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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:clozapine
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Accession:CHEBI:3766 term browser browse the term
Definition:A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Synonyms:exact_synonym: 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
 related_synonym: Clozapin;   Formula=C18H19ClN4;   InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3;   InChIKey=QZUDBNBUXVUHMW-UHFFFAOYSA-N;   SMILES=N1=C(C2=CC=CC=C2NC3=CC=C(C=C13)Cl)N4CCN(CC4)C;   clozapina;   clozapinum
 xref: Beilstein:0764984;   CAS:5786-21-0;   DrugBank:DB00363;   Drug_Central:722;   HMDB:HMDB0014507;   KEGG:C06924;   KEGG:D00283
 xref_mesh: MESH:D003024
 xref: PMID:18690109;   PMID:18766167;   PMID:20825390;   PMID:24219174;   Patent:FR1334944;   Patent:NL293201;   Patent:US3539573;   Reaxys:764984;   Wikipedia:Clozapine


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clozapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A930009A15Rik RIKEN cDNA A930009A15 gene decreases expression ISO Clozapine results in decreased expression of DCD protein CTD PMID:34122009 NCBI chr10:115,399,555...115,418,359
Ensembl chr10:115,405,891...115,418,353 		JBrowse link
G Aars1 alanyl-tRNA synthetase 1 increases expression ISO Clozapine results in increased expression of AARS1 protein CTD PMID:34122009 NCBI chr 8:111,759,781...111,784,237
Ensembl chr 8:111,759,776...111,784,296 		JBrowse link
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity ISO Clozapine results in decreased activity of ABCB11 protein CTD PMID:22646477 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases activity
multiple interactions		 ISO Clozapine results in decreased activity of ABCB1 protein
Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]		 CTD PMID:9111066 PMID:16810505 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B multiple interactions ISO Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter] CTD PMID:9111066 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315 		JBrowse link
G Abce1 ATP-binding cassette, sub-family E member 1 increases expression ISO Clozapine results in increased expression of ABCE1 protein CTD PMID:34122009 NCBI chr 8:80,410,071...80,438,369
Ensembl chr 8:80,410,091...80,438,369 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Clozapine results in increased expression of ABCG1 mRNA CTD PMID:17346280 NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions ISO Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Ablim2 actin-binding LIM protein 2 increases expression ISO Clozapine results in increased expression of ABLIM2 mRNA CTD PMID:17346280 NCBI chr 5:35,915,200...36,042,323
Ensembl chr 5:35,915,224...36,042,317 		JBrowse link
G Acat2 acetyl-Coenzyme A acetyltransferase 2 increases expression ISO Clozapine results in increased expression of ACAT2 mRNA CTD PMID:17052361 NCBI chr17:13,161,929...13,179,612
Ensembl chr17:13,161,777...13,179,634 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression ISO Clozapine results in increased expression of ACOT2 protein CTD PMID:34122009 NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647 		JBrowse link
G Acot7 acyl-CoA thioesterase 7 decreases expression ISO Clozapine results in decreased expression of ACOT7 protein CTD PMID:34122009 NCBI chr 4:152,258,872...152,356,312
Ensembl chr 4:152,262,591...152,356,312 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions ISO [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA CTD PMID:23226405 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Actb actin, beta decreases expression ISO Clozapine results in decreased expression of ACTB protein CTD PMID:34122009 NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509 		JBrowse link
G Actbl2 actin, beta-like 2 increases expression ISO Clozapine results in increased expression of ACTBL2 protein CTD PMID:34122009 NCBI chr13:111,391,547...111,394,283
Ensembl chr13:111,391,547...111,394,283 		JBrowse link
G Actr3 ARP3 actin-related protein 3 decreases expression ISO Clozapine results in decreased expression of ACTR3 protein CTD PMID:34122009 NCBI chr 1:125,320,642...125,363,464
Ensembl chr 1:125,320,642...125,363,464 		JBrowse link
G Actr5 ARP5 actin-related protein 5 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of ACTR5 protein CTD PMID:34122009 NCBI chr 2:158,466,800...158,481,131
Ensembl chr 2:158,466,808...158,481,131 		JBrowse link
G Adam1a a disintegrin and metallopeptidase domain 1a decreases expression ISO Clozapine results in decreased expression of ADAM1A mRNA CTD PMID:16715494 NCBI chr 5:121,656,667...121,659,758
Ensembl chr 5:121,656,639...121,660,134 		JBrowse link
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif 12 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of ADAMTS12 protein CTD PMID:34122009 NCBI chr15:11,064,781...11,349,321
Ensembl chr15:11,064,876...11,349,317 		JBrowse link
G Adcy5 adenylate cyclase 5 affects response to substance
multiple interactions		 EXP ADCY5 protein affects the susceptibility to Clozapine
SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]		 CTD PMID:12223546 NCBI chr16:34,974,933...35,126,108
Ensembl chr16:34,975,247...35,126,108 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of ADH5 protein CTD PMID:34122009 NCBI chr 3:138,142,961...138,161,260
Ensembl chr 3:138,148,854...138,161,260 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
multiple interactions
increases expression		 ISO
EXP		 Clozapine results in decreased expression of ADIPOQ protein
Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]
Clozapine results in increased expression of ADIPOQ protein		 CTD PMID:17933447 PMID:18162013 PMID:20564506 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adora2a adenosine A2a receptor decreases expression EXP Clozapine results in decreased expression of ADORA2A mRNA CTD PMID:17266109 NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618 		JBrowse link
G Adra1a adrenergic receptor, alpha 1a multiple interactions ISO Clozapine binds to and results in decreased activity of ADRA1A protein CTD PMID:16545797 NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617 		JBrowse link
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 decreases expression EXP Clozapine results in decreased expression of AGPAT1 mRNA CTD PMID:14647396 NCBI chr17:34,823,164...34,832,392
Ensembl chr17:34,823,236...34,832,423 		JBrowse link
G Agt angiotensinogen multiple interactions ISO Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]] CTD PMID:11549694 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression ISO Clozapine results in increased expression of AIMP1 protein CTD PMID:34122009 NCBI chr 3:132,366,259...132,390,151
Ensembl chr 3:132,366,242...132,390,131 		JBrowse link
G Ak1 adenylate kinase 1 decreases expression ISO Clozapine results in decreased expression of AK1 protein CTD PMID:34122009 NCBI chr 2:32,511,770...32,525,070
Ensembl chr 2:32,511,770...32,525,070 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases expression
increases phosphorylation
decreases expression		 ISO Clozapine results in increased expression of AKT1 mRNA; Clozapine results in increased expression of AKT1 protein
Clozapine results in increased phosphorylation of AKT1 protein
Clozapine results in decreased expression of AKT1 mRNA		 CTD PMID:15860345 PMID:19440698 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Akt2 thymoma viral proto-oncogene 2 increases expression ISO Clozapine results in increased expression of AKT2 mRNA CTD PMID:15860345 NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251 		JBrowse link
G Alb albumin multiple interactions
affects binding		 ISO Clozapine results in decreased expression of and results in decreased reduction of ALB protein
Clozapine binds to ALB protein
[[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein]		 CTD PMID:31400341 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 increases expression EXP Clozapine results in increased expression of ALDH1A1 mRNA CTD PMID:17266109 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829 		JBrowse link
G Aldob aldolase B, fructose-bisphosphate increases expression
decreases expression		 ISO Clozapine results in increased expression of ALDOB protein
Clozapine results in decreased expression of ALDOB protein		 CTD PMID:34122009 PMID:36482696 NCBI chr 4:49,535,993...49,549,546
Ensembl chr 4:49,535,995...49,549,546 		JBrowse link
G Aldoc aldolase C, fructose-bisphosphate decreases expression
increases expression		 EXP
ISO		 Clozapine results in decreased expression of ALDOC mRNA
Clozapine results in increased expression of ALDOC mRNA		 CTD PMID:15860345 PMID:16465460 NCBI chr11:78,213,899...78,218,607
Ensembl chr11:78,213,794...78,218,607 		JBrowse link
G Alyref Aly/REF export factor decreases expression ISO Clozapine results in decreased expression of ALYREF protein CTD PMID:34122009 NCBI chr11:120,485,330...120,489,342
Ensembl chr11:120,482,947...120,489,191 		JBrowse link
G Anxa1 annexin A1 decreases expression ISO Clozapine results in decreased expression of ANXA1 protein CTD PMID:34122009 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308 		JBrowse link
G Anxa5 annexin A5 decreases expression ISO Clozapine results in decreased expression of ANXA5 protein CTD PMID:34122009 NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043 		JBrowse link
G Anxa6 annexin A6 decreases expression ISO Clozapine results in decreased expression of ANXA6 protein CTD PMID:34122009 NCBI chr11:54,869,779...54,924,297
Ensembl chr11:54,869,934...54,924,271 		JBrowse link
G Ap1s1 adaptor protein complex AP-1, sigma 1 decreases expression ISO Clozapine results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr 5:137,063,852...137,074,917
Ensembl chr 5:137,063,847...137,074,989 		JBrowse link
G Ap2b1 adaptor-related protein complex 2, beta 1 subunit increases expression ISO Clozapine results in increased expression of AP2B1 mRNA CTD PMID:15860345 NCBI chr11:83,189,545...83,295,861
Ensembl chr11:83,189,850...83,295,861 		JBrowse link
G Ap3b1 adaptor-related protein complex 3, beta 1 subunit increases expression ISO Clozapine results in increased expression of AP3B1 protein CTD PMID:34122009 NCBI chr13:94,492,332...94,702,838
Ensembl chr13:94,495,468...94,702,825 		JBrowse link
G Apoa5 apolipoprotein A-V affects response to substance ISO APOA5 gene polymorphism affects the susceptibility to Clozapine CTD PMID:17726453 NCBI chr 9:46,179,906...46,183,219
Ensembl chr 9:46,179,931...46,183,217 		JBrowse link
G Apod apolipoprotein D increases expression EXP Clozapine results in increased expression of APOD mRNA; Clozapine results in increased expression of APOD protein CTD PMID:11158250 PMID:14647396 PMID:17266109 NCBI chr16:31,115,010...31,133,626
Ensembl chr16:31,115,010...31,133,626 		JBrowse link
G App amyloid beta precursor protein increases expression ISO Clozapine results in increased expression of APP protein CTD PMID:36482696 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Arc activity regulated cytoskeletal-associated protein decreases expression ISO Clozapine results in decreased expression of ARC mRNA CTD PMID:18208916 NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419 		JBrowse link
G Arhgef9 CDC42 guanine nucleotide exchange factor 9 decreases expression EXP Clozapine results in decreased expression of ARHGEF9 mRNA CTD PMID:17266109 NCBI chr  X:94,092,536...94,240,801
Ensembl chr  X:94,092,541...94,240,462 		JBrowse link
G Arl8a ADP-ribosylation factor-like 8A decreases expression ISO Clozapine results in decreased expression of ARL8A protein CTD PMID:34122009 NCBI chr 1:135,074,572...135,084,007
Ensembl chr 1:135,074,562...135,084,007 		JBrowse link
G Armt1 acidic residue methyltransferase 1 increases expression ISO Clozapine results in increased expression of ARMT1 protein CTD PMID:34122009 NCBI chr10:4,382,572...4,405,140
Ensembl chr10:4,382,467...4,405,141 		JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 affects expression EXP Clozapine affects the expression of ARPC4 mRNA CTD PMID:14647396 NCBI chr 6:113,355,074...113,367,408
Ensembl chr 6:113,355,076...113,367,409 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Clozapine results in increased expression of ASAH1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810 		JBrowse link
G Asns asparagine synthetase increases expression ISO Clozapine results in increased expression of ASNS mRNA; Clozapine results in increased expression of ASNS protein CTD PMID:15342952 PMID:17175557 PMID:36482696 NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254 		JBrowse link
G Asph aspartate-beta-hydroxylase increases expression ISO Clozapine results in increased expression of ASPH protein CTD PMID:34122009 NCBI chr 4:9,449,085...9,669,344
Ensembl chr 4:9,448,069...9,669,344 		JBrowse link
G Ass1 argininosuccinate synthetase 1 increases expression ISO Clozapine results in increased expression of ASS1 protein CTD PMID:34122009 NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684 		JBrowse link
G Atad3a ATPase family, AAA domain containing 3A decreases expression ISO Clozapine results in decreased expression of ATAD3A protein CTD PMID:34122009 NCBI chr 4:155,825,097...155,845,579
Ensembl chr 4:155,825,098...155,845,550 		JBrowse link
G Atp2a3 ATPase, Ca++ transporting, ubiquitous increases expression ISO Clozapine results in increased expression of ATP2A3 protein CTD PMID:34122009 NCBI chr11:72,851,995...72,883,869
Ensembl chr11:72,851,995...72,883,870 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO Clozapine results in decreased expression of ATP5F1B protein CTD PMID:19441803 NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260 		JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b increases expression ISO Clozapine results in increased expression of ATP5F1 protein CTD PMID:34122009 NCBI chr 3:105,850,014...105,866,579
Ensembl chr 3:105,850,014...105,867,415 		JBrowse link
G Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A decreases expression ISO Clozapine results in decreased expression of ATP6V1A protein CTD PMID:34122009 NCBI chr16:43,905,765...43,960,055
Ensembl chr16:43,905,765...43,960,068 		JBrowse link
G Atp6v1b1 ATPase, H+ transporting, lysosomal V1 subunit B1 decreases expression ISO Clozapine results in decreased expression of ATP6V1B1 protein CTD PMID:34122009 NCBI chr 6:83,719,999...83,735,837
Ensembl chr 6:83,719,972...83,735,837 		JBrowse link
G Atp6v1b2 ATPase, H+ transporting, lysosomal V1 subunit B2 decreases expression ISO Clozapine results in decreased expression of ATP6V1B2 protein CTD PMID:19441803 PMID:34122009 NCBI chr 8:69,541,388...69,566,370
Ensembl chr 8:69,541,298...69,566,363 		JBrowse link
G Atxn10 ataxin 10 increases expression ISO Clozapine results in increased expression of ATXN10 protein CTD PMID:34122009 NCBI chr15:85,220,456...85,348,038
Ensembl chr15:85,220,446...85,347,413 		JBrowse link
G Axin2 axin 2 decreases expression ISO Clozapine results in decreased expression of AXIN2 mRNA CTD PMID:16715494 NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609 		JBrowse link
G Bace2 beta-site APP-cleaving enzyme 2 increases expression ISO Clozapine results in increased expression of BACE2 protein CTD PMID:36482696 NCBI chr16:97,157,928...97,244,136
Ensembl chr16:97,157,942...97,244,136 		JBrowse link
G Bax BCL2-associated X protein increases expression
decreases expression
multiple interactions		 ISO Clozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX protein
Clozapine results in decreased expression of BAX protein
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]		 CTD PMID:16160616 PMID:17069804 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Baz1b bromodomain adjacent to zinc finger domain, 1B multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of BAZ1B protein CTD PMID:34122009 NCBI chr 5:135,214,094...135,274,985
Ensembl chr 5:135,216,118...135,274,983 		JBrowse link
G Bcar1 breast cancer anti-estrogen resistance 1 decreases expression ISO Clozapine results in decreased expression of BCAR1 protein CTD PMID:34122009 NCBI chr 8:112,437,106...112,470,481
Ensembl chr 8:112,437,106...112,470,441 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 increases expression ISO Clozapine results in increased expression of BCL2 mRNA; Clozapine results in increased expression of BCL2 protein CTD PMID:15126120 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l14 BCL2 like 14 decreases expression ISO Clozapine results in decreased expression of BCL2L14 protein CTD PMID:34122009 NCBI chr 6:134,373,292...134,415,687
Ensembl chr 6:134,373,281...134,415,699 		JBrowse link
G Bdnf brain derived neurotrophic factor decreases expression
increases expression		 ISO Clozapine results in decreased expression of BDNF mRNA
Clozapine results in increased expression of BDNF mRNA; Clozapine results in increased expression of BDNF protein		 CTD PMID:11488957 PMID:12478621 PMID:17442489 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Bet1l Bet1 golgi vesicular membrane trafficking protein like decreases expression ISO Clozapine results in decreased expression of BET1L mRNA CTD PMID:15860345 NCBI chr 7:140,433,297...140,437,306
Ensembl chr 7:140,433,307...140,437,490 		JBrowse link
G Bik BCL2-interacting killer multiple interactions
increases expression		 ISO CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA] CTD PMID:16160616 NCBI chr15:83,410,992...83,428,836
Ensembl chr15:83,411,063...83,428,835 		JBrowse link
G Bptf bromodomain PHD finger transcription factor decreases expression EXP Clozapine results in decreased expression of BPTF mRNA CTD PMID:14647396 NCBI chr11:106,923,907...107,022,982
Ensembl chr11:106,923,907...107,022,953 		JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 increases expression ISO Clozapine results in increased expression of BZW1 protein CTD PMID:34122009 NCBI chr 1:58,432,057...58,446,513
Ensembl chr 1:58,432,057...58,446,512 		JBrowse link
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit decreases expression EXP
ISO		 Clozapine results in decreased expression of CACNA1A mRNA CTD PMID:14647396 PMID:16715494 NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875 		JBrowse link
G Calcoco1 calcium binding and coiled coil domain 1 increases expression ISO Clozapine results in increased expression of CALCOCO1 protein CTD PMID:36482696 NCBI chr15:102,615,212...102,630,616
Ensembl chr15:102,615,212...102,630,613 		JBrowse link
G Calm2 calmodulin 2 increases expression ISO Clozapine results in increased expression of CALM2 mRNA CTD PMID:19289156 NCBI chr17:87,740,829...87,754,363
Ensembl chr17:87,740,840...87,754,363 		JBrowse link
G Calr calreticulin decreases expression ISO Clozapine results in decreased expression of CALR protein CTD PMID:34122009 NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563 		JBrowse link
G Calu calumenin decreases expression ISO Clozapine results in decreased expression of CALU protein CTD PMID:34122009 NCBI chr 6:29,348,105...29,376,674
Ensembl chr 6:29,348,068...29,377,109 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression
increases expression		 EXP
ISO		 Clozapine results in decreased expression of CAMK2A mRNA
Clozapine results in increased expression of CAMK2A mRNA
Clozapine results in decreased expression of CAMK2A protein		 CTD PMID:15860345 PMID:17266109 PMID:19289156 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II, beta decreases expression ISO Clozapine results in decreased expression of CAMK2B mRNA CTD PMID:15860345 NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II, delta decreases expression ISO Clozapine results in decreased expression of CAMK2D mRNA CTD PMID:15860345 NCBI chr 3:126,389,136...126,639,975
Ensembl chr 3:126,389,951...126,639,975 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV increases expression
decreases expression		 ISO Clozapine results in increased expression of CAMK4 mRNA
Clozapine results in decreased expression of CAMK4 protein		 CTD PMID:15860345 PMID:19289156 NCBI chr18:33,067,995...33,328,820
Ensembl chr18:33,067,984...33,324,281 		JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1, alpha decreases expression ISO Clozapine results in decreased expression of CAMKK1 protein CTD PMID:19289156 NCBI chr11:72,906,869...72,932,899
Ensembl chr11:72,909,834...72,932,899 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta decreases expression ISO Clozapine results in decreased expression of CAMKK2 protein CTD PMID:19289156 NCBI chr 5:122,856,064...122,918,295
Ensembl chr 5:122,869,233...122,917,472 		JBrowse link
G Canx calnexin decreases expression ISO Clozapine results in decreased expression of CANX protein CTD PMID:34122009 NCBI chr11:50,184,784...50,216,500
Ensembl chr11:50,184,788...50,216,500 		JBrowse link
G Cars1 cysteinyl-tRNA synthetase 1 increases expression ISO Clozapine results in increased expression of CARS1 protein CTD PMID:34122009 NCBI chr 7:143,110,967...143,153,827
Ensembl chr 7:143,110,967...143,153,827 		JBrowse link
G Cartpt CART prepropeptide decreases expression ISO Clozapine results in decreased expression of CARTPT mRNA CTD PMID:14696011 NCBI chr13:100,034,991...100,037,191
Ensembl chr13:100,034,997...100,037,599 		JBrowse link
G Casp1 caspase 1 increases activity ISO Clozapine results in increased activity of CASP1 protein CTD PMID:34935985 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Clozapine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein]		 CTD PMID:22700542 PMID:24709159 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Clozapine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein]		 CTD PMID:22700542 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Cat catalase multiple interactions EXP Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]] CTD PMID:14730115 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 increases expression ISO Clozapine results in increased expression of CCAR1 protein CTD PMID:34122009 NCBI chr10:62,579,707...62,628,147
Ensembl chr10:62,579,707...62,628,065 		JBrowse link
G Ccdc47 coiled-coil domain containing 47 multiple interactions
increases expression		 ISO [Cuprizone co-treated with Clozapine] results in increased expression of CCDC47 protein
Clozapine results in increased expression of CCDC47 protein		 CTD PMID:34122009 NCBI chr11:106,090,086...106,107,349
Ensembl chr11:106,088,234...106,107,170 		JBrowse link
