Prss57 (serine protease 57) - Rat Genome Database

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Gene: Prss57 (serine protease 57) Rattus norvegicus
Analyze
Symbol: Prss57
Name: serine protease 57
RGD ID: 1303330
Description: Predicted to enable heparin binding activity and serine-type endopeptidase activity. Predicted to be involved in protein maturation and proteolysis. Predicted to be located in azurophil granule lumen. Predicted to be active in extracellular space. Orthologous to human PRSS57 (serine protease 57); INTERACTS WITH bis(2-ethylhexyl) phthalate; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: complement factor D-like protein; Df2; neutrophil serine protease 4; NSP4; protease, serine, 57; protease, serine-like 1; Prssl1; PRSSL1 homolog; serine protease 1-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,563,477 - 10,573,617 (+)NCBIGRCr8
mRatBN7.279,915,667 - 9,922,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,917,484 - 9,922,922 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,798,509 - 12,803,869 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,676,590 - 14,681,950 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,535,791 - 12,541,268 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,798,310 - 12,804,668 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,798,868 - 12,804,283 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,968,017 - 12,975,388 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,431,197 - 11,436,541 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,431,196 - 11,436,541 (+)NCBI
Celera78,091,033 - 8,096,377 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
protein maturation  (IBA)
proteolysis  (IEA,ISO,ISS)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22474388   PMID:23904161   PMID:25156428  


Genomics

Comparative Map Data
Prss57
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,563,477 - 10,573,617 (+)NCBIGRCr8
mRatBN7.279,915,667 - 9,922,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,917,484 - 9,922,922 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,798,509 - 12,803,869 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,676,590 - 14,681,950 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,535,791 - 12,541,268 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,798,310 - 12,804,668 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,798,868 - 12,804,283 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,968,017 - 12,975,388 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,431,197 - 11,436,541 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,431,196 - 11,436,541 (+)NCBI
Celera78,091,033 - 8,096,377 (+)NCBICelera
Cytogenetic Map7q11NCBI
PRSS57
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819685,546 - 695,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19685,546 - 695,498 (-)EnsemblGRCh38hg38GRCh38
GRCh3719685,546 - 695,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619636,546 - 646,461 (-)NCBINCBI36Build 36hg18NCBI36
Build 3419636,545 - 646,461NCBI
Celera19120,996 - 132,062 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19455,352 - 465,453 (-)NCBIHuRef
CHM1_119685,251 - 695,165 (-)NCBICHM1_1
T2T-CHM13v2.019639,634 - 649,468 (-)NCBIT2T-CHM13v2.0
Prss57
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,617,308 - 79,630,523 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,617,308 - 79,626,795 (-)EnsemblGRCm39 Ensembl
GRCm381079,781,474 - 79,794,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,781,474 - 79,790,961 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,244,219 - 79,251,730 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,244,219 - 79,251,730 (-)NCBIMGSCv36mm8
Celera1080,796,169 - 80,803,685 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Prss57
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554957,067,844 - 7,077,048 (+)NCBIChiLan1.0ChiLan1.0
PRSS57
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,009,782 - 5,027,487 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,246,843 - 4,265,570 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019440,415 - 452,535 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119650,617 - 652,304 (-)NCBIpanpan1.1PanPan1.1panPan2
PRSS57
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,873,891 - 57,877,890 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,874,770 - 57,877,888 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,676,792 - 57,680,073 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,617,342 - 58,620,632 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,617,180 - 58,620,630 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,671,521 - 57,674,808 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,151,008 - 58,154,302 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,354,352 - 58,357,640 (+)NCBIUU_Cfam_GSD_1.0
PRSS57
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,650,879 - 77,655,712 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,649,741 - 77,657,627 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2278,325,996 - 78,327,174 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS57
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16443,859 - 449,539 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6444,098 - 449,152 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,505,941 - 8,511,532 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Prss57
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:56
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000038553
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 1 22 34 46 50 27 15 27 6 97 47 24 16 25 23

