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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1624096
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c38
Name: cytochrome P450, family 2, subfamily c, polypeptide 38
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c38increases metabolic processingISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein results in increased metabolism of ClozapinePMID:18809730 PMID:27320963
Cyp2c38multiple interactionsISOCYP2C19 (Homo sapiens)6480464CTD[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to ClozapinePMID:23397584
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