G Cck cholecystokinin multiple interactions
increases expression		 ISO Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]
Clozapine results in increased expression of CCK mRNA		 CTD PMID:10974607 PMID:16567023 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760 		JBrowse link
G Cckbr cholecystokinin B receptor increases expression EXP Clozapine results in increased expression of CCKBR mRNA CTD PMID:17266109 NCBI chr 7:105,075,201...105,085,546
Ensembl chr 7:105,074,938...105,120,105 		JBrowse link
G Ccl1 C-C motif chemokine ligand 1 decreases expression ISO Clozapine results in decreased expression of CCL1 mRNA CTD PMID:17346280 NCBI chr11:82,067,492...82,070,638
Ensembl chr11:82,067,483...82,196,516 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Clozapine results in decreased expression of CCND1 mRNA CTD PMID:15860345 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccnd3 cyclin D3 increases expression ISO Clozapine results in increased expression of CCND3 mRNA CTD PMID:15860345 NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616 		JBrowse link
G Ccnl1 cyclin L1 increases expression ISO Clozapine results in increased expression of CCNL1 mRNA CTD PMID:15860345 NCBI chr 3:65,853,333...65,869,451
Ensembl chr 3:65,853,572...65,865,670 		JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 decreases expression ISO Clozapine results in decreased expression of CCT7 protein CTD PMID:34122009 NCBI chr 6:85,428,487...85,445,459
Ensembl chr 6:85,428,496...85,445,457 		JBrowse link
G Cd276 CD276 antigen decreases expression ISO Clozapine results in decreased expression of CD276 protein CTD PMID:34122009 NCBI chr 9:58,431,581...58,463,437
Ensembl chr 9:58,431,581...58,462,720 		JBrowse link
G Cd63 CD63 antigen increases expression ISO Clozapine results in increased expression of CD63 protein CTD PMID:36482696 NCBI chr10:128,731,577...128,748,691
Ensembl chr10:128,736,858...128,748,691 		JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase increases expression ISO Clozapine results in increased expression of CDIPT protein CTD PMID:34122009 NCBI chr 7:126,575,630...126,579,671
Ensembl chr 7:126,575,086...126,579,673 		JBrowse link
G Cdk4 cyclin dependent kinase 4 increases expression ISO Clozapine results in increased expression of CDK4 mRNA CTD PMID:15860345 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Cdk5 cyclin dependent kinase 5 increases expression ISO Clozapine results in increased expression of CDK5 mRNA CTD PMID:15860345 NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528 		JBrowse link
G Cdk5r1 cyclin dependent kinase 5, regulatory subunit 1 increases expression EXP Clozapine results in increased expression of CDK5R1 mRNA CTD PMID:17266109 NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression		 EXP Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]
Clozapine results in increased expression of CEBPA mRNA; Clozapine results in increased expression of CEBPA protein		 CTD PMID:20564506 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Cenpv centromere protein V increases expression ISO Clozapine results in increased expression of CENPV protein CTD PMID:34122009 NCBI chr11:62,415,770...62,430,695
Ensembl chr11:62,415,772...62,430,087 		JBrowse link
G Cfap210 cilia and flagella associated protein 210 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of CFAP210 protein CTD PMID:34122009 NCBI chr 2:69,587,736...69,619,873
Ensembl chr 2:69,588,377...69,619,919 		JBrowse link
G Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of CHCHD2 protein CTD PMID:34122009 NCBI chr 5:129,910,002...129,916,311
Ensembl chr 5:129,909,997...129,916,311 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 decreases expression ISO Clozapine results in decreased expression of CHD4 protein CTD PMID:34122009 NCBI chr 6:125,073,144...125,107,554
Ensembl chr 6:125,072,944...125,107,554 		JBrowse link
G Chga chromogranin A decreases expression
increases expression		 ISO Clozapine results in decreased expression of CHGA mRNA
Clozapine results in increased expression of CHGA mRNA		 CTD PMID:12437575 NCBI chr12:102,521,200...102,531,286
Ensembl chr12:102,521,228...102,531,287 		JBrowse link
G Chl1 cell adhesion molecule L1-like decreases expression EXP Clozapine results in decreased expression of CHL1 mRNA CTD PMID:14647396 NCBI chr 6:103,487,372...103,709,999
Ensembl chr 6:103,487,547...103,727,172 		JBrowse link
G Chn1 chimerin 1 decreases expression EXP Clozapine results in decreased expression of CHN1 mRNA CTD PMID:14647396 NCBI chr 2:73,441,004...73,605,723
Ensembl chr 2:73,441,004...73,605,690 		JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO Clozapine results in increased expression of CHORDC1 protein CTD PMID:34122009 NCBI chr 9:18,203,563...18,225,296
Ensembl chr 9:18,203,421...18,228,738 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS affects binding
multiple interactions
increases expression		 ISO Clozapine analog binds to CHRM1 protein; Clozapine binds to CHRM1 protein
Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]
Clozapine results in increased expression of CHRM1 protein		 CTD PMID:11997696 PMID:16983399 PMID:18806925 NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951 		JBrowse link
G Ckap4 cytoskeleton-associated protein 4 increases expression ISO Clozapine results in increased expression of CKAP4 protein CTD PMID:34122009 NCBI chr10:84,362,169...84,369,752
Ensembl chr10:84,362,169...84,369,926 		JBrowse link
G Clic1 chloride intracellular channel 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of CLIC1 protein CTD PMID:34122009 NCBI chr17:35,269,219...35,277,695
Ensembl chr17:35,268,942...35,277,725 		JBrowse link
G Clic4 chloride intracellular channel 4 increases expression ISO Clozapine results in increased expression of CLIC4 protein CTD PMID:34122009 NCBI chr 4:134,941,280...135,000,071
Ensembl chr 4:134,941,280...135,000,125 		JBrowse link
G Clock clock circadian regulator affects response to substance ISO CLOCK gene SNP affects the susceptibility to Clozapine CTD PMID:15331141 NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639 		JBrowse link
G Clta clathrin light chain A decreases expression ISO Clozapine results in decreased expression of CLTA mRNA CTD PMID:15860345 NCBI chr 4:44,003,816...44,032,846
Ensembl chr 4:44,004,452...44,032,846 		JBrowse link
G Cltb clathrin light chain B decreases expression ISO Clozapine results in decreased expression of CLTB mRNA CTD PMID:15860345 NCBI chr13:54,740,199...54,759,186
Ensembl chr13:54,740,214...54,759,157 		JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression
increases expression		 EXP
ISO		 Clozapine results in decreased expression of CNP mRNA
Clozapine results in increased expression of CNP mRNA
Clozapine results in decreased expression of CNP protein		 CTD PMID:17266109 PMID:34122009 NCBI chr11:100,465,765...100,472,565
Ensembl chr11:100,465,730...100,482,555 		JBrowse link
G Coil coilin increases expression ISO Clozapine results in increased expression of COIL mRNA CTD PMID:16715494 NCBI chr11:88,864,761...88,882,439
Ensembl chr11:88,861,078...88,882,439 		JBrowse link
G Col5a2 collagen, type V, alpha 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of COL5A2 protein CTD PMID:34122009 NCBI chr 1:45,413,491...45,542,442
Ensembl chr 1:45,413,481...45,542,442 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions
increases response to substance
affects response to substance		 ISO [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]
COMT gene polymorphism results in increased susceptibility to Clozapine
COMT protein affects the susceptibility to Clozapine		 CTD PMID:15190105 PMID:17123785 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602 		JBrowse link
G Cops3 COP9 signalosome subunit 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of COPS3 protein CTD PMID:34122009 NCBI chr11:59,708,621...59,739,080
Ensembl chr11:59,708,621...59,730,664 		JBrowse link
G Coro1b coronin, actin binding protein 1B decreases expression ISO Clozapine results in decreased expression of CORO1B protein CTD PMID:34122009 NCBI chr19:4,198,610...4,204,034
Ensembl chr19:4,198,618...4,204,034 		JBrowse link
G Cplx2 complexin 2 decreases expression EXP Clozapine results in decreased expression of CPLX2 mRNA CTD PMID:17266109 NCBI chr13:54,455,447...54,531,736
Ensembl chr13:54,519,162...54,531,730
Ensembl chr13:54,519,162...54,531,730 		JBrowse link
G Cpn1 carboxypeptidase N, polypeptide 1 increases expression ISO Clozapine results in increased expression of CPN1 mRNA CTD PMID:16715494 NCBI chr19:43,944,746...43,974,990
Ensembl chr19:43,944,746...43,974,995 		JBrowse link
G Cpne1 copine I decreases expression ISO Clozapine results in decreased expression of CPNE1 protein CTD PMID:34122009 NCBI chr 2:155,913,765...155,953,847
Ensembl chr 2:155,913,762...155,953,885 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions ISO [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA CTD PMID:23226405 NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation		 EXP Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein]
Clozapine results in decreased phosphorylation of CREB1 protein		 CTD PMID:12871586 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Clozapine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein decreases expression ISO Clozapine results in decreased expression of CRHBP mRNA CTD PMID:16715494 NCBI chr13:95,567,884...95,581,339
Ensembl chr13:95,567,879...95,581,432 		JBrowse link
G Crp C-reactive protein, pentraxin-related increases expression ISO Clozapine results in increased expression of CRP protein CTD PMID:17685758 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) multiple interactions ISO CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA] CTD PMID:16160616 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455 		JBrowse link
G Csnk2a1 casein kinase 2, alpha 1 polypeptide decreases expression ISO Clozapine results in decreased expression of CSNK2A1 mRNA CTD PMID:16715494 NCBI chr 2:152,068,468...152,123,772
Ensembl chr 2:152,068,759...152,123,772 		JBrowse link
G Cst3 cystatin C increases expression EXP Clozapine results in increased expression of CST3 mRNA CTD PMID:14647396 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Cstf1 cleavage stimulation factor, 3' pre-RNA, subunit 1 decreases expression ISO Clozapine results in decreased expression of CSTF1 protein CTD PMID:34122009 NCBI chr 2:172,212,591...172,224,369
Ensembl chr 2:172,212,601...172,224,368 		JBrowse link
G Cstf2 cleavage stimulation factor, 3' pre-RNA subunit 2 decreases expression ISO Clozapine results in decreased expression of CSTF2 protein CTD PMID:34122009 NCBI chr  X:132,959,925...132,987,571
Ensembl chr  X:132,959,936...132,987,568 		JBrowse link
G Ctbp1 C-terminal binding protein 1 increases expression ISO Clozapine results in increased expression of CTBP1 protein CTD PMID:34122009 NCBI chr 5:33,405,067...33,432,348
Ensembl chr 5:33,405,067...33,432,338 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions		 ISO Clozapine results in increased expression of CTNNB1 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]		 CTD PMID:16144542 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Ctrl chymotrypsin-like increases expression ISO Clozapine results in increased expression of CTRL mRNA CTD PMID:16715494 NCBI chr 8:106,658,626...106,660,494
Ensembl chr 8:106,658,635...106,660,494 		JBrowse link
G Ctsk cathepsin K increases expression ISO Clozapine results in increased expression of CTSK mRNA CTD PMID:16715494 NCBI chr 3:95,406,521...95,416,698
Ensembl chr 3:95,406,567...95,416,673 		JBrowse link
G Cttn cortactin increases expression ISO Clozapine results in increased expression of CTTN protein CTD PMID:34122009 NCBI chr 7:143,989,468...144,024,743
Ensembl chr 7:143,989,470...144,024,746 		JBrowse link
G Cul2 cullin 2 increases expression ISO Clozapine results in increased expression of CUL2 protein CTD PMID:34122009 NCBI chr18:3,382,970...3,436,700
Ensembl chr18:3,382,988...3,436,377 		JBrowse link
G Cul3 cullin 3 increases expression ISO Clozapine results in increased expression of CUL3 protein CTD PMID:34122009 NCBI chr 1:80,242,640...80,318,426
Ensembl chr 1:80,242,640...80,318,197 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions
increases secretion
decreases secretion		 ISO Clozapine results in decreased expression of CXCL1 mRNA
belnacasan inhibits the reaction [Clozapine results in increased secretion of CXCL1 protein]
Clozapine results in decreased secretion of CXCL1 protein		 CTD PMID:17346280 PMID:34935985 PMID:36482696 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO Clozapine results in decreased secretion of CXCL10 protein CTD PMID:36482696 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 decreases secretion ISO Clozapine results in decreased secretion of CXCL8 protein CTD PMID:36482696 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
decreases secretion		 ISO Clozapine results in decreased expression of CXCL1 mRNA
Clozapine results in decreased secretion of CXCL1 protein		 CTD PMID:17346280 PMID:36482696 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459 		JBrowse link
G Cyb5b cytochrome b5 type B increases expression ISO Clozapine results in increased expression of CYB5B mRNA CTD PMID:19441803 NCBI chr 8:107,877,293...107,914,102
Ensembl chr 8:107,877,272...107,914,103 		JBrowse link
G Cyb5r1 cytochrome b5 reductase 1 increases expression ISO Clozapine results in increased expression of CYB5R1 protein CTD PMID:34122009 NCBI chr 1:134,333,519...134,339,476
Ensembl chr 1:134,333,297...134,339,478 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases metabolic processing
decreases activity		 ISO Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CYP1A1 protein results in increased metabolism of Clozapine
Clozapine results in decreased activity of CYP1A1 protein		 CTD PMID:18493746 PMID:18809730 PMID:33814510 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases response to substance
decreases metabolic processing
increases metabolic processing
affects response to substance
multiple interactions
affects metabolic processing
increases expression		 ISO
EXP		 CYP1A2 gene SNP results in decreased susceptibility to Clozapine
CYP1A2 gene SNP results in decreased metabolism of Clozapine
CYP1A2 gene SNP results in increased metabolism of Clozapine; CYP1A2 protein results in increased metabolism of Clozapine
CYP1A2 gene SNP affects the susceptibility to Clozapine; CYP1A2 protein affects the susceptibility to Clozapine
[Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Smoke affects the reaction [CYP1A2 gene polymorphism affects the metabolism of Clozapine]; Smoke promotes the reaction [CYP1A2 protein results in increased metabolism of Clozapine]
CYP1A2 gene polymorphism affects the metabolism of Clozapine; CYP1A2 protein affects the metabolism of Clozapine; CYP1A2 protein polymorphism affects the metabolism of Clozapine
Clozapine results in increased expression of CYP1A2 mRNA		 CTD PMID:11151749 PMID:11763009 PMID:12919186 PMID:12969762 PMID:15206669 More... NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
decreases activity		 ISO CYP1B1 protein results in increased metabolism of Clozapine
Clozapine results in decreased activity of CYP1B1 protein		 CTD PMID:18809730 PMID:33814510 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of Clozapine CTD PMID:18809730 PMID:27320963 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions
increases metabolic processing		 ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CYP2C19 protein results in increased metabolism of Clozapine		 CTD PMID:18809730 PMID:23397584 PMID:27320963 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions
increases metabolic processing		 ISO [Clozapine results in decreased activity of CYP2C9 protein] which results in increased susceptibility to Phenytoin; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CYP2C9 protein results in increased metabolism of Clozapine		 CTD PMID:17961958 PMID:18809730 PMID:23397584 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 affects metabolic processing
multiple interactions
increases metabolic processing		 ISO CYP2D6 protein affects the metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CYP2D6 protein results in increased metabolism of Clozapine		 CTD PMID:15286053 PMID:18809730 PMID:23397584 PMID:27320963 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 increases metabolic processing ISO CYP2J2 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Dab1 disabled 1 increases expression ISO Clozapine results in increased expression of DAB1 mRNA CTD PMID:19359144 NCBI chr 4:103,476,425...104,602,041
Ensembl chr 4:103,476,556...104,602,041 		JBrowse link
G Dab2 disabled 2, mitogen-responsive phosphoprotein increases expression ISO Clozapine results in increased expression of DAB2 protein CTD PMID:36482696 NCBI chr15:6,329,269...6,470,196
Ensembl chr15:6,329,269...6,470,193 		JBrowse link
G Daglb diacylglycerol lipase, beta increases expression ISO Clozapine results in increased expression of DAGLB protein CTD PMID:36482696 NCBI chr 5:143,450,239...143,490,197
Ensembl chr 5:143,450,339...143,491,697 		JBrowse link
G Dcaf6 DDB1 and CUL4 associated factor 6 decreases expression EXP Clozapine results in decreased expression of DCAF6 mRNA CTD PMID:14647396 NCBI chr 1:165,157,069...165,288,475
Ensembl chr 1:165,156,267...165,288,044 		JBrowse link
G Dclk1 doublecortin-like kinase 1 increases expression EXP
ISO		 Clozapine results in increased expression of DCLK1 mRNA CTD PMID:15860345 PMID:18797397 NCBI chr 3:55,149,724...55,446,489
Ensembl chr 3:55,149,785...55,446,489 		JBrowse link
G Ddc dopa decarboxylase multiple interactions
increases expression		 EXP Clozapine results in increased expression of and results in increased activity of DDC protein
Clozapine results in increased expression of DDC mRNA		 CTD PMID:16415089 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144 		JBrowse link
G Ddx46 DEAD box helicase 46 increases expression ISO Clozapine results in increased expression of DDX46 protein CTD PMID:34122009 NCBI chr13:55,782,790...55,829,080
Ensembl chr13:55,782,841...55,829,069 		JBrowse link
G Dennd10 DENN domain containing 10 increases expression ISO Clozapine results in increased expression of DENND10 mRNA CTD PMID:16715494 NCBI chr19:60,800,029...60,824,673
Ensembl chr19:60,800,023...60,824,665 		JBrowse link
G Depp1 DEPP1 autophagy regulator increases expression ISO Clozapine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755 		JBrowse link
G Dgcr6 DiGeorge syndrome critical region gene 6 decreases expression ISO Clozapine results in decreased expression of DGCR6 protein CTD PMID:34122009 NCBI chr16:17,870,736...17,889,497
Ensembl chr16:17,870,724...17,889,496 		JBrowse link
G Dgka diacylglycerol kinase, alpha decreases expression ISO Clozapine results in decreased expression of DGKA mRNA CTD PMID:15860345 NCBI chr10:128,556,000...128,581,002
Ensembl chr10:128,556,003...128,580,724 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO Clozapine results in increased expression of DHCR24 protein CTD PMID:34122009 NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression ISO Clozapine results in increased expression of DHCR7 mRNA CTD PMID:17052361 NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147 		JBrowse link
G Dhx30 DExH-box helicase 30 increases expression ISO Clozapine results in increased expression of DHX30 protein CTD PMID:34122009 NCBI chr 9:109,913,387...109,946,728
Ensembl chr 9:109,913,388...109,946,898 		JBrowse link
G Dhx38 DEAH-box helicase 38 decreases expression ISO Clozapine results in decreased expression of DHX38 protein CTD PMID:34122009 NCBI chr 8:110,274,631...110,292,493
Ensembl chr 8:110,274,643...110,292,493 		JBrowse link
G Disc1 disrupted in schizophrenia 1 decreases response to substance
affects response to substance		 ISO DISC1 gene mutant form results in decreased susceptibility to Clozapine
DISC1 protein affects the susceptibility to Clozapine		 CTD PMID:20531374 NCBI chr 8:125,773,928...125,991,882
Ensembl chr 8:125,780,934...125,988,597 		JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase decreases expression
increases expression		 ISO Clozapine results in decreased expression of DLAT mRNA
Clozapine results in increased expression of DLAT protein		 CTD PMID:15860345 PMID:34122009 NCBI chr 9:50,545,933...50,571,080
Ensembl chr 9:50,545,933...50,571,080 		JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 increases expression ISO Clozapine results in increased expression of DLG2 protein CTD PMID:34122009 NCBI chr 7:90,125,399...92,098,454
Ensembl chr 7:90,125,880...92,098,455 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression ISO Clozapine results in decreased expression of DLST protein CTD PMID:34122009 NCBI chr12:85,157,597...85,180,865
Ensembl chr12:85,157,607...85,181,619 		JBrowse link
G Dnah11 dynein, axonemal, heavy chain 11 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of DNAH11 protein CTD PMID:34122009 NCBI chr12:117,841,717...118,162,778
Ensembl chr12:117,841,717...118,162,778 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of DNAJA3 protein CTD PMID:34122009 NCBI chr16:4,501,934...4,525,559
Ensembl chr16:4,457,853...4,525,559 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 increases expression ISO Clozapine results in increased expression of DNAJB11 protein CTD PMID:34122009 NCBI chr16:22,676,595...22,698,384
Ensembl chr16:22,676,595...22,698,384 		JBrowse link
G Dpf1 double PHD fingers 1 affects expression EXP Clozapine affects the expression of DPF1 mRNA CTD PMID:14647396 NCBI chr 7:29,003,366...29,017,017
Ensembl chr 7:29,003,376...29,017,668 		JBrowse link
G Dpp3 dipeptidylpeptidase 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of DPP3 protein CTD PMID:34122009 NCBI chr19:4,957,257...4,978,315
Ensembl chr19:4,957,257...4,978,315 		JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 decreases expression ISO Clozapine results in decreased expression of DPYSL3 protein CTD PMID:34122009 NCBI chr18:43,454,044...43,571,354
Ensembl chr18:43,454,049...43,571,351 		JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 decreases expression ISO Clozapine results in decreased expression of DPYSL4 protein CTD PMID:34122009 NCBI chr 7:138,665,917...138,681,711
Ensembl chr 7:138,665,917...138,682,620 		JBrowse link
