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Gene: Pde4b (phosphodiesterase 4B, cAMP specific) Mus musculus
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Symbol: Pde4b
Name: phosphodiesterase 4B, cAMP specific
Description: Exhibits 3',5'-cyclic-AMP phosphodiesterase activity; gamma-tubulin binding activity; and ion channel binding activity. Involved in several processes, including cellular response to epinephrine stimulus; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; and regulation of muscle system process. Localizes to several cellular components, including Z disc; microtubule organizing center; and voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and respiratory system. Orthologous to human PDE4B (phosphodiesterase 4B); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cAMP-specific 3',5'-cyclic phosphodiesterase 4B; Dpde4; dunce; phosphodiesterase 4B; R74983
Orthologs:
Homo sapiens (human) : PDE4B (phosphodiesterase 4B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pde4b (phosphodiesterase 4B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde4b (phosphodiesterase 4B)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE4B (phosphodiesterase 4B)
Canis lupus familiaris (dog) : PDE4B (phosphodiesterase 4B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde4b (phosphodiesterase 4B)
Sus scrofa (pig) : PDE4B (phosphodiesterase 4B)
Chlorocebus sabaeus (African green monkey) : PDE4B (phosphodiesterase 4B)
Heterocephalus glaber (naked mole-rat) : Pde4b (phosphodiesterase 4B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl4102,087,543 - 102,607,259 (+)EnsemblGRCm38mm10GRCm38
GRCm384102,087,332 - 102,607,275 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374101,927,347 - 102,279,867 (+)NCBIGRCm37mm9NCBIm37
MGSCv364101,752,935 - 102,103,771 (+)NCBImm8
Celera4100,608,595 - 100,971,313 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Pde4b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11065
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.