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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10512
Species: Mus musculus
RGD Object: Gene
Symbol: Egr1
Name: early growth response 1
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egr1decreases expressionISOEgr1 (Rattus norvegicus)6480464CTDClozapine results in decreased expression of EGR1 mRNA; Clozapine results in decreased expression of EGR1 proteinPMID:17028028 PMID:18208916
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