G Dr1 down-regulator of transcription 1 decreases expression ISO Clozapine results in decreased expression of DR1 protein CTD PMID:34122009 NCBI chr 5:108,416,763...108,428,387
Ensembl chr 5:108,416,763...108,428,392 		JBrowse link
G Drd1 dopamine receptor D1 affects binding
affects response to substance
decreases expression		 ISO
EXP		 Clozapine binds to DRD1 protein
DRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to Clozapine
Clozapine analog binds to DRD1 protein
Clozapine results in decreased expression of DRD1 mRNA		 CTD PMID:1352677 PMID:9723970 PMID:11997696 PMID:17092969 PMID:17266109 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects response to substance
increases response to substance
affects binding
decreases expression		 ISO
EXP		 [Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein
DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine
DRD2 gene SNP results in increased susceptibility to Clozapine
Clozapine binds to DRD2 protein alternative form
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Clozapine results in decreased expression of DRD2 mRNA
[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein
DRD2 protein affects the susceptibility to Clozapine		 CTD PMID:1352677 PMID:9723970 PMID:11997696 PMID:12476322 PMID:15286066 More... NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Drd3 dopamine receptor D3 affects response to substance
decreases response to substance
multiple interactions		 ISO
EXP		 DRD3 protein affects the susceptibility to Clozapine
DRD3 gene polymorphism results in decreased susceptibility to Clozapine
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]		 CTD PMID:15579174 PMID:20029384 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295 		JBrowse link
G Drd4 dopamine receptor D4 affects binding
affects response to substance
multiple interactions		 ISO Clozapine binds to DRD4 protein
DRD4 gene polymorphism affects the susceptibility to Clozapine
Clozapine analog binds to DRD4 protein
Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein]
Clozapine binds to Drd4 protein		 CTD
RGD		 PMID:11997696 PMID:16223700 PMID:31323226 PMID:8078498 RGD:7248459 NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377 		JBrowse link
G Drp2 dystrophin related protein 2 increases expression ISO Clozapine results in increased expression of DRP2 mRNA alternative form CTD PMID:16715494 NCBI chr  X:133,304,868...133,357,323
Ensembl chr  X:133,305,300...133,357,322 		JBrowse link
G Dtnbp1 dystrobrevin binding protein 1 increases response to substance
affects response to substance		 ISO DTNBP1 gene polymorphism results in increased susceptibility to Clozapine
DTNBP1 protein affects the susceptibility to Clozapine		 CTD PMID:19369910 NCBI chr13:45,075,552...45,155,614
Ensembl chr13:45,075,551...45,155,623 		JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression ISO Clozapine results in decreased expression of DUSP1 mRNA CTD PMID:15860345 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102 		JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO Clozapine results in decreased expression of DUSP6 mRNA CTD PMID:15860345 NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 increases expression
multiple interactions		 ISO Clozapine results in increased expression of DVL3 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]		 CTD PMID:16144542 NCBI chr16:20,335,694...20,352,763
Ensembl chr16:20,335,732...20,352,760 		JBrowse link
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 decreases expression ISO Clozapine results in decreased expression of DYNC1LI1 protein CTD PMID:34122009 NCBI chr 9:114,517,899...114,552,856
Ensembl chr 9:114,517,858...114,553,370 		JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 decreases expression ISO Clozapine results in decreased expression of DYNC1LI2 protein CTD PMID:34122009 NCBI chr 8:105,144,306...105,170,415
Ensembl chr 8:105,144,312...105,169,679 		JBrowse link
G Edc4 enhancer of mRNA decapping 4 increases expression ISO Clozapine results in increased expression of EDC4 protein CTD PMID:34122009 NCBI chr 8:106,607,506...106,619,857
Ensembl chr 8:106,607,513...106,621,540 		JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 increases expression ISO Clozapine results in increased expression of EEF1A2 protein CTD PMID:34122009 NCBI chr 2:180,783,551...180,798,808
Ensembl chr 2:180,789,446...180,798,807 		JBrowse link
G Eef1d eukaryotic translation elongation factor 1 delta decreases expression ISO Clozapine results in decreased expression of EEF1D protein CTD PMID:34122009 NCBI chr15:75,766,643...75,781,425
Ensembl chr15:75,766,054...75,781,405 		JBrowse link
G Egr1 early growth response 1 decreases expression ISO Clozapine results in decreased expression of EGR1 mRNA; Clozapine results in decreased expression of EGR1 protein CTD PMID:17028028 PMID:18208916 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Egr2 early growth response 2 affects expression
decreases expression		 EXP
ISO		 Clozapine affects the expression of EGR2 mRNA
Clozapine results in decreased expression of EGR2 protein		 CTD PMID:17028028 PMID:19401217 NCBI chr10:67,370,334...67,383,354
Ensembl chr10:67,371,305...67,378,018 		JBrowse link
G Egr3 early growth response 3 affects response to substance EXP EGR3 protein affects the susceptibility to Clozapine CTD PMID:17637609 NCBI chr14:70,314,766...70,320,062
Ensembl chr14:70,314,652...70,320,063 		JBrowse link
G Eif2s3x eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked increases expression ISO Clozapine results in increased expression of EIF2S3 protein CTD PMID:34122009 NCBI chr  X:93,232,315...93,256,257
Ensembl chr  X:93,232,313...93,256,468 		JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of EIF3C protein CTD PMID:34122009 NCBI chr 7:126,146,083...126,165,538
Ensembl chr 7:126,145,627...126,165,583 		JBrowse link
G Eif3j1 eukaryotic translation initiation factor 3, subunit J1 increases expression ISO Clozapine results in increased expression of EIF3J protein CTD PMID:34122009 NCBI chr 2:121,859,061...121,884,113
Ensembl chr 2:121,859,027...121,887,079 		JBrowse link
G Eif3m eukaryotic translation initiation factor 3, subunit M multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of EIF3M protein CTD PMID:34122009 NCBI chr 2:104,830,001...104,847,372
Ensembl chr 2:104,830,001...104,847,425 		JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of EIF4A3 protein CTD PMID:34122009 NCBI chr11:119,179,189...119,190,869
Ensembl chr11:119,179,189...119,190,915 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of EIF4E protein CTD PMID:34122009 NCBI chr 3:138,231,952...138,265,457
Ensembl chr 3:138,231,940...138,265,457 		JBrowse link
G Eif5b eukaryotic translation initiation factor 5B increases expression ISO Clozapine results in increased expression of EIF5B protein CTD PMID:34122009 NCBI chr 1:38,037,091...38,094,660
Ensembl chr 1:38,037,091...38,094,660 		JBrowse link
G Eif6 eukaryotic translation initiation factor 6 decreases expression ISO Clozapine results in decreased expression of EIF6 protein CTD PMID:34122009 NCBI chr 2:155,661,757...155,668,845
Ensembl chr 2:155,661,752...155,668,845 		JBrowse link
G Elk1 ELK1, member of ETS oncogene family decreases phosphorylation EXP Clozapine results in decreased phosphorylation of ELK1 protein CTD PMID:12871586 NCBI chr  X:20,799,634...20,816,847
Ensembl chr  X:20,799,634...20,816,847 		JBrowse link
G Eno1 enolase 1, alpha non-neuron increases expression ISO Clozapine results in increased expression of ENO1 mRNA CTD PMID:15860345 NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336 		JBrowse link
G Eno3 enolase 3, beta muscle increases expression ISO Clozapine results in increased expression of ENO3 protein CTD PMID:34122009 NCBI chr11:70,543,973...70,553,339
Ensembl chr11:70,548,028...70,553,339 		JBrowse link
G Epha7 Eph receptor A7 increases expression EXP Clozapine results in increased expression of EPHA7 mRNA CTD PMID:17266109 NCBI chr 4:28,811,840...28,969,391
Ensembl chr 4:28,813,131...28,967,499 		JBrowse link
G Ephb3 Eph receptor B3 increases expression ISO Clozapine results in increased expression of EPHB3 protein CTD PMID:34122009 NCBI chr16:21,023,530...21,042,054
Ensembl chr16:21,023,505...21,042,055 		JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 decreases expression ISO Clozapine results in decreased expression of ERAP1 protein CTD PMID:34122009 NCBI chr13:74,787,692...74,841,321
Ensembl chr13:74,787,687...74,841,320 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects phosphorylation ISO Clozapine affects the phosphorylation of ERBB2 protein CTD PMID:26961615 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO Clozapine results in increased expression of and results in increased phosphorylation of ERBB4 protein CTD PMID:26961615 NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218 		JBrowse link
G Erh ERH mRNA splicing and mitosis factor increases expression ISO Clozapine results in increased expression of ERH protein CTD PMID:34122009 NCBI chr12:80,680,799...80,690,616
Ensembl chr12:80,680,796...80,691,115 		JBrowse link
G Erp44 endoplasmic reticulum protein 44 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of ERP44 protein CTD PMID:34122009 NCBI chr 4:48,190,711...48,279,635
Ensembl chr 4:48,193,323...48,279,558 		JBrowse link
G Ewsr1 Ewing sarcoma breakpoint region 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of EWSR1 protein CTD PMID:34122009 NCBI chr11:5,019,687...5,049,314
Ensembl chr11:5,019,689...5,049,266 		JBrowse link
G Exosc4 exosome component 4 increases expression ISO Clozapine results in increased expression of EXOSC4 protein CTD PMID:34122009 NCBI chr15:76,211,597...76,214,870
Ensembl chr15:76,211,597...76,214,877 		JBrowse link
G Ezr ezrin decreases expression ISO Clozapine results in decreased expression of EZR protein CTD PMID:34122009 NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183 		JBrowse link
G Fabp1 fatty acid binding protein 1, liver increases expression ISO Clozapine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007 		JBrowse link
G Fan1 FANCD2/FANCI-associated nuclease 1 increases expression ISO Clozapine results in increased expression of FAN1 protein CTD PMID:34122009 NCBI chr 7:63,994,627...64,023,874
Ensembl chr 7:63,996,506...64,023,843 		JBrowse link
G Farsa phenylalanyl-tRNA synthetase, alpha subunit increases expression ISO Clozapine results in increased expression of FARSA protein CTD PMID:34122009 NCBI chr 8:85,583,597...85,595,886
Ensembl chr 8:85,583,618...85,595,886 		JBrowse link
G Farsb phenylalanyl-tRNA synthetase, beta subunit increases expression ISO Clozapine results in increased expression of FARSB protein CTD PMID:34122009 NCBI chr 1:78,394,593...78,465,530
Ensembl chr 1:78,394,612...78,465,534 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA CTD PMID:20564506 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasl Fas ligand multiple interactions ISO [Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA; [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA CTD PMID:16510162 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fasn fatty acid synthase increases expression ISO Clozapine results in increased expression of FASN mRNA CTD PMID:16027736 PMID:17052361 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fdps farnesyl diphosphate synthetase increases expression ISO Clozapine results in increased expression of FDPS mRNA CTD PMID:17052361 NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266 		JBrowse link
G Fen1 flap structure specific endonuclease 1 increases expression ISO Clozapine results in increased expression of FEN1 protein CTD PMID:34122009 NCBI chr19:10,176,496...10,181,757
Ensembl chr19:10,176,496...10,181,533 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Clozapine results in increased expression of FGF2 mRNA CTD PMID:11264663 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Fgl1 fibrinogen-like protein 1 increases expression ISO Clozapine results in increased expression of FGL1 protein CTD PMID:36482696 NCBI chr 8:41,644,471...41,671,015
Ensembl chr 8:41,644,471...41,668,193 		JBrowse link
G Fhod1 formin homology 2 domain containing 1 decreases expression ISO Clozapine results in decreased expression of FHOD1 protein CTD PMID:34122009 NCBI chr 8:106,055,792...106,074,650
Ensembl chr 8:106,055,795...106,074,585 		JBrowse link
G Fkbp8 FK506 binding protein 8 decreases expression ISO Clozapine results in decreased expression of FKBP8 protein CTD PMID:34122009 NCBI chr 8:70,980,371...70,987,978
Ensembl chr 8:70,980,374...70,987,978 		JBrowse link
G Flot2 flotillin 2 increases expression ISO Clozapine results in increased expression of FLOT2 protein CTD PMID:34122009 NCBI chr11:77,928,757...77,951,260
Ensembl chr11:77,928,757...77,951,260 		JBrowse link
G Fmo1 flavin containing monooxygenase 1 increases metabolic processing ISO FMO1 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr 1:162,657,130...162,694,170
Ensembl chr 1:162,657,130...162,694,179 		JBrowse link
G Fmo3 flavin containing monooxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Clozapine CTD PMID:18809730 PMID:27320963 NCBI chr 1:162,781,368...162,812,097
Ensembl chr 1:162,781,369...162,812,097 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Clozapine results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 5:31,449,589...31,453,279
Ensembl chr 5:31,449,586...31,453,424 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
decreases expression
increases expression		 ISO
EXP		 Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA]
Clozapine results in decreased expression of FOS protein
Clozapine analog results in increased expression of FOS protein; Clozapine results in increased expression of FOS mRNA; Clozapine results in increased expression of FOS protein		 CTD PMID:10435392 PMID:11166331 PMID:11440804 PMID:11997696 PMID:12093589 More... NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fosb FBJ osteosarcoma oncogene B increases expression
decreases expression
multiple interactions		 EXP
ISO		 Clozapine results in increased expression of FOSB protein alternative form
Clozapine results in decreased expression of FOSB mRNA
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
Clozapine results in increased expression of FOSB mRNA; Clozapine results in increased expression of FOSB protein		 CTD PMID:11259127 PMID:12093589 PMID:12243769 PMID:15579174 PMID:19695244 NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976 		JBrowse link
G Fosl1 fos-like antigen 1 increases expression ISO Clozapine results in increased expression of FOSL1 mRNA CTD PMID:18208916 NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974 		JBrowse link
G Fosl2 fos-like antigen 2 increases expression ISO Clozapine results in increased expression of FOSL2 mRNA CTD PMID:12093589 PMID:12243769 NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186 		JBrowse link
G Foxp2 forkhead box P2 increases expression EXP Clozapine results in increased expression of FOXP2 mRNA CTD PMID:17266109 NCBI chr 6:14,901,348...15,441,976
Ensembl chr 6:14,901,348...15,441,976 		JBrowse link
G Fstl1 follistatin-like 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of FSTL1 protein CTD PMID:34122009 NCBI chr16:37,597,417...37,656,878
Ensembl chr16:37,597,235...37,656,876 		JBrowse link
G Fubp1 far upstream element (FUSE) binding protein 1 increases expression ISO Clozapine results in increased expression of FUBP1 protein CTD PMID:34122009 NCBI chr 3:151,916,059...151,942,467
Ensembl chr 3:151,916,059...151,942,463 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked decreases expression ISO Clozapine results in decreased expression of G6PD protein CTD PMID:34122009 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gabarapl2 GABA type A receptor associated protein like 2 increases expression ISO Clozapine results in increased expression of GABARAPL2 protein CTD PMID:36482696 NCBI chr 8:112,667,335...112,679,547
Ensembl chr 8:112,667,335...112,680,244 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 decreases expression EXP Clozapine results in decreased expression of GABBR1 mRNA CTD PMID:17266109 NCBI chr17:37,356,888...37,385,197
Ensembl chr17:37,356,858...37,385,959 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases expression EXP Clozapine results in increased expression of GABRA1 mRNA CTD PMID:17266109 NCBI chr11:42,021,766...42,073,893
Ensembl chr11:42,021,766...42,073,757 		JBrowse link
G Gabrb3 GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3 increases expression ISO Clozapine results in increased expression of GABRB3 mRNA CTD PMID:18923069 NCBI chr 7:57,240,266...57,478,550
Ensembl chr 7:57,069,440...57,478,550 		JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
multiple interactions
decreases methylation		 ISO
EXP		 Clozapine results in increased expression of GAD1 mRNA
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]		 CTD PMID:12887421 PMID:15061247 PMID:17942719 PMID:18757738 PMID:18923069 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358 		JBrowse link
G Gad2 glutamic acid decarboxylase 2 increases expression EXP
ISO		 Clozapine results in increased expression of GAD2 mRNA CTD PMID:17266109 PMID:18923069 NCBI chr 2:22,512,262...22,583,889
Ensembl chr 2:22,512,217...22,583,886 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO Clozapine results in increased expression of GAPDH mRNA
Clozapine results in increased expression of GAPDH protein		 CTD PMID:15860345 PMID:34122009 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase increases expression ISO Clozapine results in increased expression of GART protein CTD PMID:34122009 NCBI chr16:91,418,283...91,444,505
Ensembl chr16:91,418,074...91,443,840 		JBrowse link
G Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) increases expression ISO Clozapine results in increased expression of GATM protein CTD PMID:34122009 NCBI chr 2:122,424,954...122,441,758
Ensembl chr 2:122,424,948...122,441,784 		JBrowse link
G Gcc2 GRIP and coiled-coil domain containing 2 decreases expression ISO Clozapine results in decreased expression of GCC2 protein CTD PMID:34122009 NCBI chr10:58,091,240...58,141,421
Ensembl chr10:58,091,319...58,141,421 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Clozapine results in increased expression of GDF15 protein CTD PMID:36482696 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Clozapine results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:126,365,586...126,374,817
Ensembl chr 7:126,365,506...126,374,821 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression		 ISO Clozapine results in decreased expression of GFAP protein
Clozapine results in increased expression of GFAP mRNA		 CTD PMID:18585900 PMID:19441803 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Ghitm growth hormone inducible transmembrane protein increases expression ISO Clozapine results in increased expression of GHITM protein CTD PMID:34122009 NCBI chr14:36,842,401...36,857,279
Ensembl chr14:36,842,049...36,857,229 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 decreases expression ISO Clozapine results in decreased expression of GIMAP5 mRNA CTD PMID:16715494 NCBI chr 6:48,723,131...48,731,134
Ensembl chr 6:48,723,131...48,731,144 		JBrowse link
G Gip gastric inhibitory polypeptide increases expression ISO Clozapine results in increased expression of GIP mRNA; Clozapine results in increased expression of GIP protein CTD PMID:16402076 NCBI chr11:95,915,358...95,921,657
Ensembl chr11:95,915,371...95,921,657 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO Clozapine results in increased expression of GJA1 protein CTD PMID:18585900 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions
decreases expression		 ISO PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein] CTD PMID:37087062 NCBI chr17:31,120,841...31,155,484
Ensembl chr17:31,120,791...31,159,765 		JBrowse link
G Glrx3 glutaredoxin 3 increases expression ISO Clozapine results in increased expression of GLRX3 protein CTD PMID:34122009 NCBI chr 7:137,039,302...137,071,360
Ensembl chr 7:137,039,343...137,070,323 		JBrowse link
G Glul glutamate-ammonia ligase decreases expression ISO Clozapine results in decreased expression of GLUL protein CTD PMID:36482696 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469 		JBrowse link
G Gm4779 predicted gene 4779 increases expression ISO Clozapine results in increased expression of CXORF49 protein CTD PMID:34122009 NCBI chr  X:100,833,938...100,838,074
Ensembl chr  X:100,833,659...100,838,029 		JBrowse link
G Gna12 guanine nucleotide binding protein, alpha 12 decreases expression
increases expression		 ISO Clozapine results in decreased expression of GNA12 mRNA
Clozapine results in increased expression of GNA12 protein		 CTD PMID:15860345 PMID:34122009 NCBI chr 5:140,745,699...140,816,186
Ensembl chr 5:140,744,163...140,816,186 		JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression ISO Clozapine results in decreased expression of GNAI1 mRNA CTD PMID:15860345 NCBI chr 5:18,470,133...18,565,411
Ensembl chr 5:18,470,133...18,565,353 		JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression ISO Clozapine results in decreased expression of GNAI2 mRNA CTD PMID:15860345 NCBI chr 9:107,491,324...107,512,542
Ensembl chr 9:107,491,324...107,512,566 		JBrowse link
G Gnai3 G protein subunit alpha i3 decreases expression ISO Clozapine results in decreased expression of GNAI3 mRNA CTD PMID:15860345 NCBI chr 3:108,014,591...108,053,468
Ensembl chr 3:108,014,596...108,053,462 		JBrowse link
G Gnas GNAS complex locus decreases expression
multiple interactions
increases expression		 ISO Clozapine results in decreased expression of GNAS mRNA
[Cuprizone co-treated with Clozapine] results in decreased expression of GNAS protein
Clozapine results in increased expression of GNAS protein		 CTD PMID:15860345 PMID:34122009 NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537 		JBrowse link
G Gnb3 guanine nucleotide binding protein (G protein), beta 3 decreases response to substance
increases response to substance
affects response to substance
increases expression		 ISO GNB3 gene polymorphism results in decreased susceptibility to Clozapine
GNB3 gene polymorphism results in increased susceptibility to Clozapine
GNB3 protein affects the susceptibility to Clozapine
Clozapine results in increased expression of GNB3 protein		 CTD PMID:16139171 PMID:16141801 PMID:18855531 NCBI chr 6:124,811,203...124,817,238
