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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10486
Species: Mus musculus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2affects bindingEXP 6480464CTDClozapine binds to DRD2 protein alternative formPMID:12476322
Drd2decreases expressionEXP 6480464CTDClozapine results in decreased expression of DRD2 mRNAPMID:17266109
Drd2multiple interactionsEXP 6480464CTD[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNAPMID:15781964
Drd2affects bindingISODrd2 (Rattus norvegicus)6480464CTDClozapine analog binds to DRD2 protein; Clozapine binds to DRD2 proteinPMID:11997696 PMID:9723970
Drd2affects bindingISODRD2 (Homo sapiens)6480464CTDClozapine binds to DRD2 proteinPMID:11997696 PMID:1352677
Drd2affects response to substanceISODrd2 (Rattus norvegicus)6480464CTDDRD2 protein affects the susceptibility to ClozapinePMID:11997696
Drd2affects response to substanceISODRD2 (Homo sapiens)6480464CTDDRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to ClozapinePMID:15830237 PMID:16278074
Drd2decreases expressionISODrd2 (Rattus norvegicus)6480464CTDClozapine results in decreased expression of DRD2 mRNAPMID:15781964
Drd2increases response to substanceISODRD2 (Homo sapiens)6480464CTDDRD2 gene SNP results in increased susceptibility to ClozapinePMID:20375926
Drd2multiple interactionsISODrd2 (Rattus norvegicus)6480464CTD[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]PMID:15716360 PMID:15781964 PMID:16033416 PMID:16144542
Drd2multiple interactionsISODRD2 (Homo sapiens)6480464CTD[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL proteinPMID:15286066
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