Symbol:
Prss57
Name:
serine protease 57
RGD ID:
1303330
Description:
Predicted to enable heparin binding activity and serine-type endopeptidase activity. Predicted to be involved in protein maturation and proteolysis. Predicted to be located in azurophil granule lumen. Predicted to be active in extracellular space. Orthologous to human PRSS57 (serine protease 57); INTERACTS WITH bis(2-ethylhexyl) phthalate; bisphenol A; cadmium dichloride.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
complement factor D-like protein; Df2; neutrophil serine protease 4; NSP4; protease, serine, 57; protease, serine-like 1; Prssl1; PRSSL1 homolog; serine protease 1-like protein 1
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PRSS57 (serine protease 57) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Prss57 (serine protease 57) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Prss57 (serine protease 57) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PRSS57 (serine protease 57) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PRSS57 (serine protease 57) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PRSS57 (serine protease 57) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
PRSS57 (serine protease 57) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PAK4 (p21 (RAC1) activated kinase 4) HGNC
OMA
Alliance orthologs 3
Homo sapiens (human):
PRSS57 (serine protease 57)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Prss57 (serine protease 57)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
prtn3l.2
Alliance
DIOPT (PANTHER|PhylomeDB)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 7 10,563,477 - 10,573,617 (+) NCBI GRCr8 mRatBN7.2 7 9,915,667 - 9,922,996 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 7 9,917,484 - 9,922,922 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 7 12,798,509 - 12,803,869 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 7 14,676,590 - 14,681,950 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 7 12,535,791 - 12,541,268 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 7 12,798,310 - 12,804,668 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 12,798,868 - 12,804,283 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 7 12,968,017 - 12,975,388 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 11,431,197 - 11,436,541 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 7 11,431,196 - 11,436,541 (+) NCBI Celera 7 8,091,033 - 8,096,377 (+) NCBI Celera Cytogenetic Map 7 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Prss57 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 7 10,563,477 - 10,573,617 (+) NCBI GRCr8 mRatBN7.2 7 9,915,667 - 9,922,996 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 7 9,917,484 - 9,922,922 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 7 12,798,509 - 12,803,869 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 7 14,676,590 - 14,681,950 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 7 12,535,791 - 12,541,268 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 7 12,798,310 - 12,804,668 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 12,798,868 - 12,804,283 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 7 12,968,017 - 12,975,388 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 11,431,197 - 11,436,541 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 7 11,431,196 - 11,436,541 (+) NCBI Celera 7 8,091,033 - 8,096,377 (+) NCBI Celera Cytogenetic Map 7 q11 NCBI
PRSS57 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 19 685,546 - 695,452 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 19 685,546 - 695,498 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 19 685,546 - 695,452 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 19 636,546 - 646,461 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 19 636,545 - 646,461 NCBI Celera 19 120,996 - 132,062 (+) NCBI Celera Cytogenetic Map 19 p13.3 NCBI HuRef 19 455,352 - 465,453 (-) NCBI HuRef CHM1_1 19 685,251 - 695,165 (-) NCBI CHM1_1 T2T-CHM13v2.0 19 639,634 - 649,468 (-) NCBI T2T-CHM13v2.0
Prss57 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 10 79,617,308 - 79,630,523 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 10 79,617,308 - 79,626,795 (-) Ensembl GRCm39 Ensembl GRCm38 10 79,781,474 - 79,794,684 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 10 79,781,474 - 79,790,961 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 10 79,244,219 - 79,251,730 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 10 79,244,219 - 79,251,730 (-) NCBI MGSCv36 mm8 Celera 10 80,796,169 - 80,803,685 (-) NCBI Celera Cytogenetic Map 10 C1 NCBI cM Map 10 39.72 NCBI
Prss57 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 NW_004955495 7,067,844 - 7,077,048 (+) NCBI ChiLan1.0 ChiLan1.0
PRSS57 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 20 5,009,782 - 5,027,487 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 19 4,246,843 - 4,265,570 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 19 440,415 - 452,535 (+) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 19 650,617 - 652,304 (-) NCBI panpan1.1 PanPan1.1 panPan2
PRSS57 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 20 57,873,891 - 57,877,890 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 20 57,874,770 - 57,877,888 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 20 57,676,792 - 57,680,073 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 20 58,617,342 - 58,620,632 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 20 58,617,180 - 58,620,630 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 20 57,671,521 - 57,674,808 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 20 58,151,008 - 58,154,302 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 20 58,354,352 - 58,357,640 (+) NCBI UU_Cfam_GSD_1.0
PRSS57 Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 2 77,650,879 - 77,655,712 (+) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 2 77,649,741 - 77,657,627 (+) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 2 78,325,996 - 78,327,174 (-) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
PRSS57
.