Ensembl chr 6:124,811,203...124,817,238 		JBrowse link
G Golga3 golgin A3 increases expression ISO Clozapine results in increased expression of GOLGA3 protein CTD PMID:34122009 NCBI chr 5:110,324,723...110,374,336
Ensembl chr 5:110,324,567...110,374,336 		JBrowse link
G Golgb1 golgin B1 increases expression ISO Clozapine results in increased expression of GOLGB1 protein CTD PMID:34122009 NCBI chr16:36,695,455...36,753,447
Ensembl chr16:36,695,502...36,753,447 		JBrowse link
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial increases expression
multiple interactions		 ISO Clozapine results in increased expression of GOT2 mRNA
[Cuprizone co-treated with Clozapine] results in increased expression of GOT2 protein		 CTD PMID:15860345 PMID:34122009 NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175 		JBrowse link
G Gpd2 glycerol phosphate dehydrogenase 2, mitochondrial decreases expression ISO Clozapine results in decreased expression of GPD2 protein CTD PMID:34122009 NCBI chr 2:57,127,690...57,260,731
Ensembl chr 2:57,127,647...57,260,731 		JBrowse link
G Gpi1 glucose-6-phosphate isomerase 1 increases expression ISO Clozapine results in increased expression of GPI protein CTD PMID:34122009 NCBI chr 7:33,900,752...33,929,761
Ensembl chr 7:33,900,755...33,929,761 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO [Chloroquine co-treated with Clozapine] results in increased secretion of GPT protein CTD PMID:36482696 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression EXP Clozapine results in increased expression of GPX1 mRNA CTD PMID:14647396 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Grik2 glutamate receptor, ionotropic, kainate 2 (beta 2) increases expression ISO Clozapine results in increased expression of GRIK2 mRNA CTD PMID:18923069 NCBI chr10:48,969,776...49,666,523
Ensembl chr10:48,970,929...49,664,862 		JBrowse link
G Grik5 glutamate receptor, ionotropic, kainate 5 (gamma 2) affects expression
decreases expression		 EXP
ISO		 Clozapine affects the expression of GRIK5 mRNA
Clozapine results in decreased expression of GRIK5 mRNA		 CTD PMID:14647396 PMID:18923069 NCBI chr 7:24,709,274...24,775,421
Ensembl chr 7:24,709,274...24,771,771 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) decreases expression
increases expression		 EXP
ISO		 Clozapine results in decreased expression of GRIN1 mRNA
Clozapine results in increased expression of GRIN1 mRNA		 CTD PMID:12020038 PMID:12608697 PMID:17266109 PMID:18923069 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) decreases expression ISO Clozapine results in decreased expression of GRIN2A mRNA CTD PMID:12608697 PMID:18923069 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) decreases expression ISO Clozapine results in decreased expression of GRIN2B mRNA CTD PMID:18923069 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Grin2c glutamate receptor, ionotropic, NMDA2C (epsilon 3) decreases expression ISO Clozapine results in decreased expression of GRIN2C mRNA CTD PMID:18923069 NCBI chr11:115,139,995...115,158,123
Ensembl chr11:115,139,995...115,158,069 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 decreases expression ISO Clozapine results in decreased expression of GRK6 mRNA CTD PMID:16715494 NCBI chr13:55,592,865...55,608,740
Ensembl chr13:55,592,885...55,608,740 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression
multiple interactions		 ISO Clozapine results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]		 CTD PMID:16144542 NCBI chr 7:24,927,683...24,937,276
Ensembl chr 7:24,927,683...24,937,276 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
increases expression		 ISO Clozapine results in increased phosphorylation of GSK3B protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]		 CTD PMID:16144542 PMID:19359144 PMID:19440698 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 decreases activity
increases glutathionylation
increases expression		 ISO GSTM1 protein results in decreased activity of Clozapine
GSTM1 protein results in increased glutathionylation of Clozapine
Clozapine results in increased expression of GSTM1 mRNA		 CTD PMID:15860345 PMID:20849150 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstm2 glutathione S-transferase, mu 2 decreases expression ISO Clozapine results in decreased expression of GSTM2 mRNA CTD PMID:15860345 NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 increases glutathionylation
decreases activity
affects binding
affects metabolic processing		 ISO GSTP1 protein results in increased glutathionylation of Clozapine
Clozapine metabolite results in decreased activity of GSTP1 protein; GSTP1 protein results in decreased activity of Clozapine
Clozapine metabolite binds to GSTP1 protein
GSTP1 protein affects the metabolism of Clozapine metabolite		 CTD PMID:20849150 PMID:21639118 PMID:24185126 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G H1f2 H1.2 linker histone, cluster member increases expression ISO Clozapine results in increased expression of H1-2 protein CTD PMID:34122009 NCBI chr13:23,922,790...23,923,514
Ensembl chr13:23,922,791...23,924,350 		JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 increases expression ISO Clozapine results in increased expression of HLA-E protein CTD PMID:36482696 NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747 		JBrowse link
G H2ac18 H2A clustered histone 18 increases expression EXP Clozapine results in increased expression of H2AC18 mRNA CTD PMID:14647396 NCBI chr 3:96,152,853...96,153,439
Ensembl chr 3:96,152,813...96,153,398 		JBrowse link
G H2ac20 H2A clustered histone 20 increases expression ISO Clozapine results in increased expression of H2AC20 protein CTD PMID:34122009 NCBI chr 3:96,127,728...96,128,209
Ensembl chr 3:96,127,677...96,128,196 		JBrowse link
G H2aj H2J.A histone increases expression ISO Clozapine results in increased expression of H2AJ protein CTD PMID:34122009 NCBI chr 6:136,785,246...136,787,072
Ensembl chr 6:136,785,242...136,787,072 		JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase decreases expression ISO Clozapine results in decreased expression of HAAO protein CTD PMID:36482696 NCBI chr17:84,138,777...84,157,589
Ensembl chr17:84,138,585...84,155,392 		JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 increases expression ISO Clozapine results in increased expression of HACD3 protein CTD PMID:34122009 NCBI chr 9:64,894,265...64,929,014
Ensembl chr 9:64,894,265...64,928,975 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression ISO Clozapine results in increased expression of HADHB protein CTD PMID:34122009 NCBI chr 5:30,360,251...30,389,591
Ensembl chr 5:30,360,246...30,389,591 		JBrowse link
G Hars1 histidyl-tRNA synthetase 1 increases expression ISO Clozapine results in increased expression of HARS1 protein CTD PMID:34122009 NCBI chr18:36,899,581...36,916,258
Ensembl chr18:36,899,581...36,916,258 		JBrowse link
G Hat1 histone aminotransferase 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of HAT1 protein CTD PMID:34122009 NCBI chr 2:71,219,604...71,271,966
Ensembl chr 2:71,219,302...71,271,966 		JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of HCLS1 protein CTD PMID:34122009 NCBI chr16:36,755,345...36,783,576
Ensembl chr16:36,755,345...36,783,574 		JBrowse link
G Hdgfl2 HDGF like 2 increases expression ISO Clozapine results in increased expression of HDGFRP2 protein CTD PMID:34122009 NCBI chr17:56,386,661...56,407,605
Ensembl chr17:56,386,634...56,407,607 		JBrowse link
G Higd1a HIG1 domain family, member 1A increases expression EXP Clozapine results in increased expression of HIGD1A mRNA CTD PMID:14647396 NCBI chr 9:121,677,623...121,686,862
Ensembl chr 9:121,677,629...121,687,428 		JBrowse link
G Hmgb2 high mobility group box 2 increases expression ISO Clozapine results in increased expression of HMGB2 protein CTD PMID:34122009 NCBI chr 8:57,964,877...57,969,033
Ensembl chr 8:57,964,941...57,969,033 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions
increases activity
increases expression		 ISO [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides
Clozapine results in increased expression of HMGCR mRNA		 CTD PMID:16027736 PMID:17052361 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 increases expression ISO Clozapine results in increased expression of HMGCS1 mRNA CTD PMID:16027736 PMID:17052361 NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Clozapine results in increased expression of HMOX1 mRNA CTD PMID:18227147 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D decreases expression ISO Clozapine results in decreased expression of HNRNPD protein CTD PMID:34122009 NCBI chr 5:100,103,794...100,126,926
Ensembl chr 5:100,103,794...100,126,797 		JBrowse link
G Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 decreases expression ISO Clozapine results in decreased expression of HNRNPH2 protein CTD PMID:36482696 NCBI chr  X:133,501,928...133,507,809
Ensembl chr  X:133,501,928...133,507,809 		JBrowse link
G Homer1 homer scaffolding protein 1 increases expression
multiple interactions		 ISO Clozapine results in increased expression of HOMER1 mRNA
Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]		 CTD PMID:12464447 PMID:15860345 NCBI chr13:93,440,265...93,549,471
Ensembl chr13:93,436,143...93,541,637 		JBrowse link
G Hpcal1 hippocalcin-like 1 decreases expression ISO Clozapine results in decreased expression of HPCAL1 mRNA CTD PMID:12437575 NCBI chr12:17,740,810...17,841,943
Ensembl chr12:17,740,857...17,841,934 		JBrowse link
G Hpcal4 hippocalcin-like 4 affects expression ISO Clozapine affects the expression of HPCAL4 mRNA CTD PMID:12437575 NCBI chr 4:123,077,297...123,088,492
Ensembl chr 4:123,077,020...123,088,494 		JBrowse link
G Hpn hepsin increases expression ISO Clozapine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 7:30,798,150...30,814,751
Ensembl chr 7:30,798,150...30,814,715 		JBrowse link
G Hrh1 histamine receptor H1 affects binding ISO Clozapine binds to HRH1 protein CTD PMID:16983399 NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257 		JBrowse link
G Hrh3 histamine receptor H3 multiple interactions ISO Clozapine binds to Hrh3 protein; Clozapine inhibits the reaction [N-methylhistamine binds to Hrh3 protein] RGD PMID:10869375 RGD:632981 NCBI chr 2:179,741,258...179,746,264
Ensembl chr 2:179,741,258...179,746,281 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression ISO Clozapine results in decreased expression of HSD17B10 protein CTD PMID:34122009 NCBI chr  X:150,784,892...150,787,438
Ensembl chr  X:150,784,841...150,787,438 		JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 increases expression ISO Clozapine results in increased expression of HSD17B12 protein CTD PMID:34122009 NCBI chr 2:93,863,042...93,988,254
Ensembl chr 2:93,863,034...93,988,309 		JBrowse link
G Hspa9 heat shock protein 9 decreases expression ISO Clozapine results in decreased expression of HSPA9 protein CTD PMID:34122009 NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410 		JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A multiple interactions
affects binding		 ISO Clozapine binds to and affects the activity of HTR1A protein
Clozapine binds to HTR1A protein		 CTD PMID:9723970 PMID:15482641 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630 		JBrowse link
G Htr1d 5-hydroxytryptamine (serotonin) receptor 1D decreases expression ISO Clozapine results in decreased expression of HTR1D mRNA CTD PMID:16715494 NCBI chr 4:136,150,835...136,171,716
Ensembl chr 4:136,150,835...136,171,709 		JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A increases response to substance
increases expression
affects response to substance
multiple interactions
affects binding
decreases activity
decreases expression		 ISO
EXP		 HTR2A gene SNP results in increased susceptibility to Clozapine
Clozapine results in increased expression of HTR2A mRNA
HTR2A protein affects the susceptibility to Clozapine
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]; Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]
Clozapine binds to HTR2A protein
Clozapine results in decreased activity of HTR2A protein
Clozapine results in decreased expression of HTR2A mRNA; Clozapine results in decreased expression of HTR2A protein
Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]
Clozapine analog binds to HTR2A protein; Clozapine binds to HTR2A protein		 CTD PMID:7520908 PMID:9723970 PMID:11997696 PMID:14751426 PMID:15380371 More... NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C affects binding
affects response to substance
decreases expression		 ISO Clozapine binds to HTR2C protein
HTR2C gene polymorphism affects the susceptibility to Clozapine; HTR2C gene SNP affects the susceptibility to Clozapine; HTR2C promoter SNP affects the susceptibility to Clozapine; HTR2C protein affects the susceptibility to Clozapine
Clozapine results in decreased expression of HTR2C mRNA		 CTD PMID:9723970 PMID:12668355 PMID:15635667 PMID:16983399 PMID:17868938 More... NCBI chr  X:145,745,509...145,980,273
Ensembl chr  X:145,745,509...145,980,273 		JBrowse link
G Htr3a 5-hydroxytryptamine (serotonin) receptor 3A multiple interactions
affects response to substance		 ISO
EXP		 Clozapine binds to and results in decreased activity of HTR3A protein
HTR3A protein affects the susceptibility to Clozapine		 CTD PMID:19696922 PMID:20168265 NCBI chr 9:48,810,513...48,822,451
Ensembl chr 9:48,810,513...48,822,399 		JBrowse link
G Htr6 5-hydroxytryptamine (serotonin) receptor 6 multiple interactions
affects binding		 EXP
ISO		 Clozapine binds to and results in decreased activity of HTR6 protein
Clozapine binds to HTR6 protein
[Cuprizone co-treated with Clozapine] results in increased expression of HTR6 protein		 CTD PMID:11406289 PMID:16983399 PMID:34122009 NCBI chr 4:138,787,017...138,802,881
Ensembl chr 4:138,788,419...138,802,881 		JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 affects binding
multiple interactions		 ISO Clozapine binds to HTR7 protein
[Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]		 CTD PMID:14578406 PMID:20827463 NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907 		JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Clozapine results in increased expression of ID2 mRNA CTD PMID:12437575 NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of IDH2 protein CTD PMID:34122009 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase decreases expression ISO Clozapine results in decreased expression of IDI1 protein CTD PMID:34122009 NCBI chr13:8,935,642...8,942,432
Ensembl chr13:8,935,537...8,942,487 		JBrowse link
G Ifng interferon gamma affects expression
decreases expression		 ISO Clozapine affects the expression of IFNG protein
Clozapine results in decreased expression of IFNG mRNA		 CTD PMID:17346280 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Clozapine results in increased expression of IFNGR1 protein CTD PMID:36482696 NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Clozapine results in decreased expression of IGF1 protein CTD PMID:11769361 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Clozapine results in increased expression of IGFBP1 protein CTD PMID:36482696 NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546 		JBrowse link
G Il10 interleukin 10 decreases expression ISO Clozapine results in decreased expression of IL10 protein CTD PMID:24709159 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions		 ISO Clozapine results in increased secretion of IL1B protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of IL1B protein]		 CTD PMID:34935985 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2ra interleukin 2 receptor, alpha chain increases secretion ISO Clozapine results in increased secretion of IL2RA protein CTD PMID:8067274 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004 		JBrowse link
G Il5 interleukin 5 affects expression ISO Clozapine affects the expression of IL5 protein CTD PMID:17346280 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Ilkap integrin-linked kinase-associated serine/threonine phosphatase 2C decreases expression ISO Clozapine results in decreased expression of ILKAP mRNA CTD PMID:15860345 NCBI chr 1:91,301,568...91,326,566
Ensembl chr 1:91,301,583...91,326,537 		JBrowse link
G Inha inhibin alpha decreases expression ISO Clozapine results in decreased expression of INHA mRNA CTD PMID:16715494 NCBI chr 1:75,483,872...75,487,010
Ensembl chr 1:75,483,721...75,487,010 		JBrowse link
G Inhbe inhibin beta-E increases expression ISO Clozapine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:127,185,271...127,187,717
Ensembl chr10:127,184,726...127,190,280 		JBrowse link
G Ins2 insulin II affects secretion
increases expression		 ISO Clozapine affects the secretion of INS protein
Clozapine results in increased expression of INS protein		 CTD PMID:11769361 PMID:16601995 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Itga6 integrin alpha 6 increases expression ISO Clozapine results in increased expression of ITGA6 protein CTD PMID:34122009 NCBI chr 2:71,617,236...71,688,761
Ensembl chr 2:71,575,960...71,688,760 		JBrowse link
G Jak1 Janus kinase 1 increases expression ISO Clozapine results in increased expression of JAK1 protein CTD PMID:36482696 NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein] CTD PMID:18976543 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Jun jun proto-oncogene decreases expression
increases expression		 ISO Clozapine results in decreased expression of JUN mRNA
Clozapine results in increased expression of JUN mRNA		 CTD PMID:12093589 PMID:15860345 PMID:18208916 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Junb jun B proto-oncogene increases expression ISO Clozapine results in increased expression of JUNB mRNA CTD PMID:12093589 PMID:19695244 NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347 		JBrowse link
G Jund jun D proto-oncogene decreases expression ISO Clozapine results in decreased expression of JUND mRNA CTD PMID:12093589 NCBI chr 8:71,150,389...71,153,265
Ensembl chr 8:71,151,599...71,153,265 		JBrowse link
G Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 increases expression EXP Clozapine results in increased expression of KCNA1 mRNA CTD PMID:18797397 NCBI chr 6:126,613,426...126,622,764
Ensembl chr 6:126,617,360...126,623,347 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 multiple interactions ISO Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Kcnip3 Kv channel interacting protein 3, calsenilin decreases expression
increases expression		 EXP Clozapine results in decreased expression of KCNIP3 mRNA
Clozapine results in increased expression of KCNIP3 mRNA		 CTD PMID:17266109 PMID:18797397 NCBI chr 2:127,298,418...127,364,014
Ensembl chr 2:127,298,418...127,364,014 		JBrowse link
G Kcnk2 potassium channel, subfamily K, member 2 decreases expression EXP Clozapine results in decreased expression of KCNK2 mRNA CTD PMID:15542763 NCBI chr 1:188,940,127...189,134,951
Ensembl chr 1:188,940,127...189,134,470 		JBrowse link
G Kctd12 potassium channel tetramerisation domain containing 12 decreases expression ISO Clozapine results in decreased expression of KCTD12 protein CTD PMID:34122009 NCBI chr14:103,214,017...103,220,073
Ensembl chr14:103,214,017...103,220,073 		JBrowse link
G Kdr kinase insert domain protein receptor increases expression ISO Clozapine results in increased expression of KDR protein CTD PMID:34122009 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Khdrbs1 KH domain containing, RNA binding, signal transduction associated 1 decreases expression ISO Clozapine results in decreased expression of KHDRBS1 protein CTD PMID:34122009 NCBI chr 4:129,596,143...129,637,402
Ensembl chr 4:129,596,957...129,636,096 		JBrowse link
G Kif13b kinesin family member 13B increases expression ISO Clozapine results in increased expression of KIF13B protein CTD PMID:34122009 NCBI chr14:64,889,633...65,047,067
Ensembl chr14:64,884,714...65,047,066 		JBrowse link
G Kif5c kinesin family member 5C decreases expression ISO Clozapine results in decreased expression of KIF5C protein CTD PMID:34122009 NCBI chr 2:49,509,298...49,664,790
Ensembl chr 2:49,509,310...49,664,790 		JBrowse link
G Kiz kizuna centrosomal protein multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of KIZ protein CTD PMID:34122009 NCBI chr 2:146,697,743...146,812,018
Ensembl chr 2:146,697,784...146,812,017 		JBrowse link
G Klhdc2 kelch domain containing 2 decreases expression ISO Clozapine results in decreased expression of KLHDC2 protein CTD PMID:34122009 NCBI chr12:69,343,455...69,357,461
Ensembl chr12:69,343,455...69,357,461 		JBrowse link
G Kmt2a lysine (K)-specific methyltransferase 2A increases expression
multiple interactions
decreases expression		 ISO
EXP		 Clozapine results in increased expression of KMT2A mRNA
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]
Clozapine results in decreased expression of KMT2A mRNA		 CTD PMID:14647396 PMID:17942719 NCBI chr 9:44,714,652...44,793,492
Ensembl chr 9:44,714,652...44,792,594 		JBrowse link
G Kpna4 karyopherin subunit alpha 4 multiple interactions
increases expression		 ISO [Cuprizone co-treated with Clozapine] results in increased expression of KPNA4 protein
Clozapine results in increased expression of KPNA4 protein		 CTD PMID:34122009 NCBI chr 3:68,979,554...69,034,425
Ensembl chr 3:68,974,482...69,034,446 		JBrowse link
G Kremen1 kringle containing transmembrane protein 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of KREMEN1 protein CTD PMID:34122009 NCBI chr11:5,141,551...5,212,220
Ensembl chr11:5,141,552...5,211,558 		JBrowse link
G Lactb2 lactamase, beta 2 increases expression ISO Clozapine results in increased expression of LACTB2 protein CTD PMID:34122009 NCBI chr 1:13,695,069...13,730,749
Ensembl chr 1:13,693,554...13,730,770 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 increases expression ISO Clozapine results in increased expression of LAMP1 protein CTD PMID:34122009 NCBI chr 8:13,209,161...13,225,338
Ensembl chr 8:13,209,161...13,225,338 		JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 increases expression EXP Clozapine results in increased expression of LAMTOR3 mRNA CTD PMID:14647396 NCBI chr 3:137,624,316...137,634,523
Ensembl chr 3:137,624,267...137,634,661 		JBrowse link
G Larp7 La ribonucleoprotein 7, transcriptional regulator increases expression ISO Clozapine results in increased expression of LARP7 protein CTD PMID:34122009 NCBI chr 3:127,330,363...127,346,998
