Tle6 (TLE family member 6, subcortical maternal complex member) - Rat Genome Database
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Gene: Tle6 (TLE family member 6, subcortical maternal complex member) Rattus norvegicus
Analyze
Symbol: Tle6
Name: TLE family member 6, subcortical maternal complex member
RGD ID: 1561530
Description: Predicted to have repressing transcription factor binding activity and transcription corepressor activity. Predicted to be involved in several processes, including cytoskeleton organization; embryonic process involved in female pregnancy; and positive regulation of cell differentiation. Predicted to localize to several cellular components, including cell cortex; subcortical maternal complex; and transcription regulator complex. Human ortholog(s) of this gene implicated in infertility. Orthologous to human TLE6 (TLE family member 6, subcortical maternal complex member); INTERACTS WITH bisphenol A; cobalt dichloride; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC299637; RGD1561530; similar to Tle6 protein; transducin-like enhancer of split 6; transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila); transducin-like enhancer protein 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,107,050 - 8,118,639 (+)NCBI
Rnor_6.0 Ensembl710,962,330 - 10,988,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0710,964,136 - 10,988,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0711,133,166 - 11,155,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,582,621 - 9,591,827 (+)NCBIRGSC3.4rn4RGSC3.4
Celera76,299,927 - 6,309,683 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:16314515   PMID:18191828   PMID:18804437   PMID:19376971   PMID:26537248  