Predicted Target Of
Count of predictions: 58 Count of miRNA genes: 56 Interacting mature miRNAs: 58 Transcripts: ENSRNOT00000038553 Prediction methods: Miranda, Rnahybrid Result types: miRGate_prediction
61410 Bw19 Body weight QTL 19 6.2 0.001 body mass (VT:0001259) body weight (CMO:0000012) 7 1 44782185 Rat 1300176 Hrtrt10 Heart rate QTL 10 3.19 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 7 664270 26029351 Rat 9590102 Sffal5 Serum free fatty acids level QTL 5 8.62 0.001 blood free fatty acid amount (VT:0001553) plasma free fatty acids level (CMO:0000546) 7 5329019 50329019 Rat 1578652 Bmd15 Bone mineral density QTL 15 5.2 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) 7 9866467 60460686 Rat 1643004 Pain2 Pain QTL 2 1 mechanical nociception trait (VT:0002734) self mutilation severity score (CMO:0002145) 7 9462246 98011544 Rat 631503 Bp102 Blood pressure QTL 102 1.9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 7 1 44822433 Rat 634336 Anxrr17 Anxiety related response QTL 17 3.66 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) 7 924703 115097879 Rat 10755438 Coatc9 Coat color QTL 9 0 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) 7 3529280 48529280 Rat 9590142 Scort5 Serum corticosterone level QTL 5 24.4 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 7 1 31962314 Rat 2298547 Neuinf5 Neuroinflammation QTL 5 3.7 nervous system integrity trait (VT:0010566) spinal cord Cd74 protein level (CMO:0002131) 7 9462246 58265113 Rat 10059592 Kidm45 Kidney mass QTL 45 3.95 0.025 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 7 7573985 52573985 Rat 2317047 Wbc4 White blood cell count QTL 4 0.01 leukocyte quantity (VT:0000217) white blood cell count (CMO:0000027) 7 1 35342956 Rat 10755440 Coatc10 Coat color QTL 10 0 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) 7 7496499 52496499 Rat 2298550 Neuinf6 Neuroinflammation QTL 6 3.3 nervous system integrity trait (VT:0010566) spinal cord RT1-B protein level (CMO:0002132) 7 1 27829089 Rat 724560 Plsm3 Polydactyly-luxate syndrome (PLS) morphotypes QTL 3 0.0003 tibia length (VT:0004357) tibia length (CMO:0000450) 7 1 34000259 Rat 7411566 Bw136 Body weight QTL 136 10.4 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 7 1 31962314 Rat
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
7
1
22
34
46
50
27
15
27
6
97
47
24
16
25
23
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000038553 ⟹ ENSRNOP00000031690
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 7 9,917,484 - 9,922,922 (+) Ensembl Rnor_6.0 Ensembl 7 12,798,868 - 12,804,283 (+) Ensembl
RefSeq Acc Id:
NM_001003956 ⟹ NP_001003956
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 7 10,568,091 - 10,573,617 (+) NCBI mRatBN7.2 7 9,917,470 - 9,922,996 (+) NCBI Rnor_6.0 7 12,798,868 - 12,804,212 (+) NCBI Rnor_5.0 7 12,968,017 - 12,975,388 (+) NCBI RGSC_v3.4 7 11,431,197 - 11,436,541 (+) RGD Celera 7 8,091,033 - 8,096,377 (+) RGD
Sequence:
ATGGTGCCTGGGACAGGAGGAGGCCGGGACTGCCTGACGCTGGTCGTAGCGACTGCCCTGACCCAGCTCCTGTGGCTCCCAGGTTGCTGCGGATCCCACATTGTTGGAGGCCATGAGGTGAAGCCACA
hide sequence
RefSeq Acc Id:
XM_006240979 ⟹ XP_006241041
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 7 10,566,289 - 10,573,617 (+) NCBI mRatBN7.2 7 9,916,369 - 9,922,996 (+) NCBI Rnor_6.0 7 12,798,310 - 12,804,668 (+) NCBI Rnor_5.0 7 12,968,017 - 12,975,388 (+) NCBI
Sequence:
AGGTAGGAGTTCAAAGCCATTCTCAGCTGGATAGCTAGTTCAAGGTGCATATTGAATTAGAGGTTAGCCTCGGCTACCTGAAAAGAAACTGAACTTTCTTTCCCAAAGGTCCCCACCATGAGGAAACC