Ensembl chr 3:127,330,363...127,346,998 		JBrowse link
G Lcn3 lipocalin 3 decreases expression ISO Clozapine results in decreased expression of LCN1 protein CTD PMID:34122009 NCBI chr 2:25,655,545...25,658,110
Ensembl chr 2:25,655,581...25,658,111 		JBrowse link
G Ldhb lactate dehydrogenase B increases expression ISO Clozapine results in increased expression of LDHB mRNA CTD PMID:15860345 NCBI chr 6:142,435,975...142,453,683
Ensembl chr 6:142,435,975...142,453,683 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression
multiple interactions		 EXP
ISO		 Clozapine results in increased expression of LDLR mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]		 CTD PMID:17052361 PMID:20564506 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Leap2 liver-expressed antimicrobial peptide 2 increases expression ISO Clozapine results in increased expression of LEAP2 mRNA CTD PMID:17346280 NCBI chr11:53,313,008...53,313,963
Ensembl chr11:53,313,008...53,313,997 		JBrowse link
G Lemd2 LEM domain containing 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of LEMD2 protein CTD PMID:34122009 NCBI chr17:27,408,574...27,426,228
Ensembl chr17:27,408,574...27,423,443 		JBrowse link
G Lep leptin affects response to substance
increases expression		 ISO LEP protein affects the susceptibility to Clozapine
Clozapine results in increased expression of LEP protein		 CTD PMID:16402076 PMID:17502770 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lgals8 lectin, galactose binding, soluble 8 increases expression ISO Clozapine results in increased expression of LGALS8 protein CTD PMID:36482696 NCBI chr13:12,454,283...12,479,857
Ensembl chr13:12,454,296...12,479,825 		JBrowse link
G Lipa lysosomal acid lipase A increases expression ISO Clozapine results in increased expression of LIPA protein CTD PMID:34122009 NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874 		JBrowse link
G Lmod2 leiomodin 2 (cardiac) increases expression ISO Clozapine results in increased expression of LMOD2 protein CTD PMID:34122009 NCBI chr 6:24,597,770...24,605,413
Ensembl chr 6:24,597,761...24,605,413 		JBrowse link
G Lpl lipoprotein lipase decreases expression
increases expression		 EXP Clozapine results in decreased expression of LPL mRNA; Clozapine results in decreased expression of LPL protein
Clozapine results in increased expression of LPL mRNA		 CTD PMID:17266109 PMID:19682446 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Lrp10 low-density lipoprotein receptor-related protein 10 increases expression ISO Clozapine results in increased expression of LRP10 protein CTD PMID:36482696 NCBI chr14:54,701,260...54,707,749
Ensembl chr14:54,701,594...54,708,954 		JBrowse link
G Lrpprc leucine-rich PPR-motif containing increases expression ISO Clozapine results in increased expression of LRPPRC protein CTD PMID:34122009 NCBI chr17:85,012,675...85,098,214
Ensembl chr17:85,012,675...85,098,217 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 increases expression ISO Clozapine results in increased expression of LRRK2 protein CTD PMID:34122009 NCBI chr15:91,556,994...91,700,327
Ensembl chr15:91,557,378...91,700,323 		JBrowse link
G Lss lanosterol synthase increases expression
multiple interactions		 ISO Clozapine results in increased expression of LSS mRNA
[Cuprizone co-treated with Clozapine] results in decreased expression of LSS protein		 CTD PMID:15342952 PMID:17175557 PMID:34122009 NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972 		JBrowse link
G Lta4h leukotriene A4 hydrolase decreases expression ISO Clozapine results in decreased expression of LTA4H protein CTD PMID:34122009 NCBI chr10:93,289,258...93,320,758
Ensembl chr10:93,289,273...93,320,737 		JBrowse link
G Magt1 magnesium transporter 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MAGT1 protein CTD PMID:34122009 NCBI chr  X:105,011,690...105,055,408
Ensembl chr  X:105,011,690...105,055,512 		JBrowse link
G Mal myelin and lymphocyte protein, T cell differentiation protein decreases expression EXP Clozapine results in decreased expression of MAL mRNA CTD PMID:17266109 PMID:18797397 NCBI chr 2:127,475,146...127,498,615
Ensembl chr 2:127,475,146...127,498,615 		JBrowse link
G Maob monoamine oxidase B increases expression EXP Clozapine results in increased expression of MAOB mRNA CTD PMID:17266109 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605 		JBrowse link
G Map1a microtubule-associated protein 1 A increases expression
decreases expression		 ISO Clozapine results in increased expression of MAP1A mRNA
Clozapine results in decreased expression of MAP1A protein		 CTD PMID:15860345 PMID:34122009 NCBI chr 2:121,119,608...121,141,313
Ensembl chr 2:121,120,081...121,141,313 		JBrowse link
G Map1b microtubule-associated protein 1B decreases expression ISO Clozapine results in decreased expression of MAP1B protein CTD PMID:34122009 NCBI chr13:99,557,972...99,653,110
Ensembl chr13:99,557,954...99,653,048 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation		 ISO [Chloroquine co-treated with Clozapine] results in increased lipidation of MAP1LC3B protein
Clozapine results in increased lipidation of MAP1LC3B protein		 CTD PMID:36482696 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Map1s microtubule-associated protein 1S increases expression ISO Clozapine results in increased expression of MAP1S protein CTD PMID:34122009 NCBI chr 8:71,358,618...71,370,173
Ensembl chr 8:71,358,576...71,370,173 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 decreases expression ISO Clozapine results in decreased expression of MAP2K1 mRNA CTD PMID:15860345 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913 		JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 increases expression
decreases expression		 EXP
ISO		 Clozapine results in increased expression of MAP2K2 mRNA
Clozapine results in decreased expression of MAP2K2 mRNA		 CTD PMID:14647396 PMID:15860345 NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809 		JBrowse link
G Map2k5 mitogen-activated protein kinase kinase 5 decreases expression ISO Clozapine results in decreased expression of MAP2K5 mRNA CTD PMID:15860345 NCBI chr 9:63,071,050...63,288,964
Ensembl chr 9:63,071,050...63,285,184 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO Clozapine results in increased expression of MAP3K1 mRNA CTD PMID:15860345 NCBI chr13:111,882,962...111,954,803
Ensembl chr13:111,882,962...111,945,527 		JBrowse link
G Map3k12 mitogen-activated protein kinase kinase kinase 12 increases expression ISO Clozapine results in increased expression of MAP3K12 mRNA CTD PMID:15860345 NCBI chr15:102,406,079...102,425,311
Ensembl chr15:102,406,081...102,425,499 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
decreases expression		 EXP
ISO		 Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]
Clozapine results in decreased phosphorylation of MAPK1 protein
Clozapine results in decreased expression of MAPK1 mRNA		 CTD PMID:12871586 PMID:15860345 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 affects expression ISO Clozapine affects the expression of MAPK14 mRNA CTD PMID:15860345 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions		 EXP Clozapine results in decreased phosphorylation of MAPK3 protein
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]		 CTD PMID:12871586 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 affects expression ISO Clozapine affects the expression of MAPK6 mRNA CTD PMID:15860345 NCBI chr 9:75,294,064...75,317,303
Ensembl chr 9:75,276,344...75,317,287 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 increases expression EXP Clozapine results in increased expression of MAPK8IP1 mRNA CTD PMID:17266109 NCBI chr 2:92,214,021...92,231,608
Ensembl chr 2:92,214,021...92,231,608 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 affects expression ISO Clozapine affects the expression of MAPK9 mRNA CTD PMID:15860345 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mapre1 microtubule-associated protein, RP/EB family, member 1 multiple interactions
decreases expression		 ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MAPRE1 protein
Clozapine results in decreased expression of MAPRE1 protein		 CTD PMID:34122009 NCBI chr 2:153,583,131...153,615,237
Ensembl chr 2:153,583,194...153,615,230 		JBrowse link
G Mas1 MAS1 oncogene decreases expression ISO Clozapine results in decreased expression of MAS1 mRNA CTD PMID:16715494 NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030 		JBrowse link
G Mat2a methionine adenosyltransferase 2A decreases expression ISO Clozapine results in decreased expression of MAT2A protein CTD PMID:34122009 NCBI chr 6:72,409,779...72,416,539
Ensembl chr 6:72,409,782...72,416,541 		JBrowse link
G Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit methionine decreases expression ISO Clozapine results in decreased expression of MAT2B protein CTD PMID:34122009 NCBI chr11:40,570,141...40,586,030
Ensembl chr11:40,570,141...40,586,030 		JBrowse link
G Mbp myelin basic protein increases expression ISO
EXP		 Clozapine results in increased expression of MBP mRNA CTD PMID:17266109 PMID:17346280 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762 		JBrowse link
G Mc1r melanocortin 1 receptor increases expression ISO Clozapine results in increased expression of MC1R mRNA CTD PMID:17346280 NCBI chr 8:124,133,839...124,137,483
Ensembl chr 8:124,133,846...124,137,483 		JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MDC1 protein CTD PMID:34122009 NCBI chr17:36,152,390...36,170,562
Ensembl chr17:36,152,407...36,170,562 		JBrowse link
G Mdh1 malate dehydrogenase 1, NAD (soluble) decreases expression ISO Clozapine results in decreased expression of MDH1 protein CTD PMID:34122009 NCBI chr11:21,506,692...21,521,934
Ensembl chr11:21,506,692...21,522,367 		JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions		 ISO Clozapine results in decreased expression of MFN2 protein
PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein]		 CTD PMID:37087062 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mlkl mixed lineage kinase domain-like increases expression EXP Clozapine results in increased expression of MLKL protein CTD PMID:31220554 NCBI chr 8:112,037,879...112,065,081
Ensembl chr 8:112,038,429...112,064,809 		JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Clozapine results in decreased expression of MMP10 mRNA CTD PMID:17346280 NCBI chr 9:7,502,343...7,510,243
Ensembl chr 9:7,502,353...7,510,241 		JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) increases expression ISO Clozapine results in increased expression of MMP14 protein CTD PMID:36482696 NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO Clozapine results in decreased expression of MMP7 mRNA CTD PMID:17346280 NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,587 		JBrowse link
G Mobp myelin-associated oligodendrocytic basic protein increases expression EXP Clozapine results in increased expression of MOBP mRNA CTD PMID:15542763 PMID:17266109 NCBI chr 9:119,978,740...120,010,554
Ensembl chr 9:119,978,773...120,010,550 		JBrowse link
G Mpo myeloperoxidase affects response to substance
increases activity
increases oxidation
multiple interactions		 EXP
ISO		 MPO protein affects the susceptibility to Clozapine
Clozapine results in increased activity of MPO protein
MPO protein results in increased oxidation of Clozapine
Clozapine promotes the reaction [[MPO protein results in increased metabolism of chlorodimedone] which results in increased abundance of Hypochlorous Acid]; Clozapine promotes the reaction [MPO protein results in increased abundance of Hypochlorous Acid]		 CTD PMID:24588327 PMID:35575633 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mpp3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) decreases expression EXP Clozapine results in decreased expression of MPP3 mRNA CTD PMID:17266109 NCBI chr11:101,890,488...101,925,854
Ensembl chr11:101,890,478...101,919,287 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Clozapine affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr 1:155,003,620...155,022,560
Ensembl chr 1:155,003,023...155,022,560 		JBrowse link
G Mta2 metastasis-associated gene family, member 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MTA2 protein CTD PMID:34122009 NCBI chr19:8,919,239...8,929,659
Ensembl chr19:8,919,239...8,929,667 		JBrowse link
G Mtdh metadherin multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MTDH protein CTD PMID:34122009 NCBI chr15:34,082,613...34,143,683
Ensembl chr15:34,082,840...34,145,770 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to Clozapine; MTHFR protein affects the susceptibility to Clozapine CTD PMID:20547447 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Myadm myeloid-associated differentiation marker multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MYADM protein CTD PMID:34122009 NCBI chr 7:3,337,563...3,347,871
Ensembl chr 7:3,337,605...3,348,958 		JBrowse link
G Mybbp1a MYB binding protein (P160) 1a increases expression ISO Clozapine results in increased expression of MYBBP1A protein CTD PMID:34122009 NCBI chr11:72,332,153...72,342,596
Ensembl chr11:72,332,181...72,342,594 		JBrowse link
G Myh10 myosin, heavy polypeptide 10, non-muscle multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MYH10 protein CTD PMID:34122009 NCBI chr11:68,581,228...68,707,451
Ensembl chr11:68,582,385...68,707,458 		JBrowse link
G Myh3 myosin, heavy polypeptide 3, skeletal muscle, embryonic increases expression ISO Clozapine results in increased expression of MYH3 protein CTD PMID:34122009 NCBI chr11:66,969,101...66,993,117
Ensembl chr11:66,969,126...66,993,112 		JBrowse link
G Myl1 myosin, light polypeptide 1 increases expression ISO Clozapine results in increased expression of MYL1 protein CTD PMID:34122009 NCBI chr 1:66,963,454...66,987,091
Ensembl chr 1:66,963,454...66,984,563 		JBrowse link
G Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit decreases expression ISO Clozapine results in decreased expression of NAA10 protein CTD PMID:34122009 NCBI chr  X:72,960,476...72,965,550
Ensembl chr  X:72,960,479...72,965,550 		JBrowse link
G Nap1l4 nucleosome assembly protein 1-like 4 increases expression ISO Clozapine results in increased expression of NAP1L4 protein CTD PMID:34122009 NCBI chr 7:143,067,316...143,103,698
Ensembl chr 7:143,067,316...143,102,843 		JBrowse link
G Nat10 N-acetyltransferase 10 decreases expression ISO Clozapine results in decreased expression of NAT10 protein CTD PMID:34122009 NCBI chr 2:103,551,603...103,593,292
Ensembl chr 2:103,551,601...103,591,615 		JBrowse link
G Ncan neurocan decreases expression EXP Clozapine results in decreased expression of NCAN mRNA CTD PMID:18797397 NCBI chr 8:70,545,735...70,573,494
Ensembl chr 8:70,545,735...70,573,523 		JBrowse link
G Ncapg non-SMC condensin I complex, subunit G increases expression ISO Clozapine results in increased expression of NCAPG protein CTD PMID:34122009 NCBI chr 5:45,827,212...45,858,491
Ensembl chr 5:45,827,261...45,857,888 		JBrowse link
G Ncaph non-SMC condensin I complex, subunit H decreases expression ISO Clozapine results in decreased expression of NCAPH protein CTD PMID:34122009 PMID:36482696 NCBI chr 2:126,945,729...126,975,857
Ensembl chr 2:126,945,729...126,975,874 		JBrowse link
G Ncbp1 nuclear cap binding protein subunit 1 decreases expression ISO Clozapine results in decreased expression of NCBP1 protein CTD PMID:34122009 NCBI chr 4:46,138,732...46,172,403
Ensembl chr 4:46,138,613...46,172,403 		JBrowse link
G Ncl nucleolin increases expression EXP Clozapine results in increased expression of NCL mRNA CTD PMID:14647396 NCBI chr 1:86,272,441...86,287,177
Ensembl chr 1:86,272,441...86,287,122 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 increases expression ISO Clozapine results in increased expression of NCOA4 protein CTD PMID:36482696 NCBI chr14:31,881,884...31,901,210
Ensembl chr14:31,881,822...31,901,812 		JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression ISO Clozapine results in increased expression of NDUFV2 mRNA CTD PMID:19441803 NCBI chr17:66,385,790...66,408,554
Ensembl chr17:66,385,633...66,408,554 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 decreases expression ISO Clozapine results in decreased expression of NECTIN2 protein CTD PMID:34122009 NCBI chr 7:19,450,569...19,483,498
Ensembl chr 7:19,450,569...19,484,408 		JBrowse link
G Nedd4 neural precursor cell expressed, developmentally down-regulated 4 decreases expression EXP Clozapine results in decreased expression of NEDD4 mRNA CTD PMID:18797397 NCBI chr 9:72,569,613...72,657,133
Ensembl chr 9:72,569,628...72,657,134 		JBrowse link
G Nes nestin decreases expression ISO Clozapine results in decreased expression of NES protein CTD PMID:34122009 NCBI chr 3:87,878,400...87,887,758
Ensembl chr 3:87,878,385...87,887,758 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to Clozapine CTD PMID:21540358 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 decreases expression ISO Clozapine results in decreased expression of NFKB1 protein CTD PMID:16500086 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) decreases expression EXP
ISO		 Clozapine results in decreased expression of NGFR protein; Clozapine results in decreased expression of NGFR protein alternative form
Clozapine results in decreased expression of NGFR mRNA		 CTD PMID:12111809 PMID:14598305 PMID:16513140 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Nifk nucleolar protein interacting with the FHA domain of MKI67 decreases expression ISO Clozapine results in decreased expression of NIFK protein CTD PMID:34122009 NCBI chr 1:118,249,573...118,261,561
Ensembl chr 1:118,249,569...118,261,552 		JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO Clozapine results in increased expression of NNMT protein CTD PMID:34122009 NCBI chr 9:48,448,905...48,518,958
Ensembl chr 9:48,503,177...48,516,453 		JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression ISO Clozapine results in decreased expression of NNT protein CTD PMID:34122009 NCBI chr13:119,472,063...119,545,793
Ensembl chr13:119,471,984...119,545,533
Ensembl chr13:119,471,984...119,545,533 		JBrowse link
G Noc2l NOC2 like nucleolar associated transcriptional repressor increases expression ISO Clozapine results in increased expression of NOC2L protein CTD PMID:34122009 NCBI chr 4:156,319,112...156,332,078
Ensembl chr 4:156,320,376...156,332,073 		JBrowse link
G Nomo1 nodal modulator 1 increases expression ISO Clozapine results in increased expression of NOMO3 protein CTD PMID:34122009 NCBI chr 7:45,683,120...45,733,636
Ensembl chr 7:45,683,122...45,733,636 		JBrowse link
G Nop53 NOP53 ribosome biogenesis factor affects expression EXP Clozapine affects the expression of NOP53 mRNA CTD PMID:14647396 NCBI chr 7:15,671,760...15,680,033
Ensembl chr 7:15,670,108...15,679,999 		JBrowse link
G Notch2 notch 2 increases expression ISO Clozapine results in increased expression of NOTCH2 protein CTD PMID:36482696 NCBI chr 3:97,920,854...98,057,683
Ensembl chr 3:97,920,843...98,057,677 		JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor decreases expression ISO Clozapine results in decreased expression of NPLOC4 protein CTD PMID:34122009 NCBI chr11:120,270,624...120,328,526
Ensembl chr11:120,271,196...120,328,534 		JBrowse link
G Nptn neuroplastin increases expression EXP Clozapine results in increased expression of NPTN mRNA CTD PMID:18797397 NCBI chr 9:58,489,504...58,560,162
Ensembl chr 9:58,489,523...58,565,238 		JBrowse link
G Nptx2 neuronal pentraxin 2 decreases expression ISO Clozapine results in decreased expression of NPTX2 mRNA CTD PMID:18208916 NCBI chr 5:144,482,697...144,494,288
Ensembl chr 5:144,482,712...144,494,288 		JBrowse link
G Npy neuropeptide Y decreases expression ISO Clozapine results in decreased expression of NPY mRNA CTD PMID:16516965 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 affects response to substance
multiple interactions
increases reduction		 ISO NQO2 gene SNP affects the susceptibility to Clozapine
Clozapine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3]
NQO2 protein results in increased reduction of Clozapine metabolite		 CTD PMID:14617031 PMID:29281794 NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Clozapine results in increased expression of NR0B2 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] CTD PMID:21402137 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP Clozapine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein] CTD PMID:16581232 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
decreases expression		 ISO Clozapine results in increased expression of NR4A1 mRNA
Clozapine results in decreased expression of NR4A1 mRNA		 CTD PMID:10987852 PMID:11564422 PMID:19695244 NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression EXP Clozapine results in increased expression of NR4A2 mRNA CTD PMID:17266109 NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015 		JBrowse link
G Nrg1 neuregulin 1 increases expression
affects response to substance
affects expression		 ISO
EXP		 Clozapine results in increased expression of NRG1 mRNA
NRG1 protein affects the susceptibility to Clozapine
Clozapine affects the expression of NRG1 protein		 CTD PMID:15706234 PMID:18184445 PMID:19502011 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Nsf N-ethylmaleimide sensitive fusion protein decreases expression ISO Clozapine results in decreased expression of NSF protein CTD PMID:34122009 NCBI chr11:103,712,608...103,844,882
Ensembl chr11:103,712,608...103,844,882 		JBrowse link
G Ntng2 netrin G2 increases expression ISO Clozapine results in increased expression of NTNG2 mRNA CTD PMID:17507910 NCBI chr 2:29,084,738...29,138,111
Ensembl chr 2:29,084,553...29,143,017 		JBrowse link
G Nts neurotensin increases expression ISO Clozapine results in increased expression of NTS mRNA CTD PMID:12887421 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347 		JBrowse link
G Numa1 nuclear mitotic apparatus protein 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of NUMA1 protein CTD PMID:34122009 NCBI chr 7:101,583,169...101,664,166
Ensembl chr 7:101,583,318...101,664,171 		JBrowse link
G Numbl numb-like decreases expression EXP Clozapine results in decreased expression of NUMBL mRNA CTD PMID:18797397 NCBI chr 7:26,957,884...26,981,570
Ensembl chr 7:26,957,858...26,981,569 		JBrowse link
