RGD Reference Report - A genomic analysis of rat proteases and protease inhibitors. - Rat Genome Database

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A genomic analysis of rat proteases and protease inhibitors.

Authors: Puente, XS  Lopez-Otin, C 
Citation: Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
RGD ID: 1303943
Pubmed: PMID:15060002   (View Abstract at PubMed)
PMCID: PMC383305   (View Article at PubMed Central)
DOI: DOI:10.1101/gr.1946304   (Journal Full-text)

Proteases perform important roles in multiple biological and pathological processes. The availability of the rat genome sequence has facilitated the analysis of the complete protease repertoire or degradome of this model organism. The rat degradome consists of at least 626 proteases and homologs, which are distributed into 24 aspartic, 160 cysteine, 192 metallo, 221 serine, and 29 threonine proteases. This distribution is similar to that of the mouse degradome but is more complex than that of the human degradome composed of 561 proteases and homologs. This increased complexity of rat proteases mainly derives from the expansion of several families, including placental cathepsins, testases, kallikreins, and hematopoietic serine proteases, involved in reproductive or immunological functions. These protease families have also evolved differently in rat and mouse and may contribute to explain some functional differences between these closely related species. Likewise, genomic analysis of rat protease inhibitors has shown some differences with mouse protease inhibitors and the expansion of families of cysteine and serine protease inhibitors in rodents with respect to human. These comparative analyses may provide new views on the functional diversity of proteases and inhibitors and contribute to the development of innovative strategies for treating proteolysis diseases.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ece2Ratpeptide hormone processing  TAS  RGD 
Senp17Ratproteolysis  TAS  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Spink4Ratextracellular space  TAS  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ece2Ratmetallopeptidase activity  TAS  RGD 
Senp17Ratpeptidase activity  TAS  RGD 
Prss45Ratserine-type endopeptidase activity  TAS  RGD 
Spink4Ratserine-type endopeptidase inhibitor activity  TAS  RGD 
Wfdc12Ratserine-type endopeptidase inhibitor activity enablesNAS PMID:15060002UniProt 
Wfdc15bRatserine-type endopeptidase inhibitor activity  TAS  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ece2  (endothelin-converting enzyme 2)
Prss45  (serine protease 45)
Senp17  (Sumo1/sentrin/SMT3 specific peptidase 17)
Spink4  (serine peptidase inhibitor, Kazal type 4)
Wfdc12  (WAP four-disulfide core domain 12)
Wfdc15b  (WAP four-disulfide core domain 15B)

Objects referenced in this article
Gene SPINK6 serine peptidase inhibitor Kazal type 6 Homo sapiens
Gene Abhd12b abhydrolase domain containing 12B Rattus norvegicus
Gene Bace2 beta-secretase 2 Rattus norvegicus
Gene Capn11 calpain 11 Rattus norvegicus
Gene Cpa5 carboxypeptidase A5 Rattus norvegicus
Gene Gfpt2 glutamine-fructose-6-phosphate transaminase 2 Rattus norvegicus
Gene Ggt6 gamma-glutamyl transferase 6 Rattus norvegicus
Gene Klk10 kallikrein related-peptidase 10 Rattus norvegicus
Gene Mcpt1l3 mast cell protease 1-like 3 Rattus norvegicus
Gene Mcpt4l1 mast cell protease 4-like 1 Rattus norvegicus
Gene Mcpt8l2 mast cell protease 8-like 2 Rattus norvegicus
Gene Mcpt8l3 mast cell protease 8-like 3 Rattus norvegicus
Gene Mug2 murinoglobulin 2 Rattus norvegicus
Gene Oser1 oxidative stress responsive serine-rich 1 Rattus norvegicus
Gene Pan2 poly(A) specific ribonuclease subunit PAN2 Rattus norvegicus
Gene Prss27 serine protease 27 Rattus norvegicus
Gene Prss46 protease, serine, 46 Rattus norvegicus
Gene Prss57 serine protease 57 Rattus norvegicus
Gene Prss58 serine protease 58 Rattus norvegicus
Gene Prss59 protease, serine 59 Rattus norvegicus
Gene Psma3 proteasome 20S subunit alpha 3 Rattus norvegicus
Gene Psmb6 proteasome 20S subunit beta 6 Rattus norvegicus
Gene Senp18 Sumo1/sentrin/SMT3 specific peptidase 18 Rattus norvegicus
Gene Serpinb3 serpin family B member 3 Rattus norvegicus
Gene Slpi-ps1 secretory leukocyte peptidase inhibitor, pseudogene 1 Rattus norvegicus
Gene Slpi-ps2 secretory leukocyte peptidase inhibitor, pseudogene 2 Rattus norvegicus
Gene Spink14 serine peptidase inhibitor, Kazal type 14 Rattus norvegicus
Gene Spink2 serine peptidase inhibitor, Kazal type 2 Rattus norvegicus
Gene Spink6 serine peptidase inhibitor, Kazal type 6 Rattus norvegicus
Gene Spink7 serine peptidase inhibitor, Kazal type 7 Rattus norvegicus
Gene Spint5p serine peptidase inhibitor, Kunitz type 5 Rattus norvegicus
Gene Stfa2l1 stefin A2-like 1 Rattus norvegicus
Gene Stfa3l1 stefin A3-like 1 Rattus norvegicus
Gene Tmprss11b transmembrane serine protease 11B Rattus norvegicus
Gene Tmprss11c transmembrane protease, serine 11C Rattus norvegicus
Gene Try10 trypsin 10 Rattus norvegicus
Gene Usp54 ubiquitin specific peptidase 54 Rattus norvegicus
Gene Wfdc15a WAP four-disulfide core domain 15A Rattus norvegicus
Gene Wfdc6b WAP four-disulfide core domain 6B Rattus norvegicus
Gene Yod1 YOD1 deubiquitinase Rattus norvegicus

Additional Information