Serpine2 (serine (or cysteine) peptidase inhibitor, clade E, member 2) - Rat Genome Database

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Gene: Serpine2 (serine (or cysteine) peptidase inhibitor, clade E, member 2) Mus musculus
Analyze
Symbol: Serpine2
Name: serine (or cysteine) peptidase inhibitor, clade E, member 2
RGD ID: 70077
MGI Page MGI
Description: Enables serine-type endopeptidase inhibitor activity and signaling receptor binding activity. Involved in negative regulation of plasminogen activation and negative regulation of platelet aggregation. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; negative regulation of protein metabolic process; and negative regulation of signal transduction. Located in extracellular region and neuromuscular junction. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; musculoskeletal system; and reproductive system. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B230326M24Rik; GDN; glia-derived nexin; ne; P; PAI-1; peptidase inhibitor 7; PI-7; PI7; PN; PN-1; protease nexin 1; protease nexin I; S; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine protease inhibitor 4; serine protease-inhibitor 4; serpin E2; Spi4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39179,772,038 - 79,836,382 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl179,771,914 - 79,838,897 (-)EnsemblGRCm39 Ensembl
GRCm38179,794,317 - 79,858,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl179,794,197 - 79,861,180 (-)EnsemblGRCm38mm10GRCm38
MGSCv37179,790,896 - 79,855,240 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36179,673,221 - 79,737,660 (-)NCBIMGSCv36mm8
Celera179,823,073 - 79,887,353 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map140.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-chloroethanol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
arsenite(3-)  (EXP,ISO)
azathioprine  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbendazim  (ISO)
carbon nanotube  (EXP)
chloroethene  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (EXP)
clofibrate  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
dinophysistoxin 1  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
etoposide  (EXP)
flutamide  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
inulin  (EXP)
irinotecan  (ISO)
isoflurane  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylseleninic acid  (ISO)
miconazole  (EXP)
mifepristone  (ISO)
Mitotane  (ISO)
Muraglitazar  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP)
paracetamol  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phosgene  (EXP)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
rosuvastatin calcium  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarpogrelate  (EXP)
SB 431542  (ISO)
serotonin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sotorasib  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
tebuconazole  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thifluzamide  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vorinostat  (ISO)
WIN 55212-2  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood coagulation  (IMP)
cell differentiation  (IEA)
cerebellar granular layer morphogenesis  (IMP)
dense core granule biogenesis  (ISO)
detection of mechanical stimulus involved in sensory perception  (IMP)
embryo implantation  (ISO)
innervation  (IMP)
long-term synaptic potentiation  (IMP)
mating plug formation  (IMP)
negative regulation of blood coagulation  (ISO)
negative regulation of cell growth  (IGI)
negative regulation of cell population proliferation  (IGI)
negative regulation of endopeptidase activity  (IBA)
negative regulation of peptidase activity  (IMP)
negative regulation of phosphatidylinositol 3-kinase signaling  (IGI)
negative regulation of plasminogen activation  (IBA,IMP,ISO)
negative regulation of platelet activation  (IMP)
negative regulation of platelet aggregation  (IMP)
negative regulation of protein catabolic process  (IMP,ISO)
negative regulation of protein processing  (IC)
negative regulation of proteolysis  (ISO)
negative regulation of smoothened signaling pathway  (IGI)
negative regulation of sodium ion transport  (IGI,IMP)
nervous system development  (IEA)
platelet activation  (IMP)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
protein catabolic process  (IMP)
regulation of synaptic transmission, glutamatergic  (IMP)
regulation of timing of cell differentiation  (IMP)
response to wounding  (IMP)
secretion by cell  (IMP,ISO)
secretory granule organization  (IMP,ISO)
seminal vesicle epithelium development  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The serpin protease-nexin 1 is present in rat aortic smooth muscle cells and is upregulated in L-NAME hypertensive rats. Bouton MC, etal., Arterioscler Thromb Vasc Biol 2003 Jan 1;23(1):142-7.
2. Protease nexin-1 is expressed at the mouse met-/mesencephalic junction and FGF signaling regulates its promoter activity in primary met-/mesencephalic cells. Kury P, etal., Development 1997 Mar;124(6):1251-62.
3. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. The glia-derived protease nexin 1 persists for over 1 year in rat brain areas selectively lesioned by transient global ischaemia. Nitsch C, etal., Eur J Neurosci. 1993 Mar 1;5(3):292-7.
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. Early embryonic expression of murine coagulation system components. Ong K, etal., Thromb Haemost 2000 Dec;84(6):1023-30.
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease. Wagner SL, etal., Proc Natl Acad Sci U S A. 1989 Nov;86(21):8284-8.
13. The expression and the role of protease nexin-1 on brain edema after intracerebral hemorrhage. Wu H, etal., J Neurol Sci. 2008 Jul 15;270(1-2):172-83. Epub 2008 Apr 28.
Additional References at PubMed
PMID:2037625   PMID:7529678   PMID:7665170   PMID:8306878   PMID:8491179   PMID:8835544   PMID:8889548   PMID:8906614   PMID:8943477   PMID:9169529   PMID:10349636   PMID:10888606  
PMID:10922068   PMID:10992299   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11248026   PMID:11698595   PMID:11700028   PMID:12208516   PMID:12477932   PMID:12617826   PMID:12713735  
PMID:14595844   PMID:14610273   PMID:14645112   PMID:14733957   PMID:15489334   PMID:15509702   PMID:15509762   PMID:15533830   PMID:15944188   PMID:16141072   PMID:16141073   PMID:16284245  
PMID:16319172   PMID:16602821   PMID:16697375   PMID:16921128   PMID:16941024   PMID:17082641   PMID:17409116   PMID:17409231   PMID:17631878   PMID:18199802   PMID:18398001   PMID:18676816  
PMID:18973469   PMID:19584287   PMID:19855083   PMID:19884258   PMID:20529116   PMID:20977773   PMID:21084713   PMID:21267068   PMID:21403095   PMID:21862448   PMID:21873635   PMID:22234688  
PMID:22331468   PMID:23041623   PMID:23661674   PMID:24006456   PMID:24023701   PMID:24154525   PMID:24155177   PMID:24172014   PMID:25138159   PMID:25901736   PMID:25939592   PMID:26109427  
PMID:27059719   PMID:27793045   PMID:28190767   PMID:28705898   PMID:28706437   PMID:29530978   PMID:30254103   PMID:30532990   PMID:31040226   PMID:31383642   PMID:32325033   PMID:32495984  
PMID:33410782   PMID:34183729   PMID:35008942   PMID:35273083   PMID:35815410   PMID:36417873  