G Nup160 nucleoporin 160 increases expression ISO Clozapine results in increased expression of NUP160 protein CTD PMID:34122009 NCBI chr 2:90,504,405...90,570,217
Ensembl chr 2:90,507,559...90,566,672 		JBrowse link
G Nup50 nucleoporin 50 increases expression ISO Clozapine results in increased expression of NUP50 protein CTD PMID:34122009 NCBI chr15:84,800,100...84,827,164
Ensembl chr15:84,807,612...84,827,164 		JBrowse link
G Nup54 nucleoporin 54 decreases expression ISO Clozapine results in decreased expression of NUP54 protein CTD PMID:34122009 NCBI chr 5:92,563,399...92,583,117
Ensembl chr 5:92,563,399...92,583,078 		JBrowse link
G Nupr1 nuclear protein transcription regulator 1 increases expression ISO Clozapine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033 		JBrowse link
G Osbpl8 oxysterol binding protein-like 8 increases expression EXP Clozapine results in increased expression of OSBPL8 mRNA CTD PMID:14647396 NCBI chr10:111,000,663...111,133,110
Ensembl chr10:111,000,613...111,133,110 		JBrowse link
G Ovgp1 oviductal glycoprotein 1 increases expression ISO Clozapine results in increased expression of OVGP1 mRNA CTD PMID:17346280 NCBI chr 3:105,881,118...105,894,739
Ensembl chr 3:105,881,027...105,894,739 		JBrowse link
G Oxt oxytocin affects response to substance ISO OXT protein affects the susceptibility to Clozapine CTD PMID:20196918 NCBI chr 2:130,416,432...130,418,974
Ensembl chr 2:130,418,093...130,418,974 		JBrowse link
G Pakap paralemmin A kinase anchor protein multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of PALM2AKAP2 protein CTD PMID:34122009 NCBI chr 4:57,434,475...57,896,984
Ensembl chr 4:57,717,657...57,896,984
Ensembl chr 4:57,717,657...57,896,984
Ensembl chr 4:57,717,657...57,896,984 		JBrowse link
G Pank3 pantothenate kinase 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of PANK3 protein CTD PMID:34122009 NCBI chr11:35,660,322...35,682,112
Ensembl chr11:35,660,311...35,682,112 		JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 increases expression EXP Clozapine results in increased expression of PARK7 mRNA CTD PMID:14647396 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894 		JBrowse link
G Pcbp1 poly(rC) binding protein 1 increases expression ISO Clozapine results in increased expression of PCBP1 protein CTD PMID:34122009 NCBI chr 6:86,501,462...86,503,171
Ensembl chr 6:86,501,474...86,503,303 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) decreases expression ISO Clozapine results in decreased expression of PCK2 protein CTD PMID:34122009 NCBI chr14:55,777,721...55,787,477
Ensembl chr14:55,777,723...55,788,699 		JBrowse link
G Pclo piccolo (presynaptic cytomatrix protein) multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of PCLO protein CTD PMID:34122009 NCBI chr 5:14,564,924...14,913,479
Ensembl chr 5:14,564,932...14,913,473 		JBrowse link
G Pcm1 pericentriolar material 1 decreases expression EXP Clozapine results in decreased expression of PCM1 mRNA CTD PMID:19048012 NCBI chr 8:41,692,521...41,787,125
Ensembl chr 8:41,692,789...41,785,381 		JBrowse link
G Pcnp PEST proteolytic signal containing nuclear protein increases expression ISO Clozapine results in increased expression of PCNP protein CTD PMID:34122009 NCBI chr16:55,835,870...55,851,590
Ensembl chr16:55,827,608...55,850,102 		JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor affects expression EXP Clozapine affects the expression of PCSK1N mRNA CTD PMID:14647396 NCBI chr  X:7,786,061...7,790,649
Ensembl chr  X:7,786,061...7,790,649 		JBrowse link
G Pdcd11 programmed cell death 11 increases expression ISO Clozapine results in increased expression of PDCD11 protein CTD PMID:34122009 NCBI chr19:47,079,183...47,119,585
Ensembl chr19:47,079,207...47,120,304 		JBrowse link
G Pde10a phosphodiesterase 10A increases expression EXP
ISO		 Clozapine results in increased expression of PDE10A mRNA
Clozapine results in increased expression of PDE10A mRNA; Clozapine results in increased expression of PDE10A protein		 CTD PMID:17266109 PMID:18222493 NCBI chr17:8,742,719...9,205,480
Ensembl chr17:8,744,204...9,205,480 		JBrowse link
G Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent increases expression EXP Clozapine results in increased expression of PDE1B mRNA CTD PMID:14647396 NCBI chr15:103,411,461...103,438,483
Ensembl chr15:103,411,461...103,438,479 		JBrowse link
G Pde4a phosphodiesterase 4A, cAMP specific decreases expression ISO Clozapine results in decreased expression of PDE4A protein CTD PMID:20222156 NCBI chr 9:21,076,998...21,124,544
Ensembl chr 9:21,073,005...21,124,544 		JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific decreases expression
increases expression		 ISO Clozapine results in decreased expression of PDE4B protein
Clozapine results in increased expression of PDE4B mRNA; Clozapine results in increased expression of PDE4B protein		 CTD PMID:18222493 PMID:20222156 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456 		JBrowse link
G Pdia3 protein disulfide isomerase associated 3 decreases expression ISO Clozapine results in decreased expression of PDIA3 protein CTD PMID:34122009 NCBI chr 2:121,244,383...121,269,168
Ensembl chr 2:121,244,256...121,269,168 		JBrowse link
G Pdia4 protein disulfide isomerase associated 4 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of PDIA4 protein CTD PMID:34122009 NCBI chr 6:47,773,075...47,790,446
Ensembl chr 6:47,773,075...47,790,364 		JBrowse link
G Pdlim5 PDZ and LIM domain 5 decreases expression ISO Clozapine results in decreased expression of PDLIM5 protein CTD PMID:34122009 NCBI chr 3:141,945,346...142,101,480
Ensembl chr 3:141,945,351...142,101,454 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 decreases expression ISO Clozapine results in decreased expression of PEBP1 protein CTD PMID:34122009 NCBI chr 5:117,420,716...117,425,629
Ensembl chr 5:117,420,719...117,425,690 		JBrowse link
G Penk preproenkephalin decreases expression
increases expression		 ISO Clozapine results in decreased expression of PENK mRNA
Clozapine results in increased expression of PENK mRNA		 CTD PMID:1635659 PMID:12887421 NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819 		JBrowse link
G Pfdn5 prefoldin 5 increases expression EXP Clozapine results in increased expression of PFDN5 mRNA CTD PMID:14647396 NCBI chr15:102,234,551...102,239,925
Ensembl chr15:102,234,551...102,240,308 		JBrowse link
G Pfkp phosphofructokinase, platelet increases expression ISO Clozapine results in increased expression of PFKP mRNA CTD PMID:15860345 NCBI chr13:6,629,910...6,699,096
Ensembl chr13:6,629,804...6,698,813 		JBrowse link
G Pgam5 phosphoglycerate mutase family member 5 decreases expression ISO Clozapine results in decreased expression of PGAM5 protein CTD PMID:34122009 NCBI chr 5:110,407,001...110,417,765
Ensembl chr 5:110,406,996...110,417,779 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression ISO Clozapine results in increased expression of PGK1 mRNA CTD PMID:15860345 NCBI chr  X:105,230,706...105,247,305
Ensembl chr  X:105,230,706...105,247,305 		JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 multiple interactions ISO PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein]; PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein] CTD PMID:37087062 NCBI chr  X:35,861,846...35,869,732
Ensembl chr  X:35,861,859...35,869,732 		JBrowse link
G Phactr1 phosphatase and actin regulator 1 increases expression EXP Clozapine results in increased expression of PHACTR1 mRNA CTD PMID:14647396 NCBI chr13:42,833,909...43,292,002
Ensembl chr13:42,834,099...43,292,002 		JBrowse link
G Phf14 PHD finger protein 14 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of PHF14 protein CTD PMID:34122009 NCBI chr 6:11,907,728...12,100,155
Ensembl chr 6:11,907,808...12,081,204 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 decreases expression ISO Clozapine results in decreased expression of PIK3R3 mRNA CTD PMID:16715494 NCBI chr 4:116,078,593...116,160,253
Ensembl chr 4:116,078,815...116,160,253
Ensembl chr 4:116,078,815...116,160,253 		JBrowse link
G Pitpnb phosphatidylinositol transfer protein, beta increases expression ISO Clozapine results in increased expression of PITPNB protein CTD PMID:34122009 NCBI chr 5:111,478,563...111,536,225
Ensembl chr 5:111,478,629...111,536,225 		JBrowse link
G Pkib protein kinase inhibitor beta, cAMP dependent, testis specific decreases expression ISO Clozapine results in decreased expression of PKIB mRNA CTD PMID:15860345 NCBI chr10:57,508,077...57,617,208
Ensembl chr10:57,508,077...57,617,208 		JBrowse link
G Pkm pyruvate kinase, muscle increases expression ISO Clozapine results in increased expression of PKM mRNA CTD PMID:15860345 NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658 		JBrowse link
G Plcb1 phospholipase C, beta 1 increases expression EXP Clozapine results in increased expression of PLCB1 mRNA CTD PMID:16465460 NCBI chr 2:134,628,084...135,317,178
Ensembl chr 2:134,627,987...135,317,178 		JBrowse link
G Plp1 proteolipid protein (myelin) 1 decreases expression
increases expression		 EXP Clozapine results in decreased expression of PLP1 mRNA
Clozapine results in increased expression of PLP1 mRNA		 CTD PMID:17266109 PMID:18797397 NCBI chr  X:135,720,897...135,739,331
Ensembl chr  X:135,723,420...135,740,482 		JBrowse link
G Pls3 plastin 3 (T-isoform) decreases expression ISO Clozapine results in decreased expression of PLS3 protein CTD PMID:34122009 NCBI chr  X:74,829,259...74,918,788
Ensembl chr  X:74,829,260...74,918,788 		JBrowse link
G Pnma1 paraneoplastic antigen MA1 increases expression ISO Clozapine results in increased expression of PNMA1 protein CTD PMID:34122009 NCBI chr12:84,192,905...84,195,263
Ensembl chr12:84,192,905...84,195,263 		JBrowse link
G Pon3 paraoxonase 3 increases expression ISO Clozapine results in increased expression of PON3 protein CTD PMID:34122009 NCBI chr 6:5,216,253...5,256,236
Ensembl chr 6:5,220,852...5,256,286 		JBrowse link
G Ppa1 pyrophosphatase (inorganic) 1 increases expression ISO Clozapine results in increased expression of PPA1 protein CTD PMID:34122009 NCBI chr10:61,484,400...61,509,944
Ensembl chr10:61,484,331...61,509,947 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases expression		 EXP Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]
Clozapine results in increased expression of PPARG mRNA; Clozapine results in increased expression of PPARG protein		 CTD PMID:20564506 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform decreases expression ISO Clozapine results in decreased expression of PPM1A mRNA CTD PMID:15860345 NCBI chr12:72,804,231...72,846,593
Ensembl chr12:72,804,229...72,846,593 		JBrowse link
G Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform decreases expression ISO Clozapine results in decreased expression of PPM1B mRNA CTD PMID:15860345 NCBI chr17:85,264,169...85,331,420
Ensembl chr17:85,264,169...85,331,419 		JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta decreases expression ISO Clozapine results in decreased expression of PPP1CB mRNA CTD PMID:15860345 NCBI chr 5:32,616,192...32,651,057
Ensembl chr 5:32,616,187...32,674,777 		JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma decreases expression ISO Clozapine results in decreased expression of PPP1CC mRNA CTD PMID:15860345 NCBI chr 5:122,296,338...122,313,336
Ensembl chr 5:122,296,341...122,313,336 		JBrowse link
G Ppp1r14b protein phosphatase 1, regulatory inhibitor subunit 14B decreases expression ISO Clozapine results in decreased expression of PPP1R14B protein CTD PMID:34122009 NCBI chr19:6,952,416...6,954,692
Ensembl chr19:6,952,336...6,954,692 		JBrowse link
G Ppp1r1a protein phosphatase 1, regulatory inhibitor subunit 1A decreases expression ISO Clozapine results in decreased expression of PPP1R1A mRNA CTD PMID:15860345 NCBI chr15:103,438,706...103,446,465
Ensembl chr15:103,438,706...103,446,430 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B multiple interactions
increases phosphorylation		 EXP Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]
Clozapine results in increased phosphorylation of PPP1R1B protein		 CTD PMID:11880652 PMID:12871586 NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622 		JBrowse link
G Ppp1r2 protein phosphatase 1, regulatory inhibitor subunit 2 decreases expression ISO Clozapine results in decreased expression of PPP1R2 mRNA CTD PMID:15860345 NCBI chr16:31,070,359...31,094,095
Ensembl chr16:31,070,355...31,094,095 		JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B increases expression ISO Clozapine results in increased expression of PPP1R9B protein CTD PMID:16844384 NCBI chr11:94,882,038...94,897,724
Ensembl chr11:94,881,861...94,897,725 		JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform decreases expression ISO Clozapine results in decreased expression of PPP2CA mRNA CTD PMID:15860345 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605 		JBrowse link
G Ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform decreases expression ISO Clozapine results in decreased expression of PPP2CB mRNA CTD PMID:15860345 NCBI chr 8:34,089,672...34,109,831
Ensembl chr 8:34,089,653...34,109,469 		JBrowse link
G Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha increases expression ISO Clozapine results in increased expression of PPP2R1A mRNA CTD PMID:15860345 NCBI chr17:21,165,716...21,186,167
Ensembl chr17:21,165,573...21,186,178 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha decreases expression ISO Clozapine results in decreased expression of PPP2R2A mRNA CTD PMID:15860345 NCBI chr14:67,251,505...67,309,920
Ensembl chr14:67,251,505...67,309,893 		JBrowse link
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform multiple interactions
decreases expression
increases expression		 ISO [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein
Clozapine results in decreased expression of PPP3CA mRNA; Clozapine results in decreased expression of PPP3CA protein
Clozapine results in increased expression of PPP3CA mRNA		 CTD PMID:12437575 PMID:16033416 NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488 		JBrowse link
G Ppp4r2 protein phosphatase 4, regulatory subunit 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of PPP4R2 protein CTD PMID:34122009 NCBI chr 6:100,810,596...100,846,891
Ensembl chr 6:100,810,583...100,846,895 		JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit affects expression EXP Clozapine affects the expression of PPP5C mRNA CTD PMID:14647396 NCBI chr 7:16,738,575...16,761,812
Ensembl chr 7:16,738,565...16,761,849 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of PRDX1 protein CTD PMID:34122009 NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019 		JBrowse link
G Prkaca protein kinase, cAMP dependent, catalytic, alpha increases expression ISO Clozapine results in increased expression of PRKACA mRNA CTD PMID:15860345 NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072 		JBrowse link
G Prkacb protein kinase, cAMP dependent, catalytic, beta decreases expression
increases expression		 ISO Clozapine results in decreased expression of PRKACB mRNA; Clozapine results in decreased expression of PRKACB protein
Clozapine results in increased expression of PRKACB mRNA		 CTD PMID:11907174 PMID:15860345 NCBI chr 3:146,435,334...146,518,691
Ensembl chr 3:146,435,329...146,518,745 		JBrowse link
G Prkar2a protein kinase, cAMP dependent regulatory, type II alpha multiple interactions
decreases expression		 ISO Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2A protein]
Clozapine results in decreased expression of PRKAR2A mRNA; Clozapine results in decreased expression of PRKAR2A protein
[Cuprizone co-treated with Clozapine] results in decreased expression of PRKAR2A protein		 CTD PMID:11907174 PMID:34122009 NCBI chr 9:108,569,342...108,627,643
Ensembl chr 9:108,566,513...108,627,635 		JBrowse link
G Prkar2b protein kinase, cAMP dependent regulatory, type II beta decreases expression
multiple interactions		 ISO Clozapine results in decreased expression of PRKAR2B mRNA; Clozapine results in decreased expression of PRKAR2B protein
Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2B protein]		 CTD PMID:11907174 PMID:15860345 NCBI chr12:32,008,468...32,111,639
Ensembl chr12:32,008,475...32,111,295 		JBrowse link
G Prkcb protein kinase C, beta affects expression
increases expression		 ISO Clozapine affects the expression of PRKCB protein
Clozapine results in increased expression of PRKCB mRNA		 CTD PMID:15860345 PMID:15967061 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625 		JBrowse link
G Prkce protein kinase C, epsilon increases expression ISO Clozapine results in increased expression of PRKCE mRNA CTD PMID:15860345 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347 		JBrowse link
G Prkcz protein kinase C, zeta increases expression ISO Clozapine results in increased expression of PRKCZ mRNA CTD PMID:15860345 NCBI chr 4:155,344,579...155,445,856
Ensembl chr 4:155,344,586...155,445,818 		JBrowse link
G Prl prolactin increases secretion
multiple interactions
increases expression		 ISO Clozapine results in increased secretion of PRL protein
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein; [Risperidone co-treated with Clozapine] results in increased expression of PRL protein
Clozapine analog results in increased expression of PRL protein		 CTD PMID:11155212 PMID:11997696 PMID:15286066 PMID:18562423 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Prmt1 protein arginine N-methyltransferase 1 decreases expression ISO Clozapine results in decreased expression of PRMT1 protein CTD PMID:34122009 NCBI chr 7:44,626,179...44,635,844
Ensembl chr 7:44,625,413...44,635,992 		JBrowse link
G Proc protein C increases expression ISO Clozapine results in increased expression of PROC protein CTD PMID:20126316 NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623 		JBrowse link
G Prpf38b PRP38 pre-mRNA processing factor 38 (yeast) domain containing B decreases expression EXP Clozapine results in decreased expression of PRPF38B mRNA CTD PMID:14647396 NCBI chr 3:108,810,121...108,819,055
Ensembl chr 3:108,810,121...108,819,043 		JBrowse link
G Prpf6 pre-mRNA splicing factor 6 multiple interactions
decreases expression		 ISO [Cuprizone co-treated with Clozapine] results in decreased expression of PRPF6 protein
Clozapine results in decreased expression of PRPF6 protein		 CTD PMID:34122009 NCBI chr 2:181,243,112...181,297,454
Ensembl chr 2:181,233,661...181,297,453 		JBrowse link
G Prrc2a proline-rich coiled-coil 2A decreases expression EXP Clozapine results in decreased expression of PRRC2A mRNA CTD PMID:18797397 NCBI chr17:35,368,052...35,384,877
Ensembl chr17:35,368,052...35,383,873 		JBrowse link
G Psmb5 proteasome (prosome, macropain) subunit, beta type 5 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of PSMB5 protein CTD PMID:34122009 NCBI chr14:54,851,577...54,855,452
Ensembl chr14:54,851,576...54,855,479 		JBrowse link
G Psmb7 proteasome (prosome, macropain) subunit, beta type 7 decreases expression ISO Clozapine results in decreased expression of PSMB7 protein CTD PMID:34122009 NCBI chr 2:38,478,058...38,533,964
Ensembl chr 2:38,478,048...38,534,099 		JBrowse link
G Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 increases expression ISO Clozapine results in increased expression of PSMC3 protein CTD PMID:34122009 NCBI chr 2:90,884,361...90,889,783
Ensembl chr 2:90,884,354...90,896,714 		JBrowse link
G Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 increases expression ISO Clozapine results in increased expression of PSMC5 protein CTD PMID:34122009 NCBI chr11:106,147,011...106,153,938
Ensembl chr11:106,146,980...106,153,946 		JBrowse link
G Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 increases expression ISO Clozapine results in increased expression of PSMD14 protein CTD PMID:34122009 NCBI chr 2:61,542,038...61,630,720
Ensembl chr 2:61,542,038...61,630,720 		JBrowse link
G Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 increases expression ISO Clozapine results in increased expression of PSMD7 protein CTD PMID:34122009 NCBI chr 8:108,307,012...108,315,114
Ensembl chr 8:108,307,013...108,315,096 		JBrowse link
G Ptcd3 pentatricopeptide repeat domain 3 increases expression ISO Clozapine results in increased expression of PTCD3 protein CTD PMID:34122009 NCBI chr 6:71,857,622...71,886,080
Ensembl chr 6:71,857,622...71,885,734 		JBrowse link
G Ptgds prostaglandin D2 synthase (brain) decreases expression
increases expression		 EXP Clozapine results in decreased expression of PTGDS mRNA
Clozapine results in increased expression of PTGDS mRNA		 CTD PMID:15542763 PMID:17266109 NCBI chr 2:25,356,723...25,360,080
Ensembl chr 2:25,356,721...25,360,058 		JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 increases expression ISO Clozapine results in increased expression of PTK2 protein CTD PMID:34122009 NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129 		JBrowse link
G Ptma prothymosin alpha increases expression ISO Clozapine results in increased expression of PTMA protein CTD PMID:34122009 NCBI chr 1:86,454,442...86,458,434
Ensembl chr 1:86,454,448...86,458,434 		JBrowse link
G Ptms parathymosin increases expression EXP Clozapine results in increased expression of PTMS mRNA CTD PMID:14647396 NCBI chr 6:124,890,638...124,894,909
Ensembl chr 6:124,890,644...124,897,066 		JBrowse link
G Pvalb parvalbumin multiple interactions ISO Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA] CTD PMID:12589379 NCBI chr15:78,075,312...78,090,600
Ensembl chr15:78,075,314...78,090,600 		JBrowse link
G Pwp2 PWP2 periodic tryptophan protein homolog (yeast) increases expression ISO Clozapine results in increased expression of PWP2 protein CTD PMID:34122009 NCBI chr10:78,006,743...78,021,005
Ensembl chr10:78,006,743...78,020,983 		JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 increases expression ISO Clozapine results in increased expression of PYCR1 protein CTD PMID:34122009 NCBI chr11:120,527,591...120,534,602
Ensembl chr11:120,526,538...120,534,595 		JBrowse link
G Qdpr quinoid dihydropteridine reductase decreases expression ISO Clozapine results in decreased expression of QDPR protein CTD PMID:34122009 NCBI chr 5:45,591,374...45,607,571
Ensembl chr 5:45,591,363...45,607,578 		JBrowse link
G Rab12 RAB12, member RAS oncogene family decreases expression ISO Clozapine results in decreased expression of RAB12 mRNA CTD PMID:12437575 NCBI chr17:66,801,507...66,826,712