Sequence


Ensembl Acc Id: ENSRNOT00000038553   ⟹   ENSRNOP00000031690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,917,484 - 9,922,922 (+)Ensembl
Rnor_6.0 Ensembl712,798,868 - 12,804,283 (+)Ensembl
RefSeq Acc Id: NM_001003956   ⟹   NP_001003956
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,568,091 - 10,573,617 (+)NCBI
mRatBN7.279,917,470 - 9,922,996 (+)NCBI
Rnor_6.0712,798,868 - 12,804,212 (+)NCBI
Rnor_5.0712,968,017 - 12,975,388 (+)NCBI
RGSC_v3.4711,431,197 - 11,436,541 (+)RGD
Celera78,091,033 - 8,096,377 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240979   ⟹   XP_006241041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,566,289 - 10,573,617 (+)NCBI
mRatBN7.279,916,369 - 9,922,996 (+)NCBI
Rnor_6.0712,798,310 - 12,804,668 (+)NCBI
Rnor_5.0712,968,017 - 12,975,388 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039079716   ⟹   XP_038935644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,564,453 - 10,573,617 (+)NCBI
mRatBN7.279,915,667 - 9,922,996 (+)NCBI
RefSeq Acc Id: XM_039079718   ⟹   XP_038935646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,564,452 - 10,573,617 (+)NCBI
mRatBN7.279,915,667 - 9,922,996 (+)NCBI
RefSeq Acc Id: XM_039079723   ⟹   XP_038935651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,564,434 - 10,573,617 (+)NCBI
mRatBN7.279,916,358 - 9,922,996 (+)NCBI
RefSeq Acc Id: XM_039079724   ⟹   XP_038935652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,568,197 - 10,573,617 (+)NCBI
mRatBN7.279,917,581 - 9,922,996 (+)NCBI
RefSeq Acc Id: XM_039079725   ⟹   XP_038935653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,563,477 - 10,573,617 (+)NCBI
mRatBN7.279,916,358 - 9,922,996 (+)NCBI
RefSeq Acc Id: XM_063264089   ⟹   XP_063120159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,564,453 - 10,573,617 (+)NCBI
RefSeq Acc Id: XM_063264091   ⟹   XP_063120161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,564,452 - 10,573,617 (+)NCBI
RefSeq Acc Id: XM_063264092   ⟹   XP_063120162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,566,288 - 10,573,617 (+)NCBI
RefSeq Acc Id: NP_001003956   ⟸   NM_001003956
- Peptide Label: precursor
- UniProtKB: A6K8X4 (UniProtKB/TrEMBL),   A6K8X3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241041   ⟸   XM_006240979
- Peptide Label: isoform X2
- UniProtKB: Q6IE59 (UniProtKB/Swiss-Prot),   A0A8L2UKW0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031690   ⟸   ENSRNOT00000038553
RefSeq Acc Id: XP_038935644   ⟸   XM_039079716
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UKW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935646   ⟸   XM_039079718
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UKW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935651   ⟸   XM_039079723
- Peptide Label: isoform X3
- UniProtKB: A6K8X3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935653   ⟸   XM_039079725
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038935652   ⟸   XM_039079724
- Peptide Label: isoform X4
- UniProtKB: A0A8L2UKW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120161   ⟸   XM_063264091
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063120159   ⟸   XM_063264089
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063120162   ⟸   XM_063264092
- Peptide Label: isoform X2
- UniProtKB: Q6IE59 (UniProtKB/Swiss-Prot)
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE59-F1-model_v2 AlphaFold Q6IE59 1-278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303330 AgrOrtholog
BioCyc Gene G2FUF-34889 BioCyc
Ensembl Genes ENSRNOG00000025293 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038553.4 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:408241 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 408241 ENTREZGENE
PANTHER KALLIKREIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE PROTEASE 57 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prss57 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025293 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2UKW0 ENTREZGENE, UniProtKB/TrEMBL
  A6K8X3 ENTREZGENE, UniProtKB/TrEMBL
  A6K8X4 ENTREZGENE, UniProtKB/TrEMBL
  PRS57_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Prss57  serine protease 57  Prss57  protease, serine, 57  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Prss57  protease, serine, 57  Prssl1  protease, serine-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Prssl1  protease, serine-like 1  Df2  complement factor D-like protein  Symbol and Name updated 1299863 APPROVED
2005-02-14 Df2  complement factor D-like protein      Symbol and Name status set to provisional 70820 PROVISIONAL