Genomics

Comparative Map Data
Serpine2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39179,772,038 - 79,836,382 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl179,771,914 - 79,838,897 (-)EnsemblGRCm39 Ensembl
GRCm38179,794,317 - 79,858,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl179,794,197 - 79,861,180 (-)EnsemblGRCm38mm10GRCm38
MGSCv37179,790,896 - 79,855,240 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36179,673,221 - 79,737,660 (-)NCBIMGSCv36mm8
Celera179,823,073 - 79,887,353 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map140.97NCBI
SERPINE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,975,045 - 224,039,286 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2223,975,045 - 224,039,318 (-)EnsemblGRCh38hg38GRCh38
GRCh372224,839,762 - 224,904,003 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,548,118 - 224,612,237 (-)NCBINCBI36Build 36hg18NCBI36
Build 342224,665,383 - 224,729,498NCBI
Celera2218,605,681 - 218,669,944 (-)NCBICelera
Cytogenetic Map2q36.1NCBI
HuRef2216,691,512 - 216,755,073 (-)NCBIHuRef
CHM1_12224,846,268 - 224,910,507 (-)NCBICHM1_1
T2T-CHM13v2.02224,458,312 - 224,522,521 (-)NCBIT2T-CHM13v2.0
Serpine2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2981,124,746 - 81,188,866 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,124,804 - 81,188,826 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx989,554,492 - 89,618,567 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0994,683,384 - 94,747,462 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0993,065,906 - 93,129,981 (-)NCBIRnor_WKY
Rnor_6.0985,560,852 - 85,629,410 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl985,560,863 - 85,626,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0985,312,140 - 85,375,577 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4979,091,414 - 79,166,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1979,275,580 - 79,302,222 (-)NCBI
Celera978,614,628 - 78,678,321 (-)NCBICelera
Cytogenetic Map9q34NCBI
Serpine2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545310,027,104 - 10,076,645 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545310,049,822 - 10,076,155 (+)NCBIChiLan1.0ChiLan1.0
SERPINE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B126,610,192 - 126,636,992 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B111,221,317 - 111,285,491 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B229,797,659 - 229,854,027 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B229,797,655 - 229,861,040 (-)Ensemblpanpan1.1panPan2
SERPINE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13729,699,551 - 29,750,151 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3729,700,024 - 29,724,228 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3730,534,229 - 30,591,635 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03729,723,835 - 29,781,464 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13729,633,656 - 29,691,135 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03729,569,650 - 29,627,098 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03729,584,772 - 29,642,251 (-)NCBIUU_Cfam_GSD_1.0
Serpine2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303179,299,482 - 179,325,465 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365695,642,264 - 5,668,323 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365695,642,328 - 5,668,278 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15125,748,394 - 125,816,215 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115125,748,383 - 125,777,788 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215139,183,910 - 139,249,590 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110109,921,619 - 109,988,137 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10109,921,598 - 109,987,513 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604089,416,611 - 89,482,995 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpine2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248231,261,406 - 1,326,917 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248231,261,458 - 1,326,261 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serpine2
2418 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:294
Count of miRNA genes:244
Interacting mature miRNAs:273
Transcripts:ENSMUST00000027467, ENSMUST00000153862
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16588900688496101Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
4141625Emo4_memotionality 4 (mouse)Not determined6807134586235027Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
14697705Stsl3b_mSalmonella typhimurium susceptibility locus 3b (mouse)17413915981777715Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
1300821Lore1_mloss of righting induced by ethanol 1 (mouse)Not determined17554919192941077Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse
14696691Malq1_mmean attack latency QTL 1 (mouse)17797663787927722Mouse
14696693Avd2q1_mattack value day 2 QTL 1 (mouse)17897771790927722Mouse

