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Gene: PAK4 (p21 (RAC1) activated kinase 4) Homo sapiens
Symbol: PAK4
Name: p21 (RAC1) activated kinase 4
RGD ID: 1317048
Description: Exhibits protein serine/threonine kinase activity. Involved in negative regulation of endothelial cell apoptotic process and positive regulation of angiogenesis. Localizes to adherens junction and focal adhesion. Biomarker of clear cell renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A)-activated kinase 4; p21-activated kinase 4; PAK-4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; serine/threonine-protein kinase PAK 4
Mus musculus (house mouse) : Pak4 (p21 (RAC1) activated kinase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pak4 (p21 (RAC1) activated kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pak4 (p21 (RAC1) activated kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : PAK4 (p21 (RAC1) activated kinase 4)
Canis lupus familiaris (dog) : PAK4 (p21 (RAC1) activated kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pak4 (p21 (RAC1) activated kinase 4)
Sus scrofa (pig) : PAK4 (p21 (RAC1) activated kinase 4)
Chlorocebus sabaeus (African green monkey) : PAK4 (p21 (RAC1) activated kinase 4)
Heterocephalus glaber (naked mole-rat) : Pak4 (p21 (RAC1) activated kinase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1939,125,770 - 39,182,816 (+)EnsemblGRCh38hg38GRCh38
GRCh381939,125,786 - 39,182,816 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371939,616,417 - 39,670,046 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,308,260 - 44,361,886 (+)NCBINCBI36hg18NCBI36
Build 341944,308,301 - 44,361,882NCBI
Celera1936,418,829 - 36,473,610 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1936,063,360 - 36,116,946 (+)NCBIHuRef
CHM1_11939,617,306 - 39,670,871 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PAK4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317048
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.