Ensembl chr17:66,801,507...66,826,724 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of RAC1 protein CTD PMID:34122009 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791 		JBrowse link
G Rack1 receptor for activated C kinase 1 decreases expression ISO Clozapine results in decreased expression of RACK1 protein CTD PMID:34122009 NCBI chr11:48,691,187...48,697,068
Ensembl chr11:48,691,159...48,697,261 		JBrowse link
G Ralyl RALY RNA binding protein-like increases expression ISO Clozapine results in increased expression of RALYL protein CTD PMID:34122009 NCBI chr 3:13,535,942...14,247,347
Ensembl chr 3:13,536,715...14,247,347 		JBrowse link
G Ran RAN, member RAS oncogene family decreases expression ISO Clozapine results in decreased expression of RAN protein CTD PMID:34122009 NCBI chr 5:129,097,264...129,101,388
Ensembl chr 5:129,097,133...129,101,387 		JBrowse link
G Rap1gds1 RAP1, GTP-GDP dissociation stimulator 1 increases expression ISO Clozapine results in increased expression of RAP1GDS1 protein CTD PMID:34122009 NCBI chr 3:138,631,662...138,781,163
Ensembl chr 3:138,631,663...138,780,962 		JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 decreases expression EXP Clozapine results in decreased expression of RAPGEF4 mRNA CTD PMID:18797397 NCBI chr 2:71,811,559...72,087,818
Ensembl chr 2:71,811,584...72,087,818 		JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 affects expression ISO Clozapine affects the expression of RASGRF1 mRNA CTD PMID:12437575 NCBI chr 9:89,791,565...89,909,032
Ensembl chr 9:89,791,961...89,909,030 		JBrowse link
G Rbbp4 retinoblastoma binding protein 4, chromatin remodeling factor decreases expression ISO Clozapine results in decreased expression of RBBP4 protein CTD PMID:34122009 NCBI chr 4:129,200,893...129,229,163
Ensembl chr 4:129,200,893...129,229,163 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) decreases expression ISO Clozapine results in decreased expression of RELA protein CTD PMID:16500086 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Reln reelin decreases expression
decreases methylation
multiple interactions		 EXP
ISO		 Clozapine results in decreased expression of RELN mRNA
Clozapine results in decreased methylation of RELN promoter
Valproic Acid promotes the reaction [Clozapine results in decreased methylation of RELN promoter]
Clozapine results in decreased expression of RELN protein		 CTD PMID:17266109 PMID:18757738 PMID:19359144 NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700 		JBrowse link
G Rfc5 replication factor C (activator 1) 5 increases expression ISO Clozapine results in increased expression of RFC5 protein CTD PMID:34122009 NCBI chr 5:117,517,210...117,527,088
Ensembl chr 5:117,516,168...117,527,112 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression ISO
EXP		 Clozapine results in increased expression of RGS4 mRNA CTD PMID:15860345 PMID:17266109 NCBI chr 1:169,569,046...169,575,211
Ensembl chr 1:169,569,046...169,575,211 		JBrowse link
G Rgs7 regulator of G protein signaling 7 multiple interactions
increases expression		 ISO [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]
Clozapine results in increased expression of RGS7 mRNA		 CTD PMID:18976543 NCBI chr 1:174,886,642...175,320,287
Ensembl chr 1:174,886,653...175,320,066 		JBrowse link
G Rgs8 regulator of G-protein signaling 8 increases expression ISO Clozapine results in increased expression of RGS8 mRNA CTD PMID:15860345 NCBI chr 1:153,528,612...153,573,415
Ensembl chr 1:153,528,771...153,576,069 		JBrowse link
G Rhob ras homolog family member B increases expression ISO Clozapine results in increased expression of RHOB protein CTD PMID:36482696 NCBI chr12:8,547,661...8,550,009
Ensembl chr12:8,547,661...8,550,009 		JBrowse link
G Ric8a RIC8 guanine nucleotide exchange factor A decreases expression ISO Clozapine results in decreased expression of RIC8A protein CTD PMID:34122009 NCBI chr 7:140,437,310...140,443,644
Ensembl chr 7:140,436,870...140,444,285 		JBrowse link
G Rnf13 ring finger protein 13 increases expression ISO Clozapine results in increased expression of RNF13 protein CTD PMID:36482696 NCBI chr 3:57,643,468...57,742,846
Ensembl chr 3:57,643,483...57,742,654 		JBrowse link
G Rnf20 ring finger protein 20 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of RNF20 protein CTD PMID:34122009 NCBI chr 4:49,632,005...49,656,887
Ensembl chr 4:49,632,006...49,656,887 		JBrowse link
G Rorb RAR-related orphan receptor beta decreases expression ISO Clozapine results in decreased expression of RORB mRNA CTD PMID:11564422 NCBI chr19:18,907,966...19,088,560
Ensembl chr19:18,907,969...19,088,560 		JBrowse link
G Rpa1 replication protein A1 decreases expression ISO Clozapine results in decreased expression of RPA1 protein CTD PMID:34122009 NCBI chr11:75,191,085...75,239,478
Ensembl chr11:75,188,992...75,239,150 		JBrowse link
G Rpl11 ribosomal protein L11 increases expression ISO Clozapine results in increased expression of RPL11 protein CTD PMID:34122009 NCBI chr 4:135,776,665...135,780,704
Ensembl chr 4:135,755,576...135,780,739 		JBrowse link
G Rpl19 ribosomal protein L19 increases expression ISO Clozapine results in increased expression of RPL19 protein CTD PMID:34122009 NCBI chr11:97,912,829...97,921,319
Ensembl chr11:97,917,536...97,921,318 		JBrowse link
G Rpl30 ribosomal protein L30 increases expression ISO Clozapine results in increased expression of RPL30 protein CTD PMID:34122009 NCBI chr15:34,440,649...34,443,405
Ensembl chr15:34,440,651...34,443,786 		JBrowse link
G Rpl5 ribosomal protein L5 increases expression ISO Clozapine results in increased expression of RPL5 protein CTD PMID:34122009 NCBI chr 5:108,048,388...108,056,871
Ensembl chr 5:108,048,368...108,056,871 		JBrowse link
G Rplp2 ribosomal protein lateral stalk subunit P2 increases expression EXP Clozapine results in increased expression of RPLP2 mRNA CTD PMID:14647396 NCBI chr 7:141,027,564...141,031,272
Ensembl chr 7:141,027,283...141,031,498 		JBrowse link
G Rpn2 ribophorin II decreases expression ISO Clozapine results in decreased expression of RPN2 protein CTD PMID:34122009 NCBI chr 2:157,121,018...157,168,238
Ensembl chr 2:157,120,937...157,168,239 		JBrowse link
G Rps10 ribosomal protein S10 increases expression EXP Clozapine results in increased expression of RPS10 mRNA CTD PMID:14647396 NCBI chr17:27,849,389...27,854,218
Ensembl chr17:27,849,392...27,855,643 		JBrowse link
G Rps11 ribosomal protein S11 decreases expression ISO Clozapine results in decreased expression of RPS11 protein CTD PMID:34122009 NCBI chr 7:44,771,812...44,773,813
Ensembl chr 7:44,771,803...44,773,863 		JBrowse link
G Rps3 ribosomal protein S3 decreases expression ISO Clozapine results in decreased expression of RPS3 protein CTD PMID:34122009 NCBI chr 7:99,127,103...99,132,916
Ensembl chr 7:99,127,103...99,132,945 		JBrowse link
G Rrbp1 ribosome binding protein 1 decreases expression ISO Clozapine results in decreased expression of RRBP1 protein CTD PMID:34122009 NCBI chr 2:143,789,315...143,853,216
Ensembl chr 2:143,789,315...143,853,183 		JBrowse link
G Rsf1 remodeling and spacing factor 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of RSF1 protein CTD PMID:34122009 NCBI chr 7:97,229,103...97,341,989
Ensembl chr 7:97,229,096...97,341,985 		JBrowse link
G Rspry1 ring finger and SPRY domain containing 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of RSPRY1 protein CTD PMID:34122009 NCBI chr 8:95,328,569...95,386,905
Ensembl chr 8:95,328,565...95,386,903 		JBrowse link
G Rtcb RNA 2',3'-cyclic phosphate and 5'-OH ligase increases expression ISO Clozapine results in increased expression of RTCB protein CTD PMID:34122009 NCBI chr10:85,774,501...85,793,657
Ensembl chr10:85,774,501...85,793,687 		JBrowse link
G Rtn4 reticulon 4 increases expression EXP Clozapine results in increased expression of RTN4 mRNA CTD PMID:17266109 NCBI chr11:29,642,898...29,694,414
Ensembl chr11:29,642,947...29,694,331 		JBrowse link
G Rxrg retinoid X receptor gamma decreases expression ISO Clozapine results in decreased expression of RXRG mRNA alternative form CTD PMID:11564422 NCBI chr 1:167,425,902...167,467,191
Ensembl chr 1:167,425,953...167,467,192 		JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) decreases expression EXP Clozapine results in decreased expression of S100A9 mRNA CTD PMID:18797397 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028 		JBrowse link
G Safb scaffold attachment factor B increases expression ISO Clozapine results in increased expression of SAFB protein CTD PMID:34122009 NCBI chr17:56,891,982...56,913,294
Ensembl chr17:56,891,825...56,913,294 		JBrowse link
G Sars1 seryl-tRNA synthetase 1 decreases expression ISO Clozapine results in decreased expression of SARS1 protein CTD PMID:34122009 NCBI chr 3:108,332,180...108,352,575
Ensembl chr 3:108,332,181...108,352,525 		JBrowse link
G Satb2 special AT-rich sequence binding protein 2 increases expression ISO Clozapine results in increased expression of SATB2 protein CTD PMID:34122009 NCBI chr 1:56,833,145...57,019,350
Ensembl chr 1:56,833,140...57,017,809 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Clozapine results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 9:42,162,888...42,175,607
Ensembl chr 9:42,162,891...42,175,552 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression ISO Clozapine results in increased expression of SCD mRNA CTD PMID:16027736 PMID:17052361 NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303 		JBrowse link
G Sdcbp syndecan binding protein decreases expression
increases expression		 ISO Clozapine results in decreased expression of SDCBP protein
Clozapine results in increased expression of SDCBP protein		 CTD PMID:34122009 PMID:36482696 NCBI chr 4:6,365,713...6,396,120
Ensembl chr 4:6,365,650...6,408,423 		JBrowse link
G Sec31a SEC31 homolog A, COPII coat complex component increases expression ISO Clozapine results in increased expression of SEC31A protein CTD PMID:34122009 NCBI chr 5:100,509,508...100,564,132
Ensembl chr 5:100,509,508...100,564,093 		JBrowse link
G Sec61b SEC61 translocon subunit beta increases expression ISO Clozapine results in increased expression of SEC61B protein CTD PMID:34122009 NCBI chr 4:47,474,661...47,483,233
Ensembl chr 4:47,474,658...47,483,242 		JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator increases expression ISO Clozapine results in increased expression of SEC63 protein CTD PMID:34122009 NCBI chr10:42,637,492...42,708,510
Ensembl chr10:42,637,492...42,708,510 		JBrowse link
G Septin14 septin 14 decreases expression ISO Clozapine results in decreased expression of SEPTIN14 protein CTD PMID:34122009 NCBI chr 5:129,760,455...129,782,048
Ensembl chr 5:129,760,455...129,785,576 		JBrowse link
G Serinc1 serine incorporator 1 increases expression ISO Clozapine results in increased expression of SERINC1 protein CTD PMID:36482696 NCBI chr10:57,391,870...57,408,573
Ensembl chr10:57,391,870...57,408,626 		JBrowse link
G Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B increases expression ISO Clozapine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr12:104,094,245...104,105,805
Ensembl chr12:104,094,255...104,105,804 		JBrowse link
G Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 increases expression ISO Clozapine results in increased expression of SERPINE2 mRNA; Clozapine results in increased expression of SERPINE2 protein CTD PMID:15354176 NCBI chr 1:79,772,038...79,836,382
Ensembl chr 1:79,771,914...79,838,897 		JBrowse link
G Set SET nuclear oncogene multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of SET protein CTD PMID:34122009 NCBI chr 2:29,952,074...29,962,589
Ensembl chr 2:29,947,390...29,962,589 		JBrowse link
G Setx senataxin increases expression ISO Clozapine results in increased expression of SETX protein CTD PMID:34122009 NCBI chr 2:29,013,600...29,072,483
Ensembl chr 2:29,014,193...29,072,483 		JBrowse link
G Sf3b3 splicing factor 3b, subunit 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SF3B3 protein CTD PMID:34122009 NCBI chr 8:111,537,123...111,573,578
Ensembl chr 8:111,536,871...111,573,419 		JBrowse link
G Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) decreases expression ISO Clozapine results in decreased expression of SFPQ protein CTD PMID:34122009 NCBI chr 4:126,914,504...126,944,894
Ensembl chr 4:126,915,117...126,930,806 		JBrowse link
G Sfxn1 sideroflexin 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SFXN1 protein CTD PMID:34122009 NCBI chr13:54,225,675...54,262,365
Ensembl chr13:54,225,888...54,262,361 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression EXP
ISO		 Clozapine results in increased expression of SGK1 mRNA CTD PMID:17266109 PMID:18208916 NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802 		JBrowse link
G Sh3gl1 SH3-domain GRB2-like 1 increases expression ISO Clozapine results in increased expression of SH3GL1 protein CTD PMID:34122009 NCBI chr17:56,323,750...56,343,659
Ensembl chr17:56,323,750...56,343,635 		JBrowse link
G Sh3kbp1 SH3-domain kinase binding protein 1 increases expression ISO Clozapine results in increased expression of SH3KBP1 protein CTD PMID:34122009 NCBI chr  X:158,409,888...158,758,916
Ensembl chr  X:158,410,268...158,761,065 		JBrowse link
G Sh3pxd2b SH3 and PX domains 2B multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SH3PXD2B protein CTD PMID:34122009 NCBI chr11:32,297,777...32,378,189
Ensembl chr11:32,297,820...32,378,173 		JBrowse link
G Sim2 single-minded family bHLH transcription factor 2 decreases expression ISO Clozapine results in decreased expression of SIM2 protein CTD PMID:34122009 NCBI chr16:93,885,963...93,927,891
Ensembl chr16:93,885,790...93,927,891 		JBrowse link
G Sirt2 sirtuin 2 increases expression ISO Clozapine results in increased expression of SIRT2 protein CTD PMID:36482696 NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086 		JBrowse link
G Skp1 S-phase kinase-associated protein 1 decreases expression ISO Clozapine results in decreased expression of SKP1 protein CTD PMID:34122009 NCBI chr11:52,121,349...52,137,685
Ensembl chr11:52,122,822...52,137,685 		JBrowse link
G Slc17a6 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 increases expression EXP Clozapine results in increased expression of SLC17A6 mRNA; Clozapine results in increased expression of SLC17A6 protein CTD PMID:17266109 PMID:18155072 NCBI chr 7:51,271,578...51,320,874
Ensembl chr 7:51,271,754...51,320,867 		JBrowse link
G Slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 increases expression EXP Clozapine results in increased expression of SLC17A7 mRNA; Clozapine results in increased expression of SLC17A7 protein CTD PMID:16111724 NCBI chr 7:44,813,345...44,825,563
Ensembl chr 7:44,813,373...44,825,566 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 increases expression ISO Clozapine results in increased expression of SLC18A2 mRNA; Clozapine results in increased expression of SLC18A2 protein CTD PMID:12007678 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444 		JBrowse link
G Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 decreases expression ISO Clozapine results in decreased expression of SLC1A1 mRNA CTD PMID:12873733 NCBI chr19:28,812,535...28,891,360
Ensembl chr19:28,812,449...28,891,360 		JBrowse link
G Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 decreases activity
decreases expression		 ISO Clozapine results in decreased activity of SLC1A2 protein
Clozapine results in decreased expression of SLC1A2 mRNA; Clozapine results in decreased expression of SLC1A2 protein		 CTD PMID:11443521 PMID:12873733 NCBI chr 2:102,488,584...102,621,129
Ensembl chr 2:102,489,004...102,621,129 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Clozapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 multiple interactions ISO Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:30465787 NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486 		JBrowse link
G Slc25a13 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 increases expression ISO Clozapine results in increased expression of SLC25A13 protein CTD PMID:34122009 NCBI chr 6:6,041,218...6,217,304
Ensembl chr 6:6,041,218...6,217,173 		JBrowse link
G Slc25a24 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 increases expression ISO Clozapine results in increased expression of SLC25A24 protein CTD PMID:34122009 NCBI chr 3:109,030,465...109,075,725
Ensembl chr 3:109,030,465...109,075,773 		JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 decreases expression ISO Clozapine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599 		JBrowse link
G Slc39a7 solute carrier family 39 (zinc transporter), member 7 increases expression EXP Clozapine results in increased expression of SLC39A7 mRNA CTD PMID:14647396 NCBI chr17:34,247,240...34,250,664
Ensembl chr17:34,247,243...34,250,656 		JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 increases expression ISO Clozapine results in increased expression of SLC3A2 protein CTD PMID:36482696 NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733 		JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 decreases expression ISO Clozapine results in decreased expression of SLC6A2 mRNA CTD PMID:18923069 NCBI chr 8:93,687,100...93,728,295
Ensembl chr 8:93,686,707...93,728,295 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 affects response to substance ISO SLC6A3 5' UTR affects the susceptibility to Clozapine CTD PMID:20580759 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 multiple interactions
affects response to substance
increases expression		 ISO [SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine
SLC6A4 protein affects the susceptibility to Clozapine
Clozapine results in increased expression of SLC6A4		 CTD PMID:12007678 PMID:20452607 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 decreases expression ISO Clozapine results in decreased expression of SMARCB1 protein CTD PMID:34122009 NCBI chr10:75,732,603...75,757,448
Ensembl chr10:75,732,603...75,757,451 		JBrowse link
G Smarcc2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SMARCC2 protein CTD PMID:34122009 NCBI chr10:128,294,823...128,326,460
Ensembl chr10:128,295,117...128,326,351 		JBrowse link
G Smc2 structural maintenance of chromosomes 2 decreases expression ISO Clozapine results in decreased expression of SMC2 protein CTD PMID:34122009 NCBI chr 4:52,438,966...52,488,365
Ensembl chr 4:52,439,243...52,488,260 		JBrowse link
G Smc3 structural maintenance of chromosomes 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SMC3 protein CTD PMID:34122009 NCBI chr19:53,588,827...53,634,262
Ensembl chr19:53,588,829...53,634,264 		JBrowse link
G Snap25 synaptosomal-associated protein 25 increases expression
affects response to substance		 ISO Clozapine results in increased expression of SNAP25 mRNA
SNAP25 gene SNP affects the susceptibility to Clozapine		 CTD PMID:15823421 PMID:15860345 NCBI chr 2:136,555,359...136,624,348
Ensembl chr 2:136,555,373...136,624,348 		JBrowse link
G Snrnp200 small nuclear ribonucleoprotein 200 (U5) increases expression ISO Clozapine results in increased expression of SNRNP200 protein CTD PMID:34122009 NCBI chr 2:127,050,306...127,082,373
Ensembl chr 2:127,050,306...127,082,371 		JBrowse link
G Snrpb small nuclear ribonucleoprotein B increases expression ISO Clozapine results in increased expression of SNRPB protein CTD PMID:34122009 NCBI chr 2:130,013,560...130,031,184
Ensembl chr 2:130,013,555...130,021,323 		JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 increases expression EXP Clozapine results in increased expression of SNRPD2 mRNA CTD PMID:14647396 NCBI chr 7:18,883,370...18,886,659
Ensembl chr 7:18,883,647...18,887,467 		JBrowse link
G Snx1 sorting nexin 1 decreases expression ISO Clozapine results in decreased expression of SNX1 protein CTD PMID:34122009 NCBI chr 9:65,995,409...66,032,168
Ensembl chr 9:65,995,415...66,033,869 		JBrowse link
G Snx6 sorting nexin 6 increases expression ISO Clozapine results in increased expression of SNX6 protein CTD PMID:34122009 NCBI chr12:54,793,124...54,842,464
Ensembl chr12:54,793,134...54,842,488 		JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression
multiple interactions
decreases expression		 ISO Clozapine results in increased expression of SOD1 mRNA
Clozapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; Clozapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]
Clozapine results in decreased expression of SOD1 protein		 CTD PMID:12111809 PMID:12752374 PMID:16564057 PMID:34122009 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases expression ISO Clozapine results in decreased expression of SOD2 mRNA CTD PMID:15860345 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sod3 superoxide dismutase 3, extracellular increases expression ISO Clozapine results in increased expression of SOD3 mRNA CTD PMID:15860345 NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression
increases expression		 ISO Clozapine results in decreased expression of SOS1 mRNA
Clozapine results in increased expression of SOS1 mRNA		 CTD PMID:12437575 NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO Clozapine results in decreased expression of SPP1 mRNA CTD PMID:17346280 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 decreases expression ISO Clozapine results in decreased expression of SPTLC1 protein CTD PMID:34122009 NCBI chr13:53,486,784...53,531,401
Ensembl chr13:53,486,784...53,531,433 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Clozapine results in increased expression of SQSTM1 protein CTD PMID:36482696 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions		 ISO
EXP		 Clozapine results in increased expression of SREBF1 mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]
Clozapine results in increased expression of SREBF1 mRNA; Clozapine results in increased expression of SREBF1 protein		 CTD PMID:17052361 PMID:19682446 PMID:20564506 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Srebf2 sterol regulatory element binding factor 2 multiple interactions
increases expression		 ISO Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]; Clozapine results in increased cleavage of and results in increased activity of SREBF2 protein
Clozapine results in increased expression of SREBF2 mRNA		 CTD PMID:17052361 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580 		JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 decreases expression ISO Clozapine results in decreased expression of SRRM2 protein CTD PMID:34122009 NCBI chr17:24,009,501...24,043,715
