC4A11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	32,446,831 - 32,458,245 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	32,445,360 - 32,458,246 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	36,837,930 - 36,840,155 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC4A11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	33,897,262 - 33,911,498 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	33,897,630 - 33,908,039 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	10,600,358 - 10,613,671 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc4a11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	4,328,675 - 4,339,851 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	4,328,745 - 4,339,919 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc4a11
58 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	82
Count of miRNA genes:	61
Interacting mature miRNAs:	75
Transcripts:	ENSRNOT00000028839
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	91797474	136797474	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	112287552	135181505	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum insulin level (CMO:0000358)	3	115638168	135181505	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	3	115638168	135181505	Rat

Markers in Region

RH139715

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	117,900,465 - 117,900,760 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	123,224,485 - 123,224,779	NCBI	Rnor6.0
Rnor_5.0	3	129,722,613 - 129,722,907	UniSTS	Rnor5.0
RGSC_v3.4	3	118,313,329 - 118,313,623	UniSTS	RGSC3.4
Celera	3	116,711,283 - 116,711,577	UniSTS
RH 3.4 Map	3	1003.4	UniSTS
Cytogenetic Map	3	q36	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium					2					6	3
Low	3	26	26	10	17	10			74	29	37	11
Below cutoff		17	31	31		31	8	11			1		8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005501874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000028839 ⟹ ENSRNOP00000028839

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	117,900,223 - 117,912,674 (-)	Ensembl
Rnor_6.0 Ensembl	3	123,224,242 - 123,236,535 (-)	Ensembl

RefSeq Acc Id:

NM_001107775 ⟹ NP_001101245

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	117,900,223 - 117,912,674 (-)	NCBI
Rnor_6.0	3	123,224,242 - 123,236,535 (-)	NCBI
Rnor_5.0	3	129,722,370 - 129,734,676 (-)	NCBI
RGSC_v3.4	3	118,313,086 - 118,325,392 (-)	RGD
Celera	3	116,711,040 - 116,723,436 (-)	RGD

Sequence:

show sequence

CGGGCTCTGGTGAGTGGCCCTGCACTGTGGAACTGTTCCGAAACTTCCAGGCCGGCACCCCACG
ACTCTCAGGCCTGCGCACGCGAGCAGCCGCGGATCCAGAACAGATCTCGCGGAAAACTGTGCTT
GAGCCATGTCACAGAATGAACACTGTCAGGACTCCGGTGAATACTTCTCAGCCGCCACTCTGGG
ATACTTCAAGAATGACACAGATGATAACCCTGACGTCCGGGAGGACAGCCTGGGGGATGAGGTC
TTTGACACCGTCAACTCCTCCATTGTGTCTGGCGAGAGCATCCGTTTTTTTGTCAATGTCAACC
TTGAAGTGCAGCCTTCCAAATCTGACATAGAAGCTGCAACTGGAGGCTGCGTGCTCTTACACAC
CTCCCGCAAGTATCTGAAATTAAAGAACTTCGAGGAAGAGGTCCGTGCACACCGTGACCTGGAT
GGCTTCCTGGCCCAGGCCAGCATCATCCTGAATGAGACAGCTACCTCACTGGATGATGTGCTCC
GAACTATGCTAAACCGCTTTGCCCAGGACCCCAACCATGCAGAGCCTGATTGTGACCTGGACCT
GCTCATGGCTAAGCTCTTTACAGATGCTGGGGGCCCCATGGAGAGTAAAGTCCACCTGCTGTCA
GATACCATCCAGGGAGTGACCGCCACTGTCAGAGGACTGCAGTACGAGCAGTCATGGCTCTGCA
TCGTCTGTACCATGAAGTCCCTACAGAAGCGGCATGTGTGTATCAGCCGCCTGGTTCGGCCACA
GAACTGGGGGGAAAACTCCTGTGAGGTTCGCTTTGTCATCCTGGTGCTGGCCCCACCCAAGATG
AAAAGCACCAAGACTGCGATGGAGGTGGCACGCACATTCGCCACCATGTTCTCCGACATCACCT
TCCGCCAGAAGCTCCTGAAGACCCGCACAGAGGAAGAGTTCAAGGAGGCTTTGGTGCACCAGAG
ACAGCTGCTCACCATGATGATGCCAAGAGCAGCCGGGCACAGCATGAGCTCCCTCCATACTCAC
AGACACCCTCGGCCCCCGAAATGCAAGGACTTTTTCCCGTTTGGGAAAGGCATCTGGGTGGACA
TCATGCGCAGGTTCCCTGTGTACCCGCTGGACTTCACGGACGGCATCATTGGGAAAGGCAAGAC
TGTCGGCAAATATGTCACCACCACGCTCTTCCTCTACTTCGCCTGCCTCTTACCGACCATTGCT
TTTGGATCCCTCAACGATGAGAACACAAACGGAGCCATCGATGTGCAGAAGACCATAGCAGGAC
AGAGCATCGGAGGCCTCTTGTATGCACTGTTCTCTGGGCAGCCCCTGGTGATCCTGTTGACAAC
CGCACCCCTGGCCATCTACACCCAGGTGATCCGGGTCATCTGTGATGACTACAACCTGGACTTC
AACGCCTTCTATGCGTGGACAGGCCTGTGGAACAGCTTCTTCCTTGCGCTTTATGCCTTCCTCA
ACCTCAGCCTGCTTATGAATCTCTTTAAGAGGTCAACAGAGGAGATCATTGCTCTGTTCATTTC
CATCACGTTTGTGCTGGACGCTGTCAAGGGCATGGTCAAAATCTTCTGGAAGTACTACTATGGT
CACCACTACCACACAAAAAGGACTTCCTCCTTGGCAAGCCTGTTGGGCATTAGCAGAAGCCCCA
ACACCAGTCTCCACACTGCACTCAACACCAGCTTCTTGGCCAGCCCCATAGAGATGACTACAGC
CAGCAGCCCCATCAGTACACACTCCAACCAGGCTACTGCAGTGCTCAGCCTCCTCATCATGCTG
GGCACACTCTGGCTGGGCTACACCCTCTACCAGTTCAAGAAAAGCCCCTACCTGCACCCATGTG
TGCGTGAGACCCTGTCTGACTGTGCCCTGCCTATCGCCGTGCTCTCCTTCTCCCTCATCAGCTC
CTATGGCTTCCAGGAAATTGAGATGAGCAAGTTCCGGTACAACCCCAGCGAGAGCCTTTTTGAG
GTGGCACAGATCCACTCTCTGTCCTTCAAGGCCATCAGCAGTGCCATGGGTCTTGGCTTCCTGC
TCTCCTTGCTTTTCTTCATTGAGCAGAACCTGGTGGCCGCCCTGGTCAATGCACCAGAGAACAG
GCTGGTGAAGGGCACTGCCTATCACTGGGACCTCCTGCTGCTTGCCATCATCAATACGGGGCTG
TCTCTGTTTGGGCTACCCTGGATCCACGCCGCCTATCCCCATTCCCCTCTGCATGTGCGGGCAC
TGGCCTTAGTGGAGGAACGTGTGGAGAATGGGCACATTTATGAAACGATTGTGAATGTTAAGGA
GACTCGGCTGACTGCGCTGGGTGCCAGTGTCCTGGTGGGTCTGTCCCTGCTGCTGCTTCCATTC
CCGCTGCAGTGGATCCCCAAGCCCGTGCTCTATGGACTCTTCCTCTACATTGCGCTGACCTCCC
TGGACGGCAACCAGCTCTTCTCACGTGTAGCTCTGCTGCTCAAGGAGCAAACGTCATACCCACC
CACACACTACATCCGGAGAGTGCCCCAAAGGAAGATTCACTACTTCACGGGCCTGCAGATTCTG
CAGCTGCTTCTGCTCTGTGCGTTCGGCATGAGCTCCCTGCCCTACATGAAGATGGTCTTTCCGC
TCATCATGATTGCCATGATCCCAATCCGCTATAATCTGCTACCCCGAATCATTGAAGCCAAGTA
CTTGGATGTCATGGATGCCGAGCACAGGCCCTGACCTGCACCAGCCTCCCCATCCTTCAGGCCT
GCTCCGTGGCAATGTGTGGGGAGTATGATCTGCTGTGGCTCCAGCCCGTCCTCATTGCTGTCTT
GTGGCCTAAAGCCCCTTGGCGTTGTGGTTTTCAGAGGTGTGTGATCACCTCTCGCCCCATCAAC
ATTTAGTTTGGGGTCAGAAACACTGTCGGCGTGGGGCTGAGAAGAGTGGATATTCTTTTGATAA
AAGAGTTGATGCCCAGGAGAGAGCCCATTTCCTTGATTGTATAAGGAACTCGATTGTGCACATT
AGTGAATAAAAGTCTTGTTTCTATGCTTTAA

hide sequence

RefSeq Acc Id:

XR_005501874

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	117,902,955 - 117,912,787 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101245	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL80210	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001101245 ⟸ NM_001107775

- UniProtKB:

D3ZVP9 (UniProtKB/TrEMBL), A6HQA9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSQNEHCQDSGEYFSAATLGYFKNDTDDNPDVREDSLGDEVFDTVNSSIVSGESIRFFVNVNLE
VQPSKSDIEAATGGCVLLHTSRKYLKLKNFEEEVRAHRDLDGFLAQASIILNETATSLDDVLRT
MLNRFAQDPNHAEPDCDLDLLMAKLFTDAGGPMESKVHLLSDTIQGVTATVRGLQYEQSWLCIV
CTMKSLQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDITFR
QKLLKTRTEEEFKEALVHQRQLLTMMMPRAAGHSMSSLHTHRHPRPPKCKDFFPFGKGIWVDIM
RRFPVYPLDFTDGIIGKGKTVGKYVTTTLFLYFACLLPTIAFGSLNDENTNGAIDVQKTIAGQS
IGGLLYALFSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLNL
SLLMNLFKRSTEEIIALFISITFVLDAVKGMVKIFWKYYYGHHYHTKRTSSLASLLGISRSPNT
SLHTALNTSFLASPIEMTTASSPISTHSNQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVR
ETLSDCALPIAVLSFSLISSYGFQEIEMSKFRYNPSESLFEVAQIHSLSFKAISSAMGLGFLLS
LLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALA
LVEERVENGHIYETIVNVKETRLTALGASVLVGLSLLLLPFPLQWIPKPVLYGLFLYIALTSLD
GNQLFSRVALLLKEQTSYPPTHYIRRVPQRKIHYFTGLQILQLLLLCAFGMSSLPYMKMVFPLI
MIAMIPIRYNLLPRIIEAKYLDVMDAEHRP

hide sequence

RefSeq Acc Id:

ENSRNOP00000028839 ⟸ ENSRNOT00000028839

Protein Domains

Bicarbonate transporter-like transmembrane

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZVP9-F1-model_v2	AlphaFold	D3ZVP9	1-862	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310188	AgrOrtholog
BioCyc Gene	G2FUF-47843	BioCyc
Ensembl Genes	ENSRNOG00000021234	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000028839	ENTREZGENE
	ENSRNOP00000028839.7	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000028839	ENTREZGENE
	ENSRNOT00000028839.8	UniProtKB/TrEMBL
Gene3D-CATH	Helical hairpin bin	UniProtKB/TrEMBL
InterPro	HCO3_transpt_C	UniProtKB/TrEMBL
	HCO3_transpt_euk	UniProtKB/TrEMBL
	PTrfase/Anion_transptr	UniProtKB/TrEMBL
KEGG Report	rno:311423	UniProtKB/TrEMBL
NCBI Gene	311423	ENTREZGENE
PANTHER	HCO3_transpt_euk	UniProtKB/TrEMBL
	SODIUM BICARBONATE TRANSPORTER-LIKE PROTEIN 11	UniProtKB/TrEMBL
Pfam	HCO3_cotransp	UniProtKB/TrEMBL
PhenoGen	Slc4a11	PhenoGen
PRINTS	HCO3TRNSPORT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55804	UniProtKB/TrEMBL
UniProt	A6HQA9	ENTREZGENE, UniProtKB/TrEMBL
	D3ZVP9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Slc4a11	solute carrier family 4 member 11	Slc4a11	solute carrier family 4, sodium borate transporter, member 11	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-02-23	Slc4a11	solute carrier family 4, sodium borate transporter, member 11	Slc4a11	solute carrier family 4, sodium bicarbonate transporter-like, member 11	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Slc4a11	solute carrier family 4, sodium bicarbonate transporter-like, member 11	Slc4a11_predicted	solute carrier family 4, sodium bicarbonate transporter-like, member 11 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Slc4a11_predicted	solute carrier family 4, sodium bicarbonate transporter-like, member 11 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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