hide sequence
RefSeq Acc Id:
XM_039079716 ⟹ XP_038935644
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 7 10,564,453 - 10,573,617 (+) NCBI mRatBN7.2 7 9,915,667 - 9,922,996 (+) NCBI
RefSeq Acc Id:
XM_039079718 ⟹ XP_038935646
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 7 10,564,452 - 10,573,617 (+) NCBI mRatBN7.2 7 9,915,667 - 9,922,996 (+) NCBI
RefSeq Acc Id:
XM_039079723 ⟹ XP_038935651
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 7 10,564,434 - 10,573,617 (+) NCBI mRatBN7.2 7 9,916,358 - 9,922,996 (+) NCBI
RefSeq Acc Id:
XM_039079724 ⟹ XP_038935652
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 7 10,568,197 - 10,573,617 (+) NCBI mRatBN7.2 7 9,917,581 - 9,922,996 (+) NCBI
RefSeq Acc Id:
XM_039079725 ⟹ XP_038935653
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 7 10,563,477 - 10,573,617 (+) NCBI mRatBN7.2 7 9,916,358 - 9,922,996 (+) NCBI
RefSeq Acc Id:
XM_063264089 ⟹ XP_063120159
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 7 10,564,453 - 10,573,617 (+) NCBI
RefSeq Acc Id:
XM_063264091 ⟹ XP_063120161
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 7 10,564,452 - 10,573,617 (+) NCBI
RefSeq Acc Id:
XM_063264092 ⟹ XP_063120162
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 7 10,566,288 - 10,573,617 (+) NCBI
RefSeq Acc Id:
NP_001003956 ⟸ NM_001003956
- Peptide Label:
precursor
- UniProtKB:
A6K8X4 (UniProtKB/TrEMBL), A6K8X3 (UniProtKB/TrEMBL)
- Sequence:
MVPGTGGGRDCLTLVVATALTQLLWLPGCCGSHIVGGHEVKPHARPYMASVNFEGHHHCGGFLFHAHWVLSAAHCFSDRDPSTGLVVLGAHALLTPEPTQQVFGIAAVVSHPDFEPTTQANDICLLRL
hide sequence
RefSeq Acc Id:
XP_006241041 ⟸ XM_006240979
- Peptide Label:
isoform X2
- UniProtKB:
Q6IE59 (UniProtKB/Swiss-Prot), A0A8L2UKW0 (UniProtKB/TrEMBL)
- Sequence:
MVPGTGGGRDCLTLVVATALTQLLWLPGCCGSHIVGGHEVKPHARPYMASVNFEGHHHCGGFLFHAHWVLSAAHCFSDRDPSTGLVVLGAHALLTPEPTQQVFGIAAVVSHPDFEPTTQANDICLLRL
hide sequence
Ensembl Acc Id:
ENSRNOP00000031690 ⟸ ENSRNOT00000038553
RefSeq Acc Id:
XP_038935644 ⟸ XM_039079716
- Peptide Label:
isoform X1
- UniProtKB:
A0A8L2UKW0 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_038935646 ⟸ XM_039079718
- Peptide Label:
isoform X1
- UniProtKB:
A0A8L2UKW0 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_038935651 ⟸ XM_039079723
- Peptide Label:
isoform X3
- UniProtKB:
A6K8X3 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_038935653 ⟸ XM_039079725
- Peptide Label:
isoform X5
RefSeq Acc Id:
XP_038935652 ⟸ XM_039079724
- Peptide Label:
isoform X4
- UniProtKB:
A0A8L2UKW0 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063120161 ⟸ XM_063264091
- Peptide Label:
isoform X1
- UniProtKB:
A0A8L2UKW0 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063120159 ⟸ XM_063264089
- Peptide Label:
isoform X1
- UniProtKB:
A0A8L2UKW0 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063120162 ⟸ XM_063264092
- Peptide Label:
isoform X2
- UniProtKB:
Q6IE59 (UniProtKB/Swiss-Prot), A0A8L2UKW0 (UniProtKB/TrEMBL)
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2018-01-26
Prss57
serine protease 57
Prss57
protease, serine, 57
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2011-08-02
Prss57
protease, serine, 57
Prssl1
protease, serine-like 1
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2005-11-17
Prssl1
protease, serine-like 1
Df2
complement factor D-like protein
Symbol and Name updated
1299863 APPROVED
2005-02-14
Df2
complement factor D-like protein
Symbol and Name status set to provisional
70820 PROVISIONAL