Ensembl chr17:24,009,506...24,043,715 		JBrowse link
G Srsf2 serine and arginine-rich splicing factor 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of SRSF2 protein CTD PMID:34122009 NCBI chr11:116,740,723...116,744,511
Ensembl chr11:116,740,727...116,743,920 		JBrowse link
G Srsf5 serine and arginine-rich splicing factor 5 multiple interactions
increases expression		 ISO [Cuprizone co-treated with Clozapine] results in increased expression of SRSF5 protein
Clozapine results in increased expression of SRSF5 protein		 CTD PMID:34122009 NCBI chr12:80,992,308...80,997,277
Ensembl chr12:80,992,278...80,997,281 		JBrowse link
G Srsf7 serine and arginine-rich splicing factor 7 decreases expression ISO Clozapine results in decreased expression of SRSF7 protein CTD PMID:34122009 NCBI chr17:80,507,509...80,514,734
Ensembl chr17:80,507,509...80,514,736 		JBrowse link
G Ssr3 signal sequence receptor, gamma decreases expression ISO Clozapine results in decreased expression of SSR3 protein CTD PMID:34122009 NCBI chr 3:65,287,078...65,299,974
Ensembl chr 3:65,287,076...65,300,044 		JBrowse link
G Sst somatostatin multiple interactions ISO Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein] CTD PMID:16567023 NCBI chr16:23,708,327...23,710,041
Ensembl chr16:23,708,323...23,709,708 		JBrowse link
G Stim1 stromal interaction molecule 1 decreases expression ISO Clozapine results in decreased expression of STIM1 protein CTD PMID:34122009 NCBI chr 7:101,909,279...102,086,525
Ensembl chr 7:101,917,013...102,086,526 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Clozapine results in decreased expression of STIP1 protein CTD PMID:34122009 NCBI chr19:6,998,064...7,017,394
Ensembl chr19:6,998,070...7,017,335 		JBrowse link
G Strap serine/threonine kinase receptor associated protein decreases expression ISO Clozapine results in decreased expression of STRAP protein CTD PMID:34122009 NCBI chr 6:137,712,080...137,728,928
Ensembl chr 6:137,712,076...137,728,930 		JBrowse link
G Strn4 striatin, calmodulin binding protein 4 increases expression EXP Clozapine results in increased expression of STRN4 mRNA CTD PMID:14647396 NCBI chr 7:16,549,814...16,574,856
Ensembl chr 7:16,549,814...16,574,856 		JBrowse link
G Stx1a syntaxin 1A (brain) increases expression ISO Clozapine results in increased expression of STX1A mRNA CTD PMID:15860345 NCBI chr 5:135,051,473...135,079,954
Ensembl chr 5:135,052,336...135,079,954 		JBrowse link
G Stx1b syntaxin 1B increases expression ISO Clozapine results in increased expression of STX1B mRNA CTD PMID:15860345 NCBI chr 7:127,403,072...127,423,703
Ensembl chr 7:127,403,072...127,423,721 		JBrowse link
G Stx4a syntaxin 4A (placental) increases expression ISO Clozapine results in increased expression of STX4 mRNA CTD PMID:15860345 NCBI chr 7:127,439,832...127,450,160
Ensembl chr 7:127,423,466...127,448,191 		JBrowse link
G Stx8 syntaxin 8 affects expression ISO Clozapine affects the expression of STX8 mRNA CTD PMID:15860345 NCBI chr11:67,857,237...68,097,974
Ensembl chr11:67,857,019...68,097,974 		JBrowse link
G Stxbp1 syntaxin binding protein 1 affects expression ISO Clozapine affects the expression of STXBP1 mRNA CTD PMID:12437575 NCBI chr 2:32,677,619...32,737,249
Ensembl chr 2:32,677,614...32,737,257 		JBrowse link
G Sucla2 succinate-Coenzyme A ligase, ADP-forming, beta subunit multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SUCLA2 protein CTD PMID:34122009 NCBI chr14:73,790,226...73,833,584
Ensembl chr14:73,762,759...73,833,582 		JBrowse link
G Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit decreases expression ISO Clozapine results in decreased expression of SUCLG1 protein CTD PMID:34122009 NCBI chr 6:73,225,488...73,253,890
Ensembl chr 6:73,225,365...73,253,894 		JBrowse link
G Supt3 SPT3, SAGA and STAGA complex component increases expression ISO Clozapine results in increased expression of SUPT3H mRNA CTD PMID:16715494 NCBI chr17:45,088,005...45,430,181
Ensembl chr17:45,088,039...45,430,177 		JBrowse link
G Syn2 synapsin II decreases expression
increases expression		 EXP
ISO		 Clozapine results in decreased expression of SYN2 mRNA
Clozapine results in increased expression of SYN2 mRNA		 CTD PMID:15860345 PMID:17266109 NCBI chr 6:115,111,863...115,259,587
Ensembl chr 6:115,111,863...115,258,967 		JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein decreases expression ISO Clozapine results in decreased expression of SYNCRIP protein CTD PMID:34122009 NCBI chr 9:88,331,417...88,364,645
Ensembl chr 9:88,329,062...88,364,627 		JBrowse link
G Syt11 synaptotagmin XI increases expression ISO Clozapine results in increased expression of SYT11 mRNA CTD PMID:15860345 NCBI chr 3:88,652,006...88,682,466
Ensembl chr 3:88,652,007...88,682,471 		JBrowse link
G Syt2 synaptotagmin II increases expression EXP Clozapine results in increased expression of SYT2 mRNA CTD PMID:17266109 NCBI chr 1:134,574,319...134,680,887
Ensembl chr 1:134,574,415...134,690,331 		JBrowse link
G Syt4 synaptotagmin IV increases expression ISO Clozapine results in increased expression of SYT4 mRNA CTD PMID:15860345 NCBI chr18:31,570,861...31,580,468
Ensembl chr18:31,570,861...31,580,459 		JBrowse link
G Syt5 synaptotagmin V decreases expression ISO Clozapine results in decreased expression of SYT5 mRNA CTD PMID:12437575 NCBI chr 7:4,542,764...4,550,540
Ensembl chr 7:4,542,764...4,550,540 		JBrowse link
G Tac1 tachykinin 1 decreases expression EXP
ISO		 Clozapine results in decreased expression of TAC1 mRNA CTD PMID:10974607 PMID:17266109 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834 		JBrowse link
G Tagln transgelin decreases expression ISO Clozapine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356 		JBrowse link
G Tagln2 transgelin 2 decreases expression ISO Clozapine results in decreased expression of TAGLN2 protein CTD PMID:34122009 NCBI chr 1:172,327,813...172,334,942
Ensembl chr 1:172,327,614...172,334,947 		JBrowse link
G Taok2 TAO kinase 2 increases expression ISO Clozapine results in increased expression of TAOK2 protein CTD PMID:34122009 NCBI chr 7:126,464,848...126,485,468
Ensembl chr 7:126,464,850...126,483,875 		JBrowse link
G Tatdn1 TatD DNase domain containing 1 increases expression EXP Clozapine results in increased expression of TATDN1 mRNA CTD PMID:14647396 NCBI chr15:58,762,002...58,805,605
Ensembl chr15:58,762,004...58,805,587 		JBrowse link
G Tbc1d15 TBC1 domain family, member 15 increases expression ISO Clozapine results in increased expression of TBC1D15 protein CTD PMID:36482696 NCBI chr10:115,031,459...115,087,343
Ensembl chr10:115,033,777...115,087,372 		JBrowse link
G Tbc1d8b TBC1 domain family, member 8B increases expression ISO Clozapine results in increased expression of TBC1D8B protein CTD PMID:34122009 NCBI chr  X:138,585,730...138,654,970
Ensembl chr  X:138,585,745...138,654,154 		JBrowse link
G Tbcb tubulin folding cofactor B multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TBCB protein CTD PMID:34122009 NCBI chr 7:29,923,554...29,931,622
Ensembl chr 7:29,923,556...29,931,697 		JBrowse link
G Tbl3 transducin (beta)-like 3 increases expression ISO Clozapine results in increased expression of TBL3 protein CTD PMID:34122009 NCBI chr17:24,919,627...24,926,627
Ensembl chr17:24,916,923...24,926,634 		JBrowse link
G Tcaf1 TRPM8 channel-associated factor 1 decreases expression ISO Clozapine results in decreased expression of TCAF1 protein CTD PMID:34122009 NCBI chr 6:42,644,933...42,687,065
Ensembl chr 6:42,644,936...42,687,022 		JBrowse link
G Tes testin LIM domain protein decreases expression ISO Clozapine results in decreased expression of TES protein CTD PMID:34122009 NCBI chr 6:17,065,148...17,105,824
Ensembl chr 6:17,065,148...17,105,827 		JBrowse link
G Tgoln1 trans-golgi network protein multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TGOLN2 protein CTD PMID:34122009 NCBI chr 6:72,585,403...72,593,983
Ensembl chr 6:72,585,415...72,593,983 		JBrowse link
G Th tyrosine hydroxylase decreases activity
multiple interactions
increases activity
decreases expression
increases expression		 ISO
EXP		 Clozapine results in decreased activity of TH protein
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]; [Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine
Clozapine results in decreased expression of TH mRNA; Clozapine results in decreased expression of TH protein
Clozapine results in increased expression of TH protein
Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]		 CTD PMID:12645084 PMID:15983997 PMID:16402076 PMID:16415089 PMID:17028028 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Thra thyroid hormone receptor alpha decreases expression
increases expression		 ISO Clozapine results in decreased expression of THRA mRNA alternative form
Clozapine results in increased expression of THRA mRNA alternative form		 CTD PMID:11564422 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Thrap3 thyroid hormone receptor associated protein 3 decreases expression ISO Clozapine results in decreased expression of THRAP3 protein CTD PMID:34122009 NCBI chr 4:126,057,875...126,096,548
Ensembl chr 4:126,057,875...126,096,553 		JBrowse link
G Thrb thyroid hormone receptor beta decreases expression ISO Clozapine results in decreased expression of THRB mRNA alternative form CTD PMID:11564422 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435 		JBrowse link
G Tln2 talin 2 decreases expression ISO Clozapine results in decreased expression of TLN2 protein CTD PMID:34122009 NCBI chr 9:67,124,371...67,541,357
Ensembl chr 9:67,124,369...67,466,985 		JBrowse link
G Tm9sf2 transmembrane 9 superfamily member 2 decreases expression ISO Clozapine results in decreased expression of TM9SF2 protein CTD PMID:34122009 NCBI chr14:122,342,290...122,397,015
Ensembl chr14:122,344,450...122,397,016 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 decreases expression ISO Clozapine results in decreased expression of TMED10 protein CTD PMID:34122009 NCBI chr12:85,387,388...85,421,491
Ensembl chr12:85,387,388...85,421,621 		JBrowse link
G Tmem109 transmembrane protein 109 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of TMEM109 protein CTD PMID:34122009 NCBI chr19:10,848,021...10,859,107
Ensembl chr19:10,848,024...10,859,365 		JBrowse link
G Tmpo thymopoietin decreases expression ISO Clozapine results in decreased expression of TMPO protein CTD PMID:34122009 NCBI chr10:90,983,433...91,017,614
Ensembl chr10:90,983,433...91,017,177 		JBrowse link
G Tnf tumor necrosis factor affects response to substance
increases expression
increases secretion
multiple interactions		 ISO TNF protein affects the susceptibility to Clozapine
Clozapine results in increased expression of TNF protein
Clozapine results in increased secretion of TNF protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of TNF protein]		 CTD PMID:20521320 PMID:24709159 PMID:34935985 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfsf15 tumor necrosis factor (ligand) superfamily, member 15 decreases expression ISO Clozapine results in decreased expression of TNFSF15 mRNA CTD PMID:17346280 NCBI chr 4:63,642,837...63,663,296
Ensembl chr 4:63,642,840...63,663,350 		JBrowse link
G Tnik TRAF2 and NCK interacting kinase decreases expression EXP Clozapine results in decreased expression of TNIK mRNA CTD PMID:14647396 NCBI chr 3:28,317,362...28,724,734
Ensembl chr 3:28,317,363...28,730,007 		JBrowse link
G Top1mt DNA topoisomerase 1, mitochondrial increases expression ISO Clozapine results in increased expression of TOP1MT protein CTD PMID:34122009 NCBI chr15:75,528,878...75,551,184
Ensembl chr15:75,528,884...75,550,649 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression ISO Clozapine results in increased expression of TPI1 mRNA CTD PMID:15860345 NCBI chr 6:124,787,549...124,791,121
Ensembl chr 6:124,787,549...124,791,259 		JBrowse link
G Tpm2 tropomyosin 2, beta multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TPM2 protein CTD PMID:34122009 NCBI chr 4:43,513,726...43,523,583
Ensembl chr 4:43,514,711...43,523,765 		JBrowse link
G Tpm3 tropomyosin 3, gamma multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TPM3 protein CTD PMID:34122009 NCBI chr 3:89,979,958...90,008,209
Ensembl chr 3:89,979,956...90,008,209 		JBrowse link
G Tpm4 tropomyosin 4 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TPM4 protein CTD PMID:34122009 NCBI chr 8:72,889,132...72,906,986
Ensembl chr 8:72,884,018...72,906,986 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein decreases expression ISO Clozapine results in decreased expression of TPR protein CTD PMID:34122009 NCBI chr 1:150,268,544...150,325,686
Ensembl chr 1:150,268,589...150,325,686 		JBrowse link
G Tra2b transformer 2 beta decreases expression ISO Clozapine results in decreased expression of TRA2B protein CTD PMID:34122009 NCBI chr16:22,063,302...22,084,755
Ensembl chr16:22,063,299...22,084,755 		JBrowse link
G Trim2 tripartite motif-containing 2 decreases expression EXP Clozapine results in decreased expression of TRIM2 mRNA CTD PMID:14647396 NCBI chr 3:84,067,746...84,215,659
Ensembl chr 3:84,067,746...84,214,184 		JBrowse link
G Trim28 tripartite motif-containing 28 decreases expression ISO Clozapine results in decreased expression of TRIM28 protein CTD PMID:34122009 NCBI chr 7:12,758,079...12,764,959
Ensembl chr 7:12,733,041...12,764,962 		JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions		 ISO Clozapine results in increased expression of TP53 mRNA
CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]		 CTD PMID:16160616 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Tspan3 tetraspanin 3 decreases expression
increases expression		 ISO Clozapine results in decreased expression of TSPAN3 protein
Clozapine results in increased expression of TSPAN3 protein		 CTD PMID:34122009 PMID:36482696 NCBI chr 9:56,043,168...56,068,354
Ensembl chr 9:56,039,009...56,072,761 		JBrowse link
G Ttbk1 tau tubulin kinase 1 increases expression ISO Clozapine results in increased expression of TTBK1 protein CTD PMID:34122009 NCBI chr17:46,751,577...46,798,596
Ensembl chr17:46,753,374...46,798,601 		JBrowse link
G Ttr transthyretin decreases expression
increases expression		 EXP
ISO		 Clozapine results in decreased expression of TTR mRNA
Clozapine results in increased expression of TTR mRNA; Clozapine results in increased expression of TTR protein		 CTD PMID:15927202 PMID:17266109 NCBI chr18:20,797,266...20,807,383
Ensembl chr18:20,798,337...20,807,378 		JBrowse link
G Ttyh2 tweety family member 2 increases expression ISO Clozapine results in increased expression of TTYH2 protein CTD PMID:34122009 NCBI chr11:114,566,294...114,611,810
Ensembl chr11:114,566,257...114,611,803 		JBrowse link
G Tubal3 tubulin, alpha-like 3 increases expression ISO Clozapine results in increased expression of TUBAL3 protein CTD PMID:34122009 NCBI chr13:3,974,695...3,985,277
Ensembl chr13:3,968,274...3,985,277 		JBrowse link
G Tubb4b tubulin, beta 4B class IVB multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TUBB4B protein CTD PMID:34122009 NCBI chr 2:25,112,170...25,114,714
Ensembl chr 2:25,112,172...25,114,714 		JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO Clozapine results in increased expression of TUBB protein CTD PMID:34122009 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198 		JBrowse link
G Tubb6 tubulin, beta 6 class V decreases expression ISO Clozapine results in decreased expression of TUBB6 protein CTD PMID:34122009 NCBI chr18:67,523,801...67,535,819
Ensembl chr18:67,523,787...67,535,819 		JBrowse link
G Uap1l1 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 increases expression ISO Clozapine results in increased expression of UAP1L1 protein CTD PMID:34122009 NCBI chr 2:25,251,501...25,255,695
Ensembl chr 2:25,249,901...25,255,694 		JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of UBA2 protein CTD PMID:34122009 NCBI chr 7:33,840,121...33,868,014
Ensembl chr 7:33,840,113...33,869,024 		JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 increases expression EXP Clozapine results in increased expression of UBA52 mRNA CTD PMID:14647396 NCBI chr 8:70,960,913...70,963,067
Ensembl chr 8:70,960,913...70,963,451 		JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 affects expression EXP Clozapine affects the expression of UBE2R2 mRNA CTD PMID:14647396 NCBI chr 4:41,136,021...41,193,370
Ensembl chr 4:41,135,743...41,193,380 		JBrowse link
G Ubtf upstream binding transcription factor, RNA polymerase I decreases expression ISO Clozapine results in decreased expression of UBTF protein CTD PMID:34122009 NCBI chr11:102,195,393...102,214,738
Ensembl chr11:102,195,386...102,210,568 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases expression ISO Clozapine results in increased expression of UGT1A1 mRNA CTD PMID:18227147 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 increases glucuronidation ISO UGT1A4 protein SNP results in increased glucuronidation of Clozapine CTD PMID:15708967 NCBI chr 1:88,093,734...88,147,724
Ensembl chr 1:88,093,734...88,146,719 		JBrowse link
G Unc13a unc-13 homolog A decreases expression ISO Clozapine results in decreased expression of UNC13A mRNA CTD PMID:15860345 NCBI chr 8:72,079,356...72,124,418
Ensembl chr 8:72,077,061...72,124,401 		JBrowse link
G Unc45b unc-45 myosin chaperone B increases expression ISO Clozapine results in increased expression of UNC45B protein CTD PMID:34122009 NCBI chr11:82,802,112...82,834,284
Ensembl chr11:82,801,376...82,834,229 		JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI affects expression EXP Clozapine affects the expression of UQCR11 mRNA CTD PMID:14647396 NCBI chr10:80,238,831...80,242,655
Ensembl chr10:80,238,831...80,242,664 		JBrowse link
G Usp34 ubiquitin specific peptidase 34 increases expression ISO Clozapine results in increased expression of USP34 protein CTD PMID:34122009 NCBI chr11:23,256,433...23,440,560
Ensembl chr11:23,256,895...23,440,560 		JBrowse link
G Usp5 ubiquitin specific peptidase 5 (isopeptidase T) increases expression ISO Clozapine results in increased expression of USP5 protein CTD PMID:34122009 NCBI chr 6:124,791,982...124,806,404
Ensembl chr 6:124,791,982...124,806,447 		JBrowse link
G Utp18 UTP18 small subunit processome component increases expression ISO Clozapine results in increased expression of UTP18 protein CTD PMID:34122009 NCBI chr11:93,750,069...93,776,592
Ensembl chr11:93,750,069...93,776,592 		JBrowse link
G Vamp1 vesicle-associated membrane protein 1 increases expression ISO Clozapine results in increased expression of VAMP1 mRNA CTD PMID:15860345 NCBI chr 6:125,192,544...125,199,269
Ensembl chr 6:125,192,514...125,222,927 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 increases expression ISO Clozapine results in increased expression of VAMP2 mRNA CTD PMID:15860345 NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210 		JBrowse link
G Vapa vesicle-associated membrane protein, associated protein A increases expression ISO Clozapine results in increased expression of VAPA protein CTD PMID:34122009 NCBI chr17:65,887,048...65,925,441
Ensembl chr17:65,885,322...65,920,550 		JBrowse link
G Vapb vesicle-associated membrane protein, associated protein B and C multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of VAPB protein CTD PMID:34122009 NCBI chr 2:173,579,378...173,626,132
Ensembl chr 2:173,579,304...173,626,132 		JBrowse link
G Vcl vinculin increases expression ISO Clozapine results in increased expression of VCL protein CTD PMID:34122009 NCBI chr14:20,979,436...21,083,744
Ensembl chr14:20,979,466...21,083,744 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Clozapine results in decreased expression of VDAC1 protein CTD PMID:34122009 NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224 		JBrowse link
G Vsnl1 visinin-like 1 decreases expression ISO Clozapine results in decreased expression of VSNL1 mRNA CTD PMID:12437575 NCBI chr12:11,375,258...11,486,579
Ensembl chr12:11,375,243...11,486,614 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of WARS1 protein CTD PMID:34122009 NCBI chr12:108,825,956...108,860,095
Ensembl chr12:108,825,956...108,860,100 		JBrowse link
G Wbp1l WW domain binding protein 1 like decreases expression EXP Clozapine results in decreased expression of WBP1L mRNA CTD PMID:14647396 NCBI chr19:46,587,545...46,645,828
Ensembl chr19:46,587,523...46,645,828 		JBrowse link
G Wdr12 WD repeat domain 12 decreases expression ISO Clozapine results in decreased expression of WDR12 protein CTD PMID:34122009 NCBI chr 1:60,110,520...60,137,659
Ensembl chr 1:60,108,944...60,137,804 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Clozapine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr11:109,464,347...109,502,215
Ensembl chr11:109,464,157...109,502,793 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide decreases expression EXP Clozapine results in decreased expression of YWHAB mRNA CTD PMID:17266109 NCBI chr 2:163,837,082...163,860,508
Ensembl chr 2:163,836,880...163,860,508 		JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta increases expression ISO Clozapine results in increased expression of YWHAQ protein CTD PMID:34122009 NCBI chr12:21,440,330...21,467,437
Ensembl chr12:21,440,072...21,467,638 		JBrowse link
G Zc3hav1 zinc finger CCCH type, antiviral 1 decreases expression ISO Clozapine results in decreased expression of ZC3HAV1 protein CTD PMID:34122009 NCBI chr 6:38,282,221...38,332,859
Ensembl chr 6:38,282,221...38,331,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    role 22167
      biological role 22166
        xenobiotic 19678
          clozapine 748
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    main group molecular entity 22108
                      s-block molecular entity 21708
                        hydrogen molecular entity 21626
                          hydrides 20762
                            inorganic hydride 18674
                              pnictogen hydride 18654
                                nitrogen hydride 18521
                                  azane 18428
                                    ammonia 18427
                                      organic amino compound 18427
                                        tertiary amino compound 10297
                                          N-alkylpiperazine 3389
                                            N-methylpiperazine 1394
                                              clozapine 748
paths to the root