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Gene: Pde4b (phosphodiesterase 4B, cAMP specific) Mus musculus
Symbol: Pde4b
Name: phosphodiesterase 4B, cAMP specific
Description: Exhibits 3',5'-cyclic-AMP phosphodiesterase activity; gamma-tubulin binding activity; and ion channel binding activity. Involved in several processes, including cellular response to epinephrine stimulus; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; and regulation of muscle system process. Localizes to several cellular components, including Z disc; microtubule organizing center; and voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and respiratory system. Orthologous to human PDE4B (phosphodiesterase 4B); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cAMP-specific 3',5'-cyclic phosphodiesterase 4B; Dpde4; dunce; phosphodiesterase 4B; R74983
Homo sapiens (human) : PDE4B (phosphodiesterase 4B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pde4b (phosphodiesterase 4B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde4b (phosphodiesterase 4B)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE4B (phosphodiesterase 4B)
Canis lupus familiaris (dog) : PDE4B (phosphodiesterase 4B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde4b (phosphodiesterase 4B)
Sus scrofa (pig) : PDE4B (phosphodiesterase 4B)
Chlorocebus sabaeus (African green monkey) : PDE4B (phosphodiesterase 4B)
Heterocephalus glaber (naked mole-rat) : Pde4b (phosphodiesterase 4B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl4102,087,543 - 102,607,259 (+)EnsemblGRCm38mm10GRCm38
GRCm384102,087,332 - 102,607,275 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374101,927,347 - 102,279,867 (+)NCBIGRCm37mm9NCBIm37
MGSCv364101,752,935 - 102,103,771 (+)NCBImm8
Celera4100,608,595 - 100,971,313 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pde4b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11065
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.