Markers in Region
Serpine2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C4UniSTS
cM Map148.6UniSTS
D1Mit216  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38179,806,194 - 79,806,313UniSTSGRCm38
MGSCv37179,802,769 - 79,802,888UniSTSGRCm37
Celera179,834,941 - 79,835,060UniSTS
Cytogenetic Map1C4UniSTS
cM Map149.7UniSTS
Whitehead Genetic149.2UniSTS
Whitehead/MRC_RH11155.95UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006496459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC163657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC170750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM899460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY065983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000027467   ⟹   ENSMUSP00000027467
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl179,771,914 - 79,836,413 (-)Ensembl
GRCm38.p6 Ensembl179,794,197 - 79,858,696 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153862
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl179,792,825 - 79,836,413 (-)Ensembl
GRCm38.p6 Ensembl179,815,108 - 79,858,696 (-)Ensembl
RefSeq Acc Id: ENSMUST00000189793   ⟹   ENSMUSP00000140065
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl179,774,562 - 79,799,039 (-)Ensembl
GRCm38.p6 Ensembl179,796,845 - 79,821,322 (-)Ensembl
RefSeq Acc Id: ENSMUST00000190724   ⟹   ENSMUSP00000140255
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl179,780,752 - 79,838,897 (-)Ensembl
GRCm38.p6 Ensembl179,803,035 - 79,861,180 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191026
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl179,835,224 - 79,836,352 (-)Ensembl
GRCm38.p6 Ensembl179,857,507 - 79,858,635 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191529
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl179,794,629 - 79,798,021 (-)Ensembl
GRCm38.p6 Ensembl179,816,912 - 79,820,304 (-)Ensembl
RefSeq Acc Id: NM_009255   ⟹   NP_033281
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39179,772,038 - 79,836,382 (-)NCBI
GRCm38179,794,321 - 79,858,665 (-)NCBI
MGSCv37179,790,896 - 79,855,240 (-)RGD
Celera179,823,073 - 79,887,353 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006496459   ⟹   XP_006496522
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39179,772,038 - 79,836,229 (-)NCBI
GRCm38179,794,317 - 79,858,512 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033281   ⟸   NM_009255
- Peptide Label: precursor
- UniProtKB: Q921T7 (UniProtKB/Swiss-Prot),   Q07235 (UniProtKB/Swiss-Prot),   Q543R5 (UniProtKB/TrEMBL),   A0A8C6MXE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006496522   ⟸   XM_006496459
- Peptide Label: isoform X1
- UniProtKB: Q921T7 (UniProtKB/Swiss-Prot),   Q07235 (UniProtKB/Swiss-Prot),   Q543R5 (UniProtKB/TrEMBL),   A0A8C6MXE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027467   ⟸   ENSMUST00000027467
RefSeq Acc Id: ENSMUSP00000140255   ⟸   ENSMUST00000190724
RefSeq Acc Id: ENSMUSP00000140065   ⟸   ENSMUST00000189793
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07235-F1-model_v2 AlphaFold Q07235 1-397 view protein structure

Promoters
RGD ID:6818449
Promoter ID:MM_KWN:1303
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Lung,   MEF_B4
Transcripts:OTTMUST00000051625,   OTTMUST00000051626
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36179,854,734 - 79,855,234 (-)MPROMDB
RGD ID:6874210
Promoter ID:EPDNEW_M556
Type:multiple initiation site
Name:Serpine2_1
Description:Mus musculus serine peptidase inhibitor, clade E, member 2 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38179,858,636 - 79,858,696EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:101780 AgrOrtholog
Ensembl Genes ENSMUSG00000026249 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000027467 ENTREZGENE
  ENSMUSP00000027467.5 UniProtKB/Swiss-Prot
  ENSMUSP00000140065.2 UniProtKB/TrEMBL
  ENSMUSP00000140255.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027467 ENTREZGENE
  ENSMUST00000027467.11 UniProtKB/Swiss-Prot
  ENSMUST00000189793.7 UniProtKB/TrEMBL
  ENSMUST00000190724.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:101780 ENTREZGENE
NCBI Gene 20720 ENTREZGENE
PANTHER GLIA-DERIVED NEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Serpine2 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WQ70_MOUSE UniProtKB/TrEMBL
  A0A087WQM1_MOUSE UniProtKB/TrEMBL
  A0A8C6MXE2 ENTREZGENE
  GDN_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TWH7_MOUSE UniProtKB/TrEMBL
  Q4FJU1_MOUSE UniProtKB/TrEMBL
  Q543R5 ENTREZGENE, UniProtKB/TrEMBL
  Q921T7 ENTREZGENE
UniProt Secondary Q921T7 UniProtKB/Swiss-Prot