Genomics

Comparative Map Data
Tle6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,107,050 - 8,118,639 (+)NCBI
Rnor_6.0 Ensembl710,962,330 - 10,988,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0710,964,136 - 10,988,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0711,133,166 - 11,155,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,582,621 - 9,591,827 (+)NCBIRGSC3.4rn4RGSC3.4
Celera76,299,927 - 6,309,683 (+)NCBICelera
Cytogenetic Map7q11NCBI
TLE6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl192,977,538 - 2,995,179 (+)EnsemblGRCh38hg38GRCh38
GRCh38192,977,410 - 2,995,184 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37192,977,562 - 2,995,177 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,928,562 - 2,946,176 (+)NCBINCBI36hg18NCBI36
Build 34192,928,561 - 2,946,176NCBI
Celera192,911,604 - 2,929,249 (+)NCBI
Cytogenetic Map19p13.3NCBI
HuRef192,745,089 - 2,762,613 (+)NCBIHuRef
CHM1_1192,977,119 - 2,995,109 (+)NCBICHM1_1
Tle6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,426,738 - 81,437,021 (-)NCBIGRCm39mm39
GRCm39 Ensembl1081,426,738 - 81,436,907 (-)Ensembl
GRCm381081,590,904 - 81,601,185 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,590,904 - 81,601,073 (-)EnsemblGRCm38mm10GRCm38
MGSCv371081,053,650 - 81,063,645 (-)NCBIGRCm37mm9NCBIm37
MGSCv361080,994,034 - 81,004,029 (-)NCBImm8
Celera1082,614,086 - 82,624,081 (-)NCBICelera
Cytogenetic Map10C1NCBI
Tle6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554955,367,237 - 5,369,601 (-)NCBIChiLan1.0ChiLan1.0
TLE6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1192,953,184 - 2,978,179 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,953,184 - 2,978,179 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0192,003,011 - 2,020,577 (+)NCBIMhudiblu_PPA_v0panPan3
TLE6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,159,045 - 56,169,740 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,956,718 - 55,967,584 (-)NCBI
ROS_Cfam_1.02056,891,741 - 56,902,431 (-)NCBI
UMICH_Zoey_3.12055,946,809 - 55,957,461 (-)NCBI
UNSW_CanFamBas_1.02056,430,998 - 56,441,644 (-)NCBI
UU_Cfam_GSD_1.02056,629,592 - 56,640,312 (-)NCBI
Tle6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_024405118216,116,827 - 216,126,808 (-)NCBI
SpeTri2.0NW_0049365881,708,013 - 1,717,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLE6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1275,537,641 - 75,550,676 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,058,662 - 76,063,092 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLE6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,750,838 - 2,768,451 (+)NCBI
ChlSab1.1 Ensembl62,751,525 - 2,768,269 (+)Ensembl
Tle6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248286,149,869 - 6,157,875 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7265313832258115Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7591147750911477Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7595196950951969Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7975804554758045Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:77
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000008360, ENSRNOT00000075263
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 14 22
Low 2 35 31 23 7 23 69 21 19 11
Below cutoff 1 4 21 18 7 18 8 9 5 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008360   ⟹   ENSRNOP00000008360
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl710,962,330 - 10,988,137 (+)Ensembl
RefSeq Acc Id: XM_006225929   ⟹   XP_006225991
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera76,299,932 - 6,309,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006225930   ⟹   XP_006225992
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera76,303,294 - 6,309,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006225932   ⟹   XP_006225994
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera76,299,927 - 6,309,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006241027   ⟹   XP_006241089
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,108,902 - 8,118,639 (+)NCBI
Rnor_6.0710,964,141 - 10,988,127 (+)NCBI
Rnor_5.0711,133,166 - 11,155,220 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006241028   ⟹   XP_006241090
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0710,967,506 - 10,988,127 (+)NCBI
Rnor_5.0711,133,166 - 11,155,220 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006241030   ⟹   XP_006241092
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,108,902 - 8,118,639 (+)NCBI
Rnor_6.0710,964,136 - 10,988,127 (+)NCBI
Rnor_5.0711,133,166 - 11,155,220 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008776380   ⟹   XP_008774602
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera76,302,370 - 6,309,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595152   ⟹   XP_017450641
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0710,966,356 - 10,988,127 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595153   ⟹   XP_017450642
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,112,272 - 8,118,639 (+)NCBI
Rnor_6.0710,967,507 - 10,988,127 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017603373   ⟹   XP_017458862
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera76,302,144 - 6,309,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017603374   ⟹   XP_017458863
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera76,303,295 - 6,309,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017603375   ⟹   XP_017458864
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera76,303,295 - 6,309,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080433   ⟹   XP_038936361
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,107,050 - 8,118,639 (+)NCBI
RefSeq Acc Id: XM_039080434   ⟹   XP_038936362
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,112,538 - 8,118,639 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_006225994   ⟸   XM_006225932
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006225991   ⟸   XM_006225929
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006225992   ⟸   XM_006225930
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006241092   ⟸   XM_006241030
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006241089   ⟸   XM_006241027
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006241090   ⟸   XM_006241028
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008774602   ⟸   XM_008776380
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017458862   ⟸   XM_017603373
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017458863   ⟸   XM_017603374
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017458864   ⟸   XM_017603375
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017450641   ⟸   XM_017595152
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017450642   ⟸   XM_017595153
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000008360   ⟸   ENSRNOT00000008360
RefSeq Acc Id: XP_038936361   ⟸   XM_039080433
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936362   ⟸   XM_039080434
- Peptide Label: isoform X3
Protein Domains
WD_REPEATS_REGION

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694971
Promoter ID:EPDNEW_R5490
Type:single initiation site
Name:Tle6_1
Description:transducin-like enhancer of split 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0710,962,353 - 10,962,413EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 10984814 10984815 G A snv WKY/N (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561530 AgrOrtholog
Ensembl Genes ENSRNOG00000006350 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008360 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008360 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro Groucho_enhance UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene 299637 ENTREZGENE
PANTHER PTHR10814 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PhenoGen Tle6 PhenoGen
PRINTS GROUCHOFAMLY UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP WD40_like UniProtKB/TrEMBL
UniProt F1LXS4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-12-04 Tle6  TLE family member 6, subcortical maternal complex member  Tle6  transducin-like enhancer of split 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-03-13 Tle6  transducin-like enhancer of split 6  Tle6  transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-25 Tle6  transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)  RGD1561530  similar to Tle6 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561530  similar to Tle6 protein   RGD1561530_predicted  similar to Tle6 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561530_predicted  similar to Tle6 protein (predicted)  LOC299637  similar to Tle6 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC299637  similar to Tle6 protein      Symbol and Name status set to provisional 70820 PROVISIONAL