Eomes (eomesodermin) - Rat Genome Database

Name: Eomes
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Eomes (eomesodermin) Rattus norvegicus

Analyze

Symbol:

Eomes

Name:

eomesodermin

RGD ID:

1359706

Description:

Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and chromatin DNA binding activity. Predicted to be involved in several processes, including DNA modification; histone modification; and nervous system development. Predicted to act upstream of or within several processes, including formation of primary germ layer; nervous system development; and trophectodermal cell differentiation. Predicted to be located in chromatin and nucleus. Orthologous to human EOMES (eomesodermin); PARTICIPATES IN interleukin-12 signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

eomesodermin homolog; eomesodermin homolog (Xenopus laevis); LOC316052

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EOMES (eomesodermin)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther
Mus musculus (house mouse):	Eomes (eomesodermin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Eomes (eomesodermin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EOMES (eomesodermin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EOMES (eomesodermin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Eomes (eomesodermin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EOMES (eomesodermin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EOMES (eomesodermin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Eomes (eomesodermin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	EOMES (eomesodermin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Eomes (eomesodermin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	eomesa (eomesodermin homolog a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	eomesb (eomesodermin homolog b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	tbx-38	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	tbx-7	Alliance	DIOPT (PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	tbx-40	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	tbx-37	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	sea-1	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	118,181,340 - 118,189,186 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	118,181,777 - 118,188,316 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	8	127,144,367 - 127,152,618 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	127,144,903 - 127,151,493 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	126,369,713 - 126,375,233 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	123,376,689 - 123,383,451 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	123,398,873 - 123,402,528 (+)	NCBI
Celera	8	117,369,438 - 117,374,985 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

anxiety disorder (ISO)

autoimmune disease of the nervous system (ISO)

Colonic Neoplasms (ISO)

Gastro-Enteropancreatic Neuroendocrine Tumor (ISO)

genetic disease (ISO)

urinary bladder cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

acetaldehyde (ISO)

acetic acid (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP,ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromochloroacetic acid (ISO)

butanal (ISO)

calcitriol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

cisplatin (EXP,ISO)

Citreoviridin (ISO)

Cuprizon (EXP)

dexamethasone (ISO)

dimethylarsinic acid (ISO)

dorsomorphin (ISO)

ethanol (EXP)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

genistein (ISO)

gentamycin (EXP)

hexachlorophene (ISO)

lipopolysaccharide (ISO)

manganese(II) chloride (ISO)

methyl methanesulfonate (ISO)

methylarsonic acid (ISO)

methylmercury chloride (ISO)

Monobutylphthalate (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-methyl-N-nitrosourea (ISO)

nickel atom (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

PCB138 (ISO)

phenylmercury acetate (ISO)

phenytoin (ISO)

propanal (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

staurosporine (ISO)

T-2 toxin (ISO)

temozolomide (ISO)

testosterone (EXP)

thioacetamide (EXP)

tributylstannane (ISO)

triclosan (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

astrocyte differentiation (ISO)

blastocyst development (ISO)

brain development (ISO)

cardioblast differentiation (ISO)

CD8-positive, alpha-beta T cell differentiation involved in immune response (IBA,ISO)

cell differentiation (ISO)

cell differentiation involved in embryonic placenta development (ISO)

cerebral cortex development (ISO)

cerebral cortex neuron differentiation (ISO)

cerebral cortex regionalization (ISO)

chromatin remodeling (ISO)

DNA demethylation (ISO)

DNA methylation (ISO)

endoderm formation (ISO)

endodermal cell fate specification (IBA,ISO)

gene expression (ISO)

mesoderm formation (IBA,ISO)

mesodermal to mesenchymal transition involved in gastrulation (ISO)

negative regulation of DNA-binding transcription factor activity (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

neurogenesis (ISO)

neuron differentiation (ISO)

neuron migration (ISO)

olfactory bulb development (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of gene expression (ISO)

regulation of transcription by RNA polymerase II (IBA,ISO)

skeletal muscle cell differentiation (ISO)

stem cell population maintenance (ISO)

trophectodermal cell differentiation (ISO)

Cellular Component

chromatin (ISO)

nucleus (ISO)

Molecular Function

chromatin binding (ISO)

chromatin DNA binding (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-12 signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain.	Kimura N, etal., Brain Res Dev Brain Res 1999 Jun 2;115(2):183-93.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Eomesodermin is required for mouse trophoblast development and mesoderm formation.	Russ AP, etal., Nature 2000 Mar 2;404(6773):95-9.
10.	A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family.	Wattler S, etal., Genomics 1998 Feb 15;48(1):24-33.

Additional References at PubMed

PMID:14605368	PMID:15788452	PMID:15880683	PMID:16325584	PMID:16892058	PMID:17353897	PMID:17566017	PMID:18171685	PMID:18794345	PMID:18940588	PMID:19409883	PMID:19435790
PMID:19796622	PMID:20176728	PMID:20399120	PMID:20713518	PMID:21245162	PMID:21822279	PMID:22147266	PMID:22164283	PMID:23431145	PMID:23434913	PMID:25100583	PMID:26494787
PMID:27539959

Genomics

Comparative Map Data

Eomes
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	118,181,340 - 118,189,186 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	118,181,777 - 118,188,316 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	8	127,144,367 - 127,152,618 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	127,144,903 - 127,151,493 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	126,369,713 - 126,375,233 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	123,376,689 - 123,383,451 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	123,398,873 - 123,402,528 (+)	NCBI
Celera	8	117,369,438 - 117,374,985 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

EOMES
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	27,715,953 - 27,722,713 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	3	27,715,949 - 27,722,711 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	27,757,444 - 27,764,204 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	27,732,872 - 27,738,789 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	27,732,890 - 27,738,789	NCBI
Celera	3	27,694,279 - 27,700,196 (-)	NCBI		Celera
Cytogenetic Map	3	p24.1	NCBI
HuRef	3	27,699,819 - 27,706,575 (-)	NCBI		HuRef
CHM1_1	3	27,707,433 - 27,714,192 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	27,718,040 - 27,724,801 (-)	NCBI		T2T-CHM13v2.0

Eomes
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	118,307,254 - 118,315,200 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	118,307,280 - 118,315,200 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	118,478,186 - 118,486,132 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	118,478,212 - 118,486,132 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	118,387,307 - 118,395,250 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	118,327,042 - 118,334,830 (+)	NCBI		MGSCv36	mm8
Celera	9	118,948,428 - 118,956,371 (+)	NCBI		Celera
Cytogenetic Map	9	F3	NCBI
cM Map	9	70.21	NCBI

Eomes
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	19,281,602 - 19,286,867 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	19,280,460 - 19,287,060 (-)	NCBI	ChiLan1.0	ChiLan1.0

EOMES
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	27,923,970 - 27,930,687 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	27,925,086 - 27,930,274 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	27,601,829 - 27,608,701 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

EOMES
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	16,476,498 - 16,512,406 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	16,506,032 - 16,511,527 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	16,470,654 - 16,506,596 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	16,772,614 - 16,808,585 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	16,801,788 - 16,808,573 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	16,596,607 - 16,632,527 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	16,709,336 - 16,745,304 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	16,774,662 - 16,810,661 (+)	NCBI		UU_Cfam_GSD_1.0

Eomes
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	185,687,397 - 185,694,575 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	18,825,942 - 18,833,179 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936473	18,825,969 - 18,833,179 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EOMES
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	14,209,736 - 14,215,797 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	14,209,590 - 14,216,184 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	15,846,197 - 15,852,753 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EOMES
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	72,257,626 - 72,264,563 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666041	45,447,831 - 45,454,607 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Eomes
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624788	5,550,445 - 5,557,321 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624788	5,550,569 - 5,557,342 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Eomes
37 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	24
Count of miRNA genes:	19
Interacting mature miRNAs:	23
Transcripts:	ENSRNOT00000013530
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	46531639	119088624	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	46531639	119088624	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	46531639	119088624	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088624	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat
1599689	Iddm24	Insulin dependent diabetes mellitus QTL 24	4.72	0.001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	8	112834440	118649220	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium					3				29
Low	1	7	5	1	12	1			37	8	13	9
Below cutoff	2	19	37	26	4	26	4	4	8	27	26	2	4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_006226608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006226609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596193	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082697	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082698	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY457971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000013530 ⟹ ENSRNOP00000013530

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	118,181,777 - 118,188,316 (+)	Ensembl
Rnor_6.0 Ensembl	8	127,144,903 - 127,151,493 (+)	Ensembl

RefSeq Acc Id:

XM_039082697 ⟹ XP_038938625

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	118,181,340 - 118,189,186 (+)	NCBI

RefSeq Acc Id:

XM_039082698 ⟹ XP_038938626

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	118,181,340 - 118,187,747 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_038938625	(Get FASTA)	NCBI Sequence Viewer
	XP_038938626	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAR21241	(Get FASTA)	NCBI Sequence Viewer
	EDL76935	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000013530 ⟸ ENSRNOT00000013530

RefSeq Acc Id:	XP_038938625 ⟸ XM_039082697
- Peptide Label:	isoform X1
- UniProtKB:	D3ZY52 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938626 ⟸ XM_039082698
- Peptide Label:	isoform X2

Protein Domains

T-box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZY52-F1-model_v2	AlphaFold	D3ZY52	1-699	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359706	AgrOrtholog
BioCyc Gene	G2FUF-28818	BioCyc
Ensembl Genes	ENSRNOG00000042140	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000013530	ENTREZGENE
	ENSRNOP00000013530.6	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013530	ENTREZGENE
	ENSRNOT00000013530.6	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.820	UniProtKB/TrEMBL
InterPro	p53-like_TF_DNA-bd	UniProtKB/TrEMBL
	T-box_assoc	UniProtKB/TrEMBL
	T-box_DNA-bd	UniProtKB/TrEMBL
	T-box_sf	UniProtKB/TrEMBL
	TF_T-box	UniProtKB/TrEMBL
	TF_T-box_CS	UniProtKB/TrEMBL
NCBI Gene	316052	ENTREZGENE
PANTHER	EOMESODERMIN HOMOLOG	UniProtKB/TrEMBL
	PTHR11267	UniProtKB/TrEMBL
Pfam	T-box	UniProtKB/TrEMBL
	T-box_assoc	UniProtKB/TrEMBL
PhenoGen	Eomes	PhenoGen
PRINTS	TBOX	UniProtKB/TrEMBL
PROSITE	TBOX_1	UniProtKB/TrEMBL
	TBOX_2	UniProtKB/TrEMBL
	TBOX_3	UniProtKB/TrEMBL
SMART	TBOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49417	UniProtKB/TrEMBL
UniProt	D3ZY52	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-02	Eomes	eomesodermin	Eomes	eomesodermin homolog (Xenopus laevis)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Eomes	eomesodermin homolog (Xenopus laevis)	LOC316052	eomesodermin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-29	LOC316052	eomesodermin			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)